Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
5ht1e_human 6 N-term C => S missense 8.944e-06 1 111810 0 0.27 0.002
5ht1e_human 7 N-term T => P missense 1.787e-05 2 111934 0 0.07 0.188
5ht1e_human 10 N-term A => V missense 8.865e-06 1 112798 0 0.28 0.01
5ht1e_human 18 1.28x28 TM1 T => I missense 8.617e-06 1 116054 0 0.26 0.02
5ht1e_human 21 1.31x31 TM1 E => K missense 8.51e-06 1 117510 0 0.51 0.078
5ht1e_human 32 1.42x42 TM1 I => V missense 8.269e-06 1 120928 0 0.43 0.024
5ht1e_human 37 1.47x47 TM1 T => M missense 4.126e-05 5 121170 0 0.21 0.002
5ht1e_human 45 1.55x55 TM1 M => T missense 8.248e-06 1 121248 0 0.64 0.0
5ht1e_human 46 1.56x56 TM1 A => S missense 8.248e-06 1 121248 0 0.04 1.0
5ht1e_human 53 12.50x50 ICL1 L => V missense 8.25e-06 1 121212 0 0.0 0.999
5ht1e_human 56 2.38x38 TM2 P => S missense 8.252e-06 1 121176 0 0.01 1.0
5ht1e_human 59 2.41x41 TM2 Y => H missense 8.255e-06 1 121132 0 0.0 1.0
5ht1e_human 60 2.42x42 TM2 L => V missense 8.258e-06 1 121102 0 0.0 0.999
5ht1e_human 66 2.48x48 TM2 V => M missense 7.44e-05 9 120966 0 0.03 1.0
5ht1e_human 69 2.51x51 TM2 L => F missense 3.308e-05 4 120916 0 0.17 0.075
5ht1e_human 75 2.57x56 TM2 V => I missense 8.272e-06 1 120888 0 0.0 0.999
5ht1e_human 86 2.68x67 TM2 D => G missense 8.262e-06 1 121042 0 0.54 0.02
5ht1e_human 87 23.49x49 ECL1 R => C missense 8.263e-06 1 121028 0 0.02 0.505
5ht1e_human 87 23.49x49 ECL1 R => H missense 2.478e-05 3 121060 0 0.06 0.329
5ht1e_human 93 3.23x23 TM3 F => V missense 1.65e-05 2 121176 0 1.0 0.002
5ht1e_human 109 3.39x39 TM3 S => F missense 8.251e-06 1 121198 0 0.0 1.0
5ht1e_human 110 3.40x40 TM3 I => V missense 8.251e-06 1 121200 0 0.0 0.999 SodiumPocket MicroSwitch
5ht1e_human 111 3.41x41 TM3 L => V missense 3.301e-05 4 121174 0 0.0 0.999
5ht1e_human 112 3.42x42 TM3 H => Q missense 8.257e-06 1 121116 0 0.0 1.0
5ht1e_human 122 3.52x52 TM3 W => R missense 8.291e-06 1 120612 0 0.33 0.105
5ht1e_human 131 34.54x54 ICL2 A => T missense 8.336e-06 1 119958 0 0.24 0.97 GP (contact)
5ht1e_human 135 4.38x38 TM4 T => M missense 4.182e-05 5 119562 0 0.0 0.998
5ht1e_human 137 4.40x40 TM4 K => R missense 4.184e-05 5 119500 0 0.94 0.007
5ht1e_human 140 4.43x43 TM4 A => T missense 1.676e-05 2 119338 0 0.02 0.212
5ht1e_human 140 4.43x43 TM4 A => V missense 3.355e-05 4 119238 0 0.01 0.008
5ht1e_human 143 4.46x46 TM4 I => V missense 2.513e-05 3 119382 0 0.29 0.029
5ht1e_human 143 4.46x46 TM4 I => F missense 8.376e-06 1 119382 0 0.0 0.831
5ht1e_human 145 4.48x48 TM4 T => A missense 8.379e-06 1 119346 0 0.28 0.06
5ht1e_human 145 4.48x48 TM4 T => I missense 8.384e-06 1 119268 0 0.42 0.015
5ht1e_human 146 4.49x49 TM4 V => I missense 6.703e-05 8 119354 0 0.03 0.958
5ht1e_human 146 4.49x49 TM4 V => F missense 8.378e-06 1 119354 0 0.0 0.996
5ht1e_human 146 4.49x49 TM4 V => A missense 8.375e-06 1 119402 0 0.21 0.955
5ht1e_human 149 4.52x52 TM4 I => N missense 8.373e-06 1 119436 0 0.0 0.971
5ht1e_human 155 4.58x58 TM4 M => V missense 0.0008274 99 119652 0 0.24 0.028
5ht1e_human 157 4.60x60 TM4 P => A missense 8.346e-06 1 119820 0 0.0 1.0
5ht1e_human 157 4.60x60 TM4 P => S missense 1.669e-05 2 119820 0 0.01 1.0
5ht1e_human 162 ECL2 S => N missense 8.324e-06 1 120140 0 0.59 0.001
5ht1e_human 162 ECL2 S => T missense 8.324e-06 1 120140 0 0.69 0.04
5ht1e_human 163 ECL2 H => Q missense 8.32e-06 1 120192 0 0.43 0.017
5ht1e_human 164 ECL2 R => C missense 8.32e-06 1 120188 0 0.02 0.717
5ht1e_human 164 ECL2 R => H missense 1.664e-05 2 120208 0 0.17 0.002
5ht1e_human 165 ECL2 R => C missense 2.495e-05 3 120260 0 0.03 0.016
5ht1e_human 165 ECL2 R => H missense 8.314e-06 1 120276 0 0.08 0.005
5ht1e_human 169 ECL2 P => L missense 8.304e-06 1 120422 0 0.08 0.027
5ht1e_human 170 ECL2 P => S missense 8.304e-06 1 120430 0 0.72 0.014
5ht1e_human 170 ECL2 P => T missense 8.304e-06 1 120430 0 0.57 0.158
5ht1e_human 170 ECL2 P => L missense 3.321e-05 4 120442 0 0.32 0.008
5ht1e_human 178 ECL2 D => N missense 8.298e-06 1 120514 0 0.05 0.262
5ht1e_human 187 5.43x44 TM5 T => M missense 2.491e-05 3 120456 0 0.0 1.0
5ht1e_human 190 5.46x461 TM5 A => V missense 8.297e-06 1 120522 0 0.0 1.0
5ht1e_human 198 5.54x54 TM5 I => T missense 8.268e-06 1 120942 0 0.0 0.992
5ht1e_human 203 5.59x59 TM5 Y => H missense 8.259e-06 1 121086 0 0.09 0.33
5ht1e_human 204 5.60x60 TM5 R => W missense 1.651e-05 2 121128 0 0.0 0.997
5ht1e_human 208 5.64x64 TM5 A => T missense 0.0009156 111 121236 1 0.02 1.0 GP (contact)
5ht1e_human 213 5.69x69 TM5 Y => H missense 8.241e-06 1 121346 0 0.22 0.997 GP (contact)
5ht1e_human 213 5.69x69 TM5 Y => C missense 8.241e-06 1 121348 0 0.06 0.997 GP (contact)
5ht1e_human 216 5.72x72 TM5 R => K missense 8.24e-06 1 121364 0 0.14 0.999 GP (contact)
5ht1e_human 220 5.76x76 TM5 R => Q missense 8.24e-06 1 121360 0 0.12 0.846
5ht1e_human 232 ICL3 S => Y missense 8.239e-06 1 121376 0 0.18 0.979
5ht1e_human 233 ICL3 F => L missense 8.239e-06 1 121380 0 0.73 0.326
5ht1e_human 236 ICL3 C => F missense 8.238e-06 1 121382 0 0.31 0.021
5ht1e_human 237 ICL3 K => R missense 8.238e-06 1 121386 0 1.0 0.009
5ht1e_human 251 ICL3 D => E missense 1.647e-05 2 121404 0 0.43 0.405
5ht1e_human 252 ICL3 P => R missense 2.471e-05 3 121404 0 0.08 0.914
5ht1e_human 253 ICL3 T => I missense 2.471e-05 3 121404 0 0.17 0.261
5ht1e_human 254 ICL3 T => A missense 8.237e-06 1 121404 0 0.53 0.05
5ht1e_human 262 ICL3 S => P missense 2.471e-05 3 121410 0 0.33 0.021
5ht1e_human 262 ICL3 S => F missense 0.001219 148 121412 0 0.03 0.739
5ht1e_human 266 ICL3 P => S missense 8.237e-06 1 121406 0 0.33 0.348
5ht1e_human 266 ICL3 P => L missense 8.236e-06 1 121412 0 0.14 0.09
5ht1e_human 267 ICL3 P => A missense 1.647e-05 2 121412 0 0.9 0.007
5ht1e_human 267 ICL3 P => H missense 0.0005271 64 121412 0 0.39 0.612
5ht1e_human 267 ICL3 P => R missense 0.0003047 37 121412 0 0.65 0.004
5ht1e_human 268 ICL3 F => I missense 8.236e-06 1 121412 0 0.37 0.005
5ht1e_human 269 ICL3 D => N missense 2.471e-05 3 121412 0 0.25 0.201
5ht1e_human 273 ICL3 D => Y missense 8.236e-06 1 121412 0 0.0 0.793
5ht1e_human 274 ICL3 H => L missense 3.295e-05 4 121412 0 0.33 0.0
5ht1e_human 278 ICL3 R => C missense 4.942e-05 6 121412 0 0.0 0.973
5ht1e_human 278 ICL3 R => H missense 1.647e-05 2 121410 0 0.0 0.973
5ht1e_human 282 6.26x26 TM6 S => P missense 8.237e-06 1 121410 0 0.05 0.33 GP (contact)
5ht1e_human 287 6.31x31 TM6 R => W missense 8.237e-06 1 121406 0 0.0 0.999
5ht1e_human 287 6.31x31 TM6 R => P missense 8.237e-06 1 121408 0 0.0 0.997
5ht1e_human 291 6.35x35 TM6 R => C missense 1.647e-05 2 121404 0 0.0 0.978
5ht1e_human 310 6.54x54 TM6 K => R missense 1.647e-05 2 121408 0 0.34 0.995
5ht1e_human 320 ECL3 T => P missense 8.237e-06 1 121406 0 0.23 0.005
5ht1e_human 321 ECL3 V => M missense 2.471e-05 3 121404 0 0.33 0.829
5ht1e_human 324 7.33x32 TM7 E => Q missense 3.295e-05 4 121402 0 0.37 0.091
5ht1e_human 327 7.36x35 TM7 D => E missense 8.238e-06 1 121384 0 0.03 0.734
5ht1e_human 341 7.50x50 TM7 P => L missense 8.266e-06 1 120984 0 0.0 1.0 SodiumPocket MicroSwitch
5ht1e_human 345 7.54x54 TM7 T => M missense 8.3e-06 1 120482 0 0.0 0.999
5ht1e_human 357 8.56x56 H8 K => E missense 8.51e-06 1 117502 0 0.0 0.26
5ht1e_human 361 C-term C => R missense 1.725e-05 2 115974 0 0.17 0.048
5ht1e_human 362 C-term R => Q missense 8.665e-06 1 115406 0 0.01 0.018
5ht1e_human 363 C-term E => A missense 0.0001565 18 115020 0 0.2 0.218
5ht1e_human 20 1.30x30 TM1 T => LeufsTer8 frameshift 1.712e-05 2 116800 0 None None
5ht1e_human 164 ECL2 R => AlafsTer3 frameshift 1.664e-05 2 120196 0 None None
5ht1e_human 254 ICL3 T => ArgfsTer3 frameshift 8.237e-06 1 121404 0 None None
5ht1e_human 268 ICL3 F => LeufsTer4 frameshift 3.295e-05 4 121408 0 None None
5ht1e_human 268 ICL3 F => SerfsTer5 frameshift 2.471e-05 3 121408 0 None None
5ht1e_human 311 6.55x55 TM6 E => Ter stop gained 8.237e-06 1 121408 0 None None
5ht1e_human 331 7.40x39 TM7 W => Ter stop gained 8.242e-06 1 121324 0 None None
5ht1e_human 342 7.51x51 TM7 L => ArgfsTer27 frameshift 8.274e-06 1 120854 0 None None
5ht1e_human 362 C-term R => Ter stop gained 5.2e-05 6 115382 0 None None


Residue

Diagrams

ICL1 K K L H ICL1ECL1 R W K L ECL1ICL2 A I E Y A R K R ICL2ECL2 R S H R R L S P P P S Q C T I Q H D ECL2ICL3 H L S N R S T D S Q N S F A S C K L T Q T F C V S D F S T S D P T T E F E K F H A S I R I P P F D N D L D H P G E R Q ICL3ECL3 I Y T V ECL3N-term M N I T N C T T E A S M A I R P K N-termC-term R C R E H T C-term T I T E K M L I C M T L V V I T T L T T L L N L A V I M A I G T T Q P A N Y L I C S L A V T D L L V A V L V M P L S I I Y I V M D G Y F L C E V W L S V D M T C C T C S I L H L C V I A L D R Y W A I T N T A K R A A L M I L T V W T I S I F I S M P P L F W H V I Y T I Y S T L G A F Y I P L T L I L I L Y Y R I Y H A A K S L Y Q K R G S S R Q I S S T R E R K A A R I L G L I L G A F I L S W L P F F I K E L I V G L S S S E V A D F L T W L G Y V N S L I N P L L Y T S F N E D F K K F K L A L I
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