Variation Browser
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Receptor |
Position |
GPCRdb |
Segment |
Variant |
Mutation type |
Allele Frequency |
Allele Count |
Allele Number |
Homozygotes |
SIFT score |
PolyPhen score |
Functional annotation |
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Receptor |
Position |
GPCRdb |
Segment |
Variant |
Mutation Type |
Allele Frequency |
Allele Count |
Allele Number |
Homozygotes |
SIFT score |
PolyPhen score |
Functional annotation |
5ht1e_human |
6 |
|
N-term |
C => S |
missense |
8.944e-06 |
1 |
111810 |
0 |
0.27 |
0.002 |
|
5ht1e_human |
7 |
|
N-term |
T => P |
missense |
1.787e-05 |
2 |
111934 |
0 |
0.07 |
0.188 |
|
5ht1e_human |
10 |
|
N-term |
A => V |
missense |
8.865e-06 |
1 |
112798 |
0 |
0.28 |
0.01 |
|
5ht1e_human |
18 |
1.28x28 |
TM1 |
T => I |
missense |
8.617e-06 |
1 |
116054 |
0 |
0.26 |
0.02 |
|
5ht1e_human |
21 |
1.31x31 |
TM1 |
E => K |
missense |
8.51e-06 |
1 |
117510 |
0 |
0.51 |
0.078 |
|
5ht1e_human |
32 |
1.42x42 |
TM1 |
I => V |
missense |
8.269e-06 |
1 |
120928 |
0 |
0.43 |
0.024 |
|
5ht1e_human |
37 |
1.47x47 |
TM1 |
T => M |
missense |
4.126e-05 |
5 |
121170 |
0 |
0.21 |
0.002 |
|
5ht1e_human |
45 |
1.55x55 |
TM1 |
M => T |
missense |
8.248e-06 |
1 |
121248 |
0 |
0.64 |
0.0 |
|
5ht1e_human |
46 |
1.56x56 |
TM1 |
A => S |
missense |
8.248e-06 |
1 |
121248 |
0 |
0.04 |
1.0 |
|
5ht1e_human |
53 |
12.50x50 |
ICL1 |
L => V |
missense |
8.25e-06 |
1 |
121212 |
0 |
0.0 |
0.999 |
|
5ht1e_human |
56 |
2.38x38 |
TM2 |
P => S |
missense |
8.252e-06 |
1 |
121176 |
0 |
0.01 |
1.0 |
|
5ht1e_human |
59 |
2.41x41 |
TM2 |
Y => H |
missense |
8.255e-06 |
1 |
121132 |
0 |
0.0 |
1.0 |
|
5ht1e_human |
60 |
2.42x42 |
TM2 |
L => V |
missense |
8.258e-06 |
1 |
121102 |
0 |
0.0 |
0.999 |
|
5ht1e_human |
66 |
2.48x48 |
TM2 |
V => M |
missense |
7.44e-05 |
9 |
120966 |
0 |
0.03 |
1.0 |
|
5ht1e_human |
69 |
2.51x51 |
TM2 |
L => F |
missense |
3.308e-05 |
4 |
120916 |
0 |
0.17 |
0.075 |
|
5ht1e_human |
75 |
2.57x56 |
TM2 |
V => I |
missense |
8.272e-06 |
1 |
120888 |
0 |
0.0 |
0.999 |
|
5ht1e_human |
86 |
2.68x67 |
TM2 |
D => G |
missense |
8.262e-06 |
1 |
121042 |
0 |
0.54 |
0.02 |
|
5ht1e_human |
87 |
23.49x49 |
ECL1 |
R => C |
missense |
8.263e-06 |
1 |
121028 |
0 |
0.02 |
0.505 |
|
5ht1e_human |
87 |
23.49x49 |
ECL1 |
R => H |
missense |
2.478e-05 |
3 |
121060 |
0 |
0.06 |
0.329 |
|
5ht1e_human |
93 |
3.23x23 |
TM3 |
F => V |
missense |
1.65e-05 |
2 |
121176 |
0 |
1.0 |
0.002 |
|
5ht1e_human |
109 |
3.39x39 |
TM3 |
S => F |
missense |
8.251e-06 |
1 |
121198 |
0 |
0.0 |
1.0 |
|
5ht1e_human |
110 |
3.40x40 |
TM3 |
I => V |
missense |
8.251e-06 |
1 |
121200 |
0 |
0.0 |
0.999 |
SodiumPocket MicroSwitch |
5ht1e_human |
111 |
3.41x41 |
TM3 |
L => V |
missense |
3.301e-05 |
4 |
121174 |
0 |
0.0 |
0.999 |
|
5ht1e_human |
112 |
3.42x42 |
TM3 |
H => Q |
missense |
8.257e-06 |
1 |
121116 |
0 |
0.0 |
1.0 |
|
5ht1e_human |
122 |
3.52x52 |
TM3 |
W => R |
missense |
8.291e-06 |
1 |
120612 |
0 |
0.33 |
0.105 |
|
5ht1e_human |
131 |
34.54x54 |
ICL2 |
A => T |
missense |
8.336e-06 |
1 |
119958 |
0 |
0.24 |
0.97 |
GP (contact) |
5ht1e_human |
135 |
4.38x38 |
TM4 |
T => M |
missense |
4.182e-05 |
5 |
119562 |
0 |
0.0 |
0.998 |
|
5ht1e_human |
137 |
4.40x40 |
TM4 |
K => R |
missense |
4.184e-05 |
5 |
119500 |
0 |
0.94 |
0.007 |
|
5ht1e_human |
140 |
4.43x43 |
TM4 |
A => T |
missense |
1.676e-05 |
2 |
119338 |
0 |
0.02 |
0.212 |
|
5ht1e_human |
140 |
4.43x43 |
TM4 |
A => V |
missense |
3.355e-05 |
4 |
119238 |
0 |
0.01 |
0.008 |
|
5ht1e_human |
143 |
4.46x46 |
TM4 |
I => V |
missense |
2.513e-05 |
3 |
119382 |
0 |
0.29 |
0.029 |
|
5ht1e_human |
143 |
4.46x46 |
TM4 |
I => F |
missense |
8.376e-06 |
1 |
119382 |
0 |
0.0 |
0.831 |
|
5ht1e_human |
145 |
4.48x48 |
TM4 |
T => A |
missense |
8.379e-06 |
1 |
119346 |
0 |
0.28 |
0.06 |
|
5ht1e_human |
145 |
4.48x48 |
TM4 |
T => I |
missense |
8.384e-06 |
1 |
119268 |
0 |
0.42 |
0.015 |
|
5ht1e_human |
146 |
4.49x49 |
TM4 |
V => I |
missense |
6.703e-05 |
8 |
119354 |
0 |
0.03 |
0.958 |
|
5ht1e_human |
146 |
4.49x49 |
TM4 |
V => F |
missense |
8.378e-06 |
1 |
119354 |
0 |
0.0 |
0.996 |
|
5ht1e_human |
146 |
4.49x49 |
TM4 |
V => A |
missense |
8.375e-06 |
1 |
119402 |
0 |
0.21 |
0.955 |
|
5ht1e_human |
149 |
4.52x52 |
TM4 |
I => N |
missense |
8.373e-06 |
1 |
119436 |
0 |
0.0 |
0.971 |
|
5ht1e_human |
155 |
4.58x58 |
TM4 |
M => V |
missense |
0.0008274 |
99 |
119652 |
0 |
0.24 |
0.028 |
|
5ht1e_human |
157 |
4.60x60 |
TM4 |
P => A |
missense |
8.346e-06 |
1 |
119820 |
0 |
0.0 |
1.0 |
|
5ht1e_human |
157 |
4.60x60 |
TM4 |
P => S |
missense |
1.669e-05 |
2 |
119820 |
0 |
0.01 |
1.0 |
|
5ht1e_human |
162 |
|
ECL2 |
S => N |
missense |
8.324e-06 |
1 |
120140 |
0 |
0.59 |
0.001 |
|
5ht1e_human |
162 |
|
ECL2 |
S => T |
missense |
8.324e-06 |
1 |
120140 |
0 |
0.69 |
0.04 |
|
5ht1e_human |
163 |
|
ECL2 |
H => Q |
missense |
8.32e-06 |
1 |
120192 |
0 |
0.43 |
0.017 |
|
5ht1e_human |
164 |
|
ECL2 |
R => C |
missense |
8.32e-06 |
1 |
120188 |
0 |
0.02 |
0.717 |
|
5ht1e_human |
164 |
|
ECL2 |
R => H |
missense |
1.664e-05 |
2 |
120208 |
0 |
0.17 |
0.002 |
|
5ht1e_human |
165 |
|
ECL2 |
R => C |
missense |
2.495e-05 |
3 |
120260 |
0 |
0.03 |
0.016 |
|
5ht1e_human |
165 |
|
ECL2 |
R => H |
missense |
8.314e-06 |
1 |
120276 |
0 |
0.08 |
0.005 |
|
5ht1e_human |
169 |
|
ECL2 |
P => L |
missense |
8.304e-06 |
1 |
120422 |
0 |
0.08 |
0.027 |
|
5ht1e_human |
170 |
|
ECL2 |
P => S |
missense |
8.304e-06 |
1 |
120430 |
0 |
0.72 |
0.014 |
|
5ht1e_human |
170 |
|
ECL2 |
P => T |
missense |
8.304e-06 |
1 |
120430 |
0 |
0.57 |
0.158 |
|
5ht1e_human |
170 |
|
ECL2 |
P => L |
missense |
3.321e-05 |
4 |
120442 |
0 |
0.32 |
0.008 |
|
5ht1e_human |
178 |
|
ECL2 |
D => N |
missense |
8.298e-06 |
1 |
120514 |
0 |
0.05 |
0.262 |
|
5ht1e_human |
187 |
5.43x44 |
TM5 |
T => M |
missense |
2.491e-05 |
3 |
120456 |
0 |
0.0 |
1.0 |
|
5ht1e_human |
190 |
5.46x461 |
TM5 |
A => V |
missense |
8.297e-06 |
1 |
120522 |
0 |
0.0 |
1.0 |
|
5ht1e_human |
198 |
5.54x54 |
TM5 |
I => T |
missense |
8.268e-06 |
1 |
120942 |
0 |
0.0 |
0.992 |
|
5ht1e_human |
203 |
5.59x59 |
TM5 |
Y => H |
missense |
8.259e-06 |
1 |
121086 |
0 |
0.09 |
0.33 |
|
5ht1e_human |
204 |
5.60x60 |
TM5 |
R => W |
missense |
1.651e-05 |
2 |
121128 |
0 |
0.0 |
0.997 |
|
5ht1e_human |
208 |
5.64x64 |
TM5 |
A => T |
missense |
0.0009156 |
111 |
121236 |
1 |
0.02 |
1.0 |
GP (contact) |
5ht1e_human |
213 |
5.69x69 |
TM5 |
Y => H |
missense |
8.241e-06 |
1 |
121346 |
0 |
0.22 |
0.997 |
GP (contact) |
5ht1e_human |
213 |
5.69x69 |
TM5 |
Y => C |
missense |
8.241e-06 |
1 |
121348 |
0 |
0.06 |
0.997 |
GP (contact) |
5ht1e_human |
216 |
5.72x72 |
TM5 |
R => K |
missense |
8.24e-06 |
1 |
121364 |
0 |
0.14 |
0.999 |
GP (contact) |
5ht1e_human |
220 |
5.76x76 |
TM5 |
R => Q |
missense |
8.24e-06 |
1 |
121360 |
0 |
0.12 |
0.846 |
|
5ht1e_human |
232 |
|
ICL3 |
S => Y |
missense |
8.239e-06 |
1 |
121376 |
0 |
0.18 |
0.979 |
|
5ht1e_human |
233 |
|
ICL3 |
F => L |
missense |
8.239e-06 |
1 |
121380 |
0 |
0.73 |
0.326 |
|
5ht1e_human |
236 |
|
ICL3 |
C => F |
missense |
8.238e-06 |
1 |
121382 |
0 |
0.31 |
0.021 |
|
5ht1e_human |
237 |
|
ICL3 |
K => R |
missense |
8.238e-06 |
1 |
121386 |
0 |
1.0 |
0.009 |
|
5ht1e_human |
251 |
|
ICL3 |
D => E |
missense |
1.647e-05 |
2 |
121404 |
0 |
0.43 |
0.405 |
|
5ht1e_human |
252 |
|
ICL3 |
P => R |
missense |
2.471e-05 |
3 |
121404 |
0 |
0.08 |
0.914 |
|
5ht1e_human |
253 |
|
ICL3 |
T => I |
missense |
2.471e-05 |
3 |
121404 |
0 |
0.17 |
0.261 |
|
5ht1e_human |
254 |
|
ICL3 |
T => A |
missense |
8.237e-06 |
1 |
121404 |
0 |
0.53 |
0.05 |
|
5ht1e_human |
262 |
|
ICL3 |
S => P |
missense |
2.471e-05 |
3 |
121410 |
0 |
0.33 |
0.021 |
|
5ht1e_human |
262 |
|
ICL3 |
S => F |
missense |
0.001219 |
148 |
121412 |
0 |
0.03 |
0.739 |
|
5ht1e_human |
266 |
|
ICL3 |
P => S |
missense |
8.237e-06 |
1 |
121406 |
0 |
0.33 |
0.348 |
|
5ht1e_human |
266 |
|
ICL3 |
P => L |
missense |
8.236e-06 |
1 |
121412 |
0 |
0.14 |
0.09 |
|
5ht1e_human |
267 |
|
ICL3 |
P => A |
missense |
1.647e-05 |
2 |
121412 |
0 |
0.9 |
0.007 |
|
5ht1e_human |
267 |
|
ICL3 |
P => H |
missense |
0.0005271 |
64 |
121412 |
0 |
0.39 |
0.612 |
|
5ht1e_human |
267 |
|
ICL3 |
P => R |
missense |
0.0003047 |
37 |
121412 |
0 |
0.65 |
0.004 |
|
5ht1e_human |
268 |
|
ICL3 |
F => I |
missense |
8.236e-06 |
1 |
121412 |
0 |
0.37 |
0.005 |
|
5ht1e_human |
269 |
|
ICL3 |
D => N |
missense |
2.471e-05 |
3 |
121412 |
0 |
0.25 |
0.201 |
|
5ht1e_human |
273 |
|
ICL3 |
D => Y |
missense |
8.236e-06 |
1 |
121412 |
0 |
0.0 |
0.793 |
|
5ht1e_human |
274 |
|
ICL3 |
H => L |
missense |
3.295e-05 |
4 |
121412 |
0 |
0.33 |
0.0 |
|
5ht1e_human |
278 |
|
ICL3 |
R => C |
missense |
4.942e-05 |
6 |
121412 |
0 |
0.0 |
0.973 |
|
5ht1e_human |
278 |
|
ICL3 |
R => H |
missense |
1.647e-05 |
2 |
121410 |
0 |
0.0 |
0.973 |
|
5ht1e_human |
282 |
6.26x26 |
TM6 |
S => P |
missense |
8.237e-06 |
1 |
121410 |
0 |
0.05 |
0.33 |
GP (contact) |
5ht1e_human |
287 |
6.31x31 |
TM6 |
R => W |
missense |
8.237e-06 |
1 |
121406 |
0 |
0.0 |
0.999 |
|
5ht1e_human |
287 |
6.31x31 |
TM6 |
R => P |
missense |
8.237e-06 |
1 |
121408 |
0 |
0.0 |
0.997 |
|
5ht1e_human |
291 |
6.35x35 |
TM6 |
R => C |
missense |
1.647e-05 |
2 |
121404 |
0 |
0.0 |
0.978 |
|
5ht1e_human |
310 |
6.54x54 |
TM6 |
K => R |
missense |
1.647e-05 |
2 |
121408 |
0 |
0.34 |
0.995 |
|
5ht1e_human |
320 |
|
ECL3 |
T => P |
missense |
8.237e-06 |
1 |
121406 |
0 |
0.23 |
0.005 |
|
5ht1e_human |
321 |
|
ECL3 |
V => M |
missense |
2.471e-05 |
3 |
121404 |
0 |
0.33 |
0.829 |
|
5ht1e_human |
324 |
7.33x32 |
TM7 |
E => Q |
missense |
3.295e-05 |
4 |
121402 |
0 |
0.37 |
0.091 |
|
5ht1e_human |
327 |
7.36x35 |
TM7 |
D => E |
missense |
8.238e-06 |
1 |
121384 |
0 |
0.03 |
0.734 |
|
5ht1e_human |
341 |
7.50x50 |
TM7 |
P => L |
missense |
8.266e-06 |
1 |
120984 |
0 |
0.0 |
1.0 |
SodiumPocket MicroSwitch |
5ht1e_human |
345 |
7.54x54 |
TM7 |
T => M |
missense |
8.3e-06 |
1 |
120482 |
0 |
0.0 |
0.999 |
|
5ht1e_human |
357 |
8.56x56 |
H8 |
K => E |
missense |
8.51e-06 |
1 |
117502 |
0 |
0.0 |
0.26 |
|
5ht1e_human |
361 |
|
C-term |
C => R |
missense |
1.725e-05 |
2 |
115974 |
0 |
0.17 |
0.048 |
|
5ht1e_human |
362 |
|
C-term |
R => Q |
missense |
8.665e-06 |
1 |
115406 |
0 |
0.01 |
0.018 |
|
5ht1e_human |
363 |
|
C-term |
E => A |
missense |
0.0001565 |
18 |
115020 |
0 |
0.2 |
0.218 |
|
5ht1e_human |
20 |
1.30x30 |
TM1 |
T => LeufsTer8 |
frameshift |
1.712e-05 |
2 |
116800 |
0 |
None |
None |
|
5ht1e_human |
164 |
|
ECL2 |
R => AlafsTer3 |
frameshift |
1.664e-05 |
2 |
120196 |
0 |
None |
None |
|
5ht1e_human |
254 |
|
ICL3 |
T => ArgfsTer3 |
frameshift |
8.237e-06 |
1 |
121404 |
0 |
None |
None |
|
5ht1e_human |
268 |
|
ICL3 |
F => LeufsTer4 |
frameshift |
3.295e-05 |
4 |
121408 |
0 |
None |
None |
|
5ht1e_human |
268 |
|
ICL3 |
F => SerfsTer5 |
frameshift |
2.471e-05 |
3 |
121408 |
0 |
None |
None |
|
5ht1e_human |
311 |
6.55x55 |
TM6 |
E => Ter |
stop gained |
8.237e-06 |
1 |
121408 |
0 |
None |
None |
|
5ht1e_human |
331 |
7.40x39 |
TM7 |
W => Ter |
stop gained |
8.242e-06 |
1 |
121324 |
0 |
None |
None |
|
5ht1e_human |
342 |
7.51x51 |
TM7 |
L => ArgfsTer27 |
frameshift |
8.274e-06 |
1 |
120854 |
0 |
None |
None |
|
5ht1e_human |
362 |
|
C-term |
R => Ter |
stop gained |
5.2e-05 |
6 |
115382 |
0 |
None |
None |
|
Residue
- deleterious missense variants are shown in red
- tolerated missense variants are shown in green
- loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue
Diagrams
SnakePlot Download:
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SVG
HelixBox Download:
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SVG