Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
5ht4r_human 375 C-term P => R missense 8.238e-06 1 121396 0 nan 0.132
5ht4r_human 366 C-term G => R missense 8.238e-06 1 121390 0 nan 0.021
5ht4r_human 362 C-term V => I missense 3.296e-05 4 121374 0 nan 0.029
5ht4r_human 356 C-term H => R missense 8.844e-06 1 113076 0 nan 0.865
5ht4r_human 352 C-term N => K missense 8.652e-06 1 115584 0 nan 0.967
5ht4r_human 350 C-term T => S missense 8.555e-06 1 116884 0 0.41 0.106
5ht4r_human 350 C-term T => A missense 2.564e-05 3 116998 0 0.04 0.452
5ht4r_human 349 C-term T => A missense 8.517e-06 1 117410 0 0.16 0.051
5ht4r_human 348 C-term T => N missense 8.495e-06 1 117718 0 0.06 0.049
5ht4r_human 343 C-term T => I missense 8.361e-06 1 119596 0 0.01 0.419
5ht4r_human 339 C-term I => S missense 8.295e-06 1 120560 0 0.2 0.011
5ht4r_human 333 C-term R => H missense 3.307e-05 4 120956 0 nan 0.039
5ht4r_human 333 C-term R => C missense 1.653e-05 2 120990 0 nan 0.91
5ht4r_human 332 C-term E => G missense 2.479e-05 3 121018 0 0.03 0.281
5ht4r_human 330 C-term D => E missense 8.261e-06 1 121054 0 0.05 0.253
5ht4r_human 322 8.53x53 H8 A => V missense 8.256e-06 1 121126 0 0.0 1.0
5ht4r_human 321 8.52x52 H8 R => H missense 1.651e-05 2 121120 0 0.04 0.087
5ht4r_human 321 8.52x52 H8 R => C missense 8.256e-05 10 121128 0 0.01 0.959
5ht4r_human 318 8.49x49 H8 S => C missense 1.651e-05 2 121148 0 0.02 0.952 GP (contact)
5ht4r_human 313 7.54x54 TM7 A => T missense 2.476e-05 3 121160 0 0.01 0.995
5ht4r_human 306 7.47x47 TM7 G => V missense 8.253e-06 1 121172 0 0.04 0.85
5ht4r_human 306 7.47x47 TM7 G => R missense 8.254e-06 1 121160 0 0.02 0.976
5ht4r_human 302 7.43x42 TM7 Y => F missense 2.475e-05 3 121188 0 0.0 1.0
5ht4r_human 291 7.32x31 TM7 G => R missense 8.251e-06 1 121202 0 0.51 0.043
5ht4r_human 283 6.59x59 TM6 P => L missense 8.251e-06 1 121196 0 0.0 1.0
5ht4r_human 279 6.55x55 TM6 N => S missense 2.476e-05 3 121182 0 0.0 1.0
5ht4r_human 278 6.54x54 TM6 T => S missense 8.251e-06 1 121196 0 0.05 0.879
5ht4r_human 277 6.53x53 TM6 V => I missense 8.252e-06 1 121180 0 0.97 0.024
5ht4r_human 263 6.39x39 TM6 I => N missense 9.077e-05 11 121182 0 0.0 0.988
5ht4r_human 260 6.36x36 TM6 T => N missense 6.602e-05 8 121180 1 0.0 1.0 GP (contact)
5ht4r_human 260 6.36x36 TM6 T => A missense 8.252e-06 1 121178 0 0.0 1.0 GP (contact)
5ht4r_human 258 6.34x34 TM6 A => T missense 8.253e-06 1 121162 0 0.0 1.0 SodiumPocket MicroSwitch
5ht4r_human 255 6.31x31 TM6 T => I missense 8.253e-06 1 121172 0 0.0 0.992
5ht4r_human 253 6.29x29 TM6 T => I missense 8.253e-06 1 121168 0 0.13 0.102 GP (contact)
5ht4r_human 252 6.28x28 TM6 R => K missense 8.254e-06 1 121148 0 0.96 0.02 GP (contact)
5ht4r_human 250 6.26x26 TM6 R => H missense 6.603e-05 8 121160 0 0.04 0.993 GP (contact)
5ht4r_human 250 6.26x26 TM6 R => C missense 2.476e-05 3 121160 0 0.0 0.993 GP (contact)
5ht4r_human 247 ICL3 S => N missense 6.603e-05 8 121152 0 0.44 0.008
5ht4r_human 246 ICL3 H => R missense 8.255e-06 1 121146 0 0.27 0.036
5ht4r_human 246 ICL3 H => Y missense 8.254e-06 1 121148 0 0.01 0.745
5ht4r_human 244 ICL3 D => E missense 8.254e-06 1 121154 0 0.31 0.02
5ht4r_human 243 ICL3 A => S missense 4.128e-05 5 121120 0 0.63 0.023
5ht4r_human 242 ICL3 S => L missense 2.477e-05 3 121134 0 0.17 0.108
5ht4r_human 237 ICL3 E => K missense 0.0001816 22 121126 0 0.39 0.166
5ht4r_human 232 ICL3 A => S missense 2.477e-05 3 121118 0 0.05 0.783
5ht4r_human 231 ICL3 R => Q missense 1.651e-05 2 121114 0 0.04 0.842
5ht4r_human 231 ICL3 R => W missense 0.0001899 23 121102 0 0.0 0.996
5ht4r_human 230 5.76x76 TM5 Q => R missense 8.256e-06 1 121122 0 0.0 0.881
5ht4r_human 228 5.74x74 TM5 M => I missense 1.651e-05 2 121106 0 0.22 0.005 GP (contact)
5ht4r_human 228 5.74x74 TM5 M => T missense 8.258e-06 1 121102 0 0.76 0.012 GP (contact)
5ht4r_human 218 5.64x64 TM5 T => I missense 8.263e-06 1 121016 0 0.02 0.844 GP (contact)
5ht4r_human 217 5.63x63 TM5 V => I missense 8.265e-06 1 120990 0 0.29 0.03
5ht4r_human 216 5.62x62 TM5 Y => C missense 8.266e-06 1 120976 0 0.0 0.999
5ht4r_human 214 5.60x60 TM5 R => H missense 2.481e-05 3 120918 0 0.0 0.994
5ht4r_human 214 5.60x60 TM5 R => C missense 4.962e-05 6 120912 0 0.0 0.997
5ht4r_human 208 5.54x54 TM5 M => V missense 8.282e-06 1 120746 0 0.0 0.944
5ht4r_human 204 5.50x50 TM5 P => L missense 8.29e-06 1 120620 0 0.0 1.0 SodiumPocket MicroSwitch
5ht4r_human 203 5.49x49 TM5 I => F missense 8.293e-06 1 120580 0 0.02 0.071
5ht4r_human 200 5.46x461 TM5 A => V missense 8.307e-06 1 120386 0 0.0 0.998
5ht4r_human 199 5.45x46 TM5 V => A missense 8.312e-06 1 120304 0 0.0 0.973
5ht4r_human 195 5.41x42 TM5 T => I missense 1.668e-05 2 119922 0 0.7 0.071
5ht4r_human 191 5.37x38 TM5 P => H missense 8.387e-06 1 119238 0 0.01 0.997
5ht4r_human 191 5.37x38 TM5 P => T missense 8.389e-06 1 119198 0 0.13 0.99
5ht4r_human 187 ECL2 M => T missense 9.323e-05 11 117986 0 0.0 0.9
5ht4r_human 187 ECL2 M => L missense 8.477e-06 1 117968 0 0.88 0.042
5ht4r_human 183 ECL2 Y => H missense 1.732e-05 2 115462 0 0.41 0.024
5ht4r_human 182 ECL2 T => M missense 0.0002433 28 115106 0 0.06 0.99
5ht4r_human 182 ECL2 T => A missense 8.745e-06 1 114354 0 0.09 0.771
5ht4r_human 177 ECL2 Q => H missense 9.103e-06 1 109854 0 0.18 0.008
5ht4r_human 174 ECL2 K => T missense 2.856e-05 3 105054 0 0.17 0.568
5ht4r_human 173 ECL2 R => K missense 7.692e-05 8 104004 0 0.17 0.348
5ht4r_human 172 ECL2 K => R missense 9.744e-06 1 102630 0 0.33 0.038
5ht4r_human 158 4.62x62 TM4 M => T missense 8.263e-06 1 121026 0 0.0 0.735
5ht4r_human 150 4.54x54 TM4 T => M missense 5.786e-05 7 120986 0 0.27 0.044
5ht4r_human 149 4.53x53 TM4 P => S missense 1.653e-05 2 120980 0 0.05 1.0
5ht4r_human 148 4.52x52 TM4 I => V missense 8.265e-06 1 120988 0 0.31 0.091
5ht4r_human 143 4.47x47 TM4 G => V missense 8.268e-06 1 120944 0 0.4 0.091
5ht4r_human 140 4.44x44 TM4 L => S missense 8.273e-06 1 120878 0 0.0 0.597
5ht4r_human 139 4.43x43 TM4 A => T missense 8.276e-06 1 120830 0 0.22 0.08
5ht4r_human 137 4.41x41 TM4 R => H missense 4.14e-05 5 120774 0 0.03 0.189
5ht4r_human 137 4.41x41 TM4 R => P missense 8.28e-06 1 120774 0 0.01 0.979
5ht4r_human 137 4.41x41 TM4 R => C missense 1.656e-05 2 120782 0 0.0 0.973
5ht4r_human 135 4.39x39 TM4 P => R missense 8.282e-06 1 120750 0 0.22 0.962
5ht4r_human 131 34.55x55 ICL2 N => K missense 8.293e-06 1 120588 0 0.28 0.232 GP (contact)
5ht4r_human 123 3.55x55 TM3 C => W missense 8.356e-06 1 119670 0 0.0 1.0 GP (contact)
5ht4r_human 121 3.53x53 TM3 A => T missense 8.399e-06 1 119064 0 0.0 0.984 GP (contact)
5ht4r_human 117 3.49x49 TM3 D => G missense 1.636e-05 1 61124 0 0.0 0.994 SodiumPocket MicroSwitch
5ht4r_human 107 3.39x39 TM3 S => L missense 1.245e-05 1 80290 0 0.0 1.0
5ht4r_human 105 3.37x37 TM3 T => M missense 2.319e-05 2 86236 0 0.0 1.0
5ht4r_human 96 3.28x28 TM3 R => Q missense 9.686e-06 1 103240 0 0.15 0.984
5ht4r_human 96 3.28x28 TM3 R => W missense 9.596e-06 1 104214 0 0.22 0.534
5ht4r_human 95 3.27x27 TM3 V => I missense 9.386e-06 1 106536 0 0.35 0.107
5ht4r_human 93 3.25x25 TM3 C => R missense 9.067e-06 1 110288 0 0.0 1.0
5ht4r_human 92 3.24x24 TM3 F => C missense 8.994e-06 1 111190 0 0.0 0.998
5ht4r_human 88 23.52x52 ECL1 Y => H missense 8.62e-06 1 116006 0 0.05 0.733
5ht4r_human 85 23.49x49 ECL1 I => V missense 8.431e-06 1 118604 0 0.5 0.004
5ht4r_human 77 2.61x60 TM2 G => R missense 1.662e-05 2 120366 0 0.0 0.992
5ht4r_human 75 2.59x58 TM2 P => T missense 8.303e-06 1 120436 0 0.05 0.545
5ht4r_human 71 2.55x55 TM2 V => A missense 8.305e-06 1 120416 0 0.0 0.578
5ht4r_human 70 2.54x54 TM2 S => L missense 8.312e-06 1 120312 0 0.0 0.806
5ht4r_human 65 2.49x49 TM2 A => V missense 2.508e-05 3 119628 0 0.0 1.0
5ht4r_human 65 2.49x49 TM2 A => E missense 8.359e-06 1 119628 0 0.0 1.0
5ht4r_human 62 2.46x46 TM2 L => P missense 8.435e-06 1 118548 0 0.0 1.0
5ht4r_human 44 1.57x57 TM1 V => M missense 8.268e-06 1 120954 0 0.0 0.995
5ht4r_human 42 1.55x55 TM1 V => A missense 8.262e-06 1 121040 0 0.11 0.585
5ht4r_human 32 1.45x45 TM1 M => T missense 8.245e-06 1 121282 0 0.15 0.669
5ht4r_human 27 1.40x40 TM1 S => L missense 0.0001979 24 121294 0 0.08 0.265
5ht4r_human 24 1.37x37 TM1 T => M missense 0.0002556 31 121302 0 0.23 0.025
5ht4r_human 16 1.29x29 TM1 S => T missense 1.649e-05 2 121290 0 0.42 0.098
5ht4r_human 15 N-term G => R missense 0.0008081 98 121276 1 0.15 0.006
5ht4r_human 9 N-term S => N missense 8.265e-06 1 120992 0 0.05 0.005
5ht4r_human 7 N-term N => K missense 8.262e-06 1 121030 0 nan 0.055
5ht4r_human 7 N-term N => K missense 1.652e-05 2 121030 0 nan 0.055
5ht4r_human 5 N-term D => E missense 8.261e-06 1 121052 0 nan 0.005
5ht4r_human 335 C-term R => Ter stop gained 8.272e-06 1 120894 0 None None
5ht4r_human 261 6.37x37 TM6 L => CysfsTer25 frameshift 8.252e-06 1 121182 0 None None GP (contact)
5ht4r_human 93 3.25x25 TM3 C => Ter stop gained 9.166e-06 1 109098 0 None None
5ht4r_human 74 2.58x57 TM2 M => LeufsTer19 frameshift 0.0001588 19 119634 1 None None
5ht4r_human 66 2.50x50 TM2 D => Ter stop gained 0.0002789 3 10758 0 None None


Residue

Diagrams

ICL1 R Q L R ICL1ECL1 I W I Y ECL1ICL2 P Q L V Y R N K M ICL2ECL2 Q G W N N I G I I D L I E K R K F N Q N S N S T Y C V F M V ECL2ICL3 R A G A S S E S R P Q S A D Q H S ICL3ECL3 D Y T V ECL3N-term M D K L D A N V S S E E G F G N-termC-term C D D E R Y R R P S I L G Q T V P C S T T T I N G S T H V L R D A V E C G G Q W E S Q C H P P A T S P L V A A Q P S D T C-term S V E K V V L L T F L S T V I L M A I L G N L L V M V A V C W D K I K T N Y F I V S L A F A D L L V S V L V M P F G A I E L V Q D G E V F C L V R T S L D V L L T T A S I F H L C C I S L D R Y Y A I C C T P L R I A L M L G G C W V I P T F I S F L P I M N K P Y A I T C S V V A F Y I P F L L M V L A Y Y R I Y V T A K E H A H Q I Q M L Q T H R M R T E T K A A K T L C I I M G C F C L C W A P F F V T N I V D P F I P G Q V W T A F L W L G Y I N S G L N P F L Y A F L N K S F L I F R R A I L C
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