Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
aa2ar_human 28 1.54x54 TM1 C => ValfsTer74 frameshift 1.655e-05 2 120810 0 None None
aa2ar_human 138 4.59x59 TM4 T => SerfsTer31 frameshift 8.433e-06 1 118582 0 None None
aa2ar_human 179 5.40x411 TM5 Y => GlufsTer156 frameshift 8.238e-06 1 121388 0 None None
aa2ar_human 197 5.58x58 TM5 Y => LeufsTer134 frameshift 8.237e-06 1 121398 0 None None SodiumPocket MicroSwitch
aa2ar_human 206 5.67x67 TM5 R => Ter stop gained 1.648e-05 2 121378 0 None None GP (contact)
aa2ar_human 382 C-term D => ArgfsTer6 frameshift 1.971e-05 2 101496 0 None None
aa2ar_human 412 C-term S => LeufsTer36 frameshift 1.984e-05 2 100828 0 None None
aa2ar_human 4 1.30x30 TM1 M => T missense 0.0001264 10 79096 0 nan 0.0
aa2ar_human 6 1.32x32 TM1 S => F missense 1.138e-05 1 87846 0 0.06 0.005
aa2ar_human 7 1.33x33 TM1 S => L missense 1.084e-05 1 92226 0 0.26 0.0
aa2ar_human 8 1.34x34 TM1 V => A missense 1.998e-05 2 100104 0 nan 0.002
aa2ar_human 15 1.41x41 TM1 A => T missense 8.653e-05 10 115572 0 nan 0.004
aa2ar_human 21 1.47x47 TM1 I => V missense 3.34e-05 4 119762 0 nan 0.0
aa2ar_human 23 1.49x49 TM1 G => D missense 8.312e-06 1 120308 0 0.0 1.0
aa2ar_human 24 1.50x50 TM1 N => S missense 8.296e-06 1 120538 0 0.0 0.99
aa2ar_human 28 1.54x54 TM1 C => S missense 8.271e-06 1 120902 0 0.0 0.567
aa2ar_human 33 1.59x59 TM1 L => R missense 8.255e-06 1 121132 0 0.03 0.002
aa2ar_human 40 2.38x38 TM2 V => I missense 0.0001897 23 121232 0 0.21 0.038
aa2ar_human 49 2.47x47 TM2 A => V missense 4.129e-05 5 121102 0 0.0 0.999
aa2ar_human 50 2.48x48 TM2 A => V missense 0.00253 306 120926 7 1.0 0.0
aa2ar_human 52 2.50x50 TM2 D => N missense 8.255e-06 1 121142 0 0.0 1.0
aa2ar_human 54 2.52x52 TM2 A => T missense 8.254e-06 1 121152 0 0.01 0.893
aa2ar_human 59 2.57x56 TM2 A => T missense 8.252e-06 1 121190 0 0.0 0.33
aa2ar_human 60 2.58x57 TM2 I => V missense 8.25e-06 1 121210 0 0.06 0.039
aa2ar_human 66 2.64x63 TM2 I => V missense 8.247e-06 1 121258 0 0.05 0.063 LB (hydrophobic, Van der Waals, polar (hydrogen bond), polar (hydrogen bond with backbone))
aa2ar_human 67 2.65x64 TM2 S => R missense 8.246e-06 1 121268 0 0.0 0.672 LB (Van der Waals, polar (hydrogen bond), polar (hydrogen bond with backbone))
aa2ar_human 68 2.66x65 TM2 T => I missense 8.246e-06 1 121270 0 0.33 0.001 LB (Van der Waals)
aa2ar_human 69 2.67x66 TM2 G => R missense 1.649e-05 2 121274 0 0.0 0.996
aa2ar_human 72 23.52x52 ECL1 A => T missense 2.474e-05 3 121270 0 0.68 0.028
aa2ar_human 72 23.52x52 ECL1 A => V missense 8.245e-06 1 121284 0 0.25 0.047
aa2ar_human 88 3.36x36 TM3 T => R missense 1.649e-05 2 121322 0 0.0 0.999 LB (polar (hydrogen bond), Van der Waals)
aa2ar_human 89 3.37x37 TM3 Q => H missense 8.242e-06 1 121326 0 0.0 0.932 LB (Van der Waals)
aa2ar_human 102 3.50x50 TM3 R => H missense 8.263e-06 1 121024 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
aa2ar_human 105 3.53x53 TM3 A => T missense 8.287e-06 1 120670 0 0.04 0.447 GP (contact)
aa2ar_human 107 3.55x55 TM3 R => C missense 1.665e-05 2 120156 0 0.01 0.007 GP (contact)
aa2ar_human 111 34.52x52 ICL2 R => W missense 8.457e-06 1 118246 0 0.0 0.636 GP (contact)
aa2ar_human 116 34.57x57 ICL2 V => M missense 9.016e-06 1 110914 0 0.05 0.697 GP (contact)
aa2ar_human 121 4.42x42 TM4 A => S missense 8.964e-06 1 111552 0 0.0 0.966
aa2ar_human 123 4.44x44 TM4 G => D missense 8.929e-06 1 111996 0 0.2 0.579
aa2ar_human 125 4.46x46 TM4 I => T missense 8.884e-06 1 112566 0 0.0 0.98
aa2ar_human 130 4.51x51 TM4 V => M missense 3.51e-05 4 113958 0 0.03 0.59
aa2ar_human 136 4.57x57 TM4 G => S missense 1.702e-05 2 117524 0 0.0 0.977
aa2ar_human 140 4.61x61 TM4 M => I missense 8.354e-06 1 119696 0 0.01 0.091
aa2ar_human 141 4.62x62 TM4 L => Q missense 4.171e-05 5 119886 0 0.0 0.947
aa2ar_human 147 ECL2 G => S missense 0.004117 497 120706 9 1.0 0.001
aa2ar_human 147 ECL2 G => C missense 2.485e-05 3 120706 0 0.04 0.487
aa2ar_human 148 ECL2 Q => R missense 4.138e-05 5 120844 0 0.49 0.002
aa2ar_human 156 ECL2 S => T missense 8.251e-06 1 121200 0 0.33 0.001
aa2ar_human 158 ECL2 G => S missense 8.247e-06 1 121262 0 1.0 0.001
aa2ar_human 160 ECL2 G => R missense 0.0001814 22 121292 0 0.5 0.001
aa2ar_human 161 ECL2 E => K missense 8.243e-06 1 121320 0 0.57 0.001
aa2ar_human 165 ECL2 A => S missense 2.472e-05 3 121360 0 0.61 0.032
aa2ar_human 174 5.35x37 TM5 M => V missense 8.238e-06 1 121388 0 0.0 0.508 LB (hydrophobic, polar (hydrogen bond), Van der Waals)
aa2ar_human 179 5.40x411 TM5 Y => H missense 8.237e-06 1 121404 0 0.0 0.728
aa2ar_human 184 5.45x46 TM5 A => T missense 8.237e-05 10 121402 0 0.11 0.294
aa2ar_human 186 5.47x47 TM5 V => M missense 8.237e-06 1 121402 0 0.0 0.912 SodiumPocket MicroSwitch LB (polar (hydrogen bond))
aa2ar_human 192 5.53x53 TM5 L => P missense 8.237e-06 1 121398 0 0.0 0.918
aa2ar_human 199 5.60x60 TM5 R => W missense 8.238e-06 1 121396 0 0.02 0.055
aa2ar_human 199 5.60x60 TM5 R => Q missense 2.471e-05 3 121394 0 0.04 0.049
aa2ar_human 203 5.64x64 TM5 A => V missense 1.648e-05 2 121382 0 1.0 0.109 GP (contact)
aa2ar_human 205 5.66x66 TM5 R => Q missense 1.648e-05 2 121380 0 0.03 0.598 GP (contact)
aa2ar_human 206 5.67x67 TM5 R => Q missense 4.119e-05 5 121380 0 0.08 0.052 GP (contact)
aa2ar_human 212 5.73x73 TM5 E => K missense 8.238e-06 1 121382 0 0.15 0.006
aa2ar_human 215 ICL3 P => L missense 8.239e-06 1 121380 0 0.38 0.001
aa2ar_human 217 ICL3 P => L missense 8.239e-06 1 121370 0 0.16 0.025
aa2ar_human 217 ICL3 P => R missense 8.239e-06 1 121370 0 0.33 0.014
aa2ar_human 220 6.22x22 TM6 R => Q missense 8.239e-06 1 121378 0 0.09 0.011
aa2ar_human 222 6.24x24 TM6 R => G missense 8.239e-06 1 121374 0 0.03 0.076
aa2ar_human 222 6.24x24 TM6 R => W missense 8.239e-06 1 121374 0 0.0 0.971
aa2ar_human 222 6.24x24 TM6 R => Q missense 8.239e-06 1 121380 0 0.14 0.153
aa2ar_human 228 6.30x30 TM6 E => D missense 1.648e-05 2 121384 0 0.02 0.519 SodiumPocket MicroSwitch
aa2ar_human 229 6.31x31 TM6 V => I missense 8.238e-06 1 121384 0 0.41 0.016
aa2ar_human 242 6.44x44 TM6 F => S missense 8.238e-06 1 121386 0 0.0 1.0 SodiumPocket MicroSwitch
aa2ar_human 249 6.51x51 TM6 L => P missense 8.238e-06 1 121392 0 0.0 0.997 LB (hydrophobic, Van der Waals, polar (hydrogen bond))
aa2ar_human 261 ECL3 D => N missense 1.648e-05 2 121384 0 0.5 0.0
aa2ar_human 262 ECL3 C => G missense 8.238e-06 1 121390 0 0.02 0.238
aa2ar_human 265 ECL3 A => T missense 8.238e-06 1 121384 0 0.44 0.03
aa2ar_human 270 7.35x34 TM7 M => T missense 1.648e-05 2 121386 0 0.05 0.5 LB (hydrophobic, Van der Waals, polar (hydrogen bond))
aa2ar_human 273 7.38x37 TM7 A => G missense 8.239e-06 1 121378 0 0.16 0.008
aa2ar_human 275 7.40x39 TM7 V => I missense 0.0001895 23 121372 0 1.0 0.001
aa2ar_human 280 7.45x45 TM7 N => S missense 8.24e-06 1 121362 0 0.0 0.948
aa2ar_human 281 7.46x46 TM7 S => L missense 8.24e-06 1 121356 0 0.0 1.0
aa2ar_human 290 7.55x55 TM7 Y => F missense 2.473e-05 3 121312 0 0.42 0.011 GP (contact)
aa2ar_human 291 7.56x56 TM7 R => C missense 1.649e-05 2 121314 0 0.0 0.977 GP (contact)
aa2ar_human 291 7.56x56 TM7 R => H missense 8.243e-06 1 121316 0 0.03 0.118 GP (contact)
aa2ar_human 293 8.48x48 H8 R => C missense 7.419e-05 9 121312 0 0.0 0.936 GP (contact)
aa2ar_human 294 8.49x49 H8 E => D missense 8.244e-06 1 121304 0 0.43 0.001 GP (contact)
aa2ar_human 295 8.50x50 H8 F => L missense 8.244e-06 1 121302 0 0.0 0.926
aa2ar_human 296 8.51x51 H8 R => H missense 2.473e-05 3 121300 0 0.02 0.719 GP (contact)
aa2ar_human 300 8.55x55 H8 R => H missense 2.474e-05 3 121280 0 0.32 0.001
aa2ar_human 300 8.55x55 H8 R => L missense 8.245e-06 1 121280 0 0.33 0.011
aa2ar_human 304 8.59x59 H8 R => C missense 8.249e-06 1 121226 0 0.01 0.014
aa2ar_human 304 8.59x59 H8 R => H missense 7.425e-05 9 121210 0 0.11 0.001
aa2ar_human 306 8.61x61 H8 H => R missense 8.253e-06 1 121166 0 0.06 0.001
aa2ar_human 306 8.61x61 H8 H => Q missense 8.255e-06 1 121136 0 0.03 0.008
aa2ar_human 307 8.62x62 H8 V => I missense 1.651e-05 2 121134 0 1.0 0.0
aa2ar_human 308 8.63x63 H8 L => P missense 3.303e-05 4 121108 0 0.0 0.517
aa2ar_human 309 8.64x64 H8 R => K missense 8.258e-06 1 121090 0 1.0 0.002
aa2ar_human 320 C-term S => N missense 8.319e-06 1 120212 0 0.09 0.093
aa2ar_human 329 C-term S => N missense 8.433e-06 1 118588 0 0.17 0.002
aa2ar_human 330 C-term D => G missense 8.444e-06 1 118430 0 0.14 0.075
aa2ar_human 331 C-term G => R missense 3.383e-05 4 118224 0 0.2 0.054
aa2ar_human 334 C-term V => I missense 1.703e-05 2 117410 0 0.58 0.0
aa2ar_human 337 C-term R => C missense 8.568e-06 1 116716 0 nan 0.912
aa2ar_human 337 C-term R => H missense 1.714e-05 2 116704 0 0.05 0.875
aa2ar_human 340 C-term G => S missense 8.634e-05 10 115820 0 nan 0.019
aa2ar_human 341 C-term H => Y missense 8.641e-06 1 115724 0 nan 0.0
aa2ar_human 342 C-term P => L missense 0.000156 18 115418 0 nan 0.058 LB (hydrophobic)
aa2ar_human 344 C-term G => R missense 8.67e-06 1 115336 0 nan 0.303
aa2ar_human 345 C-term V => L missense 1.736e-05 2 115206 0 nan 0.001 LB (hydrophobic)
aa2ar_human 349 C-term G => S missense 1.752e-05 2 114148 0 nan 0.657
aa2ar_human 354 C-term P => R missense 8.864e-06 1 112818 0 nan 0.1 LB (polar (hydrogen bond))
aa2ar_human 355 C-term E => K missense 8.872e-06 1 112718 0 nan 0.004 LB (aromatic (face-to-edge), polar (hydrogen bond))
aa2ar_human 356 C-term R => Q missense 8.008e-05 9 112384 0 nan 0.003
aa2ar_human 358 C-term P => S missense 3.576e-05 4 111860 0 nan 0.298 LB (polar (hydrogen bond))
aa2ar_human 359 C-term N => S missense 1.787e-05 2 111920 0 nan 0.053
aa2ar_human 365 C-term L => P missense 9.428e-06 1 106062 0 nan 0.007
aa2ar_human 367 C-term S => N missense 3.81e-05 4 104988 0 nan 0.111 LB (hydrophobic, Van der Waals)
aa2ar_human 368 C-term G => A missense 9.546e-06 1 104760 0 nan 0.002
aa2ar_human 374 C-term S => F missense 9.714e-06 1 102944 0 nan 0.001 PTM (Phosphorylation)
aa2ar_human 375 C-term Q => P missense 9.744e-06 1 102628 0 nan 0.0 LB (polar (hydrogen bond))
aa2ar_human 378 C-term T => M missense 9.855e-06 1 101474 0 nan 0.001
aa2ar_human 383 C-term V => M missense 2.962e-05 3 101298 0 nan 0.362
aa2ar_human 384 C-term E => D missense 9.874e-06 1 101276 0 nan 0.129
aa2ar_human 388 C-term H => Y missense 1.967e-05 2 101658 0 nan 0.026
aa2ar_human 390 C-term L => P missense 9.809e-06 1 101942 0 nan 0.062
aa2ar_human 393 C-term V => A missense 9.768e-06 1 102378 0 nan 0.0 LB (hydrophobic, Van der Waals)
aa2ar_human 399 C-term G => R missense 1.944e-05 2 102876 0 nan 0.303
aa2ar_human 402 C-term D => E missense 0.002547 261 102478 5 nan 0.0
aa2ar_human 403 C-term P => R missense 1.952e-05 2 102468 0 nan 0.05
aa2ar_human 404 C-term L => P missense 1.958e-05 2 102146 0 nan 0.001


Residue

Diagrams

ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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