Variation Browser

Download
Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
ada2a_human 68 1.52x52 TM1 L => ProfsTer91 frameshift 9.29e-06 1 107638 0 None None
ada2a_human 132 3.36x36 TM3 C => AlafsTer27 frameshift 8.315e-06 1 120258 0 None None PTM (Phosphorylation)
ada2a_human 234 5.61x61 TM5 I => HisfsTer241 frameshift 1.751e-05 1 57094 0 None None GP (contact)
ada2a_human 366 ICL3 E => Ter stop gained 6.929e-05 2 28866 0 None None
ada2a_human 384 6.30x30 TM6 E => Ter stop gained 8.513e-06 1 117468 0 None None SodiumPocket MicroSwitch
ada2a_human 439 7.51x51 TM7 V => AlafsTer39 frameshift 8.243e-06 1 121310 0 None None
ada2a_human 444 7.56x56 TM7 F => SerfsTer34 frameshift 1.65e-05 2 121248 0 None None GP (contact)
ada2a_human 458 8.60x60 H8 R => GlyfsTer20 frameshift 8.271e-06 1 120910 0 None None
ada2a_human 460 C-term D => GlyfsTer15 frameshift 1.655e-05 2 120848 0 None None
ada2a_human 23 N-term A => V missense 8.812e-05 1 11348 0 0.12 0.072
ada2a_human 40 N-term A => G missense 0.002153 74 34366 1 0.56 0.037
ada2a_human 52 1.36x36 TM1 V => G missense 1.347e-05 1 74218 0 0.01 0.994
ada2a_human 73 1.57x57 TM1 V => G missense 1.781e-05 2 112266 0 0.0 0.994
ada2a_human 85 2.41x41 TM2 L => F missense 1.688e-05 2 118466 0 0.0 0.996
ada2a_human 85 2.41x41 TM2 L => H missense 8.439e-06 1 118496 0 0.0 0.998
ada2a_human 116 23.52x52 ECL1 F => L missense 8.314e-06 1 120280 0 0.0 0.969
ada2a_human 126 3.30x30 TM3 A => V missense 1.665e-05 2 120150 0 0.0 0.991
ada2a_human 126 3.30x30 TM3 A => E missense 8.323e-06 1 120150 0 0.0 0.998
ada2a_human 248 5.75x75 TM5 R => H missense 2.255e-05 1 44348 0 0.03 0.872 GP (contact)
ada2a_human 401 6.47x47 TM6 C => S missense 8.256e-06 1 121122 0 0.0 0.985


Residue

Diagrams

ICL1 R A L K ICL1ECL1 Y W Y F ECL1ICL2 A I E Y N L K R ICL2ECL2 S I E K K G G G G G P Q P A E P R C E I N D ECL2ICL3 R G P D A V A A P P G G T E R R P N G L G P E R S A G P G G A E A E P L P T Q L N G A P G E P A P A G P R D T D A L D L E E S S S S D H A E R P P G P R R P E R G P R G K G K A R A S Q V K P G D S L P R R G P G A T G I G T P A A G P G E E R V G A A K A S R W ICL3ECL3 C S V ECL3N-term M F R Q E Q P L A E G S F A P M G S L Q P D A G N A S W N G T E A P G G G A R A T P Y S L Q V N-termC-term G D R K R I V C-term T L T L V C L A G L L M L L T V F G N V L V I I A V F T S A P Q N L F L V S L A S A D I L V A T L V I P F S L A N E V M G G K A W C E I Y L A L D V L F C T S S I V H L C A I S L D R Y W S I T Q T P R R I K A I I I T V W V I S A V I S F P P L I Q K W Y V I S S C I G S F F A P C L I M I L V Y V R I Y Q I A K R R T R V P P S R R G R Q N R E K R F T F V L A V V I G V F V V C W F P F F F T Y T L T A V G P R T L F K F F F W F G Y C N S S L N P V I Y T I F N H D F K K F R R A I L C R
SnakePlot Download: PNG | SVG V N G F V T L L M L L G A L C V L T L T 1 V S L A S A D I L V A L T V I P F S L A N 2 A C L H V I S S T C F L V D L A L Y I E 3 I K A I I I T V W V I S A V I S F P P L 4 Y V L I M I L C P A F F S G I C S S I V Y 5 A V V I G V F V V C W F P F F F T Y T L 6 V P N L S S N C Y G F W F F F K F L T 7
HelixBox Download: PNG | SVG