Variation Browser
DownloadReceptor | Position | GPCRdb | Segment | Variant | Mutation type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor | Position | GPCRdb | Segment | Variant | Mutation Type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
taar1_human | 339 | C-term | S => Ter | stop gained | 1.744e-05 | 1 | 57342 | 0 | None | None | ||
taar1_human | 324 | C-term | F => SerfsTer14 | frameshift | 9.236e-06 | 1 | 108270 | 0 | None | None | ||
taar1_human | 320 | 8.59x59 | H8 | F => LeufsTer18 | frameshift | 3.523e-05 | 4 | 113552 | 0 | None | None | |
taar1_human | 291 | 7.40x39 | TM7 | W => Ter | stop gained | 0.0001408 | 17 | 120742 | 0 | None | None | LB (hydrophobic, Van der Waals, polar (hydrogen bond)) |
taar1_human | 258 | 6.42x42 | TM6 | G => Ter | stop gained | 8.265e-06 | 1 | 120998 | 0 | None | None | |
taar1_human | 246 | 6.30x30 | TM6 | E => GlyfsTer4 | frameshift | 1.653e-05 | 2 | 120978 | 0 | None | None | SodiumPocket MicroSwitch |
taar1_human | 229 | 5.77x77 | TM5 | Q => Ter | stop gained | 8.277e-06 | 1 | 120818 | 0 | None | None | |
taar1_human | 227 | 5.75x75 | TM5 | A => ProfsTer11 | frameshift | 1.656e-05 | 2 | 120784 | 0 | None | None | GP (contact) |
taar1_human | 210 | 5.58x58 | TM5 | Y => IlefsTer14 | frameshift | 8.292e-06 | 1 | 120600 | 0 | None | None | SodiumPocket MicroSwitch |
taar1_human | 187 | 5.35x36 | TM5 | S => Ter | frameshift | 8.29e-06 | 1 | 120628 | 0 | None | None | |
taar1_human | 61 | 2.42x42 | TM2 | L => SerfsTer22 | frameshift | 0.0001815 | 22 | 121192 | 0 | None | None | |
taar1_human | 53 | 12.49x49 | ICL1 | Q => AsnfsTer30 | frameshift | 1.65e-05 | 2 | 121244 | 0 | None | None | |
taar1_human | 18 | N-term | W => Ter | stop gained | 1.664e-05 | 2 | 120212 | 0 | None | None | ||
taar1_human | 330 | C-term | R => T | missense | 1.045e-05 | 1 | 95664 | 0 | 0.89 | 0.009 | ||
taar1_human | 327 | C-term | D => V | missense | 9.635e-06 | 1 | 103790 | 0 | 0.02 | 0.323 | ||
taar1_human | 325 | C-term | Q => E | missense | 9.29e-06 | 1 | 107644 | 0 | 0.28 | 0.15 | ||
taar1_human | 318 | 8.57x57 | H8 | M => T | missense | 8.558e-06 | 1 | 116854 | 0 | 0.02 | 0.0 | |
taar1_human | 315 | 8.54x54 | H8 | L => P | missense | 8.455e-06 | 1 | 118270 | 0 | 0.0 | 0.88 | |
taar1_human | 302 | 7.51x51 | TM7 | M => T | missense | 3.321e-05 | 4 | 120430 | 0 | 0.0 | 0.158 | |
taar1_human | 300 | 7.49x49 | TM7 | N => K | missense | 0.0008795 | 106 | 120518 | 1 | 0.0 | 0.996 | SodiumPocket MicroSwitch |
taar1_human | 300 | 7.49x49 | TM7 | N => S | missense | 8.296e-06 | 1 | 120538 | 0 | 0.0 | 0.996 | SodiumPocket MicroSwitch |
taar1_human | 299 | 7.48x48 | TM7 | F => S | missense | 8.294e-06 | 1 | 120570 | 0 | 0.04 | 0.356 | |
taar1_human | 298 | 7.47x47 | TM7 | T => A | missense | 1.658e-05 | 2 | 120608 | 0 | 0.3 | 0.012 | |
taar1_human | 293 | 7.42x41 | TM7 | G => R | missense | 8.283e-06 | 1 | 120722 | 0 | 0.01 | 0.988 | LB (Van der Waals) |
taar1_human | 287 | 7.36x35 | TM7 | D => V | missense | 8.273e-06 | 1 | 120876 | 0 | 0.01 | 0.491 | LB (Van der Waals, hydrophobic) |
taar1_human | 283 | 7.32x31 | TM7 | P => S | missense | 8.275e-06 | 1 | 120848 | 0 | 0.34 | 0.014 | |
taar1_human | 280 | ECL3 | I => V | missense | 8.274e-06 | 1 | 120864 | 0 | 0.12 | 0.0 | ||
taar1_human | 276 | 6.60x60 | TM6 | F => I | missense | 1.655e-05 | 2 | 120874 | 0 | 0.08 | 0.759 | |
taar1_human | 275 | 6.59x59 | TM6 | P => L | missense | 2.482e-05 | 3 | 120860 | 0 | 0.03 | 0.992 | |
taar1_human | 275 | 6.59x59 | TM6 | P => T | missense | 1.655e-05 | 2 | 120862 | 0 | 0.0 | 0.994 | |
taar1_human | 273 | 6.57x57 | TM6 | M => V | missense | 8.273e-06 | 1 | 120882 | 0 | 0.48 | 0.003 | |
taar1_human | 272 | 6.56x56 | TM6 | V => I | missense | 8.274e-06 | 1 | 120856 | 0 | 1.0 | 0.006 | |
taar1_human | 269 | 6.53x53 | TM6 | I => N | missense | 8.273e-05 | 10 | 120870 | 0 | 0.0 | 0.516 | |
taar1_human | 266 | 6.50x50 | TM6 | P => S | missense | 8.267e-06 | 1 | 120968 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch |
taar1_human | 266 | 6.50x50 | TM6 | P => A | missense | 8.267e-06 | 1 | 120968 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch |
taar1_human | 264 | 6.48x48 | TM6 | W => L | missense | 8.265e-06 | 1 | 120994 | 0 | 0.0 | 0.951 | SodiumPocket MicroSwitch LB (hydrophobic, Van der Waals, aromatic (edge-to-face)) |
taar1_human | 263 | 6.47x47 | TM6 | C => G | missense | 8.265e-06 | 1 | 120996 | 0 | 0.0 | 0.989 | |
taar1_human | 255 | 6.39x39 | TM6 | I => T | missense | 8.264e-06 | 1 | 121006 | 0 | 0.03 | 0.169 | |
taar1_human | 253 | 6.37x37 | TM6 | L => W | missense | 8.264e-06 | 1 | 121004 | 0 | 0.0 | 1.0 | GP (contact) |
taar1_human | 253 | 6.37x37 | TM6 | L => V | missense | 8.264e-06 | 1 | 121014 | 0 | 0.0 | 0.986 | GP (contact) |
taar1_human | 252 | 6.36x36 | TM6 | T => I | missense | 8.264e-06 | 1 | 121000 | 0 | 0.0 | 0.996 | GP (contact) |
taar1_human | 252 | 6.36x36 | TM6 | T => A | missense | 0.001116 | 135 | 121008 | 0 | 0.02 | 0.999 | GP (contact) |
taar1_human | 249 | 6.33x33 | TM6 | A => T | missense | 1.653e-05 | 2 | 120978 | 0 | 0.0 | 0.999 | GP (contact) |
taar1_human | 247 | 6.31x31 | TM6 | R => T | missense | 1.653e-05 | 2 | 120976 | 0 | 0.15 | 0.034 | |
taar1_human | 247 | 6.31x31 | TM6 | R => K | missense | 8.266e-06 | 1 | 120976 | 0 | 0.26 | 0.02 | |
taar1_human | 245 | 6.29x29 | TM6 | K => E | missense | 8.266e-06 | 1 | 120978 | 0 | 0.11 | 0.219 | GP (contact) |
taar1_human | 244 | 6.28x28 | TM6 | S => N | missense | 0.0006118 | 74 | 120954 | 1 | 0.51 | 0.004 | GP (contact) |
taar1_human | 238 | ICL3 | K => R | missense | 4.135e-05 | 5 | 120930 | 0 | 0.27 | 0.008 | ||
taar1_human | 237 | ICL3 | M => I | missense | 1.654e-05 | 2 | 120912 | 0 | 0.2 | 0.011 | ||
taar1_human | 234 | ICL3 | G => R | missense | 8.274e-06 | 1 | 120856 | 0 | 0.33 | 0.013 | ||
taar1_human | 229 | 5.77x77 | TM5 | Q => R | missense | 8.275e-06 | 1 | 120842 | 0 | 0.61 | 0.004 | |
taar1_human | 227 | 5.75x75 | TM5 | A => G | missense | 8.279e-06 | 1 | 120784 | 0 | 0.5 | 0.008 | GP (contact) |
taar1_human | 227 | 5.75x75 | TM5 | A => S | missense | 8.28e-06 | 1 | 120778 | 0 | 0.63 | 0.052 | GP (contact) |
taar1_human | 222 | 5.70x70 | TM5 | R => S | missense | 8.282e-06 | 1 | 120746 | 0 | 0.0 | 0.217 | |
taar1_human | 222 | 5.70x70 | TM5 | R => I | missense | 8.282e-06 | 1 | 120742 | 0 | 0.0 | 0.141 | |
taar1_human | 220 | 5.68x68 | TM5 | Q => P | missense | 8.283e-06 | 1 | 120732 | 0 | 0.02 | 0.992 | GP (contact) |
taar1_human | 218 | 5.66x66 | TM5 | K => I | missense | 8.283e-06 | 1 | 120724 | 0 | 0.0 | 0.595 | GP (contact) |
taar1_human | 218 | 5.66x66 | TM5 | K => E | missense | 8.285e-06 | 1 | 120706 | 0 | 0.02 | 0.03 | GP (contact) |
taar1_human | 217 | 5.65x65 | TM5 | A => T | missense | 0.000174 | 21 | 120678 | 0 | 0.0 | 1.0 | GP (contact) |
taar1_human | 217 | 5.65x65 | TM5 | A => S | missense | 1.657e-05 | 2 | 120678 | 0 | 0.24 | 1.0 | GP (contact) |
taar1_human | 212 | 5.60x60 | TM5 | R => T | missense | 8.291e-06 | 1 | 120606 | 0 | 0.0 | 0.857 | |
taar1_human | 198 | 5.46x461 | TM5 | S => Y | missense | 1.659e-05 | 2 | 120532 | 0 | 0.03 | 0.883 | LB (polar (hydrogen bond), Van der Waals) |
taar1_human | 197 | 5.45x46 | TM5 | T => I | missense | 2.489e-05 | 3 | 120520 | 0 | 1.0 | 0.002 | LB (polar (hydrogen bond), Van der Waals) |
taar1_human | 195 | 5.43x44 | TM5 | F => L | missense | 4.147e-05 | 5 | 120578 | 0 | 0.13 | 0.038 | |
taar1_human | 190 | 5.38x39 | TM5 | S => C | missense | 8.292e-06 | 1 | 120604 | 0 | 0.12 | 0.778 | |
taar1_human | 182 | 45.50x50 | ECL2 | C => F | missense | 4.143e-05 | 5 | 120680 | 0 | 0.0 | 0.986 | LB (polar (hydrogen bond with backbone), Van der Waals) |
taar1_human | 181 | ECL2 | G => V | missense | 0.0001657 | 20 | 120670 | 0 | 0.39 | 0.027 | ||
taar1_human | 174 | ECL2 | K => Q | missense | 8.288e-06 | 1 | 120654 | 0 | 0.56 | 0.014 | ||
taar1_human | 174 | ECL2 | K => E | missense | 1.658e-05 | 2 | 120654 | 0 | 1.0 | 0.008 | ||
taar1_human | 173 | ECL2 | Y => H | missense | 0.0002569 | 31 | 120652 | 0 | 0.44 | 0.013 | ||
taar1_human | 172 | ECL2 | Y => C | missense | 0.000547 | 66 | 120650 | 3 | 0.0 | 0.967 | ||
taar1_human | 172 | ECL2 | Y => D | missense | 8.289e-06 | 1 | 120640 | 0 | 0.0 | 0.956 | ||
taar1_human | 171 | ECL2 | I => L | missense | 0.0001907 | 23 | 120638 | 0 | 0.61 | 0.002 | ||
taar1_human | 170 | ECL2 | E => K | missense | 8.29e-06 | 1 | 120622 | 0 | 0.07 | 0.052 | ||
taar1_human | 169 | ECL2 | E => A | missense | 8.291e-06 | 1 | 120610 | 0 | 0.02 | 0.904 | ||
taar1_human | 168 | ECL2 | A => S | missense | 8.29e-06 | 1 | 120620 | 0 | 0.19 | 0.049 | ||
taar1_human | 167 | ECL2 | G => D | missense | 4.974e-05 | 6 | 120636 | 0 | 0.01 | 0.982 | ||
taar1_human | 167 | ECL2 | G => S | missense | 8.289e-06 | 1 | 120638 | 0 | 0.02 | 0.992 | ||
taar1_human | 162 | 4.64x64 | TM4 | E => D | missense | 1.658e-05 | 2 | 120640 | 0 | 0.11 | 0.02 | |
taar1_human | 162 | 4.64x64 | TM4 | E => Q | missense | 8.29e-06 | 1 | 120622 | 0 | 0.06 | 0.1 | |
taar1_human | 159 | 4.61x61 | TM4 | I => T | missense | 3.314e-05 | 4 | 120702 | 0 | 0.0 | 0.491 | |
taar1_human | 159 | 4.61x61 | TM4 | I => N | missense | 1.657e-05 | 2 | 120702 | 0 | 0.0 | 0.981 | |
taar1_human | 158 | 4.60x60 | TM4 | M => I | missense | 8.286e-06 | 1 | 120688 | 0 | 0.14 | 0.042 | |
taar1_human | 154 | 4.56x56 | TM4 | F => L | missense | 9.935e-05 | 12 | 120784 | 0 | 0.09 | 0.013 | LB (hydrophobic, Van der Waals) |
taar1_human | 152 | 4.54x54 | TM4 | A => D | missense | 8.279e-06 | 1 | 120792 | 0 | 0.03 | 0.824 | |
taar1_human | 151 | 4.53x53 | TM4 | P => A | missense | 8.277e-06 | 1 | 120812 | 0 | 0.11 | 0.789 | LB (hydrophobic, Van der Waals) |
taar1_human | 135 | 34.57x57 | ICL2 | M => I | missense | 8.274e-06 | 1 | 120854 | 0 | 1.0 | 0.006 | GP (contact) |
taar1_human | 134 | 34.56x56 | ICL2 | K => E | missense | 8.273e-06 | 1 | 120874 | 0 | 0.0 | 0.794 | PTM (Methylation) GP (contact) |
taar1_human | 129 | 34.51x51 | ICL2 | L => P | missense | 4.136e-05 | 5 | 120894 | 0 | 0.0 | 1.0 | GP (contact) |
taar1_human | 123 | 3.52x52 | TM3 | Y => C | missense | 0.0001075 | 13 | 120924 | 0 | 0.05 | 0.182 | |
taar1_human | 123 | 3.52x52 | TM3 | Y => H | missense | 1.654e-05 | 2 | 120918 | 0 | 0.01 | 0.417 | |
taar1_human | 121 | 3.50x50 | TM3 | R => L | missense | 8.27e-06 | 1 | 120912 | 0 | 0.0 | 0.997 | SodiumPocket MicroSwitch GP (contact) |
taar1_human | 121 | 3.50x50 | TM3 | R => C | missense | 0.0001406 | 17 | 120926 | 0 | 0.03 | 0.999 | SodiumPocket MicroSwitch GP (contact) |
taar1_human | 119 | 3.48x48 | TM3 | I => F | missense | 4.134e-05 | 5 | 120938 | 0 | 0.0 | 0.103 | |
taar1_human | 117 | 3.46x46 | TM3 | I => V | missense | 8.268e-06 | 1 | 120944 | 0 | 0.14 | 0.923 | |
taar1_human | 115 | 3.44x44 | TM3 | S => C | missense | 4.134e-05 | 5 | 120940 | 0 | 1.0 | 0.028 | |
taar1_human | 115 | 3.44x44 | TM3 | S => F | missense | 8.269e-06 | 1 | 120940 | 0 | 0.07 | 0.964 | |
taar1_human | 113 | 3.42x42 | TM3 | H => R | missense | 0.0001075 | 13 | 120954 | 0 | 0.0 | 0.992 | |
taar1_human | 109 | 3.38x38 | TM3 | A => V | missense | 8.265e-06 | 1 | 120988 | 0 | 0.3 | 0.35 | |
taar1_human | 104 | 3.33x33 | TM3 | I => V | missense | 0.0002231 | 27 | 120998 | 0 | 0.28 | 0.177 | LB (hydrophobic, Van der Waals) |
taar1_human | 103 | 3.32x32 | TM3 | D => N | missense | 8.264e-06 | 1 | 121006 | 0 | 0.01 | 0.999 | LB (polar (charge-assisted hydrogen bond), Van der Waals, polar (charge-charge), hydrophobic) |
taar1_human | 100 | 3.29x29 | TM3 | T => I | missense | 1.653e-05 | 2 | 121016 | 0 | 0.04 | 0.213 | LB (Van der Waals) |
taar1_human | 100 | 3.29x29 | TM3 | T => A | missense | 8.264e-06 | 1 | 121014 | 0 | 0.18 | 0.142 | LB (Van der Waals) |
taar1_human | 99 | 3.28x28 | TM3 | H => R | missense | 1.653e-05 | 2 | 121028 | 0 | 0.0 | 0.456 | |
taar1_human | 98 | 3.27x27 | TM3 | I => T | missense | 8.262e-06 | 1 | 121036 | 0 | 0.0 | 0.809 | |
taar1_human | 94 | 3.23x23 | TM3 | V => A | missense | 4.13e-05 | 5 | 121060 | 0 | 0.08 | 0.102 | |
taar1_human | 94 | 3.23x23 | TM3 | V => L | missense | 8.26e-06 | 1 | 121066 | 0 | 1.0 | 0.001 | |
taar1_human | 80 | 2.61x60 | TM2 | S => G | missense | 8.255e-06 | 1 | 121136 | 0 | 0.02 | 0.791 | |
taar1_human | 78 | 2.59x58 | TM2 | P => S | missense | 8.255e-06 | 1 | 121136 | 0 | 0.0 | 0.997 | |
taar1_human | 77 | 2.58x57 | TM2 | M => L | missense | 8.254e-06 | 1 | 121156 | 0 | 0.03 | 0.679 | |
taar1_human | 74 | 2.55x55 | TM2 | C => Y | missense | 8.254e-06 | 1 | 121150 | 0 | 0.54 | 0.021 | |
taar1_human | 72 | 2.53x53 | TM2 | L => P | missense | 8.253e-06 | 1 | 121166 | 0 | 0.0 | 0.994 | |
taar1_human | 69 | 2.50x50 | TM2 | D => G | missense | 8.252e-06 | 1 | 121176 | 0 | 0.01 | 1.0 | |
taar1_human | 65 | 2.46x46 | TM2 | M => I | missense | 8.252e-06 | 1 | 121188 | 0 | 0.01 | 0.403 | |
taar1_human | 64 | 2.45x45 | TM2 | S => F | missense | 3.301e-05 | 4 | 121188 | 0 | 0.0 | 1.0 | |
taar1_human | 63 | 2.44x44 | TM2 | H => N | missense | 2.475e-05 | 3 | 121198 | 0 | 0.03 | 0.008 | |
taar1_human | 59 | 2.40x40 | TM2 | N => D | missense | 1.65e-05 | 2 | 121202 | 0 | 0.0 | 0.999 | |
taar1_human | 58 | 2.39x39 | TM2 | T => K | missense | 8.25e-06 | 1 | 121210 | 0 | 0.03 | 0.98 | |
taar1_human | 55 | 12.51x51 | ICL1 | H => R | missense | 8.249e-05 | 10 | 121230 | 0 | 0.01 | 0.679 | |
taar1_human | 51 | 1.60x60 | TM1 | F => L | missense | 6.598e-05 | 8 | 121242 | 0 | 0.0 | 0.999 | |
taar1_human | 50 | 1.59x59 | TM1 | H => Q | missense | 8.248e-06 | 1 | 121246 | 0 | 0.01 | 0.61 | |
taar1_human | 49 | 1.58x58 | TM1 | S => L | missense | 0.0003794 | 46 | 121246 | 0 | 0.13 | 0.004 | |
taar1_human | 48 | 1.57x57 | TM1 | I => T | missense | 8.249e-06 | 1 | 121234 | 0 | 0.0 | 0.903 | |
taar1_human | 47 | 1.56x56 | TM1 | S => C | missense | 9.897e-05 | 12 | 121246 | 0 | 0.0 | 0.829 | |
taar1_human | 45 | 1.54x54 | TM1 | I => M | missense | 8.247e-06 | 1 | 121262 | 0 | 0.07 | 0.644 | |
taar1_human | 42 | 1.51x51 | TM1 | L => M | missense | 2.474e-05 | 3 | 121282 | 0 | 0.16 | 0.724 | |
taar1_human | 41 | 1.50x50 | TM1 | N => D | missense | 8.245e-06 | 1 | 121288 | 0 | 0.0 | 1.0 | |
taar1_human | 40 | 1.49x49 | TM1 | G => S | missense | 8.245e-06 | 1 | 121292 | 0 | 0.01 | 1.0 | |
taar1_human | 39 | 1.48x48 | TM1 | V => I | missense | 1.649e-05 | 2 | 121292 | 0 | 0.5 | 0.003 | |
taar1_human | 38 | 1.47x47 | TM1 | L => I | missense | 8.244e-06 | 1 | 121296 | 0 | 0.49 | 0.002 | |
taar1_human | 38 | 1.47x47 | TM1 | L => F | missense | 2.473e-05 | 3 | 121296 | 0 | 0.03 | 0.014 | |
taar1_human | 36 | 1.45x45 | TM1 | T => N | missense | 8.244e-06 | 1 | 121296 | 0 | 0.0 | 0.243 | |
taar1_human | 36 | 1.45x45 | TM1 | T => A | missense | 1.649e-05 | 2 | 121298 | 0 | 0.26 | 0.002 | |
taar1_human | 28 | 1.37x37 | TM1 | S => C | missense | 0.0006102 | 74 | 121264 | 2 | 0.18 | 0.008 | |
taar1_human | 26 | 1.35x35 | TM1 | L => R | missense | 4.126e-05 | 5 | 121196 | 0 | 0.0 | 0.903 | |
taar1_human | 24 | 1.33x33 | TM1 | A => T | missense | 8.262e-06 | 1 | 121034 | 0 | 0.35 | 0.045 | |
taar1_human | 23 | 1.32x32 | TM1 | R => H | missense | 0.000157 | 19 | 121016 | 0 | 0.06 | 0.028 | |
taar1_human | 23 | 1.32x32 | TM1 | R => L | missense | 8.263e-06 | 1 | 121016 | 0 | 0.09 | 0.491 | |
taar1_human | 23 | 1.32x32 | TM1 | R => C | missense | 0.001546 | 187 | 120980 | 1 | 0.03 | 0.048 | |
taar1_human | 20 | N-term | N => S | missense | 8.297e-06 | 1 | 120526 | 0 | 0.76 | 0.002 | ||
taar1_human | 18 | N-term | W => C | missense | 8.319e-06 | 1 | 120212 | 0 | 0.15 | 0.447 | ||
taar1_human | 18 | N-term | W => G | missense | 0.001324 | 159 | 120096 | 1 | 0.26 | 0.053 | ||
taar1_human | 18 | N-term | W => R | missense | 1.665e-05 | 2 | 120096 | 0 | 0.94 | 0.001 | ||
taar1_human | 16 | N-term | N => S | missense | 8.365e-06 | 1 | 119550 | 0 | 1.0 | 0.0 | ||
taar1_human | 16 | N-term | N => Y | missense | 8.374e-06 | 1 | 119424 | 0 | 0.37 | 0.001 | ||
taar1_human | 13 | N-term | C => Y | missense | 8.437e-06 | 1 | 118524 | 0 | 0.01 | 0.094 | ||
taar1_human | 9 | N-term | I => N | missense | 2.561e-05 | 3 | 117158 | 0 | 0.15 | 0.007 | ||
taar1_human | 3 | N-term | P => S | missense | 8.703e-06 | 1 | 114908 | 0 | 0.47 | 0.001 |
Residue
- deleterious missense variants are shown in red
- tolerated missense variants are shown in green
- loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue