Variation Browser
DownloadReceptor | Position | GPCRdb | Segment | Variant | Mutation type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor | Position | GPCRdb | Segment | Variant | Mutation Type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
tshr_human | 8 | N-term | Q => HisfsTer55 | frameshift | 8.248e-06 | 1 | 121244 | 0 | None | None | ||
tshr_human | 31 | N-term | C => Ter | stop gained | 8.24e-06 | 1 | 121352 | 0 | None | None | ||
tshr_human | 42 | N-term | K => Ter | stop gained | 8.241e-06 | 1 | 121342 | 0 | None | None | ||
tshr_human | 57 | N-term | L => GlufsTer4 | frameshift | 8.252e-06 | 1 | 121178 | 0 | None | None | ||
tshr_human | 127 | N-term | L => SerfsTer2 | frameshift | 8.248e-06 | 1 | 121244 | 0 | None | None | ||
tshr_human | 153 | N-term | F => TyrfsTer10 | frameshift | 8.275e-06 | 1 | 120840 | 0 | None | None | ||
tshr_human | 178 | N-term | E => GlnfsTer2 | frameshift | 2.473e-05 | 3 | 121310 | 0 | None | None | ||
tshr_human | 223 | N-term | G => Ter | stop gained | 8.241e-06 | 1 | 121338 | 0 | None | None | ||
tshr_human | 244 | N-term | K => Ter | stop gained | 8.238e-06 | 1 | 121382 | 0 | None | None | ||
tshr_human | 294 | N-term | G => AsnfsTer3 | frameshift | 1.663e-05 | 2 | 120284 | 0 | None | None | ||
tshr_human | 374 | N-term | Q => ArgfsTer38 | frameshift | 8.237e-06 | 1 | 121410 | 0 | None | None | ||
tshr_human | 488 | ECL1 | W => Ter | stop gained | 8.239e-06 | 1 | 121380 | 0 | None | None | ||
tshr_human | 546 | 4.50x50 | TM4 | W => Ter | stop gained | 9.885e-05 | 12 | 121398 | 0 | None | None | |
tshr_human | 601 | 5.58x58 | TM5 | Y => Ter | stop gained | 8.237e-06 | 1 | 121406 | 0 | None | None | SodiumPocket MicroSwitch |
tshr_human | 609 | 5.66x66 | TM5 | R => Ter | stop gained | 8.237e-06 | 1 | 121410 | 0 | None | None | GP (contact) |
tshr_human | 613 | ICL3 | Y => Ter | stop gained | 8.237e-06 | 1 | 121408 | 0 | None | None | ||
tshr_human | 643 | 6.54x54 | TM6 | Y => Ter | frameshift | 8.237e-06 | 1 | 121410 | 0 | None | None | LB (hydrophobic, Van der Waals, polar (hydrogen bond)) |
tshr_human | 655 | ECL3 | T => CysfsTer2 | frameshift | 2.471e-05 | 3 | 121412 | 0 | None | None | ||
tshr_human | 709 | C-term | Q => ArgfsTer20 | frameshift | 1.648e-05 | 2 | 121342 | 0 | None | None | ||
tshr_human | 2 | N-term | R => S | missense | 8.252e-06 | 1 | 121182 | 0 | nan | 0.981 | ||
tshr_human | 10 | N-term | V => E | missense | 8.247e-06 | 1 | 121260 | 0 | 0.01 | 0.36 | ||
tshr_human | 16 | N-term | P => T | missense | 1.649e-05 | 2 | 121296 | 0 | 0.03 | 0.272 | ||
tshr_human | 18 | N-term | D => Y | missense | 8.243e-06 | 1 | 121316 | 0 | 0.01 | 0.229 | ||
tshr_human | 22 | N-term | M => T | missense | 1.648e-05 | 2 | 121346 | 0 | 0.34 | 0.022 | ||
tshr_human | 27 | N-term | P => L | missense | 8.24e-06 | 1 | 121356 | 0 | 0.07 | 0.059 | ||
tshr_human | 29 | N-term | C => W | missense | 8.24e-06 | 1 | 121352 | 0 | 0.0 | 1.0 | ||
tshr_human | 32 | N-term | H => Y | missense | 1.648e-05 | 2 | 121350 | 0 | 0.54 | 0.009 | ||
tshr_human | 34 | N-term | E => K | missense | 0.0001895 | 23 | 121352 | 0 | 0.3 | 0.7 | ||
tshr_human | 36 | N-term | D => H | missense | 0.006015 | 730 | 121356 | 5 | 0.14 | 0.117 | ||
tshr_human | 40 | N-term | T => I | missense | 8.241e-06 | 1 | 121350 | 0 | 0.0 | 0.999 | ||
tshr_human | 41 | N-term | C => S | missense | 4.12e-05 | 5 | 121346 | 0 | 0.0 | 1.0 | ||
tshr_human | 42 | N-term | K => E | missense | 1.648e-05 | 2 | 121342 | 0 | 0.29 | 0.972 | ||
tshr_human | 48 | N-term | P => S | missense | 8.244e-06 | 1 | 121298 | 0 | 0.0 | 0.999 | ||
tshr_human | 49 | N-term | S => G | missense | 0.0001896 | 23 | 121288 | 0 | 0.29 | 0.39 | ||
tshr_human | 51 | N-term | P => A | missense | 8.246e-06 | 1 | 121270 | 0 | 0.02 | 0.999 | ||
tshr_human | 51 | N-term | P => L | missense | 1.65e-05 | 2 | 121248 | 0 | 0.01 | 1.0 | ||
tshr_human | 52 | N-term | P => T | missense | 0.06959 | 8437 | 121244 | 519 | 0.18 | 0.311 | ||
tshr_human | 52 | N-term | P => A | missense | 8.248e-06 | 1 | 121244 | 0 | 0.74 | 0.023 | ||
tshr_human | 56 | N-term | T => I | missense | 8.253e-06 | 1 | 121168 | 0 | 0.08 | 0.844 | ||
tshr_human | 57 | N-term | L => P | missense | 1.651e-05 | 2 | 121146 | 0 | 0.0 | 1.0 | ||
tshr_human | 68 | N-term | P => S | missense | 0.0006469 | 78 | 120576 | 0 | 0.02 | 0.988 | ||
tshr_human | 69 | N-term | S => T | missense | 8.293e-06 | 1 | 120578 | 0 | 0.09 | 0.857 | ||
tshr_human | 77 | N-term | N => K | missense | 8.333e-06 | 1 | 120008 | 0 | 0.0 | 0.999 | PTM (N-linked Glycosylation) | |
tshr_human | 83 | N-term | V => I | missense | 5.774e-05 | 7 | 121226 | 0 | 1.0 | 0.002 | ||
tshr_human | 90 | N-term | Q => P | missense | 8.244e-06 | 1 | 121298 | 0 | 0.0 | 0.966 | ||
tshr_human | 90 | N-term | Q => H | missense | 8.244e-06 | 1 | 121302 | 0 | 0.02 | 0.983 | ||
tshr_human | 92 | N-term | L => V | missense | 8.244e-06 | 1 | 121306 | 0 | 0.02 | 0.819 | ||
tshr_human | 93 | N-term | E => G | missense | 8.243e-06 | 1 | 121310 | 0 | 0.0 | 0.933 | ||
tshr_human | 101 | N-term | S => N | missense | 8.246e-06 | 1 | 121276 | 0 | 0.25 | 0.029 | ||
tshr_human | 103 | N-term | V => L | missense | 6.598e-05 | 8 | 121254 | 0 | 0.32 | 0.006 | ||
tshr_human | 105 | N-term | H => D | missense | 8.249e-06 | 1 | 121220 | 0 | 0.01 | 0.999 | ||
tshr_human | 109 | N-term | R => W | missense | 8.248e-06 | 1 | 121246 | 0 | 0.0 | 1.0 | ||
tshr_human | 109 | N-term | R => Q | missense | 1.649e-05 | 2 | 121252 | 0 | 0.36 | 1.0 | ||
tshr_human | 117 | N-term | I => L | missense | 8.245e-06 | 1 | 121288 | 0 | 0.02 | 0.685 | ||
tshr_human | 120 | N-term | D => N | missense | 8.245e-06 | 1 | 121290 | 0 | 0.12 | 0.04 | ||
tshr_human | 121 | N-term | A => V | missense | 8.245e-06 | 1 | 121290 | 0 | 0.0 | 1.0 | ||
tshr_human | 124 | N-term | E => D | missense | 4.948e-05 | 6 | 121252 | 0 | 0.11 | 0.001 | ||
tshr_human | 132 | N-term | G => R | missense | 3.339e-05 | 4 | 119796 | 0 | 0.0 | 0.904 | ||
tshr_human | 137 | N-term | G => V | missense | 1.662e-05 | 2 | 120366 | 0 | 0.0 | 1.0 | ||
tshr_human | 143 | N-term | D => E | missense | 8.284e-06 | 1 | 120714 | 0 | 0.04 | 0.354 | ||
tshr_human | 145 | N-term | T => I | missense | 4.14e-05 | 5 | 120772 | 0 | 0.0 | 0.946 | ||
tshr_human | 155 | N-term | I => L | missense | 0.0007282 | 88 | 120840 | 0 | 0.24 | 0.064 | ||
tshr_human | 155 | N-term | I => V | missense | 8.275e-06 | 1 | 120840 | 0 | 0.01 | 0.119 | ||
tshr_human | 160 | N-term | D => E | missense | 8.244e-06 | 1 | 121306 | 0 | 0.13 | 0.114 | ||
tshr_human | 162 | N-term | P => A | missense | 0.0001731 | 21 | 121310 | 0 | 0.25 | 0.441 | ||
tshr_human | 162 | N-term | P => L | missense | 8.243e-06 | 1 | 121314 | 0 | 0.57 | 0.411 | ||
tshr_human | 164 | N-term | M => L | missense | 8.243e-06 | 1 | 121318 | 0 | 0.16 | 0.056 | ||
tshr_human | 165 | N-term | T => M | missense | 1.649e-05 | 2 | 121318 | 0 | 0.0 | 0.905 | ||
tshr_human | 181 | N-term | T => S | missense | 8.245e-06 | 1 | 121292 | 0 | 0.04 | 0.32 | ||
tshr_human | 200 | N-term | T => A | missense | 8.282e-06 | 1 | 120740 | 0 | 0.0 | 0.871 | ||
tshr_human | 204 | N-term | A => V | missense | 1.659e-05 | 2 | 120554 | 0 | 0.02 | 0.95 | ||
tshr_human | 214 | N-term | T => R | missense | 8.243e-06 | 1 | 121308 | 0 | 0.27 | 0.019 | ||
tshr_human | 215 | N-term | V => A | missense | 2.473e-05 | 3 | 121318 | 0 | 0.56 | 0.002 | ||
tshr_human | 216 | N-term | I => T | missense | 7.419e-05 | 9 | 121316 | 0 | 0.0 | 0.983 | ||
tshr_human | 219 | N-term | D => N | missense | 8.242e-06 | 1 | 121330 | 0 | 0.13 | 0.07 | ||
tshr_human | 220 | N-term | A => V | missense | 2.473e-05 | 3 | 121332 | 0 | 0.03 | 0.165 | ||
tshr_human | 220 | N-term | A => E | missense | 8.242e-06 | 1 | 121332 | 0 | 0.0 | 0.848 | ||
tshr_human | 225 | N-term | Y => H | missense | 8.241e-06 | 1 | 121338 | 0 | 0.4 | 0.004 | ||
tshr_human | 228 | N-term | P => T | missense | 8.241e-06 | 1 | 121340 | 0 | 0.0 | 1.0 | ||
tshr_human | 232 | N-term | D => H | missense | 8.238e-06 | 1 | 121382 | 0 | 0.0 | 0.998 | ||
tshr_human | 233 | N-term | V => M | missense | 3.295e-05 | 4 | 121386 | 0 | 0.03 | 0.175 | ||
tshr_human | 238 | N-term | V => D | missense | 8.238e-06 | 1 | 121388 | 0 | 0.0 | 0.739 | ||
tshr_human | 240 | N-term | A => T | missense | 8.238e-06 | 1 | 121390 | 0 | 0.18 | 0.001 | ||
tshr_human | 245 | N-term | G => S | missense | 0.00014 | 17 | 121388 | 0 | 0.0 | 0.862 | ||
tshr_human | 245 | N-term | G => V | missense | 8.238e-06 | 1 | 121392 | 0 | 0.0 | 0.993 | ||
tshr_human | 247 | N-term | E => Q | missense | 8.238e-06 | 1 | 121384 | 0 | 0.03 | 0.011 | ||
tshr_human | 247 | N-term | E => K | missense | 8.238e-06 | 1 | 121384 | 0 | 0.07 | 0.032 | ||
tshr_human | 247 | N-term | E => G | missense | 4.943e-05 | 6 | 121390 | 0 | 0.05 | 0.004 | ||
tshr_human | 251 | N-term | E => Q | missense | 8.238e-06 | 1 | 121392 | 0 | 0.16 | 0.584 | ||
tshr_human | 254 | N-term | A => V | missense | 8.239e-06 | 1 | 121380 | 0 | 0.03 | 0.026 | ||
tshr_human | 266 | N-term | S => P | missense | 8.239e-06 | 1 | 121374 | 0 | 0.06 | 0.003 | ||
tshr_human | 274 | N-term | R => W | missense | 1.648e-05 | 2 | 121364 | 0 | 0.0 | 0.949 | ||
tshr_human | 274 | N-term | R => G | missense | 8.24e-06 | 1 | 121364 | 0 | 0.08 | 0.023 | ||
tshr_human | 274 | N-term | R => L | missense | 8.24e-06 | 1 | 121360 | 0 | 0.05 | 0.235 | ||
tshr_human | 275 | N-term | A => T | missense | 8.24e-06 | 1 | 121360 | 0 | 0.03 | 0.996 | ||
tshr_human | 277 | N-term | L => I | missense | 8.241e-06 | 1 | 121338 | 0 | 0.0 | 0.96 | ||
tshr_human | 279 | N-term | Y => D | missense | 8.242e-06 | 1 | 121336 | 0 | 0.0 | 0.994 | ||
tshr_human | 282 | N-term | H => Q | missense | 8.246e-06 | 1 | 121272 | 0 | 0.0 | 0.983 | ||
tshr_human | 290 | N-term | K => M | missense | 8.287e-06 | 1 | 120676 | 0 | 0.0 | 0.994 | ||
tshr_human | 290 | N-term | K => N | missense | 1.657e-05 | 2 | 120676 | 0 | 0.02 | 0.984 | ||
tshr_human | 291 | N-term | K => I | missense | 8.292e-06 | 1 | 120598 | 0 | 0.0 | 0.951 | ||
tshr_human | 294 | N-term | G => E | missense | 1.67e-05 | 2 | 119782 | 0 | 0.14 | 0.987 | ||
tshr_human | 298 | N-term | S => P | missense | 8.311e-06 | 1 | 120318 | 0 | 0.26 | 0.844 | PTM (Phosphorylation) | |
tshr_human | 301 | N-term | C => R | missense | 8.303e-06 | 1 | 120444 | 0 | 0.0 | 0.997 | ||
tshr_human | 301 | N-term | C => Y | missense | 8.302e-06 | 1 | 120452 | 0 | 0.0 | 0.999 | ||
tshr_human | 303 | N-term | E => V | missense | 1.659e-05 | 2 | 120536 | 0 | 0.3 | 0.096 | ||
tshr_human | 303 | N-term | E => D | missense | 1.659e-05 | 2 | 120538 | 0 | 0.62 | 0.005 | ||
tshr_human | 304 | N-term | S => N | missense | 8.295e-06 | 1 | 120558 | 0 | 0.02 | 0.772 | ||
tshr_human | 305 | N-term | S => R | missense | 0.0002156 | 26 | 120606 | 0 | 0.4 | 0.008 | ||
tshr_human | 307 | N-term | Q => K | missense | 8.286e-06 | 1 | 120680 | 0 | 0.36 | 0.005 | ||
tshr_human | 310 | N-term | R => C | missense | 1.655e-05 | 2 | 120846 | 0 | 0.06 | 0.761 | ||
tshr_human | 310 | N-term | R => H | missense | 0.0007032 | 85 | 120868 | 0 | 0.35 | 0.005 | ||
tshr_human | 320 | N-term | S => N | missense | 8.248e-06 | 1 | 121244 | 0 | 0.48 | 0.003 | ||
tshr_human | 323 | N-term | H => Y | missense | 8.243e-06 | 1 | 121314 | 0 | 1.0 | 0.0 | ||
tshr_human | 326 | N-term | Y => D | missense | 8.24e-06 | 1 | 121364 | 0 | 0.14 | 0.017 | ||
tshr_human | 328 | N-term | E => V | missense | 1.648e-05 | 2 | 121386 | 0 | 0.01 | 0.02 | ||
tshr_human | 333 | N-term | S => G | missense | 1.647e-05 | 2 | 121398 | 0 | 0.17 | 0.0 | ||
tshr_human | 334 | N-term | I => T | missense | 3.295e-05 | 4 | 121406 | 0 | 0.44 | 0.001 | ||
tshr_human | 335 | N-term | V => I | missense | 8.237e-06 | 1 | 121410 | 0 | 0.24 | 0.062 | ||
tshr_human | 338 | N-term | K => Q | missense | 8.237e-06 | 1 | 121410 | 0 | 0.61 | 0.015 | ||
tshr_human | 340 | N-term | K => N | missense | 1.647e-05 | 2 | 121410 | 0 | 0.95 | 0.0 | ||
tshr_human | 344 | N-term | Q => R | missense | 8.236e-06 | 1 | 121412 | 0 | 0.86 | 0.001 | ||
tshr_human | 345 | N-term | D => N | missense | 8.236e-06 | 1 | 121412 | 0 | 0.21 | 0.025 | ||
tshr_human | 346 | N-term | T => P | missense | 8.237e-06 | 1 | 121410 | 0 | 0.39 | 0.162 | ||
tshr_human | 347 | N-term | H => R | missense | 1.647e-05 | 2 | 121412 | 0 | 0.32 | 0.005 | ||
tshr_human | 350 | N-term | A => T | missense | 1.647e-05 | 2 | 121412 | 0 | 0.68 | 0.003 | ||
tshr_human | 353 | N-term | Y => H | missense | 8.236e-06 | 1 | 121412 | 0 | 0.35 | 0.03 | ||
tshr_human | 354 | N-term | V => I | missense | 1.647e-05 | 2 | 121412 | 0 | 0.3 | 0.019 | ||
tshr_human | 360 | N-term | E => Q | missense | 8.237e-06 | 1 | 121410 | 0 | 0.11 | 0.513 | ||
tshr_human | 364 | N-term | I => F | missense | 3.295e-05 | 4 | 121410 | 0 | 0.27 | 0.185 | ||
tshr_human | 368 | N-term | Q => P | missense | 8.236e-06 | 1 | 121412 | 0 | 0.08 | 0.478 | ||
tshr_human | 372 | N-term | N => T | missense | 7.413e-05 | 9 | 121410 | 0 | 0.14 | 0.249 | ||
tshr_human | 372 | N-term | N => K | missense | 8.237e-06 | 1 | 121410 | 0 | 0.13 | 0.894 | ||
tshr_human | 373 | N-term | P => R | missense | 3.295e-05 | 4 | 121410 | 0 | 0.01 | 0.867 | ||
tshr_human | 375 | N-term | E => G | missense | 8.236e-06 | 1 | 121412 | 0 | 0.11 | 0.029 | ||
tshr_human | 379 | N-term | Q => K | missense | 3.295e-05 | 4 | 121412 | 1 | 0.35 | 0.138 | ||
tshr_human | 388 | N-term | T => I | missense | 8.236e-06 | 1 | 121412 | 0 | 0.42 | 0.007 | ||
tshr_human | 389 | N-term | I => V | missense | 1.647e-05 | 2 | 121410 | 0 | 1.0 | 0.001 | ||
tshr_human | 390 | N-term | C => F | missense | 1.647e-05 | 2 | 121410 | 0 | 0.0 | 1.0 | ||
tshr_human | 390 | N-term | C => W | missense | 1.647e-05 | 2 | 121412 | 0 | 0.0 | 1.0 | ||
tshr_human | 392 | N-term | D => N | missense | 4.118e-05 | 5 | 121410 | 0 | 0.15 | 0.138 | ||
tshr_human | 393 | N-term | S => G | missense | 8.236e-06 | 1 | 121412 | 0 | 0.41 | 0.002 | ||
tshr_human | 398 | N-term | C => G | missense | 5.765e-05 | 7 | 121412 | 0 | 0.0 | 1.0 | ||
tshr_human | 399 | N-term | T => N | missense | 8.237e-06 | 1 | 121410 | 0 | 0.01 | 0.676 | ||
tshr_human | 400 | N-term | P => R | missense | 8.236e-06 | 1 | 121412 | 0 | 0.0 | 1.0 | ||
tshr_human | 403 | N-term | D => N | missense | 3.295e-05 | 4 | 121412 | 0 | 0.01 | 1.0 | ||
tshr_human | 407 | N-term | P => L | missense | 2.471e-05 | 3 | 121412 | 0 | 0.0 | 1.0 | ||
tshr_human | 407 | N-term | P => Q | missense | 8.236e-06 | 1 | 121412 | 0 | 0.0 | 1.0 | ||
tshr_human | 408 | N-term | C => R | missense | 1.647e-05 | 2 | 121412 | 0 | 0.0 | 1.0 | ||
tshr_human | 410 | N-term | D => N | missense | 8.236e-06 | 1 | 121412 | 0 | 0.0 | 0.996 | ||
tshr_human | 415 | 1.33x33 | TM1 | K => R | missense | 8.236e-06 | 1 | 121412 | 0 | 0.25 | 0.005 | |
tshr_human | 419 | 1.37x37 | TM1 | I => T | missense | 8.236e-06 | 1 | 121412 | 0 | 0.0 | 0.46 | |
tshr_human | 421 | 1.39x39 | TM1 | V => M | missense | 8.237e-06 | 1 | 121410 | 0 | 0.04 | 1.0 | |
tshr_human | 422 | 1.40x40 | TM1 | W => R | missense | 1.647e-05 | 2 | 121412 | 0 | 0.0 | 1.0 | |
tshr_human | 424 | 1.42x42 | TM1 | V => F | missense | 1.647e-05 | 2 | 121412 | 0 | 0.0 | 1.0 | |
tshr_human | 424 | 1.42x42 | TM1 | V => I | missense | 8.236e-06 | 1 | 121412 | 0 | 0.98 | 0.999 | |
tshr_human | 424 | 1.42x42 | TM1 | V => A | missense | 8.236e-06 | 1 | 121412 | 0 | 0.0 | 0.999 | |
tshr_human | 432 | 1.50x50 | TM1 | N => S | missense | 2.471e-05 | 3 | 121412 | 0 | 0.0 | 0.999 | |
tshr_human | 440 | 1.58x58 | TM1 | L => I | missense | 8.237e-06 | 1 | 121400 | 0 | 0.31 | 0.54 | |
tshr_human | 444 | ICL1 | Y => H | missense | 5.765e-05 | 7 | 121412 | 0 | 0.0 | 1.0 | ||
tshr_human | 447 | ICL1 | N => S | missense | 8.236e-06 | 1 | 121412 | 0 | 0.26 | 0.0 | ||
tshr_human | 448 | 2.38x38 | TM2 | V => I | missense | 5.765e-05 | 7 | 121412 | 1 | 0.0 | 0.999 | |
tshr_human | 450 | 2.40x40 | TM2 | R => H | missense | 0.0002883 | 35 | 121412 | 0 | 0.0 | 1.0 | |
tshr_human | 452 | 2.42x42 | TM2 | L => P | missense | 8.236e-06 | 1 | 121412 | 0 | 0.0 | 1.0 | |
tshr_human | 454 | 2.44x44 | TM2 | C => S | missense | 8.236e-06 | 1 | 121412 | 0 | 0.0 | 0.999 | |
tshr_human | 457 | 2.47x47 | TM2 | A => V | missense | 8.236e-06 | 1 | 121412 | 0 | 0.0 | 0.999 | |
tshr_human | 459 | 2.49x49 | TM2 | A => V | missense | 1.647e-05 | 2 | 121412 | 0 | 0.0 | 0.999 | |
tshr_human | 470 | 2.60x60 | TM2 | I => T | missense | 8.237e-06 | 1 | 121404 | 0 | 0.0 | 1.0 | |
tshr_human | 475 | 2.65x65 | TM2 | L => F | missense | 1.647e-05 | 2 | 121400 | 0 | 0.25 | 0.238 | |
tshr_human | 487 | ECL1 | D => N | missense | 4.119e-05 | 5 | 121384 | 0 | 0.02 | 0.329 | ||
tshr_human | 495 | 3.26x26 | TM3 | N => Y | missense | 8.24e-06 | 1 | 121358 | 0 | 0.01 | 0.891 | |
tshr_human | 495 | 3.26x26 | TM3 | N => S | missense | 4.944e-05 | 6 | 121350 | 1 | 0.56 | 0.03 | |
tshr_human | 496 | 3.27x27 | TM3 | T => K | missense | 8.241e-06 | 1 | 121340 | 0 | 0.04 | 0.389 | |
tshr_human | 500 | 3.31x31 | TM3 | F => V | missense | 8.242e-06 | 1 | 121334 | 0 | 0.02 | 0.797 | |
tshr_human | 504 | 3.35x35 | TM3 | A => S | missense | 8.244e-06 | 1 | 121302 | 0 | 0.06 | 0.684 | |
tshr_human | 506 | 3.37x37 | TM3 | E => K | missense | 8.244e-06 | 1 | 121294 | 0 | 0.0 | 0.999 | LB (polar (charge-assisted hydrogen bond)) |
tshr_human | 508 | 3.39x39 | TM3 | S => L | missense | 8.245e-06 | 1 | 121282 | 0 | 0.0 | 0.999 | |
tshr_human | 511 | 3.42x42 | TM3 | T => M | missense | 3.298e-05 | 4 | 121294 | 0 | 0.0 | 1.0 | |
tshr_human | 514 | 3.45x45 | TM3 | V => I | missense | 2.473e-05 | 3 | 121296 | 0 | 0.03 | 0.043 | |
tshr_human | 516 | 3.47x47 | TM3 | T => N | missense | 1.649e-05 | 2 | 121300 | 0 | 0.0 | 1.0 | |
tshr_human | 516 | 3.47x47 | TM3 | T => I | missense | 8.244e-06 | 1 | 121300 | 0 | 0.0 | 1.0 | |
tshr_human | 518 | 3.49x49 | TM3 | E => V | missense | 8.245e-06 | 1 | 121290 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch |
tshr_human | 519 | 3.50x50 | TM3 | R => C | missense | 4.123e-05 | 5 | 121272 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch GP (contact) |
tshr_human | 519 | 3.50x50 | TM3 | R => H | missense | 1.649e-05 | 2 | 121274 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch GP (contact) |
tshr_human | 520 | 3.51x51 | TM3 | W => S | missense | 8.245e-06 | 1 | 121280 | 0 | 0.0 | 1.0 | |
tshr_human | 520 | 3.51x51 | TM3 | W => C | missense | 8.244e-06 | 1 | 121294 | 0 | 0.0 | 1.0 | |
tshr_human | 522 | 3.53x53 | TM3 | A => T | missense | 2.473e-05 | 3 | 121302 | 0 | 1.0 | 0.983 | GP (contact) |
tshr_human | 524 | 3.55x55 | TM3 | T => I | missense | 8.244e-06 | 1 | 121304 | 0 | 0.0 | 0.444 | GP (contact) |
tshr_human | 525 | 3.56x56 | TM3 | F => S | missense | 0.0001319 | 16 | 121316 | 0 | 0.11 | 0.984 | GP (contact) |
tshr_human | 526 | 34.50x50 | ICL2 | A => T | missense | 4.122e-05 | 5 | 121302 | 0 | 0.0 | 0.999 | GP (contact) |
tshr_human | 527 | 34.51x51 | ICL2 | M => V | missense | 8.243e-06 | 1 | 121316 | 0 | 0.07 | 0.73 | GP (contact) |
tshr_human | 528 | 34.52x52 | ICL2 | R => C | missense | 8.244e-06 | 1 | 121306 | 0 | 0.0 | 0.91 | GP (contact) |
tshr_human | 528 | 34.52x52 | ICL2 | R => H | missense | 7.419e-05 | 9 | 121318 | 0 | 0.05 | 0.063 | GP (contact) |
tshr_human | 531 | 34.55x55 | ICL2 | R => W | missense | 3.297e-05 | 4 | 121340 | 0 | 0.0 | 0.999 | GP (contact) |
tshr_human | 531 | 34.55x55 | ICL2 | R => G | missense | 8.241e-06 | 1 | 121340 | 0 | 0.01 | 0.987 | GP (contact) |
tshr_human | 531 | 34.55x55 | ICL2 | R => Q | missense | 8.243e-06 | 1 | 121322 | 0 | 0.2 | 0.969 | GP (contact) |
tshr_human | 534 | 4.38x38 | TM4 | R => C | missense | 0.0005191 | 63 | 121360 | 0 | 0.03 | 0.099 | |
tshr_human | 534 | 4.38x38 | TM4 | R => S | missense | 8.24e-06 | 1 | 121360 | 0 | 0.0 | 0.785 | |
tshr_human | 534 | 4.38x38 | TM4 | R => H | missense | 0.0001071 | 13 | 121360 | 0 | 0.09 | 0.043 | |
tshr_human | 538 | 4.42x42 | TM4 | A => S | missense | 2.472e-05 | 3 | 121376 | 0 | 0.0 | 1.0 | |
tshr_human | 541 | 4.45x45 | TM4 | I => V | missense | 5.767e-05 | 7 | 121390 | 0 | 0.46 | 0.005 | |
tshr_human | 541 | 4.45x45 | TM4 | I => N | missense | 8.238e-06 | 1 | 121388 | 0 | 0.0 | 0.776 | |
tshr_human | 545 | 4.49x49 | TM4 | G => C | missense | 8.238e-06 | 1 | 121394 | 0 | 0.0 | 1.0 | |
tshr_human | 549 | 4.53x53 | TM4 | C => R | missense | 8.237e-06 | 1 | 121404 | 0 | 0.0 | 0.94 | |
tshr_human | 553 | 4.57x57 | TM4 | A => T | missense | 3.295e-05 | 4 | 121402 | 0 | 0.0 | 0.99 | |
tshr_human | 553 | 4.57x57 | TM4 | A => S | missense | 8.237e-06 | 1 | 121402 | 0 | 0.01 | 0.987 | |
tshr_human | 558 | 4.62x62 | TM4 | V => L | missense | 8.237e-06 | 1 | 121400 | 0 | 0.27 | 0.019 | |
tshr_human | 561 | ECL2 | S => N | missense | 8.237e-06 | 1 | 121402 | 0 | 0.02 | 0.97 | ||
tshr_human | 566 | ECL2 | V => I | missense | 8.237e-06 | 1 | 121400 | 0 | 0.0 | 0.999 | ||
tshr_human | 568 | ECL2 | I => N | missense | 4.942e-05 | 6 | 121398 | 0 | 0.0 | 1.0 | ||
tshr_human | 574 | ECL2 | T => S | missense | 0.0005189 | 63 | 121402 | 1 | 0.01 | 0.951 | ||
tshr_human | 575 | ECL2 | E => K | missense | 8.237e-06 | 1 | 121402 | 0 | 0.04 | 0.045 | ||
tshr_human | 579 | 5.36x36 | TM5 | A => T | missense | 8.237e-06 | 1 | 121402 | 0 | 0.01 | 0.575 | |
tshr_human | 582 | 5.39x39 | TM5 | Y => F | missense | 1.647e-05 | 2 | 121404 | 0 | 0.0 | 0.999 | |
tshr_human | 586 | 5.43x43 | TM5 | V => A | missense | 8.237e-06 | 1 | 121406 | 0 | 0.0 | 0.96 | LB (Van der Waals, polar (hydrogen bond)) |
tshr_human | 588 | 5.45x45 | TM5 | T => M | missense | 1.647e-05 | 2 | 121406 | 0 | 0.19 | 0.0 | |
tshr_human | 591 | 5.48x48 | TM5 | I => V | missense | 8.237e-06 | 1 | 121406 | 0 | 1.0 | 0.044 | |
tshr_human | 595 | 5.52x52 | TM5 | V => I | missense | 0.0001894 | 23 | 121406 | 0 | 0.76 | 0.003 | |
tshr_human | 596 | 5.53x53 | TM5 | I => T | missense | 4.942e-05 | 6 | 121406 | 0 | 0.02 | 0.419 | |
tshr_human | 597 | 5.54x54 | TM5 | V => I | missense | 1.647e-05 | 2 | 121406 | 0 | 1.0 | 0.017 | |
tshr_human | 600 | 5.57x57 | TM5 | C => S | missense | 8.237e-06 | 1 | 121406 | 0 | 0.0 | 0.999 | |
tshr_human | 602 | 5.59x59 | TM5 | V => M | missense | 8.237e-06 | 1 | 121406 | 0 | 0.0 | 0.197 | |
tshr_human | 606 | 5.63x63 | TM5 | I => T | missense | 8.237e-06 | 1 | 121406 | 0 | 0.13 | 0.008 | |
tshr_human | 609 | 5.66x66 | TM5 | R => Q | missense | 7.413e-05 | 9 | 121408 | 0 | 0.29 | 0.951 | GP (contact) |
tshr_human | 611 | ICL3 | P => L | missense | 8.237e-06 | 1 | 121408 | 0 | 0.0 | 1.0 | ||
tshr_human | 613 | ICL3 | Y => C | missense | 2.471e-05 | 3 | 121408 | 0 | 0.02 | 0.994 | ||
tshr_human | 617 | 6.28x28 | TM6 | D => E | missense | 8.236e-06 | 1 | 121412 | 0 | 0.04 | 0.007 | GP (contact) |
tshr_human | 626 | 6.37x37 | TM6 | M => T | missense | 8.236e-06 | 1 | 121412 | 0 | 0.0 | 0.999 | GP (contact) |
tshr_human | 635 | 6.46x46 | TM6 | I => L | missense | 8.236e-06 | 1 | 121412 | 0 | 1.0 | 0.001 | |
tshr_human | 635 | 6.46x46 | TM6 | I => M | missense | 2.471e-05 | 3 | 121410 | 0 | 0.21 | 0.007 | |
tshr_human | 637 | 6.48x48 | TM6 | M => T | missense | 8.236e-06 | 1 | 121412 | 0 | 0.01 | 0.979 | SodiumPocket MicroSwitch |
tshr_human | 646 | 6.57x57 | TM6 | S => P | missense | 8.236e-06 | 1 | 121412 | 0 | 0.0 | 0.992 | |
tshr_human | 649 | 6.60x60 | TM6 | L => M | missense | 2.471e-05 | 3 | 121412 | 0 | 0.51 | 0.047 | |
tshr_human | 652 | ECL3 | P => S | missense | 8.236e-06 | 1 | 121412 | 0 | 0.0 | 1.0 | ||
tshr_human | 654 | ECL3 | I => F | missense | 2.471e-05 | 3 | 121412 | 0 | 0.0 | 1.0 | ||
tshr_human | 657 | 7.32x31 | TM7 | S => G | missense | 8.236e-06 | 1 | 121412 | 0 | 0.0 | 0.492 | |
tshr_human | 667 | 7.42x41 | TM7 | Y => H | missense | 8.236e-06 | 1 | 121412 | 0 | 0.01 | 1.0 | LB (polar (hydrogen bond)) |
tshr_human | 669 | 7.44x43 | TM7 | L => F | missense | 8.236e-06 | 1 | 121412 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch |
tshr_human | 676 | 7.51x51 | TM7 | F => L | missense | 8.236e-06 | 1 | 121412 | 0 | 0.0 | 0.999 | |
tshr_human | 678 | 7.53x53 | TM7 | Y => C | missense | 8.236e-06 | 1 | 121412 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch |
tshr_human | 679 | 7.54x54 | TM7 | A => V | missense | 8.236e-06 | 1 | 121412 | 0 | 0.01 | 0.997 | |
tshr_human | 680 | 7.55x55 | TM7 | I => V | missense | 8.236e-06 | 1 | 121412 | 0 | 0.06 | 0.071 | GP (contact) |
tshr_human | 684 | 8.49x49 | H8 | A => D | missense | 8.237e-06 | 1 | 121410 | 0 | 0.02 | 0.206 | GP (contact) |
tshr_human | 688 | 8.53x53 | H8 | D => E | missense | 8.237e-06 | 1 | 121410 | 0 | 0.0 | 1.0 | |
tshr_human | 689 | 8.54x54 | H8 | V => G | missense | 4.118e-05 | 5 | 121410 | 0 | 0.0 | 0.986 | |
tshr_human | 691 | 8.56x56 | H8 | I => L | missense | 8.237e-06 | 1 | 121410 | 0 | 0.3 | 0.169 | |
tshr_human | 694 | 8.59x59 | H8 | S => N | missense | 8.237e-06 | 1 | 121402 | 0 | 0.02 | 0.207 | |
tshr_human | 696 | 8.61x61 | H8 | F => I | missense | 8.237e-06 | 1 | 121404 | 0 | 0.06 | 0.037 | |
tshr_human | 696 | 8.61x61 | H8 | F => L | missense | 8.237e-06 | 1 | 121404 | 0 | 0.14 | 0.012 | |
tshr_human | 700 | C-term | K => E | missense | 0.0001071 | 13 | 121394 | 1 | 1.0 | 0.008 | ||
tshr_human | 701 | C-term | R => C | missense | 9.062e-05 | 11 | 121386 | 0 | 0.08 | 0.828 | ||
tshr_human | 701 | C-term | R => H | missense | 1.648e-05 | 2 | 121392 | 1 | 0.77 | 0.008 | ||
tshr_human | 702 | C-term | Q => R | missense | 3.295e-05 | 4 | 121392 | 0 | 0.42 | 0.011 | ||
tshr_human | 707 | C-term | R => W | missense | 1.648e-05 | 2 | 121342 | 0 | 0.0 | 0.98 | ||
tshr_human | 707 | C-term | R => G | missense | 8.241e-06 | 1 | 121342 | 0 | 0.0 | 0.806 | ||
tshr_human | 707 | C-term | R => Q | missense | 0.0001072 | 13 | 121320 | 0 | 0.03 | 0.082 | ||
tshr_human | 716 | C-term | S => I | missense | 8.248e-06 | 1 | 121246 | 0 | 0.0 | 0.57 | ||
tshr_human | 716 | C-term | S => N | missense | 8.248e-06 | 1 | 121246 | 0 | 0.09 | 0.046 | ||
tshr_human | 721 | C-term | V => F | missense | 0.001081 | 131 | 121210 | 0 | 0.24 | 0.091 | ||
tshr_human | 721 | C-term | V => I | missense | 8.25e-06 | 1 | 121210 | 0 | 0.32 | 0.001 | ||
tshr_human | 724 | C-term | V => F | missense | 8.251e-06 | 1 | 121202 | 0 | 0.07 | 0.188 | ||
tshr_human | 725 | C-term | T => I | missense | 2.476e-05 | 3 | 121178 | 0 | 0.17 | 0.005 | ||
tshr_human | 728 | C-term | M => V | missense | 8.244e-06 | 1 | 121296 | 0 | 0.46 | 0.001 | ||
tshr_human | 729 | C-term | R => W | missense | 8.244e-06 | 1 | 121298 | 0 | 0.02 | 0.649 | ||
tshr_human | 731 | C-term | G => C | missense | 1.649e-05 | 2 | 121316 | 0 | nan | 0.556 | ||
tshr_human | 731 | C-term | G => V | missense | 8.243e-06 | 1 | 121310 | 0 | nan | 0.005 | ||
tshr_human | 735 | C-term | M => V | missense | 8.243e-06 | 1 | 121316 | 0 | nan | 0.001 | ||
tshr_human | 742 | C-term | I => V | missense | 8.24e-06 | 1 | 121352 | 0 | nan | 0.012 | ||
tshr_human | 742 | C-term | I => T | missense | 1.648e-05 | 2 | 121346 | 0 | nan | 0.088 | ||
tshr_human | 744 | C-term | N => K | missense | 0.005002 | 607 | 121346 | 15 | nan | 0.004 | ||
tshr_human | 745 | C-term | S => C | missense | 4.944e-05 | 6 | 121352 | 0 | nan | 0.698 | PTM (Phosphorylation) | |
tshr_human | 748 | C-term | T => I | missense | 8.24e-06 | 1 | 121358 | 0 | nan | 0.099 | PTM (Phosphorylation) | |
tshr_human | 751 | C-term | K => R | missense | 7.416e-05 | 9 | 121366 | 0 | nan | 0.004 | ||
tshr_human | 752 | C-term | Q => K | missense | 8.24e-06 | 1 | 121362 | 0 | nan | 0.045 | ||
tshr_human | 753 | C-term | G => S | missense | 8.239e-06 | 1 | 121370 | 0 | nan | 0.005 | ||
tshr_human | 758 | C-term | E => K | missense | 4.121e-05 | 5 | 121344 | 0 | nan | 0.075 | ||
tshr_human | 760 | C-term | M => T | missense | 2.473e-05 | 3 | 121304 | 0 | nan | 0.0 | ||
tshr_human | 761 | C-term | Q => K | missense | 8.245e-06 | 1 | 121292 | 0 | nan | 0.045 | ||
tshr_human | 762 | C-term | T => M | missense | 8.247e-06 | 1 | 121254 | 0 | nan | 0.79 |
Residue
- deleterious missense variants are shown in red
- tolerated missense variants are shown in green
- loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue