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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
5ht1b_human 7.39x38 355 TM7 T => N 500.0↑ K(i) (Binding - Radioligand competition/displacement) Pindolol Parker EM et al (1993) Vass M et al (2018)
5ht1b_human 4.61x61 185 TM4 F => A 2.564↑ K(i) (Binding - Radioligand competition/displacement) 8-OH-DPAT Granas C et al (1998) Vass M et al (2018)
5ht1b_human 4.61x61 185 TM4 F => A 1.096↑ K(i) (Binding - Radioligand competition/displacement) 5-HT Granas C et al (2001) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => V N/A N/A Pauwels PJ et al (1999)
5ht1b_human 7.38x37 354 TM7 F => Y 1.714↓ K(d) (Binding - Radioligand saturation) [3H]GR125743 Granas C et al (2001) Vass M et al (2018)
5ht1b_human 6.55x55 334 TM6 S => A N/A N/A Granas C et al (1998)
5ht1b_human 6.55x55 334 TM6 S => A 1.499↑ K(i) (Binding - Radioligand competition/displacement) Sumatriptan Granas C et al (1998) Vass M et al (2018)
5ht1b_human 5.42x43 212 TM5 S => A 2.674↑ K(i) (Binding - Radioligand competition/displacement) Methysergide Granas C et al (1998)
5ht1b_human 6.55x55 334 TM6 S => A 1.072↓ pK(i) (Binding - Radioligand competition/displacement) Ergotamine Wang C et al (2013) Vass M et al (2018)
5ht1b_human 4.61x61 185 TM4 F => M 1.235↓ K(i) (Binding - Radioligand competition/displacement) 5-HT Granas C et al (1998) Vass M et al (2018)
5ht1b_human 7.39x38 355 TM7 T => N 6.536↑ K(i) (Binding - Radioligand competition/displacement) Desoxypropranolol Glennon RA et al (1996) Vass M et al (2018)
5ht1b_human 7.36x35 352 TM7 D => A Decreased effect (Binding - Radioligand competition/displacement) 5-HT Granas C et al (1999) Vass M et al (2018)
5ht1b_human 4.61x61 185 TM4 F => M 1.714↓ K(d) (Binding - Radioligand saturation) [3H]GR125743 Granas C et al (2001) Vass M et al (2018)
5ht1b_human 4.57x57 181 TM4 S => A 1.101↑ K(i) (Binding - Radioligand competition/displacement) Methiothepin Granas C et al (1998) Vass M et al (2018)
5ht1b_human 45.51x51 200 ECL2 V => A 1.288↓ pK(i) (Binding - Radioligand competition/displacement) 5-HT Wang C et al (2013) Vass M et al (2018)
5ht1b_human 6.55x55 334 TM6 S => A 6.026↓ pK(i) (Binding - Radioligand competition/displacement) 5-HT Wang C et al (2013) Vass M et al (2018)
5ht1b_human 7.39x38 355 TM7 T => N 46.44↓ K(i) (Binding - Radioligand competition/displacement) Rauwolscine Parker EM et al (1993) Vass M et al (2018)
5ht1b_human 7.38x37 354 TM7 F => Y 2.825↑ K(i) (Binding - Radioligand competition/displacement) Methiothepin Granas C et al (1998) Vass M et al (2018)
5ht1b_human 5.39x40 209 TM5 T => A 1.585↑ pK(i) (Binding - Radioligand competition/displacement) LSD Wang C et al (2013) Vass M et al (2018)
5ht1b_human 6.47x47 326 TM6 C => A No effect (Binding - Radioligand competition/displacement) Methiothepin Granas C et al (1999) Vass M et al (2018)
5ht1b_human 6.55x55 334 TM6 S => A 4.14↓ K(i) (Binding - Radioligand competition/displacement) 5-HT Granas C et al (2001) Vass M et al (2018)
5ht1b_human 7.39x38 355 TM7 T => N 500.0↑ K(i) (Binding - Radioligand competition/displacement) Pindolol Oksenberg D et al (1992) Vass M et al (2018)
5ht1b_human 7.39x38 355 TM7 T => N 3.003↑ K(i) (Binding - Radioligand competition/displacement) DHE Oksenberg D et al (1992) Vass M et al (2018)
5ht1b_human 7.38x37 354 TM7 F => Y 1.207↓ K(i) (Binding - Radioligand competition/displacement) Sumatriptan Granas C et al (1998) Vass M et al (2018)
5ht1b_human 6.52x52 331 TM6 F => A 2.915↑ K(d) (Binding - Radioligand saturation) [3H]5-HT Granas C et al (2001) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => H N/A N/A Pauwels PJ et al (1999)
5ht1b_human 6.52x52 331 TM6 F => A 1.553↑ K(i) (Binding - Radioligand competition/displacement) Sumatriptan Granas C et al (1998)
5ht1b_human 4.61x61 185 TM4 F => M 1.757↑ K(i) (Binding - Radioligand competition/displacement) 8-OH-DPAT Granas C et al (1998) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => S N/A N/A Pauwels PJ et al (1999)
5ht1b_human 7.39x38 355 TM7 T => N 1000.0↑ K(i) (Binding - Radioligand competition/displacement) Alprenolol Oksenberg D et al (1992) Vass M et al (2018)
5ht1b_human 7.39x38 355 TM7 T => N N/A N/A Glennon RA et al (1996)
5ht1b_human 6.52x52 331 TM6 F => A 1.876↑ K(i) (Binding - Radioligand competition/displacement) Granas C et al (1998)
5ht1b_human 3.37x37 134 TM3 T => A 21.878↓ pK(i) (Binding - Radioligand competition/displacement) 5-HT Wang C et al (2013) Vass M et al (2018)
5ht1b_human 7.38x37 354 TM7 F => A 1.667↑ K(i) (Binding - Radioligand competition/displacement) L-694,247 Granas C et al (1998) Vass M et al (2018)
5ht1b_human 6.52x52 331 TM6 F => A 2.123↑ K(i) (Binding - Radioligand competition/displacement) 5-HT Granas C et al (1998)
5ht1b_human 7.39x38 355 TM7 T => N 500.0↑ K(i) (Binding - Radioligand competition/displacement) (-)Propranolol Glennon RA et al (1996) Vass M et al (2018)
5ht1b_human 6.52x52 331 TM6 F => A 1.0 pK(i) (Binding - Radioligand competition/displacement) LSD Wang C et al (2013) Vass M et al (2018)
5ht1b_human 7.39x38 355 TM7 T => N 7.462↓ K(i) (Binding - Radioligand competition/displacement) Methysergide Oksenberg D et al (1992) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => K N/A N/A Pauwels PJ et al (1999)
5ht1b_human 5.42x43 212 TM5 S => A 1.167↑ K(d) (Binding - Radioligand saturation) [3H]GR125743 Granas C et al (2001) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => R N/A N/A Pauwels PJ et al (1999)
5ht1b_human 7.39x38 355 TM7 T => N 1.25↑ K(i) (Binding - Radioligand competition/displacement) 5-HT Oksenberg D et al (1992) Vass M et al (2018)
5ht1b_human 7.39x38 355 TM7 T => N 1.626↑ K(d) (Binding - Radioligand saturation) 5-CT Parker EM et al (1993) Vass M et al (2018)
5ht1b_human 7.39x38 355 TM7 T => N 3.167↓ K(i) (Binding - Radioligand competition/displacement) Methiothepin Oksenberg D et al (1992) Vass M et al (2018)
5ht1b_human 7.38x37 354 TM7 F => Y 1.361↑ K(i) (Binding - Radioligand competition/displacement) 5-HT Granas C et al (1998) Vass M et al (2018)
5ht1b_human 5.42x43 212 TM5 S => A 1.59↑ K(d) (Binding - Radioligand saturation) [3H]5-HT Granas C et al (2001) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => W N/A N/A Pauwels PJ et al (1999)
5ht1b_human 6.34x34 313 TM6 T => N N/A N/A Pauwels PJ et al (1999)
5ht1b_human 7.39x38 355 TM7 T => N 5.646↓ K(i) (Binding - Radioligand competition/displacement) Sumatriptan Parker EM et al (1993) Vass M et al (2018)
5ht1b_human 6.52x52 331 TM6 F => A 2.584↑ K(d) (Binding - Radioligand saturation) [3H]5-HT Granas C et al (1998)
5ht1b_human 7.38x37 354 TM7 F => Y 2.1↓ K(i) (Binding - Radioligand competition/displacement) L-694,247 Granas C et al (1998) Vass M et al (2018)
5ht1b_human 7.35x34 351 TM7 F => A 1.995↓ pK(i) (Binding - Radioligand competition/displacement) 5-HT Wang C et al (2013) Vass M et al (2018)
5ht1b_human 7.38x37 354 TM7 F => A 1.286↓ K(d) (Binding - Radioligand saturation) [3H]GR125743 Granas C et al (2001) Vass M et al (2018)
5ht1b_human 6.52x52 331 TM6 F => A 1.549↓ pK(i) (Binding - Radioligand competition/displacement) Ergotamine Wang C et al (2013) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => F N/A N/A Pauwels PJ et al (1999)
5ht1b_human 45.52x52 201 ECL2 V => A 3.165↑ pK(i) (Binding - Radioligand competition/displacement) LSD Wang C et al (2013) Vass M et al (2018)
5ht1b_human 7.38x37 354 TM7 F => A 1.499↑ K(i) (Binding - Radioligand competition/displacement) 5-CT Granas C et al (1998) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => I N/A N/A Pauwels PJ et al (1999)
5ht1b_human 6.55x55 334 TM6 S => A 1.996↑ pK(i) (Binding - Radioligand competition/displacement) LSD Wang C et al (2013) Vass M et al (2018)
5ht1b_human 6.55x55 334 TM6 S => A 1.118↓ K(i) (Binding - Radioligand competition/displacement) 5-HT Granas C et al (2001) Vass M et al (2018)
5ht1b_human 5.42x43 212 TM5 S => A N/A N/A Granas C et al (1998)
5ht1b_human 4.57x57 181 TM4 S => A 1.176↓ K(i) (Binding - Radioligand competition/displacement) Methysergide Granas C et al (1998) Vass M et al (2018)
5ht1b_human 4.61x61 185 TM4 F => M 1.89↑ K(i) (Binding - Radioligand competition/displacement) Methysergide Granas C et al (1998) Vass M et al (2018)
5ht1b_human 7.39x38 355 TM7 T => N 14.737↓ K(i) (Binding - Radioligand competition/displacement) Sumatriptan Oksenberg D et al (1992) Vass M et al (2018)
5ht1b_human 3.37x37 134 TM3 T => A 1.202↑ pK(i) (Binding - Radioligand competition/displacement) Ergotamine Wang C et al (2013) Vass M et al (2018)
5ht1b_human 6.52x52 331 TM6 F => A 2.123↑ K(i) (Binding - Radioligand competition/displacement) 5-HT Granas C et al (2001) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => P N/A N/A Pauwels PJ et al (1999)
5ht1b_human 7.39x38 355 TM7 T => N 11.275↓ K(i) (Binding - Radioligand competition/displacement) 5-MeO-DMT Parker EM et al (1993) Vass M et al (2018)
5ht1b_human 4.57x57 181 TM4 S => A 1.267↓ K(i) (Binding - Radioligand competition/displacement) 5-CT Granas C et al (1998) Vass M et al (2018)
5ht1b_human 7.43x42 359 TM7 Y => A 2.288↑ pK(i) (Binding - Radioligand competition/displacement) 5-HT Wang C et al (2013) Vass M et al (2018)
5ht1b_human 6.52x52 331 TM6 F => A 10.753↑ K(i) (Binding - Radioligand competition/displacement) 5-HT Granas C et al (2001) Vass M et al (2018)
5ht1b_human 45.52x52 201 ECL2 V => A 1.0 pK(i) (Binding - Radioligand competition/displacement) 5-HT Wang C et al (2013) Vass M et al (2018)
5ht1b_human 6.55x55 334 TM6 S => A 1.029↓ K(d) (Binding - Radioligand saturation) [3H]5-HT Granas C et al (2001) Vass M et al (2018)
5ht1b_human 7.38x37 354 TM7 F => Y 1.361↑ K(i) (Binding - Radioligand competition/displacement) 5-HT Granas C et al (2001) Vass M et al (2018)
5ht1b_human 5.46x461 216 TM5 A => S 1.738↓ pK(i) (Binding - Radioligand competition/displacement) 5-HT Wang C et al (2013) Vass M et al (2018)
5ht1b_human 7.38x37 354 TM7 F => A 1.035↑ K(i) (Binding - Radioligand competition/displacement) Sumatriptan Granas C et al (1998) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => D N/A N/A Pauwels PJ et al (1999)
5ht1b_human 4.61x61 185 TM4 F => M 1.235↓ K(i) (Binding - Radioligand competition/displacement) 5-HT Granas C et al (2001) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => R N/A N/A Pauwels PJ et al (1999)
5ht1b_human 203 ECL2 T => A 1.0 pK(i) (Binding - Radioligand competition/displacement) LSD Wang C et al (2013) Vass M et al (2018)
5ht1b_human 6.55x55 334 TM6 S => E N/A N/A Parker EM et al (1996)
5ht1b_human 4.61x61 185 TM4 F => M 1.458↑ K(d) (Binding - Radioligand saturation) [3H]5-HT Granas C et al (2001) Vass M et al (2018)
5ht1b_human 4.61x61 185 TM4 F => A 1.176↑ K(i) (Binding - Radioligand competition/displacement) L-694,247 Granas C et al (1998) Vass M et al (2018)
5ht1b_human 203 ECL2 T => A 1.698↓ pK(i) (Binding - Radioligand competition/displacement) Ergotamine Wang C et al (2013) Vass M et al (2018)
5ht1b_human 5.42x43 212 TM5 S => A N/A N/A Granas C et al (1998)
5ht1b_human 4.57x57 181 TM4 S => A 1.118↓ K(i) (Binding - Radioligand competition/displacement) 5-HT Granas C et al (1998) Vass M et al (2018)
5ht1b_human 5.42x43 212 TM5 S => A 15.133↓ K(i) (Binding - Radioligand competition/displacement) Granas C et al (1998)
5ht1b_human 7.39x38 355 TM7 T => N N/A N/A Adham N et al (1994)
5ht1b_human 7.39x38 355 TM7 T => N 23.62↓ K(i) (Binding - Radioligand competition/displacement) Dipropyl-5-CT Parker EM et al (1993) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => E N/A N/A Pauwels PJ et al (1999)
5ht1b_human 6.55x55 334 TM6 S => E 1.617↓ K(d) (Binding - Radioligand saturation) 5-HT Parker EM et al (1996) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => M N/A N/A Pauwels PJ et al (1999)
5ht1b_human 7.36x35 352 TM7 D => A 2.513↑ pK(i) (Binding - Radioligand competition/displacement) LSD Wang C et al (2013) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => H N/A N/A Pauwels PJ et al (1999)
5ht1b_human 7.39x38 355 TM7 T => N N/A N/A Parker EM et al (1993)
5ht1b_human 6.55x55 334 TM6 S => A 1.033↑ K(d) (Binding - Radioligand saturation) [3H]5-HT Granas C et al (1998) Vass M et al (2018)
5ht1b_human 5.46x461 216 TM5 A => S 1.318↑ pK(i) (Binding - Radioligand competition/displacement) Ergotamine Wang C et al (2013) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => C N/A N/A Pauwels PJ et al (1999)
5ht1b_human 4.61x61 185 TM4 F => M 2.717↑ K(i) (Binding - Radioligand competition/displacement) Sumatriptan Granas C et al (1998) Vass M et al (2018)
5ht1b_human 6.55x55 334 TM6 S => A 1.364↑ K(i) (Binding - Radioligand competition/displacement) Methysergide Granas C et al (1998) Vass M et al (2018)
5ht1b_human 4.61x61 185 TM4 F => A 1.364↑ K(i) (Binding - Radioligand competition/displacement) 5-CT Granas C et al (1998) Vass M et al (2018)
5ht1b_human 2.37x37 82 TM2 T => I N/A N/A Brockhoff A et al (2010)
5ht1b_human 5.42x43 212 TM5 S => A 4.651↑ K(i) (Binding - Radioligand competition/displacement) Methiothepin Granas C et al (1998)
5ht1b_human 7.39x38 355 TM7 T => N >10.0↓ K(i) (Binding - Radioligand competition/displacement) Didesoxopropranolol Glennon RA et al (1996) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => N N/A N/A Pauwels PJ et al (1999)
5ht1b_human 7.36x35 352 TM7 D => A 2.137↑ pK(i) (Binding - Radioligand competition/displacement) 5-HT Wang C et al (2013) Vass M et al (2018)
5ht1b_human 7.38x37 354 TM7 F => Y N/A N/A Granas C et al (1998)
5ht1b_human 3.53x53 150 TM3 A => V N/A N/A Downing T et al (2011)
5ht1b_human 7.38x37 354 TM7 F => A 1.128↓ K(i) (Binding - Radioligand competition/displacement) Methysergide Granas C et al (1998) Vass M et al (2018)
5ht1b_human 4.61x61 185 TM4 F => A 1.096↑ K(i) (Binding - Radioligand competition/displacement) 5-HT Granas C et al (1998) Vass M et al (2018)
5ht1b_human 4.61x61 185 TM4 F => A 5.65↓ K(i) (Binding - Radioligand competition/displacement) 5-HT Granas C et al (2001) Vass M et al (2018)
5ht1b_human 3.37x37 134 TM3 T => A 3.981↓ pK(i) (Binding - Radioligand competition/displacement) LSD Wang C et al (2013) Vass M et al (2018)
5ht1b_human 4.57x57 181 TM4 S => A 1.55↑ K(d) (Binding - Radioligand saturation) [3H]5-HT Granas C et al (1998) Vass M et al (2018)
5ht1b_human 6.52x52 331 TM6 F => A 1.349↓ pK(i) (Binding - Radioligand competition/displacement) 5-HT Wang C et al (2013) Vass M et al (2018)
5ht1b_human 5.42x43 212 TM5 S => A 1.03↑ K(i) (Binding - Radioligand competition/displacement) 5-HT Granas C et al (2001) Vass M et al (2018)
5ht1b_human 4.61x61 185 TM4 F => A 1.06↑ K(d) (Binding - Radioligand saturation) [3H]5-HT Granas C et al (2001) Vass M et al (2018)
5ht1b_human 7.35x34 351 TM7 F => A 1.996↑ pK(i) (Binding - Radioligand competition/displacement) LSD Wang C et al (2013) Vass M et al (2018)
5ht1b_human 4.61x61 185 TM4 F => A 1.429↓ K(d) (Binding - Radioligand saturation) [3H]GR125743 Granas C et al (2001) Vass M et al (2018)
5ht1b_human 7.38x37 354 TM7 F => Y 1.938↑ K(d) (Binding - Radioligand saturation) [3H]5-HT Granas C et al (1998) Vass M et al (2018)
5ht1b_human 6.52x52 331 TM6 F => A 2.151↑ K(i) (Binding - Radioligand competition/displacement) Methysergide Granas C et al (1998)
5ht1b_human 6.52x52 331 TM6 F => A N/A N/A Granas C et al (1998)
5ht1b_human 7.39x38 355 TM7 T => N N/A N/A Oksenberg D et al (1992)
5ht1b_human 4.57x57 181 TM4 S => A 1.429↑ K(i) (Binding - Radioligand competition/displacement) L-694,247 Granas C et al (1998) Vass M et al (2018)
5ht1b_human 5.42x43 212 TM5 S => A 1.0 pK(i) (Binding - Radioligand competition/displacement) LSD Wang C et al (2013) Vass M et al (2018)
5ht1b_human 6.54x54 333 TM6 I => K 1.04↑ K(i) (Binding - Radioligand competition/displacement) 5-CT Parker EM et al (1996) Vass M et al (2018)
5ht1b_human 4.61x61 185 TM4 F => M 2.71↑ K(i) (Binding - Radioligand competition/displacement) Methiothepin Granas C et al (1998) Vass M et al (2018)
5ht1b_human 45.52x52 201 ECL2 V => A 1.949↑ pK(i) (Binding - Radioligand competition/displacement) Ergotamine Wang C et al (2013) Vass M et al (2018)
5ht1b_human 202 ECL2 N => A N/A N/A Marie J et al (2001)
5ht1b_human 6.55x55 334 TM6 S => A 4.95↑ K(i) (Binding - Radioligand competition/displacement) 8-OH-DPAT Granas C et al (1998) Vass M et al (2018)
5ht1b_human 6.55x55 334 TM6 S => A 3.497↑ K(d) (Binding - Radioligand saturation) [3H]GR125743 Granas C et al (2001) Vass M et al (2018)
5ht1b_human 4.61x61 185 TM4 F => A N/A N/A Granas C et al (1998)
5ht1b_human 7.39x38 355 TM7 T => N 15.625↓ K(i) (Binding - Radioligand competition/displacement) 8-OH-DPAT Oksenberg D et al (1992) Vass M et al (2018)
5ht1b_human 3.27x27 124 TM3 F => C N/A N/A Sanders AR et al (2002)
5ht1b_human 7.38x37 354 TM7 F => A N/A N/A Granas C et al (1998)
5ht1b_human 7.38x37 354 TM7 F => Y 1.038↑ K(i) (Binding - Radioligand competition/displacement) Methysergide Granas C et al (1998) Vass M et al (2018)
5ht1b_human 6.55x55 334 TM6 S => E 3.623↑ K(i) (Binding - Radioligand competition/displacement) Lysergol Parker EM et al (1996) Vass M et al (2018)
5ht1b_human 7.39x38 355 TM7 T => N 142.857↑ K(i) (Binding - Radioligand competition/displacement) CP-93,129 Parker EM et al (1993) Vass M et al (2018)
5ht1b_human 5.42x43 212 TM5 S => A 1.028↑ K(i) (Binding - Radioligand competition/displacement) 5-HT Granas C et al (2001) Vass M et al (2018)
5ht1b_human 6.58x58 337 TM6 M => A 1.175↑ pK(i) (Binding - Radioligand competition/displacement) Ergotamine Wang C et al (2013) Vass M et al (2018)
5ht1b_human 6.58x58 337 TM6 M => A 2.513↑ pK(i) (Binding - Radioligand competition/displacement) LSD Wang C et al (2013) Vass M et al (2018)
5ht1b_human 6.48x48 327 TM6 W => A No effect (Binding - Radioligand competition/displacement) 5-HT Granas C et al (1999) Vass M et al (2018)
5ht1b_human 4.61x61 185 TM4 F => M 1.364↑ K(i) (Binding - Radioligand competition/displacement) 5-CT Granas C et al (1998) Vass M et al (2018)
5ht1b_human 5.39x40 209 TM5 T => A 1.318↑ pK(i) (Binding - Radioligand competition/displacement) Ergotamine Wang C et al (2013) Vass M et al (2018)
5ht1b_human 7.39x38 355 TM7 T => N 2.584↑ K(i) (Binding - Radioligand competition/displacement) 5-HT Parker EM et al (1993) Vass M et al (2018)
5ht1b_human 7.39x38 355 TM7 T => N 3.942↓ K(i) (Binding - Radioligand competition/displacement) NIONE Glennon RA et al (1996) Vass M et al (2018)
5ht1b_human 3.29x29 126 TM3 L => A 4.169↓ pK(i) (Binding - Radioligand competition/displacement) 5-HT Wang C et al (2013) Vass M et al (2018)
5ht1b_human 6.48x48 327 TM6 W => A N/A N/A Granas C et al (1999)
5ht1b_human 7.38x37 354 TM7 F => A 2.033↑ K(i) (Binding - Radioligand competition/displacement) Methiothepin Granas C et al (1998) Vass M et al (2018)
5ht1b_human 45.51x51 200 ECL2 V => A 1.996↑ pK(i) (Binding - Radioligand competition/displacement) LSD Wang C et al (2013) Vass M et al (2018)
5ht1b_human 7.39x38 355 TM7 T => N 1.333↑ K(i) (Binding - Radioligand competition/displacement) 5-CT Oksenberg D et al (1992) Vass M et al (2018)
5ht1b_human 7.39x38 355 TM7 T => N 5.556↓ K(i) (Binding - Radioligand competition/displacement) Metergoline Parker EM et al (1993) Vass M et al (2018)
5ht1b_human 5.42x43 212 TM5 S => A 1.408↑ K(d) (Binding - Radioligand saturation) [3H]5-HT Granas C et al (1998)
5ht1b_human 203 ECL2 T => A 1.148↓ pK(i) (Binding - Radioligand competition/displacement) 5-HT Wang C et al (2013) Vass M et al (2018)
5ht1b_human 4.61x61 185 TM4 F => M 1.7↓ K(i) (Binding - Radioligand competition/displacement) L-694,247 Granas C et al (1998) Vass M et al (2018)
5ht1b_human 45.51x51 200 ECL2 V => A 1.024↑ pK(i) (Binding - Radioligand competition/displacement) Ergotamine Wang C et al (2013) Vass M et al (2018)
5ht1b_human 6.52x52 331 TM6 F => A N/A N/A Granas C et al (1998)
5ht1b_human 6.55x55 334 TM6 S => A N/A N/A Granas C et al (1998)
5ht1b_human 6.47x47 326 TM6 C => A No effect (Binding - Radioligand competition/displacement) 5-HT Granas C et al (1999) Vass M et al (2018)
5ht1b_human 6.54x54 333 TM6 I => K 1.155↓ K(d) (Binding - Radioligand saturation) 5-HT Parker EM et al (1996) Vass M et al (2018)
5ht1b_human 7.39x38 355 TM7 T => N 2.653↑ K(i) (Binding - Radioligand competition/displacement) Deshydroxypropranolol Glennon RA et al (1996) Vass M et al (2018)
5ht1b_human 6.55x55 334 TM6 S => A 1.118↓ K(i) (Binding - Radioligand competition/displacement) 5-HT Granas C et al (1998) Vass M et al (2018)
5ht1b_human 7.39x38 355 TM7 T => A 1.259↑ pK(i) (Binding - Radioligand competition/displacement) LSD Wang C et al (2013) Vass M et al (2018)
5ht1b_human 4.61x61 185 TM4 F => M N/A N/A Granas C et al (1998)
5ht1b_human 7.38x37 354 TM7 F => A 1.664↑ K(i) (Binding - Radioligand competition/displacement) 5-HT Granas C et al (2001) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => A N/A N/A Pauwels PJ et al (1999)
5ht1b_human 7.38x37 354 TM7 F => Y 2.151↑ K(i) (Binding - Radioligand competition/displacement) 5-HT Granas C et al (2001) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => L N/A N/A Pauwels PJ et al (1999)
5ht1b_human 6.34x34 313 TM6 T => A N/A N/A Pauwels PJ et al (1999)
5ht1b_human 7.39x38 355 TM7 T => N N/A N/A Glennon RA et al (1996)
5ht1b_human 7.39x38 355 TM7 T => N 8.418↓ K(i) (Binding - Radioligand competition/displacement) Methysergide Parker EM et al (1993) Vass M et al (2018)
5ht1b_human 7.36x35 352 TM7 D => A N/A N/A Granas C et al (1999)
5ht1b_human 6.47x47 326 TM6 C => A N/A N/A Granas C et al (1999)
5ht1b_human 4.57x57 181 TM4 S => A 1.414↓ K(i) (Binding - Radioligand competition/displacement) Sumatriptan Granas C et al (1998) Vass M et al (2018)
5ht1b_human 4.61x61 185 TM4 F => M 2.79↓ K(i) (Binding - Radioligand competition/displacement) 5-HT Granas C et al (2001) Vass M et al (2018)
5ht1b_human 4.61x61 185 TM4 F => M 1.062↑ EC50 (Functional - cAMP accumulation) 8-OH-DPAT Granas C et al (1998)
5ht1b_human 7.38x37 354 TM7 F => Y 1.59↑ K(d) (Binding - Radioligand saturation) [3H]5-HT Granas C et al (2001) Vass M et al (2018)
5ht1b_human 7.39x38 355 TM7 T => N N/A N/A Glennon RA et al (1996)
5ht1b_human 7.36x35 352 TM7 D => A 1.259↑ pK(i) (Binding - Radioligand competition/displacement) Ergotamine Wang C et al (2013) Vass M et al (2018)
5ht1b_human 6.48x48 327 TM6 W => A 300.0↓ (Binding - Radioligand competition/displacement) Methiothepin Granas C et al (1999) Vass M et al (2018)
5ht1b_human 4.57x57 181 TM4 S => A N/A N/A Granas C et al (1998)
5ht1b_human 6.52x52 331 TM6 F => A 16.923↓ K(i) (Binding - Radioligand competition/displacement) Methiothepin Granas C et al (1998)
5ht1b_human 6.34x34 313 TM6 T => T N/A N/A Pauwels PJ et al (1999)
5ht1b_human 5.42x43 212 TM5 S => A 1.288↓ pK(i) (Binding - Radioligand competition/displacement) 5-HT Wang C et al (2013) Vass M et al (2018)
5ht1b_human 6.55x55 334 TM6 S => E 5.66↓ K(i) (Binding - Radioligand competition/displacement) 5-CT Parker EM et al (1996) Vass M et al (2018)
5ht1b_human 5.46x461 216 TM5 A => S 2.513↑ pK(i) (Binding - Radioligand competition/displacement) LSD Wang C et al (2013) Vass M et al (2018)
5ht1b_human 7.38x37 354 TM7 F => A 1.789↑ K(i) (Binding - Radioligand competition/displacement) 5-HT Granas C et al (1998) Vass M et al (2018)
5ht1b_human 4.61x61 185 TM4 F => A 1.412↑ K(i) (Binding - Radioligand competition/displacement) Methiothepin Granas C et al (1998) Vass M et al (2018)
5ht1b_human 7.43x42 359 TM7 Y => A 3.086↑ pK(i) (Binding - Radioligand competition/displacement) Ergotamine Wang C et al (2013) Vass M et al (2018)
5ht1b_human 5.39x40 209 TM5 T => A 1.35↑ pK(i) (Binding - Radioligand competition/displacement) 5-HT Wang C et al (2013) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => K N/A N/A Pauwels PJ et al (1999)
5ht1b_human 4.61x61 185 TM4 F => A 3.623↑ K(i) (Binding - Radioligand competition/displacement) Sumatriptan Granas C et al (1998) Vass M et al (2018)
5ht1b_human 7.39x38 355 TM7 T => N 1000.0↑ K(i) (Binding - Radioligand competition/displacement) (-)-propranolol Parker EM et al (1993) Vass M et al (2018)
5ht1b_human 7.35x34 351 TM7 F => A 1.148↓ pK(i) (Binding - Radioligand competition/displacement) Ergotamine Wang C et al (2013) Vass M et al (2018)
5ht1b_human 7.39x38 355 TM7 T => A 1.905↓ pK(i) (Binding - Radioligand competition/displacement) 5-HT Wang C et al (2013) Vass M et al (2018)
5ht1b_human 5.42x43 212 TM5 S => A 1.202↓ pK(i) (Binding - Radioligand competition/displacement) Ergotamine Wang C et al (2013) Vass M et al (2018)
5ht1b_human 7.43x42 359 TM7 Y => A 1.259↓ pK(i) (Binding - Radioligand competition/displacement) LSD Wang C et al (2013) Vass M et al (2018)
5ht1b_human 4.61x61 185 TM4 F => A 3.401↑ K(i) (Binding - Radioligand competition/displacement) Methysergide Granas C et al (1998) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => T N/A N/A Pauwels PJ et al (1999)
5ht1b_human 5.42x43 212 TM5 S => A 1.03↑ K(i) (Binding - Radioligand competition/displacement) 5-HT Granas C et al (1998)
5ht1b_human 4.61x61 185 TM4 F => A 1.241↑ K(d) (Binding - Radioligand saturation) [3H]5-HT Granas C et al (1998) Vass M et al (2018)
5ht1b_human 6.55x55 334 TM6 S => A 2.5↑ K(i) (Binding - Radioligand competition/displacement) 5-CT Granas C et al (1998) Vass M et al (2018)
5ht1b_human 6.52x52 331 TM6 F => A 2.331↑ K(d) (Binding - Radioligand saturation) [3H]GR125743 Granas C et al (2001) Vass M et al (2018)
5ht1b_human 5.42x43 212 TM5 S => A 1.225↑ K(i) (Binding - Radioligand competition/displacement) Sumatriptan Granas C et al (1998)
5ht1b_human 7.38x37 354 TM7 F => A 1.167↑ K(d) (Binding - Radioligand saturation) [3H]5-HT Granas C et al (2001) Vass M et al (2018)
5ht1b_human 4.61x61 185 TM4 F => A 1.576↓ EC50 (Functional - cAMP accumulation) 8-OH-DPAT Granas C et al (1998)
5ht1b_human 6.54x54 333 TM6 I => K N/A N/A Parker EM et al (1996)
5ht1b_human 6.54x54 333 TM6 I => K 1.103↓ K(i) (Binding - Radioligand competition/displacement) Lysergol Parker EM et al (1996) Vass M et al (2018)
5ht1b_human 4.61x61 185 TM4 F => M 1.825↑ K(d) (Binding - Radioligand saturation) [3H]5-HT Granas C et al (1998) Vass M et al (2018)
5ht1b_human 7.39x38 355 TM7 T => N N/A N/A Parker EM et al (1993)
5ht1b_human 6.55x55 334 TM6 S => A 1.25↓ K(i) (Binding - Radioligand competition/displacement) L-694,247 Granas C et al (1998) Vass M et al (2018)
5ht1b_human 7.38x37 354 TM7 F => A 1.721↑ K(d) (Binding - Radioligand saturation) [3H]5-HT Granas C et al (1998) Vass M et al (2018)
5ht1b_human 7.38x37 354 TM7 F => A 1.789↑ K(i) (Binding - Radioligand competition/displacement) 5-HT Granas C et al (2001) Vass M et al (2018)
5ht1b_human 7.39x38 355 TM7 T => N 8.0↓ K(i) (Binding - Radioligand competition/displacement) Metergoline Oksenberg D et al (1992) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => Q N/A N/A Pauwels PJ et al (1999)
5ht1b_human 7.38x37 354 TM7 F => Y 1.667↑ K(i) (Binding - Radioligand competition/displacement) 5-CT Granas C et al (1998) Vass M et al (2018)
5ht1b_human 6.55x55 334 TM6 S => A 1.355↑ K(i) (Binding - Radioligand competition/displacement) Methiothepin Granas C et al (1998) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => F N/A N/A Pauwels PJ et al (1999)
5ht1b_human 6.47x47 326 TM6 C => A No effect (Binding - Radioligand competition/displacement) Sumatriptan Granas C et al (1999) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => Q N/A N/A Pauwels PJ et al (1999)
5ht1b_human 6.34x34 313 TM6 T => I N/A N/A Pauwels PJ et al (1999)
5ht1b_human 6.48x48 327 TM6 W => A 60.0↓ (Binding - Radioligand competition/displacement) Sumatriptan Granas C et al (1999) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => G N/A N/A Pauwels PJ et al (1999)
5ht1b_human 3.29x29 126 TM3 L => A 1.513↑ pK(i) (Binding - Radioligand competition/displacement) Ergotamine Wang C et al (2013) Vass M et al (2018)
5ht1b_human 3.29x29 126 TM3 L => A 1.996↑ pK(i) (Binding - Radioligand competition/displacement) LSD Wang C et al (2013) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => Y N/A N/A Pauwels PJ et al (1999)
5ht1b_human 7.39x38 355 TM7 T => A 1.175↑ pK(i) (Binding - Radioligand competition/displacement) Ergotamine Wang C et al (2013) Vass M et al (2018)
5ht1b_human 7.39x38 355 TM7 T => N 500.0↑ K(i) (Binding - Radioligand competition/displacement) Propranolol Oksenberg D et al (1992) Vass M et al (2018)
5ht1b_human 6.34x34 313 TM6 T => G N/A N/A Pauwels PJ et al (1999)
5ht1b_human 7.39x38 355 TM7 T => N >10.0↓ K(i) (Binding - Radioligand competition/displacement) Compound F Glennon RA et al (1996) Vass M et al (2018)
5ht1b_human 6.58x58 337 TM6 M => A 1.096↑ pK(i) (Binding - Radioligand competition/displacement) 5-HT Wang C et al (2013) Vass M et al (2018)


Residue

Diagrams

ICL1 R K L H ICL1ECL1 R W T L ECL1ICL2 A V E Y S A K R ICL2ECL2 R Q A K A E E E V S E C V V N T D ECL2ICL3 N R T G K R L T R A Q L I T D S P G S T S S V T S I N S R V P D V P S E S G S P V Y V N Q V K V R V S D A L L E K K ICL3ECL3 C K D A C W F ECL3N-term M E E P G A Q C A P P P P A G S E T W V P Q A N L S S A P S Q N C S A K D Y I Y Q D S I N-termC-term R F K C T S C-term S L P W K V L L V M L L A L I T L A T T L S N A F V I A T V Y R T T P A N Y L I A S L A V T D L L V S I L V M P I S T M Y T V T G G Q V V C D F W L S S D I T C C T A S I L H L C V I A L D R Y W A I T D T P K R A A V M I A L V W V F S I S I S L P P F F W H I L Y T V Y S T V G A F Y F P T L L L I A L Y G R I Y V E A R S R I L K Q T P K L M A A R E R K A T K T L G I I L G A F I V C W L P F F I I S L V M P I H L A I F D F F T W L G Y L N S L I N P I I Y T M S N E D F H K F K Q A L I
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
A N S L T T A L T I L A L L M V L L V K 1 A S L A V T D L L V S L I V M P I S T M Y 2 V C L H L I S A T C C T I D S S L W F D 3 A A V M I A L V W V F S I S I S L P P F 4 Y L A I L L L T P F Y F A G V T S Y V T Y 5 G I I L G A F I V C W L P F F I I S L V 6 I P N I L S N L Y G L W T F F D F I A 7
Download: PNG | SVG




Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT1B receptor
TM2
2x37 2.37x37 T82
TM3
3x27 3.27x27 F124
3x29 3.29x29 L126
3x37 3.37x37 T134
3x53 3.53x53 A150
TM4
4x57 4.57x57 S181
4x61 4.61x61 F185
TM5
5x40 5.39x40 T209
5x43 5.42x43 S212
5x461 5.46x461 A216
TM6
6x34 6.34x34 T313
6x47 6.47x47 C326
6x48 6.48x48 W327
6x52 6.52x52 F331
6x54 6.54x54 I333
6x55 6.55x55 S334
6x58 6.58x58 M337
TM7
7x34 7.35x34 F351
7x35 7.36x35 D352
7x37 7.38x37 F354
7x38 7.39x38 T355
7x42 7.43x42 Y359