Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
5ht7r_human 7.35x34 366 TM7 E => D 1.023↓ pK(d) (Binding - Radioligand saturation) [3H]SB269970 Impellizzeri AA et al (2015) Vass M et al (2018)
5ht7r_human 7.35x34 366 TM7 E => R Abolished effect pK(d) (Binding - Radioligand saturation) [3H]5-CT Impellizzeri AA et al (2015) Vass M et al (2018)
5ht7r_human 7.35x34 366 TM7 E => D 2.188↓ pK(d) (Binding - Radioligand saturation) [3H]5-CT Impellizzeri AA et al (2015) Vass M et al (2018)
5ht7r_human 401 C-term C => S 3.891↑ K(d) (Binding - Radioligand competition/displacement) Olanzapine Manfra O et al (2015) Vass M et al (2018)
5ht7r_human 7.33x32 364 TM7 W => V 1.148↑ pK(d) (Binding - Radioligand saturation) [3H]5-CT Impellizzeri AA et al (2015) Vass M et al (2018)
5ht7r_human 7.43x42 374 TM7 Y => F 9.12↓ pK(d) (Binding - Radioligand saturation) [3H]5-CT Impellizzeri AA et al (2015) Vass M et al (2018)
5ht7r_human 7.36x35 367 TM7 R => V Abolished effect pK(d) (Binding - Radioligand saturation) [3H]5-CT Impellizzeri AA et al (2015) Vass M et al (2018)
5ht7r_human 7.35x34 366 TM7 E => R Abolished effect pK(d) (Binding - Radioligand saturation) [3H]SB269970 Impellizzeri AA et al (2015) Vass M et al (2018)
5ht7r_human 7.36x35 367 TM7 R => V Abolished effect pK(d) (Binding - Radioligand saturation) [3H]SB269970 Impellizzeri AA et al (2015) Vass M et al (2018)
5ht7r_human 7.43x42 374 TM7 Y => F 3.388↓ pK(d) (Binding - Radioligand saturation) [3H]SB269970 Impellizzeri AA et al (2015) Vass M et al (2018)
5ht7r_human 7.43x42 374 TM7 Y => A 21.878↓ pK(d) (Binding - Radioligand saturation) [3H]5-CT Impellizzeri AA et al (2015) Vass M et al (2018)
5ht7r_human 7.43x42 374 TM7 Y => A 1.818↑ pK(d) (Binding - Radioligand saturation) [3H]SB269970 Impellizzeri AA et al (2015) Vass M et al (2018)
5ht7r_human 7.33x32 364 TM7 W => V 1.622↓ pK(d) (Binding - Radioligand saturation) [3H]SB269970 Impellizzeri AA et al (2015) Vass M et al (2018)
5ht7r_human 7.35x34 366 TM7 E => A 1.259↓ pK(d) (Binding - Radioligand saturation) [3H]SB269970 Impellizzeri AA et al (2015) Vass M et al (2018)
5ht7r_human 7.43x42 374 TM7 Y => T 9.12↓ pK(d) (Binding - Radioligand saturation) [3H]5-CT Impellizzeri AA et al (2015) Vass M et al (2018)
5ht7r_human 7.35x34 366 TM7 E => A 5.888↓ pK(d) (Binding - Radioligand saturation) [3H]5-CT Impellizzeri AA et al (2015) Vass M et al (2018)
5ht7r_human 7.35x34 366 TM7 E => T Abolished effect pK(d) (Binding - Radioligand saturation) [3H]SB269970 Impellizzeri AA et al (2015) Vass M et al (2018)
5ht7r_human 7.43x42 374 TM7 Y => T 8.913↓ pK(d) (Binding - Radioligand saturation) [3H]SB269970 Impellizzeri AA et al (2015) Vass M et al (2018)
5ht7r_human 7.35x34 366 TM7 E => T Abolished effect pK(d) (Binding - Radioligand saturation) [3H]5-CT Impellizzeri AA et al (2015) Vass M et al (2018)
5ht7r_human 8.49x49 390 H8 D => K 2.63↓ pK(d) (Binding - Radioligand saturation) [3H]SB269970 Impellizzeri AA et al (2015) Vass M et al (2018)
5ht7r_human 401 C-term C => S 1.385↓ K(d) (Binding - Radioligand saturation) [3H]5-CT Manfra O et al (2015) Vass M et al (2018)
5ht7r_human 42 N-term G => V N/A N/A Bastiani CA et al (2003)
5ht7r_human 8.49x49 390 H8 D => K 2.188↓ pK(d) (Binding - Radioligand saturation) [3H]5-CT Impellizzeri AA et al (2015) Vass M et al (2018)
5ht7r_human 8.48x48 389 H8 R => D 1.995↓ pK(d) (Binding - Radioligand saturation) [3H]5-CT Impellizzeri AA et al (2015) Vass M et al (2018)
5ht7r_human 401 C-term C => S 1.312↑ K(d) (Binding - Radioligand competition/displacement) Clozapine Manfra O et al (2015) Vass M et al (2018)
5ht7r_human 8.48x48 389 H8 R => D 1.289↑ pK(d) (Binding - Radioligand saturation) [3H]SB269970 Impellizzeri AA et al (2015) Vass M et al (2018)


Residue

Diagrams

ICL1 K K L R ICL1ECL1 G K W I F ECL1ICL2 P L T Y P V R Q ICL2ECL2 W A Q N V N D D K V C L I S Q ECL2ICL3 F P R V E P D S V I A L N G I V K L Q K E V E E C A N L S R L L K H E R K N ICL3ECL3 C G T S ECL3N-term M M D V N S S G R P D L Y G H L R S F L L P E V G R G L P D L S P D G G A D P V A G S W A P H L L S E V T A S P A P T W D A P P D N A S G C G E Q I N Y N-termC-term Q C Q Y R N I N R K L S A A G M H E A L K L A E R P E R P E F V L R A C T R R V L L R P E K R P P V S V W V L Q S P D H H N W L A D K M L T T V E K K V M I H D C-term G R V E K V V I G S I L T L I T L L T I A G N C L V V I S V C F V Q P S N Y L I V S L A L A D L S V A V A V M P F V S V T D L I G G H F F C N V F I A M D V M C C T A S I M T L C V I S I D R Y L G I T R N G K C M A K M I L S V W L L S A S I T L P P L F G D F G Y T I Y S T A V A F Y I P M S V M L F M Y Y Q I Y K A A R K S A A K H K F P G I S I F K R E Q K A A T T L G I I V G A F T V C W L P F F L L S T A R P F I C S C I P L W V E R T F L W L G Y A N S L I N P F I Y A F F N R D Y R S L R T T L L
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
C N G A I T L L T I L T L I S G I V V K 1 V S L A L A D L S V A A V V M P F V S V T 2 V C L T M I S A T C C M V D M A I F V N 3 M A K M I L S V W L L S A S I T L P P L 4 Y M F L M V S M P I Y F A V A T S Y I T Y 5 G I I V G A F T V C W L P F F L L S T A 6 F P N I L S N A Y G L W L F T R E V W 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT7 receptor
TM7
7x32 7.33x32 W364
7x34 7.35x34 E366
7x35 7.36x35 R367
7x42 7.43x42 Y374
H8
8x48 8.48x48 R389
8x49 8.49x49 D390