Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
5ht7r_mouse 6.30x30 325 TM6 E => G N/A N/A Obosi LA et al (1997)
5ht7r_mouse 3.50x50 183 TM3 R => A N/A N/A Obosi LA et al (1997)
5ht7r_mouse 6.32x32 327 TM6 K => S N/A N/A Obosi LA et al (1997)
5ht7r_mouse 3.53x53 186 TM3 G => C N/A N/A van den Berg L et al (2004)
5ht7r_mouse 6.30x30 325 TM6 E => G N/A N/A Obosi LA et al (1997)
5ht7r_mouse 5.66x66 270 TM5 R => A N/A N/A Obosi LA et al (1997)
5ht7r_mouse 5.63x63 267 TM5 K => A N/A N/A Obosi LA et al (1997)
5ht7r_mouse 6.32x32 327 TM6 K => S 1.088↑ IC50 (Binding - Radioligand competition/displacement) Methiothepin Obosi LA et al (1997) Vass M et al (2018)
5ht7r_mouse 5.67x67 271 TM5 K => A N/A N/A Obosi LA et al (1997)
5ht7r_mouse 6.30x30 325 TM6 E => G 1.008↑ K(d) (Binding - Radioligand saturation) [3H]5-HT Obosi LA et al (1997) Vass M et al (2018)
5ht7r_mouse 3.50x50 183 TM3 R => A 3.268↑ IC50 (Binding - Radioligand competition/displacement) Methiothepin Obosi LA et al (1997) Vass M et al (2018)
5ht7r_mouse 6.30x30 325 TM6 E => G 1.29↓ IC50 (Binding - Radioligand competition/displacement) Methiothepin Obosi LA et al (1997) Vass M et al (2018)
5ht7r_mouse 6.32x32 327 TM6 K => S 1.349↓ K(d) (Binding - Radioligand saturation) [3H]5-HT Obosi LA et al (1997) Vass M et al (2018)
5ht7r_mouse 3.50x50 183 TM3 R => A N/A N/A Obosi LA et al (1997)
5ht7r_mouse 6.32x32 327 TM6 K => S N/A N/A Obosi LA et al (1997)


Residue

Diagrams

ICL1 K K L R ICL1ECL1 G K W I F ECL1ICL2 P L T Y P V R Q ICL2ECL2 W A Q N V N D D K V C L I S Q ECL2ICL3 F P R V Q P E S V I S L N G V V K L Q K E V E E C A N L S R L L K H E R K N ICL3ECL3 C G T S ECL3N-term M M D V N S S G R P D L Y G H L R S L I L P E V G R R L Q D L S P D G G A H S V V S S W M P H L L S G F P E V T A S P A P T W D A P P D N V S G C G E Q I N Y N-termC-term Q C Q Y R N I N R K L S A A G M H E A L K L A E R P E R S E F V L Q N C D H C G K K G H D T C-term G R V E K V V I G S I L T L I T L L T I A G N C L V V I S V C F V Q P S N Y L I V S L A L A D L S V A V A V M P F V S V T D L I G G H F F C N V F I A M D V M C C T A S I M T L C V I S I D R Y L G I T R N G K C M A K M I L S V W L L S A S I T L P P L F G D F G Y T I Y S T A V A F Y I P M S V M L F M Y Y Q I Y K A A R K S A A K H K F S G I S I F K R E Q K A A T T L G I I V G A F T V C W L P F F L L S T A R P F I C S C I P L W V E R T C L W L G Y A N S L I N P F I Y A F F N R D Y R S L R T T L L
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
C N G A I T L L T I L T L I S G I V V K 1 V S L A L A D L S V A A V V M P F V S V T 2 V C L T M I S A T C C M V D M A I F V N 3 M A K M I L S V W L L S A S I T L P P L 4 Y M F L M V S M P I Y F A V A T S Y I T Y 5 G I I V G A F T V C W L P F F L L S T A 6 F P N I L S N A Y G L W L C T R E V W 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT7 receptor
TM3
3x50 3.50x50 R183
3x53 3.53x53 G186
TM5
5x63 5.63x63 K267
5x66 5.66x66 R270
5x67 5.67x67 K271
TM6
6x30 6.30x30 E325
6x32 6.32x32 K327