Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
ackr1_human 23 N-term E => A N/A N/A Tournamille C et al (1997)
ackr1_human 2.44x44 100 TM2 A => T N/A N/A Yazdanbakhsh K et al (2000)
ackr1_human 7.25x24 276 TM7 C => S N/A N/A Tournamille C et al (1997)
ackr1_human 2.44x44 100 TM2 A => T N/A N/A Tournamille C et al (1998)
ackr1_human 51 N-term C => S N/A N/A Tournamille C et al (1997)
ackr1_human 89 ICL1 R => C N/A N/A Tournamille C et al (1998)
ackr1_human 89 ICL1 R => C N/A N/A Yazdanbakhsh K et al (2000)
ackr1_human 54 N-term C => S N/A N/A Tournamille C et al (1997)
ackr1_human 2.44x44 100 TM2 A => T N/A N/A Estalote AC et al (2005)
ackr1_human 22 N-term F => V N/A N/A Tournamille C et al (1997)


Residue

Diagrams

ICL1 L F R W Q L ICL1ECL1 T R S S A ECL1ICL2 Q ICL2ECL2 G A S G G L C T L I Y S T E ECL2ICL3 K A L G M G ICL3ECL3 L L L L S ECL3N-term M G N C L H R A E L S P S T E N S S Q L D F E D V W N S S Y G V N D S F P D G D Y G A N L E A A A P C H S C N-termC-term E G W S S H L D T L G S K S C-term N L L D D S A L P F F I L T S V L G I L A S S T V L F M L F R P C P G W P V L A Q L A V G S A L F S I V V P V L A P G L G S L C S L G Y C V W Y G S A F A Q A L L L G C H A S L G H R L G A G V P G L T L G L T V G I W G V A A L L T L P V T L A S L K A L Q A T H T V A C L A I F V L L P L G L F G A K G L K P G P W M N I L W A W F I F W W P H G V V L G L D F L V R S K T C L A Q Q A L D L L L N L A E A L A I L H C V A T P L L L A L F C H Q L L P P A T R T S L P L
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
S S A L I G L V S T L I F F P L A S D D 1 A Q L A V G S A L F S I V V P V L A P G 2 C G L L L A Q A F A S G Y W V C Y G L S 3 T L G L T V G I W G V A A L L T L P V 4 F L G L P L L V F I A L C A V T H T A Q 5 M N I L W A W F I F W W P H G V V L G L 6 L P T A V C H L I A L A E A L N L L L 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
ACKR1
TM2
2x44 2.44x44 A100
TM7
7x24 7.25x24 C276