Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
acm2_human 4.57x57 155 TM4 W => A N/A N/A Heitz F et al (1999)
acm2_human 7.42x41 429 TM7 C => A N/A Single-point (Binding - Radioligand competition/displacement) BR-384 Suga H et al (2010) Vass M et al (2018)
acm2_human 3.32x32 103 TM3 D => N 1.481↑ Kapp (Binding - Radioligand competition/displacement) Arylacetylene oxime-2 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 1860.0↓ Kapp (Binding - Radioligand competition/displacement) L607,207 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 7.32x31 419 TM7 N => D N/A N/A Gnagey AL et al (1999)
acm2_human 1.31x31 22 TM1 E => Q 1.015↑ IC50 (Binding - Radioligand competition/displacement) Gallamine Leppik RA et al (1994) Kooistra AJ et al (2013)
acm2_human 5.39x40 187 TM5 T => A 1.059↑ K(d) (Binding - Radioligand saturation) [3H]QNB Heitz F et al (1999) Kooistra AJ et al (2013)
acm2_human 3.28x28 99 TM3 W => A 1.038↓ K(d) (Binding - Radioligand saturation) [3H]N-methyl scopolamine Heitz F et al (1999) Kooistra AJ et al (2013)
acm2_human 3.28x28 99 TM3 W => F 2.558↑ Single-point (Binding - Radioligand competition/displacement) BR-384 Suga H et al (2010) Vass M et al (2018)
acm2_human 3.32x32 103 TM3 D => A N/A N/A Schwarz RD et al (1999)
acm2_human 457 C-term C => A 1.621↑ pK(i) (Binding - Radioligand competition/displacement) Carbachol Hayashi MK et al (1997) Kooistra AJ et al (2013)
acm2_human 6.38x38 390 TM6 L => S 3.034↓ K(d) (Binding - Radioligand saturation) [3H]N-methyl scopolamine Kostenis E et al (1997) Kooistra AJ et al (2013)
acm2_human 2.50x50 69 TM2 D => N 3.802↑ pK(i) (Binding - Radioligand competition/displacement) McN-A343 Suga H et al (2013) Vass M et al (2018)
acm2_human 414 ECL3 A => D 1.585↑ pIC50 (Binding - Radioligand competition/displacement) UH-AH 37 Ellis J et al (2000) Kooistra AJ et al (2013)
acm2_human 45.51x51 177 ECL2 Y => A 3.162↓ pK(i) (Binding - Radioligand competition/displacement) Carbachol Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 1.978↓ Kapp (Binding - Radioligand competition/displacement) Aryl-ene-yne oxime-11 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 3.26x26 97 TM3 D => N 107.152↓ pK(i) (Binding - Radioligand competition/displacement) Acetylcholine Suga H et al (2010) Vass M et al (2018)
acm2_human 3.32x32 103 TM3 D => E 1.667↑ logK (Binding - Radioligand competition/displacement) carbachol Page KM et al (1995) Kooistra AJ et al (2013)
acm2_human 172 ECL2 E => P 2.512↓ pKapp (Binding - Radioligand competition/displacement) Gallamine Huang XP et al (2005) Kooistra AJ et al (2013)
acm2_human 175 ECL2 E => Q N/A N/A Gregory KJ et al (2010)
acm2_human 3.49x49 120 TM3 D => N N/A N/A Leppik RA et al (1994)
acm2_human 3.32x32 103 TM3 D => E 1.149↑ logK (Binding - Radioligand competition/displacement) Methylfurmethide Page KM et al (1995) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 1.183↑ logKapp (Binding - Radioligand competition/displacement) Oxotremorine-M Hulme EC et al (1999) Kooistra AJ et al (2013)
acm2_human 34.54x54 132 ICL2 P => R N/A N/A Blin N et al (1995)
acm2_human 3.32x32 103 TM3 D => E 1.213↓ Kapp (Binding - Radioligand competition/displacement) Arylacetylene oxime-4 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 179 ECL2 Q => A 1.056↓ K(d) (Binding - Radioligand saturation) [3H]QNB Heitz F et al (1999) Kooistra AJ et al (2013)
acm2_human 1.31x31 22 TM1 E => Q 1.157↑ K(d) (Binding - Radioligand saturation) [3H]N-methyl scopolamine Leppik RA et al (1994) Kooistra AJ et al (2013)
acm2_human 3.56x56 127 TM3 K => R N/A N/A Blin N et al (1995)
acm2_human 45.51x51 177 ECL2 Y => A 1.259↓ pK(i) (Binding - Radioligand competition/displacement) AC-42 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 1.0 logKapp (Binding - Radioligand competition/displacement) McN-A343 Hulme EC et al (1999) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => N 3.349↓ Kapp (Binding - Radioligand competition/displacement) Aryl-ene-yne oxime-5 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 6.51x51 403 TM6 Y => A 79.433↓ pK(i) (Binding - Radioligand competition/displacement) Carbachol Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 7.32x31 419 TM7 N => K 7.943↓ pKapp (Binding - Radioligand competition/displacement) W84 Huang XP et al (2005) Kooistra AJ et al (2013)
acm2_human 6.30x30 382 TM6 E => Q 1.096↑ IC50 (Binding - Radioligand competition/displacement) Gallamine Leppik RA et al (1994) Kooistra AJ et al (2013)
acm2_human 6.33x33 385 TM6 V => A 1.764↓ IC50 (Binding - Radioligand competition/displacement) Carbachol Kostenis E et al (1997) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 1.708↓ Kapp (Binding - Radioligand competition/displacement) Arylacetylene oxime-1 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 45.51x51 177 ECL2 Y => A 1.585↓ pK(i) (Binding - Radioligand competition/displacement) Pilocarpine Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 45.51x51 177 ECL2 Y => A N/A N/A Gregory KJ et al (2010)
acm2_human 7.32x31 419 TM7 N => A 1.585↑ pK(i) (Binding - Radioligand competition/displacement) Pilocarpine Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.36x36 107 TM3 S => A 3.162↓ pK(i) (Binding - Radioligand competition/displacement) NDMC Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => N 2.455↓ pK(i) (Binding - Radioligand competition/displacement) McN-A343 Suga H et al (2010) Vass M et al (2018)
acm2_human 5.42x43 190 TM5 T => A 3.462↓ K(d) (Binding - Radioligand saturation) [3H]N-methyl scopolamine Heitz F et al (1999) Kooistra AJ et al (2013)
acm2_human 45.51x51 177 ECL2 Y => A 1.0 pK(d) (Binding - Radioligand saturation) [3H]QNB Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 2.025↓ Kapp (Binding - Radioligand competition/displacement) Aryl-ene-yne oxime-6 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 6.37x37 389 TM6 I => L 2.306↓ K(d) (Binding - Radioligand saturation) [3H]N-methyl scopolamine Kostenis E et al (1997) Kooistra AJ et al (2013)
acm2_human 7.32x31 419 TM7 N => A 3.165↑ pK(i) (Binding - Radioligand competition/displacement) Acetylcholine Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 2.50x50 69 TM2 D => N N/A N/A Leppik RA et al (1994)
acm2_human 3.32x32 103 TM3 D => E 1.2↑ logK (Binding - Radioligand competition/displacement) L658,903 Page KM et al (1995) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 9.545↓ Kapp (Binding - Radioligand competition/displacement) Arecoline Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 2.50x50 69 TM2 D => N 2.512↓ IC50 (Binding - Radioligand competition/displacement) Gallamine Leppik RA et al (1994) Kooistra AJ et al (2013)
acm2_human 7.32x31 419 TM7 N => A 1.0 pK(i) (Binding - Radioligand competition/displacement) Carbachol Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.29x29 100 TM3 L => A 39.811↓ pK(i) (Binding - Radioligand competition/displacement) Carbachol Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 175 ECL2 E => Q 1.995↓ pKapp (Binding - Radioligand competition/displacement) W84 Huang XP et al (2005) Kooistra AJ et al (2013)
acm2_human 6.51x51 403 TM6 Y => A 3.162↓ pK(d) (Binding - Radioligand saturation) [3H]QNB Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E Decreased effect K(d) (Binding - Radioligand saturation) [3H]N-methyl scopolamine Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 6.51x51 403 TM6 Y => A N/A N/A Heitz F et al (1999)
acm2_human 3.32x32 103 TM3 D => E 1.5↓ Kapp (Binding - Radioligand competition/displacement) Oxotremorine-M Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 6.30x30 382 TM6 E => Q 1.038↓ K(d) (Binding - Radioligand saturation) [3H]N-methyl scopolamine Leppik RA et al (1994) Kooistra AJ et al (2013)
acm2_human 172 ECL2 E => L 1.585↓ pKapp (Binding - Radioligand competition/displacement) W84 Huang XP et al (2005) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => N 1.949↓ Kapp (Binding - Radioligand competition/displacement) Arylacetylene oxime-3 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 3.0↓ Kapp (Binding - Radioligand competition/displacement) Aryl-ene-yne oxime-8 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => N 512.861↓ pK(i) (Binding - Radioligand competition/displacement) Acetylcholine Suga H et al (2013) Vass M et al (2018)
acm2_human 5.39x40 187 TM5 T => A 2.808↓ K(d) (Binding - Radioligand saturation) [3H]N-methyl scopolamine Heitz F et al (1999) Kooistra AJ et al (2013)
acm2_human 1.31x31 22 TM1 E => Q N/A N/A Leppik RA et al (1994)
acm2_human 3.32x32 103 TM3 D => E 1.0 Kapp (Binding - Radioligand competition/displacement) Aryl-ene-yne oxime-10 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 7.34x33 421 TM7 V => L 1.0 pIC50 (Binding - Radioligand competition/displacement) UH-AH 37 Ellis J et al (2000) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 1.224↑ logK (Binding - Radioligand competition/displacement) L660,863 Page KM et al (1995) Kooistra AJ et al (2013)
acm2_human 7.36x35 423 TM7 T => H 3.981↓ pKapp (Binding - Radioligand competition/displacement) Gallamine Huang XP et al (2005) Kooistra AJ et al (2013)
acm2_human 7.36x35 423 TM7 T => A 2.513↑ pK(i) (Binding - Radioligand competition/displacement) Acetylcholine Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 6.37x37 389 TM6 I => L N/A N/A Kostenis E et al (1997)
acm2_human 172 ECL2 E => P 2.512↓ pKapp (Binding - Radioligand competition/displacement) W84 Huang XP et al (2005) Kooistra AJ et al (2013)
acm2_human 6.38x38 390 TM6 L => S N/A N/A Kostenis E et al (1997)
acm2_human 3.28x28 99 TM3 W => A 2.512↓ pK(d) (Binding - Radioligand saturation) [3H]QNB Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.36x36 107 TM3 S => A 1.0 pK(i) (Binding - Radioligand competition/displacement) 77-LH-28-1 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => N 1.702↓ Kapp (Binding - Radioligand competition/displacement) McN-A343 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 6.33x33 385 TM6 V => A N/A N/A Kostenis E et al (1997)
acm2_human 2.61x60 80 TM2 Y => A 1.585↓ pK(i) (Binding - Radioligand competition/displacement) Acetylcholine Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 1.032↑ logKapp (Binding - Radioligand competition/displacement) N-methyl scopolamine Hulme EC et al (1999) Kooistra AJ et al (2013)
acm2_human 3.29x29 100 TM3 L => A 19.953↓ pK(d) (Binding - Radioligand saturation) [3H]QNB Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.33x33 104 TM3 Y => A 2.512↓ pK(i) (Binding - Radioligand competition/displacement) NDMC Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 7.32x31 419 TM7 N => K 12.589↓ pKapp (Binding - Radioligand competition/displacement) Gallamine Huang XP et al (2005) Kooistra AJ et al (2013)
acm2_human 2.57x56 76 TM2 S => A 1.0↑ Single-point (Binding - Radioligand competition/displacement) BR-384 Suga H et al (2010) Vass M et al (2018)
acm2_human 2.61x60 80 TM2 Y => A 1.995↓ pK(i) (Binding - Radioligand competition/displacement) NDMC Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.28x28 99 TM3 W => A 3.981↓ pK(i) (Binding - Radioligand competition/displacement) Carbachol Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 4.41x41 139 TM4 M => R N/A N/A Blin N et al (1995)
acm2_human 3.32x32 103 TM3 D => E 1.555↑ logK (Binding - Radioligand competition/displacement) acetylcholine Page KM et al (1995) Kooistra AJ et al (2013)
acm2_human 2.61x60 80 TM2 Y => A 2.512↓ pK(d) (Binding - Radioligand saturation) [3H]QNB Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 7.36x35 423 TM7 T => A 1.996↑ pK(i) (Binding - Radioligand competition/displacement) 77-LH-28-1 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E N/A N/A Hulme EC et al (1999)
acm2_human 3.49x49 120 TM3 D => N 1.096↑ IC50 (Binding - Radioligand competition/displacement) Gallamine Leppik RA et al (1994) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => N 1.639↓ Kapp (Binding - Radioligand competition/displacement) Arylacetylene oxime-4 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 6.57x57 409 TM6 I => V 1.585↑ pIC50 (Binding - Radioligand competition/displacement) UH-AH 37 Ellis J et al (2000) Kooistra AJ et al (2013)
acm2_human 3.49x49 120 TM3 D => N 1.435↑ K(d) (Binding - Radioligand saturation) [3H]N-methyl scopolamine Leppik RA et al (1994) Kooistra AJ et al (2013)
acm2_human 6.34x34 386 TM6 T => A N/A N/A Kostenis E et al (1997)
acm2_human 7.32x31 419 TM7 N => V 1.585↑ pKapp (Binding - Radioligand competition/displacement) Gallamine Huang XP et al (2005) Kooistra AJ et al (2013)
acm2_human 3.29x29 100 TM3 L => A 1.259↑ pK(i) (Binding - Radioligand competition/displacement) AC-42 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 7.32x31 419 TM7 N => V 2.513↑ pKapp (Binding - Radioligand competition/displacement) W84 Huang XP et al (2005) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 1.401↑ Kapp (Binding - Radioligand competition/displacement) McN-A343 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 3.26x26 97 TM3 D => N 1.071↑ IC50 (Binding - Radioligand competition/displacement) Gallamine Leppik RA et al (1994) Kooistra AJ et al (2013)
acm2_human 6.48x48 400 TM6 W => A N/A N/A Heitz F et al (1999)
acm2_human 3.32x32 103 TM3 D => N >339.286↓ Kapp (Binding - Radioligand competition/displacement) Carbachol Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 7.32x31 419 TM7 N => A 1.585↑ pK(i) (Binding - Radioligand competition/displacement) Arecoline Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => N 108.0↓ Kapp (Binding - Radioligand competition/displacement) Aryl-ene-yne oxime-9 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 5.62x62 210 TM5 S => Y N/A N/A Kostenis E et al (1997)
acm2_human 3.29x29 100 TM3 L => A 63.096↓ pK(i) (Binding - Radioligand competition/displacement) Acetylcholine Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 6.30x30 382 TM6 E => Q 1.017↑ IC50 (Binding - Radioligand competition/displacement) Gallamine Leppik RA et al (1994) Kooistra AJ et al (2013)
acm2_human 45.51x51 177 ECL2 Y => Q 50.119↓ pKapp (Binding - Radioligand competition/displacement) W84 Huang XP et al (2005) Kooistra AJ et al (2013)
acm2_human 6.51x51 403 TM6 Y => A 1.995↓ pK(i) (Binding - Radioligand competition/displacement) NDMC Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.28x28 99 TM3 W => A 1000.0↑ pK(i) (Binding - Radioligand competition/displacement) 77-LH-28-1 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.29x29 100 TM3 L => A 1.0 pK(i) (Binding - Radioligand competition/displacement) McN-A343 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 6.49x49 401 TM6 A => T 1.259↑ pIC50 (Binding - Radioligand competition/displacement) 4-DAMP Ellis J et al (2000) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 6.429↓ Kapp (Binding - Radioligand competition/displacement) Pilocarpine Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 6.51x51 403 TM6 Y => A 3.984↑ pK(i) (Binding - Radioligand competition/displacement) 77-LH-28-1 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 2.61x60 80 TM2 Y => A 1.259↑ pK(i) (Binding - Radioligand competition/displacement) McN-A343 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 7.32x31 419 TM7 N => E 2.513↑ pKapp (Binding - Radioligand kinetics (association/dissociation)) [3H]N-methyl scopolamine Gnagey AL et al (1999) Kooistra AJ et al (2013)
acm2_human 3.28x28 99 TM3 W => A 2.512↓ pK(i) (Binding - Radioligand competition/displacement) Pilocarpine Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => A N/A N/A Heitz F et al (1999)
acm2_human 3.32x32 103 TM3 D => N N/A N/A Schwarz RD et al (1999)
acm2_human 6.37x37 389 TM6 I => L 6.236↓ IC50 (Binding - Radioligand competition/displacement) Carbachol Kostenis E et al (1997) Kooistra AJ et al (2013)
acm2_human 2.50x50 69 TM2 D => N 1.289↑ pK(i) (Binding - Radioligand competition/displacement) Acetylcholine Suga H et al (2013) Vass M et al (2018)
acm2_human 3.33x33 104 TM3 Y => A 39.811↓ pK(d) (Binding - Radioligand saturation) [3H]QNB Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => N 15.136↓ pK(i) (Binding - Radioligand competition/displacement) N-methyl scopolamine Suga H et al (2010) Vass M et al (2018)
acm2_human 3.32x32 103 TM3 D => E 1.391↑ logK (Binding - Radioligand competition/displacement) Ach,NEt Page KM et al (1995) Kooistra AJ et al (2013)
acm2_human 45.51x51 177 ECL2 Y => A 1.259↑ pK(i) (Binding - Radioligand competition/displacement) McN-A343 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 6.33x33 385 TM6 V => A 1.845↓ K(d) (Binding - Radioligand saturation) [3H]N-methyl scopolamine Kostenis E et al (1997) Kooistra AJ et al (2013)
acm2_human 3.26x26 97 TM3 D => N 1.492↓ K(d) (Binding - Radioligand saturation) [3H]N-methyl scopolamine Leppik RA et al (1994) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => N 183.545↓ Kapp (Binding - Radioligand competition/displacement) Arecoline Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 3.29x29 100 TM3 L => A 25.119↓ pK(i) (Binding - Radioligand competition/displacement) Arecoline Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.33x33 104 TM3 Y => A 3.162↓ pK(i) (Binding - Radioligand competition/displacement) 77-LH-28-1 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 7.36x35 423 TM7 T => A 1.585↑ pK(i) (Binding - Radioligand competition/displacement) Arecoline Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => N 2.818↓ pK(i) (Binding - Radioligand competition/displacement) McN-A343 Suga H et al (2013) Vass M et al (2018)
acm2_human 6.52x52 404 TM6 N => Q 14.667↓ K(d) (Binding - Radioligand saturation) [3H]QNB Heitz F et al (1999) Kooistra AJ et al (2013)
acm2_human 6.38x38 390 TM6 L => S 1.028↓ IC50 (Binding - Radioligand competition/displacement) Carbachol Kostenis E et al (1997) Kooistra AJ et al (2013)
acm2_human 3.33x33 104 TM3 Y => A 251.189↓ pK(i) (Binding - Radioligand competition/displacement) Carbachol Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 5.62x62 210 TM5 S => Y N/A N/A Blin N et al (1995)
acm2_human 3.32x32 103 TM3 D => E 1.031↑ logK (Binding - Radioligand competition/displacement) Tetramethylammonium Page KM et al (1995) Kooistra AJ et al (2013)
acm2_human 6.51x51 403 TM6 Y => A 100.0↓ pK(i) (Binding - Radioligand competition/displacement) Acetylcholine Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => N 97.5↓ Kapp (Binding - Radioligand competition/displacement) Oxotremorine-M Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 417 ECL3 I => V 1.259↑ pIC50 (Binding - Radioligand competition/displacement) UH-AH 37 Ellis J et al (2000) Kooistra AJ et al (2013)
acm2_human 5.42x43 190 TM5 T => A 4.444↓ K(d) (Binding - Radioligand saturation) [3H]QNB Heitz F et al (1999) Kooistra AJ et al (2013)
acm2_human 3.29x29 100 TM3 L => A 15.849↓ pK(i) (Binding - Radioligand competition/displacement) NDMC Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 1.0 logK (Binding - Radioligand competition/displacement) McN-A343 Page KM et al (1995) Kooistra AJ et al (2013)
acm2_human 6.58x58 410 TM6 N => S 1.585↑ pIC50 (Binding - Radioligand competition/displacement) UH-AH 37 Ellis J et al (2000) Kooistra AJ et al (2013)
acm2_human 45.51x51 177 ECL2 Y => A 18.621↓ pK(i) (Binding - Radioligand competition/displacement) Gallamine Valant C et al (2008) Kooistra AJ et al (2013)
acm2_human 7.32x31 419 TM7 N => K 10.0↓ pKapp (Binding - Radioligand kinetics (association/dissociation)) [3H]N-methyl scopolamine Gnagey AL et al (1999) Kooistra AJ et al (2013)
acm2_human 2.61x60 80 TM2 Y => A 2.513↑ pK(i) (Binding - Radioligand competition/displacement) AC-42 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 4.57x57 155 TM4 W => A 16.667↓ K(d) (Binding - Radioligand saturation) [3H]QNB Heitz F et al (1999) Kooistra AJ et al (2013)
acm2_human 6.30x30 382 TM6 E => Q N/A N/A Leppik RA et al (1994)
acm2_human 172 ECL2 E => L 1.585↓ pKapp (Binding - Radioligand competition/displacement) Gallamine Huang XP et al (2005) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => N 26.5↓ Kapp (Binding - Radioligand competition/displacement) Aryl-ene-yne oxime-7 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 3.28x28 99 TM3 W => A 3.981↓ pK(i) (Binding - Radioligand competition/displacement) Acetylcholine Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.36x36 107 TM3 S => A 1.585↓ pK(i) (Binding - Radioligand competition/displacement) Pilocarpine Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 7.36x35 423 TM7 T => A 2.512↓ pK(d) (Binding - Radioligand saturation) [3H]QNB Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.33x33 104 TM3 Y => A 2.512↓ pK(i) (Binding - Radioligand competition/displacement) AC-42 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.26x26 97 TM3 D => N 1.778↓ pK(i) (Binding - Radioligand competition/displacement) N-methyl scopolamine Suga H et al (2010) Vass M et al (2018)
acm2_human 3.32x32 103 TM3 D => E 2.875↓ Kapp (Binding - Radioligand competition/displacement) Aryl-ene-yne oxime-7 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 3.28x28 99 TM3 W => A 2.513↑ pK(i) (Binding - Radioligand competition/displacement) McN-A343 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 1.031↑ logKapp (Binding - Radioligand competition/displacement) Tetramethylammonium Hulme EC et al (1999) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 1.025↑ logKapp (Binding - Radioligand competition/displacement) Tetraethylammonium Hulme EC et al (1999) Kooistra AJ et al (2013)
acm2_human 7.32x31 419 TM7 N => A 1.259↓ pK(i) (Binding - Radioligand competition/displacement) AC-42 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 457 C-term C => A 1.412↑ pK(i) (Binding - Radioligand competition/displacement) Carbachol Hayashi MK et al (1997) Kooistra AJ et al (2013)
acm2_human 5.62x62 210 TM5 S => Y N/A N/A Bluml K et al (1994)
acm2_human 2.61x60 80 TM2 Y => A 25.0↑ pK(i) (Binding - Radioligand competition/displacement) 77-LH-28-1 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => N 2.583↓ Kapp (Binding - Radioligand competition/displacement) Arylacetylene oxime-1 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 3.36x36 107 TM3 S => A 5.012↓ pK(i) (Binding - Radioligand competition/displacement) Arecoline Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.33x33 104 TM3 Y => A 398.107↓ pK(i) (Binding - Radioligand competition/displacement) Acetylcholine Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 7.36x35 423 TM7 T => A 2.512↓ pK(i) (Binding - Radioligand competition/displacement) AC-42 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 5.39x40 187 TM5 T => A N/A N/A Heitz F et al (1999)
acm2_human 6.53x53 405 TM6 V => I 1.259↓ pIC50 (Binding - Radioligand competition/displacement) UH-AH 37 Ellis J et al (2000) Kooistra AJ et al (2013)
acm2_human 179 ECL2 Q => A 1.445↑ K(d) (Binding - Radioligand saturation) [3H]N-methyl scopolamine Heitz F et al (1999) Kooistra AJ et al (2013)
acm2_human 3.53x53 124 TM3 C => S N/A N/A Blin N et al (1995)
acm2_human 3.33x33 104 TM3 Y => A 1.0 pK(i) (Binding - Radioligand competition/displacement) McN-A343 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 7.36x35 423 TM7 T => A 1.259↑ pK(i) (Binding - Radioligand competition/displacement) Pilocarpine Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 45.51x51 177 ECL2 Y => A 1.0 pK(i) (Binding - Radioligand competition/displacement) NDMC Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 1.025↑ logK (Binding - Radioligand competition/displacement) Tetraethylammonium Page KM et al (1995) Kooistra AJ et al (2013)
acm2_human 3.49x49 120 TM3 D => N 1.247↑ IC50 (Binding - Radioligand competition/displacement) Gallamine Leppik RA et al (1994) Kooistra AJ et al (2013)
acm2_human 2.61x60 80 TM2 Y => A N/A N/A Gregory KJ et al (2010)
acm2_human 3.32x32 103 TM3 D => E 1.415↓ Kapp (Binding - Radioligand competition/displacement) Aryl-ene-yne oxime-5 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 1.667↑ logKapp (Binding - Radioligand competition/displacement) Carbachol Hulme EC et al (1999) Kooistra AJ et al (2013)
acm2_human 3.26x26 97 TM3 D => N N/A N/A Leppik RA et al (1994)
acm2_human 7.36x35 423 TM7 T => H 7.943↓ pKapp (Binding - Radioligand competition/displacement) W84 Huang XP et al (2005) Kooistra AJ et al (2013)
acm2_human 6.49x49 401 TM6 A => T 5.0↑ pIC50 (Binding - Radioligand competition/displacement) Pirenzepine Ellis J et al (2000) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 5.0↓ Kapp (Binding - Radioligand competition/displacement) Aryl-ene-yne oxime-12 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 6.34x34 386 TM6 T => A N/A N/A Kostenis E et al (1997)
acm2_human 7.32x31 419 TM7 N => A 1.996↑ pK(i) (Binding - Radioligand competition/displacement) 77-LH-28-1 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 7.32x31 419 TM7 N => A 1.585↑ pK(d) (Binding - Radioligand saturation) [3H]QNB Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 6.49x49 401 TM6 A => T 3.165↑ pIC50 (Binding - Radioligand competition/displacement) UH-AH 37 Ellis J et al (2000) Kooistra AJ et al (2013)
acm2_human 3.36x36 107 TM3 S => A 1.995↓ pK(d) (Binding - Radioligand saturation) [3H]QNB Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 415 ECL3 P => K 1.259↑ pIC50 (Binding - Radioligand competition/displacement) UH-AH 37 Ellis J et al (2000) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 1.133↑ Kapp (Binding - Radioligand competition/displacement) Arylacetylene oxime-2 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => N 1.565↓ Kapp (Binding - Radioligand competition/displacement) Aryl-ene-yne oxime-11 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 3.29x29 100 TM3 L => A 10.0↓ pK(i) (Binding - Radioligand competition/displacement) Pilocarpine Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 173 ECL2 D => N N/A N/A Gregory KJ et al (2010)
acm2_human 5.42x43 190 TM5 T => A N/A N/A Heitz F et al (1999)
acm2_human 5.62x62 210 TM5 S => Y 1.931↑ IC50 (Binding - Radioligand competition/displacement) Carbachol Bluml K et al (1994) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 1.12↑ logK (Binding - Radioligand competition/displacement) Pilocarpine Page KM et al (1995) Kooistra AJ et al (2013)
acm2_human 6.33x33 385 TM6 V => A N/A N/A Kostenis E et al (1997)
acm2_human 45.51x51 177 ECL2 Y => A 1.585↓ pK(i) (Binding - Radioligand competition/displacement) Arecoline Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 2.61x60 80 TM2 Y => A 1.585↓ pK(i) (Binding - Radioligand competition/displacement) Pilocarpine Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.26x26 97 TM3 D => N 1.096↑ pK(i) (Binding - Radioligand competition/displacement) McN-A343 Suga H et al (2010) Vass M et al (2018)
acm2_human 3.32x32 103 TM3 D => E 3.0↓ Kapp (Binding - Radioligand competition/displacement) Aryl-ene-yne oxime-9 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 6.38x38 390 TM6 L => S N/A N/A Kostenis E et al (1997)
acm2_human 3.32x32 103 TM3 D => N Decreased effect K(d) (Binding - Radioligand saturation) [3H]N-methyl scopolamine Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 6.49x49 401 TM6 A => T N/A N/A Ellis J et al (2000)
acm2_human 7.36x35 423 TM7 T => A 1.996↑ pK(i) (Binding - Radioligand competition/displacement) McN-A343 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.33x33 104 TM3 Y => A 100.0↓ pK(i) (Binding - Radioligand competition/displacement) Pilocarpine Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.33x33 104 TM3 Y => A 100.0↓ pK(i) (Binding - Radioligand competition/displacement) Arecoline Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 6.51x51 403 TM6 Y => A 1.585↑ pK(i) (Binding - Radioligand competition/displacement) McN-A343 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E N/A N/A Schwarz RD et al (1999)
acm2_human 3.36x36 107 TM3 S => A 19.953↓ pK(i) (Binding - Radioligand competition/displacement) Carbachol Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 6.34x34 386 TM6 T => A 1.859↑ IC50 (Binding - Radioligand competition/displacement) Carbachol Kostenis E et al (1997) Kooistra AJ et al (2013)
acm2_human 2.61x60 80 TM2 Y => A 5.012↓ pK(i) (Binding - Radioligand competition/displacement) Carbachol Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 1.31x31 22 TM1 E => Q 1.131↑ IC50 (Binding - Radioligand competition/displacement) Gallamine Leppik RA et al (1994) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 1.316↓ Kapp (Binding - Radioligand competition/displacement) Arylacetylene oxime-3 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 7.32x31 419 TM7 N => D 3.984↑ pKapp (Binding - Radioligand kinetics (association/dissociation)) [3H]N-methyl scopolamine Gnagey AL et al (1999) Kooistra AJ et al (2013)
acm2_human 3.36x36 107 TM3 S => A 19.953↓ pK(i) (Binding - Radioligand competition/displacement) Acetylcholine Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 3.231↓ K(d) (Binding - Radioligand saturation) [3H]N-methyl scopolamine Heitz F et al (1999) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => N 77.143↓ Kapp (Binding - Radioligand competition/displacement) Pilocarpine Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 3.28x28 99 TM3 W => A 1.585↑ pK(i) (Binding - Radioligand competition/displacement) Arecoline Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 6.49x49 401 TM6 A => T 1.0 pIC50 (Binding - Radioligand competition/displacement) AF-DX 116 Ellis J et al (2000) Kooistra AJ et al (2013)
acm2_human 7.32x31 419 TM7 N => K N/A N/A Gnagey AL et al (1999)
acm2_human 3.32x32 103 TM3 D => N >19000.0↓ Kapp (Binding - Radioligand competition/displacement) L607,207 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 6.52x52 404 TM6 N => A N/A N/A Heitz F et al (1999)
acm2_human 2.61x60 80 TM2 Y => A 1.995↓ pK(i) (Binding - Radioligand competition/displacement) Arecoline Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 1.045↑ logK (Binding - Radioligand competition/displacement) Ach,N(Et)2 Page KM et al (1995) Kooistra AJ et al (2013)
acm2_human 3.28x28 99 TM3 W => F 1.585↑ pK(i) (Binding - Radioligand competition/displacement) McN-A343 Suga H et al (2010) Vass M et al (2018)
acm2_human 3.28x28 99 TM3 W => A 62.5↑ pK(i) (Binding - Radioligand competition/displacement) AC-42 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 45.51x51 177 ECL2 Y => F N/A N/A Derrien A et al (2001)
acm2_human 3.28x28 99 TM3 W => A 1.259↑ pK(i) (Binding - Radioligand saturation) NDMC Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 1.272↑ logK (Binding - Radioligand competition/displacement) Formylcholine Page KM et al (1995) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => N 60.0↓ Kapp (Binding - Radioligand competition/displacement) Aryl-ene-yne oxime-8 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 6.37x37 389 TM6 I => L N/A N/A Kostenis E et al (1997)
acm2_human 3.32x32 103 TM3 D => N 467.735↓ pK(i) (Binding - Radioligand competition/displacement) Acetylcholine Suga H et al (2010) Vass M et al (2018)
acm2_human 3.32x32 103 TM3 D => A 11.628↑ Single-point (Binding - Radioligand competition/displacement) BR-384 Suga H et al (2010) Vass M et al (2018)
acm2_human 3.32x32 103 TM3 D => N 65.0↓ Kapp (Binding - Radioligand competition/displacement) Aryl-ene-yne oxime-12 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 2.50x50 69 TM2 D => N 1.621↑ pK(i) (Binding - Radioligand competition/displacement) N-methyl scopolamine Suga H et al (2013) Vass M et al (2018)
acm2_human 6.51x51 403 TM6 Y => A 39.811↓ pK(i) (Binding - Radioligand competition/displacement) Pilocarpine Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 1.183↑ logK (Binding - Radioligand competition/displacement) Oxotremorine-M Page KM et al (1995) Kooistra AJ et al (2013)
acm2_human 7.36x35 423 TM7 T => A 1.585↓ pK(i) (Binding - Radioligand competition/displacement) NDMC Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 7.32x31 419 TM7 N => V 1.259↑ pIC50 (Binding - Radioligand competition/displacement) UH-AH 37 Ellis J et al (2000) Kooistra AJ et al (2013)
acm2_human 45.51x51 177 ECL2 Y => A 3.165↑ pK(i) (Binding - Radioligand competition/displacement) 77-LH-28-1 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 2.50x50 69 TM2 D => N 3.118↓ IC50 (Binding - Radioligand competition/displacement) Gallamine Leppik RA et al (1994) Kooistra AJ et al (2013)
acm2_human 3.28x28 99 TM3 W => F 1.479↓ pK(i) (Binding - Radioligand competition/displacement) N-methyl scopolamine Suga H et al (2010) Vass M et al (2018)
acm2_human 5.62x62 210 TM5 S => Y 1.42↑ K(d) (Binding - Radioligand saturation) [3H]N-methyl scopolamine Bluml K et al (1994) Kooistra AJ et al (2013)
acm2_human 6.51x51 403 TM6 Y => A 1.259↓ pK(i) (Binding - Radioligand competition/displacement) AC-42 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 7.32x31 419 TM7 N => E N/A N/A Gnagey AL et al (1999)
acm2_human 3.32x32 103 TM3 D => N 12.7↓ Kapp (Binding - Radioligand competition/displacement) Aryl-ene-yne oxime-6 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 6.51x51 403 TM6 Y => A 19.953↓ pK(i) (Binding - Radioligand competition/displacement) Arecoline Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 1.111↓ K(d) (Binding - Radioligand saturation) [3H]QNB Heitz F et al (1999) Kooistra AJ et al (2013)
acm2_human 3.26x26 97 TM3 D => N 1.447↑ IC50 (Binding - Radioligand competition/displacement) Gallamine Leppik RA et al (1994) Kooistra AJ et al (2013)
acm2_human 45.51x51 177 ECL2 Y => Q 1.995↓ pKapp (Binding - Radioligand competition/displacement) Gallamine Huang XP et al (2005) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => N 2.326↑ Single-point (Binding - Radioligand competition/displacement) BR-384 Suga H et al (2010) Vass M et al (2018)
acm2_human 3.32x32 103 TM3 D => N 43.0↓ Kapp (Binding - Radioligand competition/displacement) Aryl-ene-yne oxime-10 Schwarz RD et al (1999) Kooistra AJ et al (2013)
acm2_human 175 ECL2 E => Q 1.995↓ pKapp (Binding - Radioligand competition/displacement) Gallamine Huang XP et al (2005) Kooistra AJ et al (2013)
acm2_human 3.36x36 107 TM3 S => A 1.0 pK(i) (Binding - Radioligand competition/displacement) AC-42 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.36x36 107 TM3 S => A 1.259↑ pK(i) (Binding - Radioligand competition/displacement) McN-A343 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 7.32x31 419 TM7 N => A 1.0 pK(i) (Binding - Radioligand competition/displacement) NDMC Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.29x29 100 TM3 L => A 1.259↓ pK(i) (Binding - Radioligand competition/displacement) 77-LH-28-1 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => E 1.555↑ logKapp (Binding - Radioligand competition/displacement) Acetylcholine Hulme EC et al (1999) Kooistra AJ et al (2013)
acm2_human 172 ECL2 E => Q N/A N/A Gregory KJ et al (2010)
acm2_human 3.26x26 97 TM3 D => N 2.326↑ Single-point (Binding - Radioligand competition/displacement) BR-384 Suga H et al (2010) Vass M et al (2018)
acm2_human 3.28x28 99 TM3 W => A 2.278↓ K(d) (Binding - Radioligand saturation) [3H]QNB Heitz F et al (1999) Kooistra AJ et al (2013)
acm2_human 7.32x31 419 TM7 N => A 1.259↑ pK(i) (Binding - Radioligand competition/displacement) McN-A343 Gregory KJ et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => A 8.986↑ Single-point (Binding - Radioligand competition/displacement) Acetylcholine Suga H et al (2010) Vass M et al (2018)
acm2_human 4.57x57 155 TM4 W => F 5.659↑ Single-point (Binding - Radioligand competition/displacement) BR-384 Suga H et al (2010) Kooistra AJ et al (2013)
acm2_human 3.32x32 103 TM3 D => N 10.141↑ Single-point (Binding - Radioligand competition/displacement) Acetylcholine Suga H et al (2010) Vass M et al (2018)


Residue

Diagrams

ICL1 R H L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P V K R ICL2ECL2 V R T V E D G E C Y I Q F F S ECL2ICL3 P V A N Q D P V S P S L V Q G R I V K P N N N N M P S S D D G L E H N K I Q N G K A P R D P V T E N C V Q G E E K E S S N D S T S V S A V A S N M R D D E I T Q D E N T V S T S L G H S K D E N S K Q T C I R I G T K T P K S D S C T P T N T T V E V V G S S G Q N G D E K Q N I V A R K I V K M T K Q P A K K ICL3ECL3 A P C I ECL3N-term M N N S T N S S N N S L A L T S P Y N-termC-term C H Y K N I G A T R C-term K T F E V V F I V L V A G S L S L V T I I G N I L V M V S I K V N T V N N Y F L F S L A C A D L I I G V F S M N L Y T L Y T V I G G P V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G M M I A A A W V L S F I L W A P A I L F W Q F I V G N A A V T F G T A I A A F Y L P V I I M T V L Y W H I S R A S K S R I K K D K K E K P P P S R E K K V T R T I L A I L L A F I I T W A P Y N V M V L I N T F C P N T V W T I G Y W L C Y I N S T I N P A C Y A L C N A T F K H F K K T L L M
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
I N G I I T V L S L S G A V L V I F V V 1 F S L A C A D L I I G F V S M N L Y T L Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G M M I A A A W V L S F I L W A P A I 4 Y L V T M I I V P L Y F A A I A T G F T V 5 L A I L L A F I I T W A P Y N V M V L I 6 A P N I T S N I Y C L W Y G I T W V T 7
Download: PNG | SVG




Residue Table


GPCRdb(A)
GPCRdb(A)
M2 receptor
TM1
1x31 1.31x31 E22
TM2
2x50 2.50x50 D69
2x56 2.57x56 S76
2x60 2.61x60 Y80
TM3
3x26 3.26x26 D97
3x28 3.28x28 W99
3x29 3.29x29 L100
3x32 3.32x32 D103
3x33 3.33x33 Y104
3x36 3.36x36 S107
3x49 3.49x49 D120
3x53 3.53x53 C124
3x56 3.56x56 K127
TM4
4x41 4.41x41 M139
4x57 4.57x57 W155
TM5
5x40 5.39x40 T187
5x43 5.42x43 T190
5x62 5.62x62 S210
TM6
6x30 6.30x30 E382
6x33 6.33x33 V385
6x34 6.34x34 T386
6x37 6.37x37 I389
6x38 6.38x38 L390
6x48 6.48x48 W400
6x49 6.49x49 A401
6x51 6.51x51 Y403
6x52 6.52x52 N404
6x53 6.53x53 V405
6x57 6.57x57 I409
6x58 6.58x58 N410
TM7
7x31 7.32x31 N419
7x33 7.34x33 V421
7x35 7.36x35 T423
7x41 7.42x41 C429