Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
adrb1_melga 8.59x59 358 H8 C => A N/A N/A Warne T et al (2008)
adrb1_melga 7.37x36 327 TM7 F => A N/A N/A N/A
adrb1_melga 3.27x27 116 TM3 C => L N/A N/A Warne T et al (2011)
adrb1_melga 8.59x59 358 H8 C => A N/A N/A N/A
adrb1_melga 2.53x53 90 TM2 M => V N/A N/A N/A
adrb1_melga 34.53x53 149 ICL2 Y => A N/A N/A Warne T et al (2008)
adrb1_melga 6.27x27 282 TM6 A => L N/A N/A N/A
adrb1_melga 3.27x27 116 TM3 C => L N/A N/A Warne T et al (2008)
adrb1_melga 5.58x58 227 TM5 Y => A N/A N/A N/A
adrb1_melga 7.48x48 338 TM7 F => M N/A N/A N/A
adrb1_melga 3.27x27 116 TM3 C => L N/A N/A N/A
adrb1_melga 1.59x59 68 TM1 R => S N/A N/A N/A


Residue

Diagrams

ICL1 Q R L Q ICL1ECL1 T W L W ECL1ICL2 P F R Y Q S L M ICL2ECL2 W W R D E D P Q A L K C Y Q D P G C C D F V T ECL2ICL3 G R F Y G S Q E Q P Q P P P L P Q H Q P I L G N G R A S K ICL3ECL3 R D L V ECL3N-term M G D G W L P P D C G P H N R S G G G G A T A A P T G S R Q V S N-termC-term F P R K A D R R L H A G G Q P A P L P G G F I S T L G S P E H S P G G T W S D C N G G T R G G S E S S L E E R H S K T S R S E S K M E R E K N I L A T T R F Y C T F L G N G D K A V F C T V L R I V K L F E D A T C T C P H T H K L K M K W R F K Q H Q A C-term A E L L S Q Q W E A G M S L L M A L V V L L I V A G N V L V I A A I G R T T L T N L F I T S L A C A D L V M G L L V V P F G A T L V V R G G S F L C E C W T S L D V L C V T A S I E T L C V I A I D R Y L A I T S T R A R A K V I I C T V W A I S A L V S F L P I M M H N R A Y A I A S S I I S F Y I P L L I M I F V Y L R V Y R E A K E Q I R K I D R C E R K T S R V M A M R E H K A L K T L G I I M G V F T L C W L P F F L V N I V N V F N P D W L F V F F N W L G Y A N S A F N P I I Y C R S P D F K R F R K A L L C
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
V N G A V I L L V V L A M L L S M G A E 1 T S L A C A D L V M G L L V V P F G A T L 2 V C L T E I S A T V C L V D L S T W C E 3 A K V I I C T V W A I S A L V S F L P I 4 Y V F I M I L L P I Y F S I I S S A I A Y 5 G I I M G V F T L C W L P F F L V N I V 6 I P N F A S N A Y G L W N F F V F L W 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
β1-adrenoceptor
TM1
1x59 1.59x59 R68
TM2
2x53 2.53x53 M90
TM3
3x27 3.27x27 C116
TM5
5x58 5.58x58 Y227
TM6
6x27 6.27x27 A282
TM7
7x36 7.37x36 F327
7x48 7.48x48 F338
H8
8x59 8.59x59 C358