Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
adrb2_bovin 6.34x34 272 TM6 L => H N/A N/A Ballesteros JA et al (2001)
adrb2_bovin 4.61x61 169 TM4 I => C N/A N/A Ballesteros JA et al (2001)
adrb2_bovin 3.53x53 134 TM3 A => H N/A N/A Ballesteros JA et al (2001)
adrb2_bovin 6.31x31 269 TM6 H => K N/A N/A Ballesteros JA et al (2001)
adrb2_bovin 3.49x49 130 TM3 D => N N/A N/A Ballesteros JA et al (2001)
adrb2_bovin 6.29x29 267 TM6 K => R N/A N/A Ballesteros JA et al (2001)
adrb2_bovin 7.39x38 312 TM7 N => C N/A N/A Ballesteros JA et al (2001)
adrb2_bovin 8.59x59 341 H8 C => G N/A N/A Loudon RP et al (1997)
adrb2_bovin 6.34x34 272 TM6 L => A N/A N/A Ballesteros JA et al (2001)
adrb2_bovin 6.28x28 266 TM6 L => S N/A N/A Ballesteros JA et al (2001)
adrb2_bovin 7.39x38 312 TM7 N => F N/A N/A Ballesteros JA et al (2001)
adrb2_bovin 7.38x37 311 TM7 L => F N/A N/A Ballesteros JA et al (2001)
adrb2_bovin 6.47x47 285 TM6 C => S N/A N/A Shi L et al (2002)
adrb2_bovin 6.30x30 268 TM6 E => H N/A N/A Ballesteros JA et al (2001)
adrb2_bovin 6.30x30 268 TM6 E => A N/A N/A Ballesteros JA et al (2001)
adrb2_bovin 6.30x30 268 TM6 E => Q N/A N/A Ballesteros JA et al (2001)
adrb2_bovin 3.32x32 113 TM3 D => H N/A N/A Ballesteros JA et al (2001)


Residue

Diagrams

ICL1 E R L Q ICL1ECL1 M W T F ECL1ICL2 P F K Y Q C L L ICL2ECL2 W Y R A S H K E A I N C Y A K E T C C D F F T ECL2ICL3 G R F H A Q N V S Q V E Q D G R S G L G Q R R T ICL3ECL3 D N L I ECL3N-term M G Q P G N R S V F L L A P N A S H A P D Q N V T N-termC-term L R R S S L K A Y G N G C S S N S N D R T D Y T G E Q S G Y H L G E E K D S E L L C E D P P G T E N F V N Q Q G T V P S D S I D S Q G R N C S T N D S L L C-term L E R D E A W V V G M G I L M S L I V L A I V F G N V L V I T A I A K F T V T N Y F I T S L A C A D L V M G L A V V P F G A C H I L M K G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y L A I T S T K N K A R V V I L M V W I V S G L T S F L P I Q M H N Q P Y A I A S S I V S F Y L P L V V M V F V Y S R V F Q V A K R Q L Q K I D K S E S K F Y L K E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I K R K E I Y I L L N W L G Y I N S A F N P L I Y C R S P D F Q E F R I A L L C
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
V N G F V I A L V I L S M L I G M G V V 1 T S L A C A D L V M G A L V V P F G A C H 2 V C L T E I S A T V C L V D I S T W F E 3 A R V V I L M V W I V S G L T S F L P I 4 Y V F V M V V L P L Y F S V I S S A I A Y 5 G I I M G T F T L C W L P F F I V N I V 6 L P N F A S N I Y G L W N L L I Y I E 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
β2-adrenoceptor
TM3
3x32 3.32x32 D113
3x49 3.49x49 D130
3x53 3.53x53 A134
TM4
4x61 4.61x61 I169
TM6
6x28 6.28x28 L266
6x29 6.29x29 K267
6x30 6.30x30 E268
6x31 6.31x31 H269
6x34 6.34x34 L272
6x47 6.47x47 C285
TM7
7x37 7.38x37 L311
7x38 7.39x38 N312
H8
8x59 8.59x59 C341