Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
cxcr4_human 26 N-term E => A N/A N/A Zhou N et al (2001)
cxcr4_human 6.55x55 259 TM6 I => W Abolished EC50 (Functional - IP accumulation) KRH1636-6 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 5.32x33 193 TM5 D => N 4.083↓ K(i) (Binding - Radioligand competition/displacement) AMD3100(Zn)2 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 6.55x55 259 TM6 I => A 1.318↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 6.55x55 259 TM6 I => A Abolished EC50 (Functional - IP accumulation) KRH1636-5 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 7.32x31 281 TM7 H => A 6.135↑ K(i) (Binding - Radioligand competition/displacement) AMD3100 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 2.63x63 97 TM2 D => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 21 N-term Y => A N/A N/A Brelot A et al (2000)
cxcr4_human 3.29x29 113 TM3 H => A Abolished IC50 (Binding - Radioligand competition/displacement) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 1.39x39 45 TM1 Y => A 15.083↓ EC50 (Functional - IP accumulation) KRH1636-6 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 3.29x29 113 TM3 H => A 34.483↓ EC50 (Functional - IP accumulation) [Aib]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 7.32x31 281 TM7 H => A 3.086↑ K(i) (Binding - Radioligand competition/displacement) AMD3100 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 6.55x55 259 TM6 I => W 1.153↑ EC50 (Functional - IP accumulation) CXCL12 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 5.35x36 196 TM5 V => A 4.065↓ EC50 (Functional - Ca2+ accumulation) CXCL12 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 5.39x40 200 TM5 Q => A 20.833↓ EC50 (Functional - IP accumulation) KRH1636-6 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 6.51x51 255 TM6 Y => A 1.182↓ K(i) (Binding - Radioligand competition/displacement) AMD11070 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 6.64x64 268 TM6 E => A 1.03↑ K(d) (Binding - Radioligand saturation) CXCL12 Zhou H et al (2000) 10.5281/zenodo.58160
cxcr4_human 179 ECL2 E => Q N/A N/A Wang ZX et al (1998)
cxcr4_human 3.29x29 113 TM3 H => A 120.0↓ EC50 (Functional - IP accumulation) FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 183 ECL2 R => A 1.681↑ K(i) (Binding - Radioligand competition/displacement) AMD3100 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 6.55x55 259 TM6 I => W 2.84↓ K(d) (Binding - Radioligand competition/displacement) CXCL12 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 4.61x62 172 TM4 F => A 1.0 K(i) (Binding - Radioligand competition/displacement) AMD8721 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 3.33x33 117 TM3 T => A 1.423↓ EC50 (Functional - IP accumulation) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => N 17.568↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 6.55x55 259 TM6 I => A 8.0↑ K(i) (Binding - Radioligand competition/displacement) AMD3389 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 2.60x60 94 TM2 W => A 12.0↓ EC50 (Functional - IP accumulation) CXCL12 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 5.35x36 196 TM5 V => A 16.364↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 176 ECL2 N => A N/A N/A Chabot DJ et al (2000)
cxcr4_human 182 ECL2 D => K N/A N/A Wang ZX et al (1998)
cxcr4_human 3.29x29 113 TM3 H => A 3.571↓ K(i) (Binding - Radioligand competition/displacement) AMD3100(Zn)2 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 5.35x36 196 TM5 V => A 1.072↑ EC50 (Functional - IP accumulation) CXCL12 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 7.35x34 284 TM7 I => A 1.236↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2004) 10.5281/zenodo.58160
cxcr4_human 8.53x53 312 H8 S => A N/A N/A Lu Z et al (1997)
cxcr4_human 176 ECL2 N => A 2.37↑ K(d) (Binding - Radioligand competition/displacement) CXCL12 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 7.39x38 288 TM7 E => A 1.448↓ IC50 (Binding - Radioligand competition/displacement) [Aib]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 4.60x61 171 TM4 D => N 10.75↓ K(i) (Binding - Radioligand competition/displacement) AMD8721 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 10 N-term D => A N/A N/A Brelot A et al (2000)
cxcr4_human 3.25x25 109 TM3 C => A N/A N/A Zhou H et al (2000)
cxcr4_human 5.39x40 200 TM5 Q => W 22.0↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 176 ECL2 N => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 4.60x61 171 TM4 D => N 93.243↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 5.46x461 207 TM5 G => F 1.455↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 45.51x51 187 ECL2 D => F N/A N/A Wang ZX et al (1998)
cxcr4_human 6.51x51 255 TM6 Y => A 1.481↑ EC50 (Functional - IP accumulation) FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 2.63x63 97 TM2 D => A 10.0↑ EC50 (Functional - IP accumulation) FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 45.51x51 187 ECL2 D => N N/A N/A Wang ZX et al (1998)
cxcr4_human 6.64x64 268 TM6 E => A N/A N/A Zhou H et al (2000)
cxcr4_human 4.60x61 171 TM4 D => N 14.607↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 3.32x32 116 TM3 Y => A Abolished EC50 (Functional - IP accumulation) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 3.35x35 119 TM3 N => S ~1.471↓ Single-point (Functional - cAMP accumulation) CXCL12 Berchiche YA et al (2007) 10.5281/zenodo.58160
cxcr4_human 7.38x37 287 TM7 T => A 1.0 K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 6.51x51 255 TM6 Y => A 1.85↓ K(i) (Binding - Radioligand competition/displacement) AMD3389 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 45.51x51 187 ECL2 D => A 2.136↓ IC50 (Binding - Radioligand saturation) CXCL12 N/A 10.5281/zenodo.58160
cxcr4_human 7.35x34 284 TM7 I => A 1.533↓ EC50 (Functional - IP accumulation) CXCL12 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 5.35x36 196 TM5 V => M N/A N/A Brelot A et al (1999)
cxcr4_human 6.52x52 256 TM6 Y => A 4.494↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2004) 10.5281/zenodo.58160
cxcr4_human 6.52x52 256 TM6 Y => A 9.5↓ K(i) (Binding - Radioligand competition/displacement) AMD3479 Rosenkilde MM et al (2004) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => N 5.231↓ K(i) (Binding - Radioligand competition/displacement) AMD2936 Gerlach LO et al (2001) 10.5281/zenodo.58160
cxcr4_human 7.39x38 288 TM7 E => D 2.682↓ IC50 (Binding - Radioligand saturation) CXCL12 N/A 10.5281/zenodo.58160
cxcr4_human 5.39x40 200 TM5 Q => W 1.111↑ EC50 (Functional - IP accumulation) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 5.42x43 203 TM5 H => A 1.318↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 5.39x40 200 TM5 Q => A 27.0↓ K(i) (Binding - Radioligand competition/displacement) AMD8899 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 3.32x32 116 TM3 Y => A 3.545↓ K(i) (Binding - Radioligand competition/displacement) AMD11070 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 3.26x26 110 TM3 K => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 4.60x61 171 TM4 D => N 37.838↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Gerlach LO et al (2001) 10.5281/zenodo.58160
cxcr4_human 5.32x33 193 TM5 D => N 1.095↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Gerlach LO et al (2001) 10.5281/zenodo.58160
cxcr4_human 4.60x61 171 TM4 D => A 6.457↓ pEC50 (Functional - Ca2+ accumulation) CXCL12 Kufareva I et al (2014) 10.5281/zenodo.58160
cxcr4_human 45.51x51 187 ECL2 D => S N/A N/A Wang ZX et al (1998)
cxcr4_human 5.32x33 193 TM5 D => N 1.114↑ K(d) (Binding - Radioligand competition/displacement) CXCL12 Gerlach LO et al (2001) 10.5281/zenodo.58160
cxcr4_human 7.28x27 277 TM7 E => A N/A N/A Zhou H et al (2000)
cxcr4_human 3.29x29 113 TM3 H => A 22.727↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 182 ECL2 D => K N/A N/A Wang ZX et al (1998)
cxcr4_human 5.32x33 193 TM5 D => R N/A N/A Brelot A et al (1999)
cxcr4_human 4.64x65 175 TM4 A => F 250.0↓ K(i) (Binding - Radioligand competition/displacement) AMD8721 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 3.29x29 113 TM3 H => A 1.757↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 45.51x51 187 ECL2 D => A N/A N/A Chabot DJ et al (2000)
cxcr4_human 2.50x50 84 TM2 D => N N/A N/A Brelot A et al (2000)
cxcr4_human 45.51x51 187 ECL2 D => A N/A N/A Chabot DJ et al (2000)
cxcr4_human 176 ECL2 N => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 22 N-term D => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 7.32x31 281 TM7 H => A 160.0↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 7.32x31 281 TM7 H => A 2.0↓ EC50 (Functional - IP accumulation) FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 4.58x59 169 TM4 I => C 1.953↑ K(d) (Binding - Radioligand saturation) FC131 Boulais PE et al (2013) 10.5281/zenodo.58160
cxcr4_human 2.60x60 94 TM2 W => A 12.0↓ EC50 (Functional - IP accumulation) CXCL12 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 4.64x65 175 TM4 A => F 75.294↓ K(i) (Binding - Radioligand competition/displacement) AMD3529 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 4.60x61 171 TM4 D => N 18.571↓ K(i) (Binding - Radioligand competition/displacement) AMD3100(Zn)2 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 189 ECL2 F => A N/A N/A Wang ZX et al (1998)
cxcr4_human 3.29x29 113 TM3 H => A 63.158↓ IC50 (Binding - Radioligand competition/displacement) FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 3.29x29 113 TM3 H => A N/A N/A Rosenkilde MM et al (2004)
cxcr4_human 22 N-term D => A N/A N/A Brelot A et al (2000)
cxcr4_human 177 ECL2 V => C 1.153↓ K(d) (Binding - Radioligand saturation) FC131 Boulais PE et al (2013) 10.5281/zenodo.58160
cxcr4_human 2.50x50 84 TM2 D => N N/A N/A Brelot A et al (2000)
cxcr4_human 7.32x31 281 TM7 H => A 4.321↓ K(d) (Binding - Radioligand competition/displacement) CXCL12 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 182 ECL2 D => G N/A N/A Brelot A et al (2000)
cxcr4_human 7.25x24 274 TM7 C => A N/A N/A Zhou H et al (2000)
cxcr4_human 192 ECL2 N => D N/A N/A Brelot A et al (1999)
cxcr4_human 4.53x53 164 TM4 A => C 1.871↓ K(d) (Binding - Radioligand saturation) FC131 Boulais PE et al (2013) 10.5281/zenodo.58160
cxcr4_human 7.26x25 275 TM7 E => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 176 ECL2 N => D N/A N/A Brelot A et al (2000)
cxcr4_human 6.58x58 262 TM6 D => N 12.449↓ IC50 (Binding - Radioligand competition/displacement) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 26 N-term E => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 6.58x58 262 TM6 D => N 464.286↓ K(i) (Binding - Radioligand competition/displacement) AMD3100(Zn)2 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 5.35x36 196 TM5 V => A 85.0↓ K(i) (Binding - Radioligand competition/displacement) AMD3479 Rosenkilde MM et al (2004) 10.5281/zenodo.58160
cxcr4_human 4.54x54 165 TM4 L => C 1.747↓ K(d) (Binding - Radioligand saturation) FC131 Boulais PE et al (2013) 10.5281/zenodo.58160
cxcr4_human 2 N-term E => A N/A N/A Brelot A et al (2000)
cxcr4_human 7.39x38 288 TM7 E => A 70.787↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 189 ECL2 F => A 11.494↑ EC50 (Functional - IP accumulation) KRH1636-5 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 45.51x51 187 ECL2 D => A N/A N/A Brelot A et al (1999)
cxcr4_human 176 ECL2 N => A 4.607↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 7.35x34 284 TM7 I => A 6.8↓ EC50 (Functional - IP accumulation) KRH1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 3.33x33 117 TM3 T => A 2.941↑ EC50 (Functional - IP accumulation) KRH1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 7.39x38 288 TM7 E => A Abolished EC50 (Functional - IP accumulation) KRH1636-5 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 182 ECL2 D => A 2.727↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 183 ECL2 R => A Abolished EC50 (Functional - IP accumulation) KRH1636-5 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 5.32x33 193 TM5 D => N 1.876↑ K(i) (Binding - Radioligand competition/displacement) Cyclam (Zn) Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 7.39x38 288 TM7 E => A 263.158↓ IC50 (Binding - Radioligand competition/displacement) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 5.39x40 200 TM5 Q => A 1.0 K(i) (Binding - Radioligand competition/displacement) AMD3479 Rosenkilde MM et al (2004) 10.5281/zenodo.58160
cxcr4_human 4.60x61 171 TM4 D => N 10.0↓ K(i) (Binding - Radioligand competition/displacement) AMD2849 Gerlach LO et al (2001) 10.5281/zenodo.58160
cxcr4_human 7.32x31 281 TM7 H => A 1.157↑ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 7.32x31 281 TM7 H => A 6.235↓ EC50 (Functional - IP accumulation) KRH1636-5 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 7.39x38 288 TM7 E => A N/A N/A Rosenkilde MM et al (2004)
cxcr4_human 4.60x61 171 TM4 D => N N/A N/A Brelot A et al (2000)
cxcr4_human 6.51x51 255 TM6 Y => A 2.0↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 7.39x38 288 TM7 E => A 1.232↓ K(d) (Binding - Radioligand competition/displacement) CXCL12 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 5.39x40 200 TM5 Q => W 1.818↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 7.45x45 294 TM7 H => A 1.133↓ K(i) (Binding - Radioligand competition/displacement) Cyclam (Zn) Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 2.63x63 97 TM2 D => N N/A N/A Brelot A et al (2000)
cxcr4_human 2.60x60 94 TM2 W => A 90.551↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 7.39x38 288 TM7 E => A 100.0↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => A N/A N/A Brelot A et al (2000)
cxcr4_human 7.39x38 288 TM7 E => A Abolished EC50 (Functional - IP accumulation) KRH1636-6 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 2.63x63 97 TM2 D => A 15.625↑ EC50 (Functional - IP accumulation) KRH1636-5 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 5.32x33 193 TM5 D => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 6.55x55 259 TM6 I => W 8.0↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 7.32x31 281 TM7 H => A 5.556↑ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 189 ECL2 F => A 12.048↑ EC50 (Functional - IP accumulation) KRH1636-6 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 4.63x64 174 TM4 F => A N/A N/A Rosenkilde MM et al (2004)
cxcr4_human 178 ECL2 S => C 1.241↓ K(d) (Binding - Radioligand saturation) FC131 Boulais PE et al (2013) 10.5281/zenodo.58160
cxcr4_human 181 ECL2 D => K N/A N/A Wang ZX et al (1998)
cxcr4_human 5.38x39 199 TM5 F => A 1.0 EC50 (Functional - IP accumulation) [Aib]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 15 N-term E => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 6.48x48 252 TM6 W => A 1.775↓ EC50 (Functional - IP accumulation) FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 3.49x49 133 TM3 D => N ~1.667↓ Single-point (Functional - cAMP accumulation) CXCL12 Berchiche YA et al (2007) 10.5281/zenodo.58160
cxcr4_human 5.35x36 196 TM5 V => A 1.175↓ EC50 (Functional - IP accumulation) FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 7.39x38 288 TM7 E => A 66.667↓ EC50 (Functional - IP accumulation) CXCL12 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 3.33x33 117 TM3 T => A 1.934↑ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2004) 10.5281/zenodo.58160
cxcr4_human 6.64x64 268 TM6 E => A N/A N/A Brelot A et al (2000)
cxcr4_human 7.39x38 288 TM7 E => A 69.469↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 2.63x63 97 TM2 D => N Abolished EC50 (Functional - Ca2+ accumulation) CXCL12 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 7 N-term Y => A N/A N/A Brelot A et al (2000)
cxcr4_human 5.32x33 193 TM5 D => S N/A N/A Brelot A et al (1999)
cxcr4_human 5.35x36 196 TM5 V => A 3.077↓ EC50 (Functional - IP accumulation) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 7.39x38 288 TM7 E => A N/A EC50 (Functional - IP accumulation) KRH1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 4.61x62 172 TM4 F => A 1.416↑ K(i) (Binding - Radioligand competition/displacement) AMD3529 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 2.63x63 97 TM2 D => A 13.333↓ EC50 (Functional - IP accumulation) CXCL12 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => N 6.897↑ K(i) (Binding - Radioligand competition/displacement) AMD3389 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 189 ECL2 F => A 3.846↑ EC50 (Functional - IP accumulation) KRH1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 5.32x33 193 TM5 D => N N/A N/A Gerlach LO et al (2003)
cxcr4_human 4.64x65 175 TM4 A => F 130.0↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 7.32x31 281 TM7 H => A N/A N/A Gerlach LO et al (2003)
cxcr4_human 190 ECL2 Y => A 1.379↓ EC50 (Functional - IP accumulation) [Aib]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 45.51x51 187 ECL2 D => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 7.32x31 281 TM7 H => A 1.733↓ EC50 (Functional - IP accumulation) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 1.24x24 30 TM1 R => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 182 ECL2 D => A 3.596↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 4.60x61 171 TM4 D => N 8.182↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 4.43x43 154 TM4 K => C 2.247↓ K(d) (Binding - Radioligand saturation) FC131 Boulais PE et al (2013) 10.5281/zenodo.58160
cxcr4_human 2.63x63 97 TM2 D => A 4.464↑ IC50 (Binding - Radioligand competition/displacement) FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 4.60x61 171 TM4 D => N 53.846↓ EC50 (Functional - IP accumulation) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 191 ECL2 P => A 1.136↓ IC50 (Binding - Radioligand saturation) CXCL12 N/A 10.5281/zenodo.58160
cxcr4_human 7.32x31 281 TM7 H => A 55.0↓ K(i) (Binding - Radioligand competition/displacement) AMD8721 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 3.35x35 119 TM3 N => K 1.905↑ IC50 (Binding - Radioligand competition/displacement) T140 Zhang WB et al (2002) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => N N/A N/A Gerlach LO et al (2003)
cxcr4_human 4.64x65 175 TM4 A => C Abolished K(d) (Binding - Radioligand saturation) FC131 Boulais PE et al (2013) 10.5281/zenodo.58160
cxcr4_human 3.29x29 113 TM3 H => A 11.765↓ EC50 (Functional - IP accumulation) KRH1636-5 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 7.32x31 281 TM7 H => A 1.5↓ K(i) (Binding - Radioligand competition/displacement) AMD3479 Rosenkilde MM et al (2004) 10.5281/zenodo.58160
cxcr4_human 6.51x51 255 TM6 Y => A 1.067↓ EC50 (Functional - IP accumulation) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 181 ECL2 D => A N/A N/A Wang ZX et al (1998)
cxcr4_human 3.29x29 113 TM3 H => A 2.727↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Gerlach LO et al (2001) 10.5281/zenodo.58160
cxcr4_human 11 N-term N => Q N/A N/A Brelot A et al (2000)
cxcr4_human 6.52x52 256 TM6 Y => A 1.682↓ IC50 (Binding - Radioligand saturation) CXCL12 N/A 10.5281/zenodo.58160
cxcr4_human 5.38x39 199 TM5 F => A 1.072↑ EC50 (Functional - IP accumulation) CXCL12 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 7.32x31 281 TM7 H => A 2.182↓ K(i) (Binding - Radioligand competition/displacement) AMD11070 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 4.60x61 171 TM4 D => N 12.0↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 7.32x31 281 TM7 H => A 21.277↑ K(i) (Binding - Radioligand competition/displacement) AMD3100 Gerlach LO et al (2001) 10.5281/zenodo.58160
cxcr4_human 182 ECL2 D => G N/A N/A Brelot A et al (2000)
cxcr4_human 4.47x47 158 TM4 V => C 1.214↑ K(d) (Binding - Radioligand saturation) FC131 Boulais PE et al (2013) 10.5281/zenodo.58160
cxcr4_human 5.39x40 200 TM5 Q => W 36.0↓ K(i) (Binding - Radioligand competition/displacement) AMD8899 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 7.38x37 287 TM7 T => A 4.0↑ K(i) (Binding - Radioligand competition/displacement) AMD8721 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 2.60x60 94 TM2 W => A 10.417↑ EC50 (Functional - IP accumulation) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 21 N-term Y => A N/A Single-point (Binding - Radioligand competition/displacement) CXCL12 Zhou N et al (2001) 10.5281/zenodo.58160
cxcr4_human 183 ECL2 R => A Abolished EC50 (Functional - IP accumulation) KRH1636-6 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 4.60x61 171 TM4 D => N 263.158↓ IC50 (Binding - Radioligand competition/displacement) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 3.35x35 119 TM3 N => D 1.038↓ IC50 (Binding - Radioligand competition/displacement) T140 Zhang WB et al (2002) 10.5281/zenodo.58160
cxcr4_human 45.51x51 187 ECL2 D => A 1.486↑ EC50 (Functional - IP accumulation) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 14 N-term E => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 7.39x38 288 TM7 E => A 2.0↓ IC50 (Binding - Radioligand saturation) CXCL12 N/A 10.5281/zenodo.58160
cxcr4_human 3.29x29 113 TM3 H => A 1.529↑ K(i) (Binding - Radioligand competition/displacement) cyclam N/A 10.5281/zenodo.58160
cxcr4_human 4.60x61 171 TM4 D => N 34.483↓ IC50 (Binding - Radioligand competition/displacement) [Aib]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 3.37x37 121 TM3 Y => A 1.727↓ K(i) (Binding - Radioligand competition/displacement) AMD11070 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 7.45x45 294 TM7 H => A 1.892↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 6.48x48 252 TM6 W => A 7.6↓ EC50 (Functional - IP accumulation) KRH1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 5.38x39 199 TM5 F => A 1.38↓ EC50 (Functional - IP accumulation) KRH1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 182 ECL2 D => N 1.139↑ K(d) (Binding - Radioligand competition/displacement) CXCL12 Gerlach LO et al (2001) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => N 21.364↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 22 N-term D => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 5.42x43 203 TM5 H => A N/A N/A Gerlach LO et al (2001)
cxcr4_human 4.60x61 171 TM4 D => N 89.231↓ K(i) (Binding - Radioligand competition/displacement) AMD2936 Gerlach LO et al (2001) 10.5281/zenodo.58160
cxcr4_human 5.42x43 203 TM5 H => A 1.088↑ K(i) (Binding - Radioligand competition/displacement) AMD3100 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 5.42x43 203 TM5 H => A 4.0↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 5.35x36 196 TM5 V => A 2.024↑ EC50 (Functional - IP accumulation) KRH1636-5 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 343 C-term E => X N/A N/A Hernandez PA et al (2003)
cxcr4_human 7.35x34 284 TM7 I => A 1.31↓ EC50 (Functional - IP accumulation) [Aib]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 4.45x45 156 TM4 V => C 1.247↓ K(d) (Binding - Radioligand saturation) FC131 Boulais PE et al (2013) 10.5281/zenodo.58160
cxcr4_human 182 ECL2 D => A N/A N/A Brelot A et al (2000)
cxcr4_human 26 N-term E => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 11 N-term N => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 5.46x461 207 TM5 G => F 3.371↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 5.42x43 203 TM5 H => A 1.072↑ EC50 (Functional - IP accumulation) CXCL12 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 3.33x33 117 TM3 T => A 9.804↑ EC50 (Functional - IP accumulation) KRH1636-5 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => N N/A N/A Rosenkilde MM et al (2004)
cxcr4_human 189 ECL2 F => A 3.636↓ IC50 (Binding - Radioligand saturation) CXCL12 N/A 10.5281/zenodo.58160
cxcr4_human 3.29x29 113 TM3 H => A 1.4↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 179 ECL2 E => C 1.153↓ K(d) (Binding - Radioligand saturation) FC131 Boulais PE et al (2013) 10.5281/zenodo.58160
cxcr4_human 183 ECL2 R => A N/A N/A Wang ZX et al (1998)
cxcr4_human 182 ECL2 D => N N/A N/A Gerlach LO et al (2001)
cxcr4_human 45.52x52 188 ECL2 R => A 1.8↓ EC50 (Functional - IP accumulation) FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 20 N-term D => A N/A N/A Brelot A et al (2000)
cxcr4_human 6.58x58 262 TM6 D => N 1.355↑ K(i) (Binding - Radioligand competition/displacement) cyclam N/A 10.5281/zenodo.58160
cxcr4_human 6.55x55 259 TM6 I => W Abolished EC50 (Functional - IP accumulation) KRH1636-5 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 7.28x27 277 TM7 E => A N/A N/A Brelot A et al (2000)
cxcr4_human 3.35x35 119 TM3 N => D 1.297↑ IC50 (Binding - Radioligand competition/displacement) AMD3100 Zhang WB et al (2002) 10.5281/zenodo.58160
cxcr4_human 4.63x64 174 TM4 F => A 3.551↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2004) 10.5281/zenodo.58160
cxcr4_human 3.29x29 113 TM3 H => A 20.408↓ IC50 (Binding - Radioligand competition/displacement) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 3.29x29 113 TM3 H => A 1.786↑ EC50 (Functional - IP accumulation) CXCL12 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 176 ECL2 N => L N/A N/A Zhou H et al (1999)
cxcr4_human 4.60x61 171 TM4 D => N 14.607↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2004) 10.5281/zenodo.58160
cxcr4_human 4.64x65 175 TM4 A => F 58.0↓ K(i) (Binding - Radioligand competition/displacement) AMD8899 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 6.51x51 255 TM6 Y => A Abolished EC50 (Functional - IP accumulation) KRH1636-5 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 7.35x34 284 TM7 I => A 4.0↓ EC50 (Functional - IP accumulation) KRH1636-5 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 7.28x27 277 TM7 E => A N/A N/A Brelot A et al (2000)
cxcr4_human 6.58x58 262 TM6 D => A N/A N/A Zhou H et al (2000)
cxcr4_human 1.24x24 30 TM1 R => A N/A N/A Chabot DJ et al (2000)
cxcr4_human 6.51x51 255 TM6 Y => A 2.75↓ K(i) (Binding - Radioligand competition/displacement) AMD8721 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 4.60x61 171 TM4 D => N 13.0↓ K(i) (Binding - Radioligand competition/displacement) AMD8899 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 5.39x40 200 TM5 Q => A 1.59↑ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 6.55x55 259 TM6 I => W 1.824↓ K(i) (Binding - Radioligand competition/displacement) AMD3529 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 5.32x33 193 TM5 D => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 3.32x32 116 TM3 Y => A 263.158↓ IC50 (Binding - Radioligand competition/displacement) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 2.63x63 97 TM2 D => A 8.264↑ EC50 (Functional - IP accumulation) [Aib]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 5.42x43 203 TM5 H => A 1.088↑ K(i) (Binding - Radioligand competition/displacement) AMD3100 Gerlach LO et al (2001) 10.5281/zenodo.58160
cxcr4_human 190 ECL2 Y => A 1.175↓ EC50 (Functional - IP accumulation) FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 45.51x51 187 ECL2 D => A 3.953↑ EC50 (Functional - IP accumulation) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 28 N-term C => A N/A N/A Chabot DJ et al (2000)
cxcr4_human 45.50x50 186 ECL2 C => A 8.147↓ K(d) (Binding - Radioligand saturation) CXCL12 Zhou H et al (2000) 10.5281/zenodo.58160
cxcr4_human 5.35x36 196 TM5 V => A 1.072↑ EC50 (Functional - IP accumulation) CXCL12 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 45.51x51 187 ECL2 D => A 8.667↓ EC50 (Functional - IP accumulation) CXCL12 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 6.64x64 268 TM6 E => A Inversed (e.g. NAM to PAM) Single-point (Binding - Radioligand competition/displacement) vMIP-II Zhou N et al (2001) 10.5281/zenodo.58160
cxcr4_human 5.42x43 203 TM5 H => A 6.897↓ EC50 (Functional - IP accumulation) [Aib]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 45.51x51 187 ECL2 D => A 8.667↓ EC50 (Functional - IP accumulation) CXCL12 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 4.60x61 171 TM4 D => N 8.375↓ IC50 (Binding - Radioligand competition/displacement) KRK1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 3.37x37 121 TM3 Y => A 2.941↓ EC50 (Functional - Ca2+ accumulation) CXCL12 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 181 ECL2 D => A N/A N/A Brelot A et al (1999)
cxcr4_human 7.53x53 302 TM7 Y => A 5.227↓ IC50 (Binding - Radioligand saturation) CXCL12 N/A 10.5281/zenodo.58160
cxcr4_human 6.51x51 255 TM6 Y => A 4.592↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 4.60x61 171 TM4 D => N 27.551↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 5.39x40 200 TM5 Q => W 1.212↑ EC50 (Functional - IP accumulation) FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 5.35x36 196 TM5 V => A 1.577↑ K(d) (Binding - Radioligand competition/displacement) CXCL12 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 7.49x49 298 TM7 N => A 1.692↑ IC50 (Binding - Radioligand saturation) CXCL12 N/A 10.5281/zenodo.58160
cxcr4_human 190 ECL2 Y => A 1.25↑ EC50 (Functional - IP accumulation) CXCL12 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 7.38x37 287 TM7 T => A 18.182↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 4.61x62 172 TM4 F => C 1.3↓ K(d) (Binding - Radioligand saturation) FC131 Boulais PE et al (2013) 10.5281/zenodo.58160
cxcr4_human 6.51x51 255 TM6 Y => A 3.0↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 5.32x33 193 TM5 D => A N/A N/A Wang ZX et al (1998)
cxcr4_human 3.29x29 113 TM3 H => A 8.333↓ EC50 (Functional - IP accumulation) KRH1636-6 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 3.33x33 117 TM3 T => A 1.4↓ EC50 (Functional - IP accumulation) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 5.35x36 196 TM5 V => A N/A N/A Rosenkilde MM et al (2004)
cxcr4_human 176 ECL2 N => C Abolished K(d) (Binding - Radioligand saturation) FC131 Boulais PE et al (2013) 10.5281/zenodo.58160
cxcr4_human 5.32x33 193 TM5 D => N 2.464↓ K(i) (Binding - Radioligand competition/displacement) AMD3100(Zn)2 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 182 ECL2 D => A 1.545↓ IC50 (Binding - Radioligand saturation) CXCL12 N/A 10.5281/zenodo.58160
cxcr4_human 5.35x36 196 TM5 V => A 2.593↓ K(d) (Binding - Radioligand competition/displacement) CXCL12 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 4.57x57 168 TM4 T => A N/A N/A Rosenkilde MM et al (2004)
cxcr4_human 7.32x31 281 TM7 H => A 6.327↓ IC50 (Binding - Radioligand competition/displacement) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 4.60x61 171 TM4 D => A Abolished IC50 (Binding - Radioligand saturation) CXCL12 N/A 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 5.42x43 203 TM5 H => A 2.0↓ K(i) (Binding - Radioligand competition/displacement) AMD8899 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 2.63x63 97 TM2 D => A Abolished IC50 (Binding - Radioligand competition/displacement) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 2.60x60 94 TM2 W => A 1.534↓ K(d) (Binding - Radioligand competition/displacement) CXCL12 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 182 ECL2 D => N N/A N/A Brelot A et al (2000)
cxcr4_human 4.64x65 175 TM4 A => F 40.449↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 2.60x60 94 TM2 W => A 15.385↑ EC50 (Functional - IP accumulation) KRH1636-5 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 4.64x65 175 TM4 A => F 2.222↓ K(d) (Binding - Radioligand competition/displacement) CXCL12 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 182 ECL2 D => G N/A N/A Brelot A et al (1999)
cxcr4_human 3.32x32 116 TM3 Y => A Abolished EC50 (Functional - IP accumulation) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 192 ECL2 N => D N/A N/A Brelot A et al (1999)
cxcr4_human 190 ECL2 Y => A N/A Single-point (Binding - Radioligand competition/displacement) CXCL12 Zhou N et al (2001) 10.5281/zenodo.58160
cxcr4_human 5.40x41 201 TM5 F => G N/A N/A Brelot A et al (1999)
cxcr4_human 4.64x65 175 TM4 A => F 38.636↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 4.60x61 171 TM4 D => N 8.235↓ K(i) (Binding - Radioligand competition/displacement) AMD3529 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 4.60x61 171 TM4 D => N 66.667↓ K(i) (Binding - Radioligand competition/displacement) Cyclam (Zn) Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 2.63x63 97 TM2 D => A 6.803↑ EC50 (Functional - IP accumulation) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => A N/A N/A Brelot A et al (2000)
cxcr4_human 179 ECL2 E => K N/A N/A Wang ZX et al (1998)
cxcr4_human 3.29x29 113 TM3 H => A 12.5↓ IC50 (Binding - Radioligand competition/displacement) KRK1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 6.55x55 259 TM6 I => W 3.0↓ EC50 (Functional - IP accumulation) KRH1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 5.39x40 200 TM5 Q => W 4.235↓ K(i) (Binding - Radioligand competition/displacement) AMD3529 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => N 12.5↓ IC50 (Binding - Radioligand competition/displacement) KRK1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 3.25x25 109 TM3 C => A 9.382↓ K(d) (Binding - Radioligand saturation) CXCL12 Zhou H et al (2000) 10.5281/zenodo.58160
cxcr4_human 5.35x36 196 TM5 V => A 2.0↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 25 N-term K => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 7.38x37 287 TM7 T => A 1.318↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 7.32x31 281 TM7 H => A 1.154↓ EC50 (Functional - IP accumulation) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => N 82.0↓ K(i) (Binding - Radioligand competition/displacement) AMD8899 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 7.39x38 288 TM7 E => A 70.787↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2004) 10.5281/zenodo.58160
cxcr4_human 3.25x25 109 TM3 C => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 8.59x59 318 H8 T => A N/A N/A Haribabu B et al (1997)
cxcr4_human 5.39x40 200 TM5 Q => A 4.0↓ K(i) (Binding - Radioligand competition/displacement) AMD3389 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 45.52x52 188 ECL2 R => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 181 ECL2 D => A N/A N/A Wang ZX et al (1998)
cxcr4_human 6.55x55 259 TM6 I => A 1.3↑ EC50 (Functional - IP accumulation) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 6.55x55 259 TM6 I => A 1.5↓ K(i) (Binding - Radioligand competition/displacement) AMD3479 Rosenkilde MM et al (2004) 10.5281/zenodo.58160
cxcr4_human 6.51x51 255 TM6 Y => A 2.931↓ EC50 (Functional - IP accumulation) [Aib]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 5.42x43 203 TM5 H => A 1.198↓ K(d) (Binding - Radioligand competition/displacement) CXCL12 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 183 ECL2 R => A Abolished EC50 (Functional - IP accumulation) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 5.42x43 203 TM5 H => A 1.42↓ EC50 (Functional - IP accumulation) KRH1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 45.51x51 187 ECL2 D => A 2.857↑ EC50 (Functional - IP accumulation) FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 2.63x63 97 TM2 D => N 3.592↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 4.52x52 163 TM4 P => A 3.909↓ IC50 (Binding - Radioligand saturation) CXCL12 N/A 10.5281/zenodo.58160
cxcr4_human 7.39x38 288 TM7 E => A 461.182↓ K(i) (Binding - Radioligand competition/displacement) AMD11070 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 189 ECL2 F => A 9.346↑ EC50 (Functional - IP accumulation) [Aib]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 7.32x31 281 TM7 H => A 2.538↓ K(i) (Binding - Radioligand competition/displacement) cyclam N/A 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => N 650.0↓ K(i) (Binding - Radioligand competition/displacement) AMD3479 Rosenkilde MM et al (2004) 10.5281/zenodo.58160
cxcr4_human 5 N-term S => A N/A N/A Zhou N et al (2001)
cxcr4_human 1.39x39 45 TM1 Y => A 2.198↑ IC50 (Binding - Radioligand saturation) CXCL12 N/A 10.5281/zenodo.58160
cxcr4_human 183 ECL2 R => A N/A N/A Brelot A et al (2000)
cxcr4_human 3.29x29 113 TM3 H => A 192.308↓ EC50 (Functional - IP accumulation) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 45.52x52 188 ECL2 R => A 3.448↓ EC50 (Functional - IP accumulation) [Aib]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 20 N-term D => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 5.40x41 201 TM5 F => L N/A N/A Brelot A et al (1999)
cxcr4_human 4.60x61 171 TM4 D => N 11.382↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => E 1.909↓ IC50 (Binding - Radioligand saturation) CXCL12 N/A 10.5281/zenodo.58160
cxcr4_human 4.56x56 167 TM4 L => C 1.082↑ K(d) (Binding - Radioligand saturation) FC131 Boulais PE et al (2013) 10.5281/zenodo.58160
cxcr4_human 26 N-term E => A N/A N/A Brelot A et al (2000)
cxcr4_human 3.36x36 120 TM3 L => F 3.457↓ K(d) (Binding - Radioligand competition/displacement) CXCL12 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 7.25x24 274 TM7 C => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 183 ECL2 R => A 14.925↑ EC50 (Functional - IP accumulation) CXCL12 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 5.42x43 203 TM5 H => A 1.222↑ K(i) (Binding - Radioligand competition/displacement) AMD11070 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 6.64x64 268 TM6 E => A N/A N/A Brelot A et al (2000)
cxcr4_human 7.35x34 284 TM7 I => A 2.0↓ K(i) (Binding - Radioligand competition/displacement) AMD8899 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 5.42x43 203 TM5 H => A 2.04↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 6.51x51 255 TM6 Y => A Abolished EC50 (Functional - IP accumulation) KRH1636-6 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 45.52x52 188 ECL2 R => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 7.32x31 281 TM7 H => A 1.1↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 6.51x51 255 TM6 Y => A 3.591↓ IC50 (Binding - Radioligand saturation) CXCL12 N/A 10.5281/zenodo.58160
cxcr4_human 5.35x36 196 TM5 V => M N/A N/A Brelot A et al (1999)
cxcr4_human 183 ECL2 R => A 2.0↓ EC50 (Functional - IP accumulation) KRH1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 45.52x52 188 ECL2 R => A N/A N/A Brelot A et al (1999)
cxcr4_human 45.51x51 187 ECL2 D => K N/A N/A Wang ZX et al (1998)
cxcr4_human 3.33x33 117 TM3 T => A 2.899↑ EC50 (Functional - IP accumulation) [Aib]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 6.64x64 268 TM6 E => A N/A N/A Zhou N et al (2001)
cxcr4_human 4.52x52 163 TM4 P => C 2.653↓ K(d) (Binding - Radioligand saturation) FC131 Boulais PE et al (2013) 10.5281/zenodo.58160
cxcr4_human 7.39x38 288 TM7 E => A 2.331↑ IC50 (Binding - Radioligand competition/displacement) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 181 ECL2 D => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 10 N-term D => A 2.147↓ K(d) (Binding - Radioligand saturation) CXCL12 Zhou H et al (2000) 10.5281/zenodo.58160
cxcr4_human 1.47x47 53 TM1 I => L N/A N/A Schuller U et al (2005)
cxcr4_human 5.39x40 200 TM5 Q => A 15.5↓ K(i) (Binding - Radioligand competition/displacement) AMD8721 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 7 N-term Y => A N/A N/A Zhou N et al (2001)
cxcr4_human 7.43x42 292 TM7 F => A Abolished IC50 (Binding - Radioligand saturation) CXCL12 N/A 10.5281/zenodo.58160
cxcr4_human 45.51x51 187 ECL2 D => A N/A N/A Wang ZX et al (1998)
cxcr4_human 6.52x52 256 TM6 Y => A N/A N/A Rosenkilde MM et al (2004)
cxcr4_human 4.48x48 159 TM4 G => C 1.147↓ K(d) (Binding - Radioligand saturation) FC131 Boulais PE et al (2013) 10.5281/zenodo.58160
cxcr4_human 7.32x31 281 TM7 H => A 5.556↑ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2004) 10.5281/zenodo.58160
cxcr4_human 6.51x51 255 TM6 Y => A 9.0↓ K(i) (Binding - Radioligand competition/displacement) AMD8899 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 3.41x41 125 TM3 L => W N/A N/A Lebon G et al (2011)
cxcr4_human 182 ECL2 D => N N/A N/A Gerlach LO et al (2003)
cxcr4_human 2.63x63 97 TM2 D => N 289.545↓ K(i) (Binding - Radioligand competition/displacement) AMD11070 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 4.44x44 155 TM4 V => C 1.232↑ K(d) (Binding - Radioligand saturation) FC131 Boulais PE et al (2013) 10.5281/zenodo.58160
cxcr4_human 5.32x33 193 TM5 D => N 1.412↑ K(i) (Binding - Radioligand competition/displacement) cyclam N/A 10.5281/zenodo.58160
cxcr4_human 5.39x40 200 TM5 Q => A 15.0↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 1.39x39 45 TM1 Y => A 10.053↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 6.55x55 259 TM6 I => A N/A N/A Rosenkilde MM et al (2004)
cxcr4_human 22 N-term D => A N/A N/A Brelot A et al (2000)
cxcr4_human 20 N-term D => A N/A N/A Zhou N et al (2001)
cxcr4_human 10 N-term D => A N/A N/A Zhou H et al (2000)
cxcr4_human 176 ECL2 N => Q N/A N/A Potempa S et al (1997)
cxcr4_human 7.32x31 281 TM7 H => A 5.181↑ K(d) (Binding - Radioligand competition/displacement) CXCL12 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 6.64x64 268 TM6 E => A N/A Single-point (Binding - Radioligand competition/displacement) vMIP-II Zhou N et al (2001) 10.5281/zenodo.58160
cxcr4_human 190 ECL2 Y => A 1.852↑ EC50 (Functional - IP accumulation) KRH1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 7.45x45 294 TM7 H => A N/A N/A Gerlach LO et al (2003)
cxcr4_human 45.51x51 187 ECL2 D => A 3.25↓ IC50 (Binding - Radioligand competition/displacement) KRK1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 7.25x24 274 TM7 C => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 1.24x24 30 TM1 R => A N/A N/A Chabot DJ et al (2000)
cxcr4_human 7.38x37 287 TM7 T => A 2.0↓ K(i) (Binding - Radioligand competition/displacement) AMD8899 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 7.28x27 277 TM7 E => A 5.412↓ K(d) (Binding - Radioligand saturation) CXCL12 Zhou H et al (2000) 10.5281/zenodo.58160
cxcr4_human 6.51x51 255 TM6 Y => A 1.538↓ EC50 (Functional - IP accumulation) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 7.32x31 281 TM7 H => A 4.009↓ EC50 (Functional - Ca2+ accumulation) CXCL12 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 5.42x43 203 TM5 H => A N/A EC50 (Functional - IP accumulation) KRH1636-5 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 5.39x40 200 TM5 Q => A 1.111↑ EC50 (Functional - IP accumulation) FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 3.32x32 116 TM3 Y => A 9.619↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 13 N-term T => A N/A N/A Chabot DJ et al (2000)
cxcr4_human 7.39x38 288 TM7 E => A 115.0↓ K(i) (Binding - Radioligand competition/displacement) AMD3479 Rosenkilde MM et al (2004) 10.5281/zenodo.58160
cxcr4_human 26 N-term E => A N/A Single-point (Binding - Radioligand competition/displacement) vMIP-II Zhou N et al (2001) 10.5281/zenodo.58160
cxcr4_human 182 ECL2 D => G N/A N/A Brelot A et al (1999)
cxcr4_human 6.55x55 259 TM6 I => A 1.685↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 3.29x29 113 TM3 H => A 1.767↓ K(i) (Binding - Radioligand competition/displacement) Cyclam (Zn) Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 45.52x52 188 ECL2 R => A 14.667↓ EC50 (Functional - IP accumulation) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 7 N-term Y => A Inversed (e.g. NAM to PAM) Single-point (Binding - Radioligand competition/displacement) CXCL12 Zhou N et al (2001) 10.5281/zenodo.58160
cxcr4_human 184 ECL2 Y => A N/A N/A Brelot A et al (1999)
cxcr4_human 6.55x55 259 TM6 I => A 1.0 K(i) (Binding - Radioligand competition/displacement) AMD8899 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 3.29x29 113 TM3 H => A 1.757↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Gerlach LO et al (2001) 10.5281/zenodo.58160
cxcr4_human 3.29x29 113 TM3 H => A 13.75↓ K(i) (Binding - Radioligand competition/displacement) AMD3389 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 5.32x33 193 TM5 D => N 1.099↑ K(i) (Binding - Radioligand competition/displacement) AMD3100 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 3.25x25 109 TM3 C => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 2.63x63 97 TM2 D => A 13.333↓ EC50 (Functional - IP accumulation) CXCL12 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 7.32x31 281 TM7 H => A 17.105↓ IC50 (Binding - Radioligand competition/displacement) FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 7.35x34 284 TM7 I => A 25.5↓ EC50 (Functional - IP accumulation) KRH1636-6 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 7.39x38 288 TM7 E => A 34.97↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 329 C-term L => A N/A N/A Fan GH et al (2002)
cxcr4_human 25 N-term K => A N/A N/A Brelot A et al (2000)
cxcr4_human 3.35x35 119 TM3 N => D Abolished IC50 (Binding - Radioligand competition/displacement) ALX40-4C Zhang WB et al (2002) 10.5281/zenodo.58160
cxcr4_human 3.35x35 119 TM3 N => K ~6.25↓ Single-point (Functional - cAMP accumulation) CXCL12 Berchiche YA et al (2007) 10.5281/zenodo.58160
cxcr4_human 182 ECL2 D => N 3.21↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => N 17.85↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 2.60x60 94 TM2 W => A 18.182↑ IC50 (Binding - Radioligand competition/displacement) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 7.39x38 288 TM7 E => A Abolished EC50 (Functional - IP accumulation) [Aib]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 6.51x51 255 TM6 Y => A 1.235↓ EC50 (Functional - Ca2+ accumulation) CXCL12 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 182 ECL2 D => N 1.083↑ K(i) (Binding - Radioligand competition/displacement) cyclam N/A 10.5281/zenodo.58160
cxcr4_human 45.52x52 188 ECL2 R => A N/A N/A Wang ZX et al (1998)
cxcr4_human 6.58x58 262 TM6 D => N 2.243↓ K(d) (Binding - Radioligand competition/displacement) CXCL12 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 4.60x61 171 TM4 D => N 9.592↓ IC50 (Binding - Radioligand competition/displacement) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 6.51x51 255 TM6 Y => A 1.605↓ K(d) (Binding - Radioligand competition/displacement) CXCL12 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 45.51x51 187 ECL2 D => A 1.115↑ IC50 (Binding - Radioligand competition/displacement) [Aib]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => N 5454.545↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 5.39x40 200 TM5 Q => W 1.035↑ EC50 (Functional - IP accumulation) [Aib]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => N N/A N/A Hatse S et al (2001)
cxcr4_human 184 ECL2 Y => A N/A N/A Zhou N et al (2001)
cxcr4_human 190 ECL2 Y => A 1.0 EC50 (Functional - IP accumulation) KRH1636-6 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 11 N-term N => Q N/A N/A Brelot A et al (2000)
cxcr4_human 6.58x58 262 TM6 D => N 19.231↓ EC50 (Functional - IP accumulation) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 45.50x50 186 ECL2 C => A N/A N/A Zhou H et al (2000)
cxcr4_human 5.42x43 203 TM5 H => A 1.231↓ K(i) (Binding - Radioligand competition/displacement) cyclam N/A 10.5281/zenodo.58160
cxcr4_human 5.39x40 200 TM5 Q => W 3.034↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 3.32x32 116 TM3 Y => A Abolished EC50 (Functional - IP accumulation) FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 5.38x39 199 TM5 F => A Abolished EC50 (Functional - IP accumulation) KRH1636-6 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 5.40x41 201 TM5 F => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 7.38x37 287 TM7 T => A 2.593↓ K(d) (Binding - Radioligand competition/displacement) CXCL12 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 1.25x25 31 TM1 E => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 5.46x461 207 TM5 G => W N/A N/A Rosenkilde MM et al (2004)
cxcr4_human 183 ECL2 R => A 1.061↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 45.51x51 187 ECL2 D => V N/A N/A Chabot DJ et al (1999)
cxcr4_human 7.35x34 284 TM7 I => A 4.049↑ K(i) (Binding - Radioligand competition/displacement) AMD3529 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 5.32x33 193 TM5 D => R N/A N/A Labrosse B et al (2001)
cxcr4_human 7.33x32 282 TM7 K => A N/A N/A Brelot A et al (2000)
cxcr4_human 6.48x48 252 TM6 W => A 14.417↓ EC50 (Functional - IP accumulation) KRH1636-6 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 7.45x45 294 TM7 H => A 1.273↓ IC50 (Binding - Radioligand saturation) CXCL12 N/A 10.5281/zenodo.58160
cxcr4_human 184 ECL2 Y => A N/A N/A Brelot A et al (1999)
cxcr4_human 182 ECL2 D => N N/A N/A Wang ZX et al (1998)
cxcr4_human 5.35x36 196 TM5 V => A 1.083↓ EC50 (Functional - IP accumulation) KRH1636-6 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 13 N-term T => A N/A N/A Chabot DJ et al (2000)
cxcr4_human 179 ECL2 E => A N/A N/A Brelot A et al (2000)
cxcr4_human 7.32x31 281 TM7 H => A 62.0↓ EC50 (Functional - IP accumulation) KRH1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 2.53x53 87 TM2 F => A Abolished IC50 (Binding - Radioligand saturation) CXCL12 N/A 10.5281/zenodo.58160
cxcr4_human 5.38x39 199 TM5 F => A 1.678↑ EC50 (Functional - IP accumulation) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 7.32x31 281 TM7 H => A 1.059↓ K(i) (Binding - Radioligand competition/displacement) AMD3529 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 6.51x51 255 TM6 Y => A 3.03↑ K(d) (Binding - Radioligand competition/displacement) CXCL12 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 4.64x65 175 TM4 A => F 430.0↓ K(i) (Binding - Radioligand competition/displacement) AMD3479 Rosenkilde MM et al (2004) 10.5281/zenodo.58160
cxcr4_human 1.26x26 32 TM1 E => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 190 ECL2 Y => A 1.412↓ EC50 (Functional - IP accumulation) KRH1636-5 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 4.49x49 160 TM4 V => C 2.088↓ K(d) (Binding - Radioligand saturation) FC131 Boulais PE et al (2013) 10.5281/zenodo.58160
cxcr4_human 5.40x41 201 TM5 F => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 7.45x45 294 TM7 H => A N/A N/A Gerlach LO et al (2001)
cxcr4_human 179 ECL2 E => A N/A N/A Wang ZX et al (1998)
cxcr4_human 5.42x43 203 TM5 H => A 4.235↓ K(i) (Binding - Radioligand competition/displacement) AMD3529 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 45.51x51 187 ECL2 D => A 5.917↑ EC50 (Functional - IP accumulation) [Aib]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 45.50x50 186 ECL2 C => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 6.58x58 262 TM6 D => N 96.053↓ IC50 (Binding - Radioligand competition/displacement) FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 6.59x59 263 TM6 S => A 6.067↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 6.64x64 268 TM6 E => A Inversed (e.g. NAM to PAM) Single-point (Binding - Radioligand competition/displacement) CXCL12 Zhou N et al (2001) 10.5281/zenodo.58160
cxcr4_human 3.29x29 113 TM3 H => A 33.333↓ EC50 (Functional - IP accumulation) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 4.60x61 171 TM4 D => N 28.462↓ K(i) (Binding - Radioligand competition/displacement) cyclam N/A 10.5281/zenodo.58160
cxcr4_human 3.29x29 113 TM3 H => A 3.364↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 179 ECL2 E => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 2.63x63 97 TM2 D => N 1.33↓ K(d) (Binding - Radioligand competition/displacement) CXCL12 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => N 263.158↓ IC50 (Binding - Radioligand competition/displacement) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 181 ECL2 D => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 7.38x37 287 TM7 T => A 6.061↑ K(i) (Binding - Radioligand competition/displacement) AMD3389 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 2.60x60 94 TM2 W => A 4.717↑ IC50 (Binding - Radioligand competition/displacement) KRK1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 6.51x51 255 TM6 Y => A 1.364↑ EC50 (Functional - IP accumulation) CXCL12 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 7.45x45 294 TM7 H => A 1.796↓ K(d) (Binding - Radioligand competition/displacement) CXCL12 Gerlach LO et al (2001) 10.5281/zenodo.58160
cxcr4_human 11 N-term N => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 3.33x33 117 TM3 T => A 1.133↓ EC50 (Functional - IP accumulation) CXCL12 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 2.63x63 97 TM2 D => N 3.504↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 334 C-term R => X N/A N/A Kawai T et al (2005)
cxcr4_human 7.39x38 288 TM7 E => A 13.5↓ K(i) (Binding - Radioligand competition/displacement) AMD8721 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 3.32x32 116 TM3 Y => A 15.857↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 11 N-term N => Q N/A N/A Brelot A et al (1997)
cxcr4_human 5.32x33 193 TM5 D => E N/A N/A Brelot A et al (1999)
cxcr4_human 271 ECL3 K => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 45.51x51 187 ECL2 D => A 2.075↑ EC50 (Functional - IP accumulation) KRH1636-5 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 6.55x55 259 TM6 I => W 1.153↑ EC50 (Functional - IP accumulation) CXCL12 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 5.36x37 197 TM5 V => N N/A N/A Wang ZX et al (1998)
cxcr4_human 6.55x55 259 TM6 I => W 2.864↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 5.35x36 196 TM5 V => A 2.8↓ EC50 (Functional - IP accumulation) KRH1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 190 ECL2 Y => A N/A Single-point (Binding - Radioligand competition/displacement) CXCL12 Zhou N et al (2001) 10.5281/zenodo.58160
cxcr4_human 5.42x43 203 TM5 H => A 1.739↑ K(i) (Binding - Radioligand competition/displacement) AMD3100 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 45.52x52 188 ECL2 R => A 2.833↑ EC50 (Functional - IP accumulation) CXCL12 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 11 N-term N => A N/A N/A Chabot DJ et al (2000)
cxcr4_human 182 ECL2 D => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 5.32x33 193 TM5 D => A N/A N/A Brelot A et al (2000)
cxcr4_human 45.51x51 187 ECL2 D => V N/A N/A Wang ZX et al (1998)
cxcr4_human 5.39x40 200 TM5 Q => A 1.072↑ EC50 (Functional - IP accumulation) CXCL12 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 2.60x60 94 TM2 W => A 20.833↑ IC50 (Binding - Radioligand competition/displacement) [Aib]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 7.45x45 294 TM7 H => A 1.272↑ K(i) (Binding - Radioligand competition/displacement) AMD3100(Zn)2 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 2.60x60 94 TM2 W => A 40.0↑ EC50 (Functional - IP accumulation) FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => N 1.149↑ K(i) (Binding - Radioligand competition/displacement) AMD2849 Gerlach LO et al (2001) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => N 173.959↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 3.36x36 120 TM3 L => F 1.5↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 3.26x26 110 TM3 K => A N/A N/A Brelot A et al (2000)
cxcr4_human 2.60x60 94 TM2 W => A 18.868↑ EC50 (Functional - IP accumulation) KRH1636-6 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 4.60x61 171 TM4 D => N 80.0↓ K(i) (Binding - Radioligand competition/displacement) AMD3108 Gerlach LO et al (2001) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 6.64x64 268 TM6 E => A N/A Single-point (Binding - Radioligand competition/displacement) CXCL12 Zhou N et al (2001) 10.5281/zenodo.58160
cxcr4_human 5.39x40 200 TM5 Q => W 1.647↓ EC50 (Functional - IP accumulation) KRH1636-5 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 6.55x55 259 TM6 I => W 163.636↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 2.60x60 94 TM2 W => A 1.324↓ EC50 (Functional - Ca2+ accumulation) CXCL12 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 189 ECL2 F => A 3.472↑ EC50 (Functional - IP accumulation) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 6.55x55 259 TM6 I => A 1.869↑ K(i) (Binding - Radioligand competition/displacement) AMD3529 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 7.35x34 284 TM7 I => A 11.5↓ K(i) (Binding - Radioligand competition/displacement) AMD3479 Rosenkilde MM et al (2004) 10.5281/zenodo.58160
cxcr4_human 190 ECL2 Y => A 1.269↓ EC50 (Functional - IP accumulation) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 2.63x63 97 TM2 D => N Abolished pEC50 (Functional - Ca2+ accumulation) CXCL12 Kufareva I et al (2014) 10.5281/zenodo.58160
cxcr4_human 7.35x34 284 TM7 I => A 8.696↑ K(i) (Binding - Radioligand competition/displacement) AMD3389 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 189 ECL2 F => A 3.802↑ EC50 (Functional - IP accumulation) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 330 C-term S => A N/A N/A Orsini MJ et al (1999)
cxcr4_human 182 ECL2 D => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 6.58x58 262 TM6 D => A 2.0↓ IC50 (Binding - Radioligand saturation) CXCL12 N/A 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => N 1.304↑ K(i) (Binding - Radioligand competition/displacement) Cyclam (Zn) Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 7.35x34 284 TM7 I => A 5.0↓ EC50 (Functional - IP accumulation) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 5.39x40 200 TM5 Q => W 1.654↓ EC50 (Functional - IP accumulation) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 5.39x40 200 TM5 Q => W 1.2↓ EC50 (Functional - IP accumulation) CXCL12 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 28 N-term C => A N/A N/A Zhou H et al (2000)
cxcr4_human 7.32x31 281 TM7 H => A 12.917↓ EC50 (Functional - IP accumulation) KRH1636-6 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 6.55x55 259 TM6 I => A 1.4↓ EC50 (Functional - IP accumulation) CXCL12 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 7.32x31 281 TM7 H => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 6.48x48 252 TM6 W => A 2.091↓ IC50 (Binding - Radioligand saturation) CXCL12 N/A 10.5281/zenodo.58160
cxcr4_human 5.32x33 193 TM5 D => N 5.818↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Gerlach LO et al (2001) 10.5281/zenodo.58160
cxcr4_human 3.35x35 119 TM3 N => S 5.662↓ IC50 (Binding - Radioligand competition/displacement) ALX40-4C Zhang WB et al (2002) 10.5281/zenodo.58160
cxcr4_human 2 N-term E => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 6.51x51 255 TM6 Y => A 26.5↓ K(i) (Binding - Radioligand competition/displacement) AMD3479 Rosenkilde MM et al (2004) 10.5281/zenodo.58160
cxcr4_human 6.55x55 259 TM6 I => W 1.364↑ EC50 (Functional - IP accumulation) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => N 780.0↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 5.32x33 193 TM5 D => A N/A N/A Brelot A et al (1999)
cxcr4_human 4.60x61 171 TM4 D => K N/A N/A Wang ZX et al (1998)
cxcr4_human 179 ECL2 E => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 2 N-term E => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 3.29x29 113 TM3 H => A 1.751↑ K(d) (Binding - Radioligand competition/displacement) CXCL12 Gerlach LO et al (2001) 10.5281/zenodo.58160
cxcr4_human 183 ECL2 R => A 1.225↓ EC50 (Functional - IP accumulation) FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 344 C-term S => A N/A N/A Orsini MJ et al (1999)
cxcr4_human 6.48x48 252 TM6 W => A 5.517↓ EC50 (Functional - IP accumulation) [Aib]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 189 ECL2 F => A 4.0↑ EC50 (Functional - IP accumulation) FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 6.55x55 259 TM6 I => W 4.274↑ EC50 (Functional - IP accumulation) [Aib]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 20 N-term D => A N/A N/A Brelot A et al (2000)
cxcr4_human 45.51x51 187 ECL2 D => A N/A N/A Chabot DJ et al (2000)
cxcr4_human 5.39x40 200 TM5 Q => W 3.0↓ K(i) (Binding - Radioligand competition/displacement) AMD3389 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 5.42x43 203 TM5 H => A 1.072↑ EC50 (Functional - IP accumulation) CXCL12 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 4.60x61 171 TM4 D => N 8.333↓ EC50 (Functional - IP accumulation) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 45.51x51 187 ECL2 D => A 4.818↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 7.45x45 294 TM7 H => A 1.961↑ K(i) (Binding - Radioligand competition/displacement) AMD3100 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 3.37x37 121 TM3 Y => A 2.101↑ K(i) (Binding - Radioligand competition/displacement) AMD3100 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 5.39x40 200 TM5 Q => A N/A N/A Zhou N et al (2001)
cxcr4_human 3.35x35 119 TM3 N => S 32.453↓ IC50 (Binding - Radioligand competition/displacement) AMD3100 Zhang WB et al (2002) 10.5281/zenodo.58160
cxcr4_human 183 ECL2 R => A Abolished EC50 (Functional - IP accumulation) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 11 N-term N => A N/A N/A Chabot DJ et al (2000)
cxcr4_human 183 ECL2 R => A N/A N/A Zhou N et al (2001)
cxcr4_human 4.59x60 170 TM4 P => C 1.388↓ K(d) (Binding - Radioligand saturation) FC131 Boulais PE et al (2013) 10.5281/zenodo.58160
cxcr4_human 7.33x32 282 TM7 K => A N/A N/A Brelot A et al (2000)
cxcr4_human 3.37x37 121 TM3 Y => A 2.408↓ K(d) (Binding - Radioligand competition/displacement) CXCL12 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 7.39x38 288 TM7 E => A 190.0↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 1.32x32 38 TM1 K => A N/A N/A Brelot A et al (2000)
cxcr4_human 6.58x58 262 TM6 D => N 83.333↓ K(i) (Binding - Radioligand competition/displacement) AMD3100(Zn)2 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 3.37x37 121 TM3 Y => A 1.045↓ IC50 (Binding - Radioligand saturation) CXCL12 N/A 10.5281/zenodo.58160
cxcr4_human 6.51x51 255 TM6 Y => A 2.838↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 2.60x60 94 TM2 W => A 12.658↑ IC50 (Binding - Radioligand competition/displacement) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => N 181.818↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Gerlach LO et al (2001) 10.5281/zenodo.58160
cxcr4_human 7.35x34 284 TM7 I => A 1.481↑ EC50 (Functional - IP accumulation) FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 1.24x24 30 TM1 R => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 5.32x33 193 TM5 D => N N/A N/A Gerlach LO et al (2001)
cxcr4_human 3.36x36 120 TM3 L => F 1.538↑ K(i) (Binding - Radioligand competition/displacement) AMD3389 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 6.55x55 259 TM6 I => W 1.2↓ K(i) (Binding - Radioligand competition/displacement) AMD3389 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 183 ECL2 R => A 14.925↑ EC50 (Functional - IP accumulation) CXCL12 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => N 14.865↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Gerlach LO et al (2001) 10.5281/zenodo.58160
cxcr4_human 179 ECL2 E => A N/A N/A Brelot A et al (2000)
cxcr4_human 5.42x43 203 TM5 H => A 2.022↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 5.32x33 193 TM5 D => E N/A N/A Brelot A et al (1999)
cxcr4_human 7.32x31 281 TM7 H => A N/A N/A Hatse S et al (2001)
cxcr4_human 7.32x31 281 TM7 H => A 1.1↓ K(i) (Binding - Radioligand competition/displacement) AMD3389 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 4.64x65 175 TM4 A => F 40.449↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2004) 10.5281/zenodo.58160
cxcr4_human 7.35x34 284 TM7 I => A 418.182↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 4.60x61 171 TM4 D => N 141.667↓ K(i) (Binding - Radioligand competition/displacement) AMD3100(Zn)2 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 7.35x34 284 TM7 I => A 1.533↓ EC50 (Functional - IP accumulation) CXCL12 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 5.58x58 219 TM5 Y => A 2.136↓ IC50 (Binding - Radioligand saturation) CXCL12 N/A 10.5281/zenodo.58160
cxcr4_human 4.62x63 173 TM4 I => C 1.394↓ K(d) (Binding - Radioligand saturation) FC131 Boulais PE et al (2013) 10.5281/zenodo.58160
cxcr4_human 6.55x55 259 TM6 I => W 5.169↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2004) 10.5281/zenodo.58160
cxcr4_human 5.42x43 203 TM5 H => A 2.667↓ EC50 (Functional - IP accumulation) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 1.25x25 31 TM1 E => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 6.55x55 259 TM6 I => A 5.464↑ EC50 (Functional - IP accumulation) [Aib]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 5.35x36 196 TM5 V => A 1.431↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 45.52x52 188 ECL2 R => A 1.012↑ EC50 (Functional - IP accumulation) KRH1636-5 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 4.60x61 171 TM4 D => C 2.329↓ K(d) (Binding - Radioligand saturation) FC131 Boulais PE et al (2013) 10.5281/zenodo.58160
cxcr4_human 6.55x55 259 TM6 I => A Abolished K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 5.39x40 200 TM5 Q => A N/A N/A Rosenkilde MM et al (2004)
cxcr4_human 5.32x33 193 TM5 D => N N/A N/A Brelot A et al (1999)
cxcr4_human 45.51x51 187 ECL2 D => A 2.222↑ EC50 (Functional - IP accumulation) KRH1636-6 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 5.32x33 193 TM5 D => A N/A N/A Labrosse B et al (2001)
cxcr4_human 45.51x51 187 ECL2 D => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 7.33x32 282 TM7 K => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 7.39x38 288 TM7 E => A 6.471↓ K(i) (Binding - Radioligand competition/displacement) AMD3529 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => N 525.0↓ K(i) (Binding - Radioligand competition/displacement) AMD8721 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 7.32x31 281 TM7 H => A N/A N/A Rosenkilde MM et al (2004)
cxcr4_human 5.42x43 203 TM5 H => A 1.857↓ K(i) (Binding - Radioligand competition/displacement) AMD3100(Zn)2 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 5.39x40 200 TM5 Q => A 1.072↑ EC50 (Functional - IP accumulation) CXCL12 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 5.35x36 196 TM5 V => A 1.2↓ EC50 (Functional - IP accumulation) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 6.55x55 259 TM6 I => A 7.299↑ EC50 (Functional - IP accumulation) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 7.25x24 274 TM7 C => A N/A N/A Chabot DJ et al (2000)
cxcr4_human 3.36x36 120 TM3 L => F 1.0 K(i) (Binding - Radioligand competition/displacement) AMD8899 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 2.63x63 97 TM2 D => A 1.062↓ IC50 (Binding - Radioligand competition/displacement) KRK1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 7.32x31 281 TM7 H => A 31.379↓ IC50 (Binding - Radioligand competition/displacement) [Aib]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 5.46x461 207 TM5 G => W 3.034↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 7.35x34 284 TM7 I => A 5.0↓ EC50 (Functional - IP accumulation) [D-Arg]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 5.42x43 203 TM5 H => A 3.0↓ K(i) (Binding - Radioligand competition/displacement) AMD3100(Zn)2 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => N 3.867↓ EC50 (Functional - IP accumulation) CXCL12 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 45.52x52 188 ECL2 R => A N/A N/A Brelot A et al (2000)
cxcr4_human 45.52x52 188 ECL2 R => A N/A N/A Brelot A et al (2000)
cxcr4_human 3.32x32 116 TM3 Y => A Abolished EC50 (Functional - IP accumulation) CXCL12 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 5.35x36 196 TM5 V => A 1.307↑ K(i) (Binding - Radioligand competition/displacement) AMD3529 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 181 ECL2 D => A N/A N/A Brelot A et al (2000)
cxcr4_human 7.32x31 281 TM7 H => A 7.875↓ IC50 (Binding - Radioligand competition/displacement) KRK1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 3.32x32 116 TM3 Y => A Abolished IC50 (Binding - Radioligand competition/displacement) KRK1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 5.42x43 203 TM5 H => A 1.45↓ EC50 (Functional - IP accumulation) FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 6.58x58 262 TM6 D => N 15.25↓ EC50 (Functional - IP accumulation) FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 189 ECL2 F => A 1.2↓ EC50 (Functional - IP accumulation) CXCL12 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 7.35x34 284 TM7 I => A N/A N/A Rosenkilde MM et al (2004)
cxcr4_human 6.58x58 262 TM6 D => N N/A N/A Gerlach LO et al (2001)
cxcr4_human 182 ECL2 D => N 2.571↓ K(i) (Binding - Radioligand competition/displacement) AMD3100(Zn)2 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 7.26x25 275 TM7 E => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 1.39x39 45 TM1 Y => A 8.0↓ EC50 (Functional - IP accumulation) KRH1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 3.29x29 113 TM3 H => A 2.022↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2004) 10.5281/zenodo.58160
cxcr4_human 4.64x65 175 TM4 A => F 111.95↓ K(i) (Binding - Radioligand competition/displacement) AMD3389 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 7.32x31 281 TM7 H => A 1.2↓ EC50 (Functional - IP accumulation) CXCL12 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 7.32x31 281 TM7 H => A 1.857↓ K(i) (Binding - Radioligand competition/displacement) AMD3100(Zn)2 Gerlach LO et al (2003) 10.5281/zenodo.58160
cxcr4_human 325 C-term S => A N/A N/A Signoret N et al (1998)
cxcr4_human 4.61x62 172 TM4 F => A 5.0↓ K(i) (Binding - Radioligand competition/displacement) AMD8899 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 5.38x39 199 TM5 F => G N/A N/A Brelot A et al (1999)
cxcr4_human 5.39x40 200 TM5 Q => A Abolished K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 5.42x43 203 TM5 H => A N/A EC50 (Functional - IP accumulation) KRH1636-6 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 45.52x52 188 ECL2 R => A N/A N/A Wang ZX et al (1998)
cxcr4_human 4.60x61 171 TM4 D => N 2.056↓ K(d) (Binding - Radioligand competition/displacement) CXCL12 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 4.61x62 172 TM4 F => A 5.091↓ K(i) (Binding - Radioligand competition/displacement) AMD3465 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 5.42x43 203 TM5 H => A 1.182↓ K(d) (Binding - Radioligand competition/displacement) CXCL12 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 3.32x32 116 TM3 Y => A Abolished EC50 (Functional - IP accumulation) CXCL12 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 45.51x51 187 ECL2 D => A 1.139↑ IC50 (Binding - Radioligand competition/displacement) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 20 N-term D => A N/A N/A Chabot DJ et al (1999)
cxcr4_human 5.38x39 199 TM5 F => A 1.304↑ EC50 (Functional - IP accumulation) [Cit]FC131 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 5.39x40 200 TM5 Q => W 7.083↓ EC50 (Functional - IP accumulation) KRH1636-6 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 7.39x38 288 TM7 E => A 270.0↓ K(i) (Binding - Radioligand competition/displacement) AMD8899 Rosenkilde MM et al (2007) 10.5281/zenodo.58160
cxcr4_human 4.60x61 171 TM4 D => N 1250.909↓ K(i) (Binding - Radioligand competition/displacement) AMD11070 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 190 ECL2 Y => A 1.25↑ EC50 (Functional - IP accumulation) CXCL12 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 2.45x45 79 TM2 H => A 1.376↑ IC50 (Binding - Radioligand saturation) CXCL12 N/A 10.5281/zenodo.58160
cxcr4_human 45.51x51 187 ECL2 D => A N/A N/A Brelot A et al (2000)
cxcr4_human 45.51x51 187 ECL2 D => V N/A N/A Wang ZX et al (1998)
cxcr4_human 6.58x58 262 TM6 D => N 51.685↓ K(i) (Binding - Radioligand competition/displacement) AMD3100 Rosenkilde MM et al (2004) 10.5281/zenodo.58160
cxcr4_human 183 ECL2 R => A 1.364↓ K(i) (Binding - Radioligand competition/displacement) AMD11070 Wong RS et al (2008) 10.5281/zenodo.58160
cxcr4_human 1.39x39 45 TM1 Y => A 2.267↓ EC50 (Functional - IP accumulation) CXCL12 Thiele S et al (2014) 10.5281/zenodo.58160
cxcr4_human 6.51x51 255 TM6 Y => A 3.4↓ EC50 (Functional - IP accumulation) KRH1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 3.29x29 113 TM3 H => A 26.0↓ EC50 (Functional - IP accumulation) KRH1636 Zachariassen ZG et al (2015) 10.5281/zenodo.58160
cxcr4_human 5.39x40 200 TM5 Q => W 20.0↓ EC50 (Functional - IP accumulation) KRH1636