Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
drd4_human 373 ICL3 T => K N/A N/A Pauwels PJ et al (2001)
drd4_human 7.35x34 430 TM7 V => Y N/A K(i) (Binding - Radioligand competition/displacement) CPPMA Simpson MM et al (1999) Kooistra AJ et al (2013)
drd4_human 3.29x29 112 TM3 M => V N/A N/A Simpson MM et al (1999)
drd4_human 3.28x28 111 TM3 L => F N/A N/A Simpson MM et al (1999)
drd4_human 5.40x41 194 TM5 V => G N/A N/A Liu IS et al (1996)
drd4_human 2.61x60 91 TM2 F => V N/A N/A Simpson MM et al (1999)
drd4_human 2.60x59 90 TM2 L => W N/A N/A Simpson MM et al (1999)
drd4_human 2.64x63 94 TM2 S => L N/A N/A Simpson MM et al (1999)
drd4_human 3.36x36 119 TM3 C => S N/A N/A Alberts GL et al (1998)
drd4_human 7.35x34 430 TM7 V => Y 8.228↓ K(d) (Binding - Radioligand saturation) N-methylspiperone Simpson MM et al (1999) Kooistra AJ et al (2013)


Residue

Diagrams

ICL1 R A L Q ICL1ECL1 G G A W L L ECL1ICL2 P L R Y N R Q G ICL2ECL2 L N D V R G R D P A V C R L E ECL2ICL3 L H G R A P R R P S G P G P P S P T P P A P R L P Q D P C G P D C A P P A P G L P R G P C G P D C A P A A P G L P P D P C G P D C A P P A P G L P Q D P C G P D C A P P A P G L P R G P C G P D C A P P A P G L P Q D P C G P D C A P P A P G L P P D P C G S N C A P P D A V R A A A L P P Q T P P Q T R R R R R ICL3ECL3 P A C S V ECL3N-term M G N R S T A D A D G L L A G R G P A A G A S A G A S A G L N-termC-term A C C C-term A G Q G A A A L V G G V L L I G A V L A G N S L V C V S V A T E T P T N S F I V S L A A A D L L L A L L V L P L F V Y S E V Q S P R L C D A L M A M D V M L C T A S I F N L C A I S V D R F V A V A V G S R R Q L L L I G A T W L L S A A V A A P V L C G D R D Y V V Y S S V C S F F L P C P L M L L L Y W A T F R G L Q R W E V A R R A K A K I T G R E R K A M R V L P V V V G A F L L C W T P F F V V H I T Q A L C P P R L V S A V T W L G Y V N S A L N P V I Y T V F N A E F R K F R N V A L R
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
S N G A L V A G I L L V G G V L A A A G 1 V S L A A A D L L L A L L V L P L F V Y S 2 A C L N F I S A T C L M V D M A M L A D 3 Q L L L I G A T W L L S A A V A A P V 4 Y L L L M L P C P L F F S C V S S Y V V Y 5 P V V V G A F L L C W T P F F V V H I T 6 V P N L A S N V Y G L W T V A S V L R 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
D4 receptor
TM2
2x59 2.60x59 L90
2x60 2.61x60 F91
2x63 2.64x63 S94
TM3
3x28 3.28x28 L111
3x29 3.29x29 M112
3x36 3.36x36 C119
TM5
5x41 5.40x41 V194
TM7
7x34 7.35x34 V430