Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
glp1r_human 7.49x49 394 TM7 Q => A 1.479↓ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2013) Yang D et al (2016)
glp1r_human 204 ECL1 M => A 28.184↓ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.33x32 378 TM7 T => A 1.017↑ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 7.37x36 382 TM7 I => A 2.239↓ pIC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 7.42x41 387 TM7 E => A 1.995↓ pEC50 (Functional - cAMP accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.39x38 384 TM7 L => A 5.0↓ IC50 (Binding - Radioligand competition/displacement) exendin 4 Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 7.35x34 380 TM7 R => D 1853.032↓ EC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 7.34x33 379 TM7 L => R 16.138↓ IC50 (Binding - Radioligand competition/displacement) GLP-1-(Asp15Glu) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 207 ECL1 T => A 1.95↓ pEC50 (Functional - Ca2+ accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 6.42x42 353 TM6 T => A Abolished effect pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Wootten D et al (2013) Yang D et al (2016)
glp1r_human 7.49x49 394 TM7 Q => N 1.585↓ pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2016) Yang D et al (2016)
glp1r_human 1.50x50 155 TM1 S => A 1.047↑ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2013) Yang D et al (2016)
glp1r_human 3.36x36 233 TM3 M => A 69.7↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 207 ECL1 T => A 1.023↓ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 1.43x43 148 TM1 Y => F Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 7.42x41 387 TM7 E => A 2.455↓ pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 204 ECL1 M => A 46.774↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 2.68x68 198 TM2 D => E 1.083↑ IC50 (Binding - Radioligand competition/displacement) exendin(9-39) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 7.40x39 385 TM7 F => A 1.004↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 214 ECL1 W => A 269.153↓ pEC50 (Functional - ERK activation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 127 N-term E => A 1.84↓ EC50 (Functional - cAMP accumulation) GLP-1-(Ala8Gly) Patterson JT et al (2013) Graaf Cd et al (2016)
glp1r_human 205 ECL1 Y => A 2.138↓ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 45.51x51 297 ECL2 W => A 1.585↑ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Koole C et al (2012) Yang D et al (2016)
glp1r_human 222 ECL1 D => A 1.072↑ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 4.61x61 285 TM4 G => A 1.996↑ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 7.32x31 377 TM7 G => A 3.311↑ pEC50 (Functional - ERK activation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 2.67x67 197 TM2 K => I 6.5↓ IC50 (Binding - Radioligand competition/displacement) exendin 4 Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 210 ECL1 Q => A 169.824↓ pEC50 (Functional - ERK activation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.39x38 384 TM7 L => A 11.482↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 294 ECL2 E => A 25.119↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 221 ECL1 Q => A 1.412↑ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 36 N-term V => A 2.8↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Underwood CR et al (2010) Yang D et al (2016)
glp1r_human 223 ECL1 S => A 1.122↑ pEC50 (Functional - Ca2+ accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 299 ECL2 R => A 1.995↓ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 7.39x38 384 TM7 L => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 207 ECL1 T => A 1.0 pEC50 (Functional - Ca2+ accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 215 ECL1 D => A 1.995↓ pEC50 (Functional - cAMP accumulation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 45.50x50 296 ECL2 C => A 3.984↑ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(1-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 214 ECL1 W => A 1.514↓ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 372 ECL3 D => A 12.589↓ pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.34x33 379 TM7 L => A 1.514↓ pIC50 (Binding - Radioligand competition/displacement) exendin(9-39) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 293 ECL2 D => A 1.0 pEC50 (Functional - ERK activation) glucagon-like peptide 1-(1-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 5.36x37 306 TM5 W => A Abolished effect pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 68 N-term E => K 8.427↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Day JW et al (2011) Graaf Cd et al (2016)
glp1r_human 6.60x60 371 TM6 M => A 1.23↓ pIC50 (Binding - Radioligand competition/displacement) exendin(9-39) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 211 ECL1 Q => A 1.148↑ pEC50 (Functional - cAMP accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 221 ECL1 Q => A 1.549↓ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 32 N-term L => A 9.455↓ EC50 (Functional - cAMP accumulation) exendin 4 Underwood CR et al (2010) Graaf Cd et al (2016)
glp1r_human 7.36x35 381 TM7 F => A 2.57↓ pEC50 (Functional - Ca2+ accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 205 ECL1 Y => A 13.49↓ pEC50 (Functional - cAMP accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 220 ECL1 Y => A 1.202↓ pEC50 (Functional - Ca2+ accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 4.65x65 289 TM4 Y => A 1.096↑ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 7.42x41 387 TM7 E => A 3.89↓ pK(d) (Binding - Radioligand saturation) exendin(9-39) Coopman K et al (2011) Yang D et al (2016)
glp1r_human 7.34x33 379 TM7 L => R >5.495↓ IC50 (Binding - Radioligand competition/displacement) GLP-1-(Gly10Glu) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 7.40x39 385 TM7 F => A 1.349↓ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.35x34 380 TM7 R => G 3.61↑ IC50 (Binding - Radioligand competition/displacement) GLP-1-(Asp15Arg) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 4.63x63 287 TM4 V => A 1.995↓ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(1-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 2.67x67 197 TM2 K => I 49.508↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 211 ECL1 Q => A 1.318↑ pEC50 (Functional - Ca2+ accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 2.68x68 198 TM2 D => N Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 203 ECL1 W => A 1.594↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 6.52x52 363 TM6 H => A 5.012↓ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Wootten D et al (2013) Yang D et al (2016)
glp1r_human 3.36x36 233 TM3 M => A 21.967↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 219 ECL1 S => A 1.413↓ pEC50 (Functional - cAMP accumulation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 36 N-term V => A 1.289↓ IC50 (Binding - Radioligand competition/displacement) exendin 4 Underwood CR et al (2010) Graaf Cd et al (2016)
glp1r_human 7.41x40 386 TM7 T => A 1.259↑ pEC50 (Functional - cAMP accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.35x34 380 TM7 R => D 4.367↑ IC50 (Binding - Radioligand competition/displacement) GLP-1-(Asp15Arg) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 211 ECL1 Q => A 1.072↓ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 373 ECL3 E => A 1.024↑ pIC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 68 N-term E => K 10.667↓ EC50 (Functional - cAMP accumulation) Oxyntomodulin(30-37) Day JW et al (2011) Graaf Cd et al (2016)
glp1r_human 128 N-term E => A 1.4↓ EC50 (Functional - cAMP accumulation) exendin-4(1-30)(Gly2Ala) Patterson JT et al (2013) Graaf Cd et al (2016)
glp1r_human 7.35x34 380 TM7 R => D 4.082↑ EC50 (Functional - cAMP accumulation) GLP-1-(Asp15Lys) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 7.36x35 381 TM7 F => R 1.585↓ EC50 (Functional - cAMP accumulation) GLP-1-(Gly10Asp) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 123 N-term L => A 1.545↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Underwood CR et al (2010) Graaf Cd et al (2016)
glp1r_human 219 ECL1 S => A 1.148↓ pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 121 N-term R => A 1.579↓ IC50 (Binding - Radioligand competition/displacement) exendin 4 Underwood CR et al (2010) Graaf Cd et al (2016)
glp1r_human 4.54x54 278 TM4 L => M 1.056↑ EC50 (Functional - cAMP accumulation) compound 3 Rye Underwood C et al (2011) Graaf Cd et al (2016)
glp1r_human 7.36x35 381 TM7 F => E >3030.303↓ EC50 (Functional - cAMP accumulation) GLP-1-(Asp15Glu) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 5.39x39 309 TM5 I => A 3.311↓ pIC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 215 ECL1 D => A 1.445↓ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 214 ECL1 W => A 1.445↓ pEC50 (Functional - cAMP accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 372 ECL3 D => A 10.965↓ pEC50 (Functional - Ca2+ accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 211 ECL1 Q => R 2.8↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 32 N-term L => A 1.092↑ EC50 (Functional - cAMP accumulation) Chimer 2 Patterson JT et al (2013) Graaf Cd et al (2016)
glp1r_human 4.66x66 290 TM4 L => A 1.585↓ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(1-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 7.39x38 384 TM7 L => A 2.138↓ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 4.67x67 291 TM4 Y => A 2.512↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 45.52x52 298 ECL2 T => A 2.513↑ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Koole C et al (2012) Yang D et al (2016)
glp1r_human 7.32x31 377 TM7 G => A 1.096↓ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.49x49 394 TM7 Q => A 1.778↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Wootten D et al (2013) Yang D et al (2016)
glp1r_human 4.65x65 289 TM4 Y => A 1.259↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 5.36x37 306 TM5 W => A 1.818↑ pIC50 (Binding - Radioligand competition/displacement) exendin(9-39) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 90 N-term P => A 5.455↓ EC50 (Functional - cAMP accumulation) exendin 4 Underwood CR et al (2010) Graaf Cd et al (2016)
glp1r_human 7.36x35 381 TM7 F => A 1.95↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 2.71x71 201 TM2 L => A 15.488↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 6.53x53 364 TM6 E => Q 40.0↑ IC50 (Binding - Radioligand competition/displacement) exendin 4 Yang D et al (2016) Yang D et al (2016)
glp1r_human 7.34x33 379 TM7 L => R 1.0 EC50 (Functional - cAMP accumulation) GLP-1-(Gly10Lys) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 219 ECL1 S => A 47.863↓ pEC50 (Functional - ERK activation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 300 ECL2 N => A 125.893↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 4.64x64 288 TM4 K => A 22.909↓ pIC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 374 ECL3 H => A 1.148↑ pEC50 (Functional - cAMP accumulation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 2.60x60 190 TM2 R => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 7.40x39 385 TM7 F => A 1.175↑ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 374 ECL3 H => A 1.072↓ pIC50 (Binding - Radioligand competition/displacement) exendin(9-39) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 212 ECL1 H => A 1.096↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 2.56x56 186 TM2 S => A 1.0 pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2013) Yang D et al (2016)
glp1r_human 4.62x62 286 TM4 I => A 1.0 pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Koole C et al (2012) Yang D et al (2016)
glp1r_human 211 ECL1 Q => A 4.169↓ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.43x42 388 TM7 L => I 80.7↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 7.34x33 379 TM7 L => E 10.8↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 210 ECL1 Q => A 1.318↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 5.32x33 302 TM5 N => A 15.849↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 7.36x35 381 TM7 F => A 5.129↓ pEC50 (Functional - Ca2+ accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.42x41 387 TM7 E => N 1.42↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 7.34x33 379 TM7 L => R >21.877↓ EC50 (Functional - cAMP accumulation) GLP-1-(Gly10His) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 89 N-term L => A Abolished effect IC50 (Binding - Radioligand competition/displacement) exendin 4 Underwood CR et al (2010) Graaf Cd et al (2016)
glp1r_human 7.35x34 380 TM7 R => D 6.024↑ EC50 (Functional - cAMP accumulation) GLP-1-(Asp15Arg) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 218 ECL1 L => A 398.107↓ pEC50 (Functional - ERK activation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 3.38x38 235 TM3 Y => A 21.878↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Coopman K et al (2011) Graaf Cd et al (2016)
glp1r_human 2.67x67 197 TM2 K => A Abolished effect EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 7.35x34 380 TM7 R => A 29.512↓ pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.36x35 381 TM7 F => E >19.055↓ EC50 (Functional - cAMP accumulation) GLP-1-(Asp15Lys) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 7.46x45 391 TM7 T => A 3.316↓ EC50 (Functional - cAMP accumulation) compound 3 Rye Underwood C et al (2011) Graaf Cd et al (2016)
glp1r_human 128 N-term E => A 1.105↓ EC50 (Functional - cAMP accumulation) Chimer 2X Patterson JT et al (2013) Graaf Cd et al (2016)
glp1r_human 7.41x40 386 TM7 T => A 1.0 pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 128 N-term E => M 2.679↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Day JW et al (2011) Graaf Cd et al (2016)
glp1r_human 82 N-term N => L 2.346↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Chen Q et al (2010) Graaf Cd et al (2016)
glp1r_human 7.34x33 379 TM7 L => A 7.079↓ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.34x33 379 TM7 L => A 2.57↓ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 35 N-term T => A 2.727↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Underwood CR et al (2010) Graaf Cd et al (2016)
glp1r_human 82 N-term N => L 1.647↑ IC50 (Binding - unknown pharmacological activity) glucagon-like peptide 1-(7-37) Chen Q et al (2010) Graaf Cd et al (2016)
glp1r_human 2.68x68 198 TM2 D => E 57.533↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 45.50x50 296 ECL2 C => A 7.943↓ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 7.33x32 378 TM7 T => A 3.086↑ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.38x37 383 TM7 K => A Abolished effect pEC50 (Functional - Ca2+ accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 2.68x68 198 TM2 D => E 1.52↑ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(9-36) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 4.60x60 284 TM4 W => A 28.184↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Coopman K et al (2011) Yang D et al (2016)
glp1r_human 3.37x37 234 TM3 Q => E 1.337↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(15-36) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 4.62x62 286 TM4 I => A 1.0 pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 205 ECL1 Y => A 3.548↓ pEC50 (Functional - Ca2+ accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 36 N-term V => A 6.545↓ EC50 (Functional - cAMP accumulation) exendin 4 Underwood CR et al (2010) Graaf Cd et al (2016)
glp1r_human 295 ECL2 G => A 1.995↓ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(1-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 214 ECL1 W => A 1.622↓ pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 3.37x37 234 TM3 Q => E 16.267↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 376 ECL3 R => A 1.549↓ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 213 ECL1 Q => A 1.0 pEC50 (Functional - cAMP accumulation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 2.60x60 190 TM2 R => K 2.165↑ IC50 (Binding - Radioligand competition/displacement) exendin(9-39) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 293 ECL2 D => A 25.119↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 372 ECL3 D => A 31.623↓ pEC50 (Functional - cAMP accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 3.37x37 234 TM3 Q => N 2.899↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 5.34x35 304 TM5 N => A 1.259↑ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 213 ECL1 Q => A 1.288↓ pEC50 (Functional - Ca2+ accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 220 ECL1 Y => A 1.549↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 2.67x67 197 TM2 K => I 27.667↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 7.36x35 381 TM7 F => A 13.183↓ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 4.64x64 288 TM4 K => A Abolished effect pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(1-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 7.38x37 383 TM7 K => A 79.433↓ pEC50 (Functional - cAMP accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.35x34 380 TM7 R => D >7.752↓ IC50 (Binding - Radioligand competition/displacement) GLP-1-(Gly10His) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 295 ECL2 G => A 1.0 pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 5.40x40 310 TM5 R => A 1258.925↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Coopman K et al (2011) Graaf Cd et al (2016)
glp1r_human 45.52x52 298 ECL2 T => A 1.585↑ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 206 ECL1 S => A 2.457↑ pEC50 (Functional - cAMP accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 2.68x68 198 TM2 D => A 42.658↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Coopman K et al (2011) Yang D et al (2016)
glp1r_human 3.44x44 241 TM3 Y => A 1.045↑ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 7.33x32 378 TM7 T => A 1.122↑ pIC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 210 ECL1 Q => A 3.472↑ pEC50 (Functional - ERK activation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 128 N-term E => Q 1.689↑ IC50 (Binding - Radioligand competition/displacement) exendin 4 Underwood CR et al (2010) Graaf Cd et al (2016)
glp1r_human 7.43x42 388 TM7 L => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 299 ECL2 R => A 25.119↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 223 ECL1 S => A 1.289↑ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 211 ECL1 Q => A 2.399↓ pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 219 ECL1 S => A 1.35↑ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 6.42x42 353 TM6 T => A Abolished effect pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2013) Yang D et al (2016)
glp1r_human 212 ECL1 H => A 2.291↓ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 4.67x67 291 TM4 Y => A 1.259↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(1-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 3.36x36 233 TM3 M => A 3.833↓ IC50 (Binding - Radioligand competition/displacement) exendin 4 Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 206 ECL1 S => A 1.259↑ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 374 ECL3 H => A 1.023↓ pEC50 (Functional - Ca2+ accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.36x35 381 TM7 F => R 1.613↑ IC50 (Binding - Radioligand competition/displacement) GLP-1-(Gly10His) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 203 ECL1 W => A 1.4↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 7.38x37 383 TM7 K => A Abolished effect pEC50 (Functional - ERK activation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.41x40 386 TM7 T => A 9.804↑ pEC50 (Functional - ERK activation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 1.40x40 145 TM1 Y => A 1.3↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 376 ECL3 R => A 1.445↓ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 222 ECL1 D => A 2.042↓ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 204 ECL1 M => A 13.49↓ pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 6.56x56 367 TM6 F => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(9-36) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 7.35x34 380 TM7 R => D 21.0↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 203 ECL1 W => A 1.288↓ pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.35x34 380 TM7 R => D 1.905↑ EC50 (Functional - cAMP accumulation) GLP-1-(Gly10Arg) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 3.37x37 234 TM3 Q => E 4.132↑ IC50 (Binding - Radioligand competition/displacement) exendin(9-39) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 223 ECL1 S => A 64.565↓ pEC50 (Functional - ERK activation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 214 ECL1 W => A 1.82↓ pEC50 (Functional - Ca2+ accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.40x39 385 TM7 F => A 3.89↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 218 ECL1 L => A 3.236↓ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.32x31 377 TM7 G => A 7.943↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.42x41 387 TM7 E => A 1.862↓ pIC50 (Binding - Radioligand competition/displacement) exendin(9-39) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 7.35x34 380 TM7 R => D >5.248↓ EC50 (Functional - cAMP accumulation) GLP-1-(Gly10Asp) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 7.36x35 381 TM7 F => E 16.218↓ EC50 (Functional - cAMP accumulation) GLP-1-(Asp15Arg) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 7.42x41 387 TM7 E => A 1.585↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 203 ECL1 W => A 3.388↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.41x40 386 TM7 T => A 1.175↓ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 3.36x36 233 TM3 M => A 1.154↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(15-36) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 7.35x34 380 TM7 R => G 1.739↑ EC50 (Functional - cAMP accumulation) GLP-1-(Gly10Lys) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 221 ECL1 Q => A 1.698↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.43x42 388 TM7 L => A 208.3↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 221 ECL1 Q => A 204.174↓ pEC50 (Functional - ERK activation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 128 N-term E => A 2.368↓ IC50 (Binding - Radioligand competition/displacement) exendin 4 Underwood CR et al (2010) Graaf Cd et al (2016)
glp1r_human 6.42x42 353 TM6 T => A Abolished effect pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Wootten D et al (2013) Yang D et al (2016)
glp1r_human 5.36x37 306 TM5 W => A 109.648↓ pIC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 5.33x34 303 TM5 M => A 1.0 pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 2.71x71 201 TM2 L => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 7.39x38 384 TM7 L => A 14.454↓ pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 212 ECL1 H => A 10.204↑ pEC50 (Functional - ERK activation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 372 ECL3 D => A 151.356↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.39x38 384 TM7 L => A 1.053↑ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 7.42x41 387 TM7 E => A 2.455↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Coopman K et al (2011) Graaf Cd et al (2016)
glp1r_human 1.43x43 148 TM1 Y => F 4.255↑ IC50 (Binding - Radioligand competition/displacement) exendin(9-39) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 7.34x33 379 TM7 L => R 145.03↓ EC50 (Functional - cAMP accumulation) GLP-1-(Asp15Glu) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 295 ECL2 G => A 1.0 pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Koole C et al (2012) Yang D et al (2016)
glp1r_human 6.53x53 364 TM6 E => Q 10.638↑ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(9-36) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 6.53x53 364 TM6 E => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 6.53x53 364 TM6 E => A 3.981↓ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Wootten D et al (2016) Yang D et al (2016)
glp1r_human 7.36x35 381 TM7 F => A 1.096↓ pIC50 (Binding - Radioligand competition/displacement) exendin(9-39) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 7.34x33 379 TM7 L => E >12.048↓ IC50 (Binding - Radioligand competition/displacement) GLP-1-(Asp15Arg) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 6.53x53 364 TM6 E => A 31.623↓ pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2016) Yang D et al (2016)
glp1r_human 6.53x53 364 TM6 E => A Abolished effect EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 7.38x37 383 TM7 K => A 2.239↓ pEC50 (Functional - ERK activation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 373 ECL3 E => A 7.413↓ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 6.53x53 364 TM6 E => Q 50.0↑ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 7.35x34 380 TM7 R => D 5.076↑ IC50 (Binding - Radioligand competition/displacement) GLP-1-(Gly10Arg) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 373 ECL3 E => A 46.774↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 5.35x36 305 TM5 Y => A 1.064↑ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 213 ECL1 Q => A 2.455↓ pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 221 ECL1 Q => A 2.239↓ pEC50 (Functional - Ca2+ accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 1.44x44 149 TM1 T => S 1.449↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 202 ECL1 K => A 18.621↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 217 ECL1 L => A 1.548↑ pEC50 (Functional - Ca2+ accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.40x39 385 TM7 F => A 1.658↑ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.36x35 381 TM7 F => E >5.618↓ IC50 (Binding - Radioligand competition/displacement) GLP-1-(Gly10Arg) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 202 ECL1 K => A 8.913↓ pEC50 (Functional - Ca2+ accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 372 ECL3 D => A 15.849↓ pEC50 (Functional - Ca2+ accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 5.34x35 304 TM5 N => A 1.259↑ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(1-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 127 N-term E => A 1.7↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Underwood CR et al (2010) Yang D et al (2016)
glp1r_human 7.37x36 382 TM7 I => A 2.57↓ pEC50 (Functional - cAMP accumulation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.35x34 380 TM7 R => G >14.706↑ IC50 (Binding - Radioligand competition/displacement) GLP-1-(Gly10Lys) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 4.65x65 289 TM4 Y => A 1.259↑ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(1-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 6.53x53 364 TM6 E => Q 2.0↑ IC50 (Binding - Radioligand competition/displacement) exendin(9-39) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 207 ECL1 T => A 6.026↓ pEC50 (Functional - cAMP accumulation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 5.36x37 306 TM5 W => A 25.119↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 7.39x38 384 TM7 L => A 6.166↓ pIC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 213 ECL1 Q => A 11.765↑ pEC50 (Functional - ERK activation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.34x33 379 TM7 L => E >21.877↓ EC50 (Functional - cAMP accumulation) GLP-1-(Gly10His) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 4.61x61 285 TM4 G => A 2.513↑ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(1-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 7.46x45 391 TM7 T => A 2.818↓ pK(d) (Binding - Radioligand saturation) exendin(9-39) Coopman K et al (2011) Yang D et al (2016)
glp1r_human 215 ECL1 D => A 1.047↑ pEC50 (Functional - Ca2+ accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 8.47x47 406 H8 N => A 2.188↑ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Wootten D et al (2013) Yang D et al (2016)
glp1r_human 89 N-term L => A Abolished effect EC50 (Functional - cAMP accumulation) exendin 4 Underwood CR et al (2010) Graaf Cd et al (2016)
glp1r_human 7.35x34 380 TM7 R => A 2.692↓ pIC50 (Binding - Radioligand competition/displacement) exendin(9-39) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 4.65x65 289 TM4 Y => A 1.259↓ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Koole C et al (2012) Yang D et al (2016)
glp1r_human 373 ECL3 E => A 1.096↑ pIC50 (Binding - Radioligand competition/displacement) exendin(9-39) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 7.36x35 381 TM7 F => A 1.778↓ pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.34x33 379 TM7 L => A Abolished effect pEC50 (Functional - Ca2+ accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 215 ECL1 D => A 1.549↓ pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 5.50x50 320 TM5 N => A 1.862↑ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Wootten D et al (2013) Yang D et al (2016)
glp1r_human 211 ECL1 Q => A 1.047↑ pEC50 (Functional - Ca2+ accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 1.47x47 152 TM1 Y => A 31.623↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Coopman K et al (2011) Yang D et al (2016)
glp1r_human 217 ECL1 L => A 1.122↓ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 3.43x43 240 TM3 N => Q 1.996↑ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2016) Yang D et al (2016)
glp1r_human 2.50x50 180 TM2 H => A Abolished effect pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2013) Yang D et al (2016)
glp1r_human 127 N-term E => Q 1.236↓ EC50 (Functional - cAMP accumulation) exendin 4 Underwood CR et al (2010) Graaf Cd et al (2016)
glp1r_human 205 ECL1 Y => A 2.884↓ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 4.61x61 285 TM4 G => A 1.0 pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Koole C et al (2012) Yang D et al (2016)
glp1r_human 6.53x53 364 TM6 E => A 1.585↓ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2016) Yang D et al (2016)
glp1r_human 88 N-term Y => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Underwood CR et al (2010) Yang D et al (2016)
glp1r_human 294 ECL2 E => A 1.259↑ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 2.71x71 201 TM2 L => A 9.12↓ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 45.51x51 297 ECL2 W => H 50.1↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 205 ECL1 Y => A 794.328↓ pEC50 (Functional - ERK activation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 214 ECL1 W => A 5.129↓ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.35x34 380 TM7 R => A Abolished effect pEC50 (Functional - Ca2+ accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 3.37x37 234 TM3 Q => E Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 7.36x35 381 TM7 F => R 1.2↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 7.36x35 381 TM7 F => S 2.174↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 214 ECL1 W => A 2.884↓ pEC50 (Functional - cAMP accumulation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 223 ECL1 S => A 2.291↓ pEC50 (Functional - Ca2+ accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.34x33 379 TM7 L => R 1.699↓ IC50 (Binding - Radioligand competition/displacement) GLP-1-(Asp15Arg) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 2.68x68 198 TM2 D => E 433.5↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 223 ECL1 S => A 2.754↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.38x37 383 TM7 K => A 1.514↓ pIC50 (Binding - Radioligand competition/displacement) exendin(9-39) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 36 N-term V => A 5.182↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Underwood CR et al (2010) Graaf Cd et al (2016)
glp1r_human 217 ECL1 L => A 2.5↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 7.40x39 385 TM7 F => A 1.072↓ pIC50 (Binding - Radioligand competition/displacement) exendin(9-39) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 214 ECL1 W => A 1.66↓ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.38x37 383 TM7 K => A 9.772↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.36x35 381 TM7 F => A 1.259↓ pEC50 (Functional - cAMP accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 45.50x50 296 ECL2 C => A Abolished effect pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(1-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 212 ECL1 H => A 2.088↑ pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.35x34 380 TM7 R => G >2.801↑ IC50 (Binding - Radioligand competition/displacement) GLP-1-(Gly10Glu) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 372 ECL3 D => A 3.89↓ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 299 ECL2 R => A 31.623↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 7.42x41 387 TM7 E => N 2.083↑ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 4.65x65 289 TM4 Y => A 1.35↑ pIC50 (Binding - Radioligand competition/displacement) exendin(9-39) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 7.39x38 384 TM7 L => A 2.512↓ pEC50 (Functional - Ca2+ accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.42x41 387 TM7 E => A 1.259↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 5.50x50 320 TM5 N => A 17.783↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Wootten D et al (2013) Yang D et al (2016)
glp1r_human 2.68x68 198 TM2 D => E 58.197↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 207 ECL1 T => A 154.882↓ pEC50 (Functional - ERK activation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 205 ECL1 Y => A 6.31↓ pEC50 (Functional - cAMP accumulation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 372 ECL3 D => A 67.608↓ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 295 ECL2 G => A 1.259↑ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(1-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 2.60x60 190 TM2 R => A 27.542↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Coopman K et al (2011) Yang D et al (2016)
glp1r_human 7.42x41 387 TM7 E => D 2.653↑ IC50 (Binding - Radioligand competition/displacement) GLP-1-(Ala8Ser) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 206 ECL1 S => A 1.318↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.36x35 381 TM7 F => R 1.023↓ EC50 (Functional - cAMP accumulation) GLP-1-(Gly10Arg) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 2.71x71 201 TM2 L => A 15.136↓ pEC50 (Functional - Ca2+ accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 3.50x50 247 TM3 E => A 2.138↓ pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2013) Yang D et al (2016)
glp1r_human 217 ECL1 L => A 9.12↓ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 6.52x52 363 TM6 H => A 22.909↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Wootten D et al (2013) Yang D et al (2016)
glp1r_human 7.37x36 382 TM7 I => A 2.688↑ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 372 ECL3 D => A 1.259↓ pIC50 (Binding - Radioligand competition/displacement) exendin(9-39) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 7.47x46 392 TM7 S => A 2.188↑ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Wootten D et al (2013) Yang D et al (2016)
glp1r_human 2.50x50 180 TM2 H => A Abolished effect pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Wootten D et al (2013) Yang D et al (2016)
glp1r_human 2.67x67 197 TM2 K => A 630.957↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Coopman K et al (2011) Graaf Cd et al (2016)
glp1r_human 7.35x34 380 TM7 R => A 186.209↓ pEC50 (Functional - cAMP accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 222 ECL1 D => A 1.072↑ pEC50 (Functional - Ca2+ accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 5.34x35 304 TM5 N => A 1.995↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 202 ECL1 K => A 2.188↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 2.60x60 190 TM2 R => A 169.824↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Coopman K et al (2011) Graaf Cd et al (2016)
glp1r_human 7.46x45 391 TM7 T => A 1.122↑ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Coopman K et al (2011) Graaf Cd et al (2016)
glp1r_human 204 ECL1 M => A Abolished effect pEC50 (Functional - Ca2+ accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 4.62x62 286 TM4 I => A 1.996↑ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(1-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 115 N-term N => L 1.0 IC50 (Binding - unknown pharmacological activity) glucagon-like peptide 1-(7-37) Chen Q et al (2010) Graaf Cd et al (2016)
glp1r_human 3.36x36 233 TM3 M => F 1.5↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 2.68x68 198 TM2 D => E 2.029↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(15-36) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 218 ECL1 L => A 7.079↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 3.37x37 234 TM3 Q => A 44.668↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Coopman K et al (2011) Graaf Cd et al (2016)
glp1r_human 373 ECL3 E => A 32.359↓ pEC50 (Functional - cAMP accumulation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 300 ECL2 N => A 1.513↑ pIC50 (Binding - Radioligand competition/displacement) exendin(9-39) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 5.35x36 305 TM5 Y => A 1.0 pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Koole C et al (2012) Yang D et al (2016)
glp1r_human 207 ECL1 T => A 1.82↓ pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 4.64x64 288 TM4 K => A 1.486↑ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 1.43x43 148 TM1 Y => F 7.25↓ IC50 (Binding - Radioligand competition/displacement) exendin 4 Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 7.34x33 379 TM7 L => R >7.752↓ IC50 (Binding - Radioligand competition/displacement) GLP-1-(Gly10His) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 7.37x36 382 TM7 I => A 1.175↑ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.35x34 380 TM7 R => G >2.865↑ IC50 (Binding - Radioligand competition/displacement) GLP-1-(Gly10His) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 202 ECL1 K => A 1.698↓ pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 294 ECL2 E => A 1.585↑ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Koole C et al (2012) Yang D et al (2016)
glp1r_human 7.34x33 379 TM7 L => R 140.806↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 3.37x37 234 TM3 Q => E 1.934↓ IC50 (Binding - Radioligand competition/displacement) GLP-1-(Ala8Ser) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 7.33x32 378 TM7 T => A 2.513↑ pEC50 (Functional - cAMP accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 6.52x52 363 TM6 H => A 6.31↓ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2013) Yang D et al (2016)
glp1r_human 127 N-term E => A 6.842↓ IC50 (Binding - Radioligand competition/displacement) exendin 4 Underwood CR et al (2010) Graaf Cd et al (2016)
glp1r_human 7.34x33 379 TM7 L => E >34.674↓ EC50 (Functional - cAMP accumulation) GLP-1-(Asp15Arg) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 217 ECL1 L => A 1.096↓ pEC50 (Functional - cAMP accumulation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 210 ECL1 Q => A 1.445↓ pEC50 (Functional - Ca2+ accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.35x34 380 TM7 R => A 1.549↓ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.39x38 384 TM7 L => A 6.761↓ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 215 ECL1 D => A 2.692↓ pEC50 (Functional - cAMP accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 2.67x67 197 TM2 K => I 2.558↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(15-36) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 5.32x33 302 TM5 N => A 1.995↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(1-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 1.43x43 148 TM1 Y => F 1.385↑ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(9-36) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 7.35x34 380 TM7 R => G 2.755↑ EC50 (Functional - cAMP accumulation) GLP-1-(Asp15Lys) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 5.40x40 310 TM5 R => A 3.467↓ pIC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 2.60x60 190 TM2 R => L Abolished effect EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 5.33x34 303 TM5 M => A 3.981↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 45.51x51 297 ECL2 W => A Abolished effect pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(1-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 206 ECL1 S => A 1.445↑ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 4.63x63 287 TM4 V => A 1.259↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(1-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 5.36x37 306 TM5 W => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 4.68x68 292 TM4 E => A 100.0↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 4.64x64 288 TM4 K => A 1.413↓ pIC50 (Binding - Radioligand competition/displacement) exendin(9-39) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 3.36x36 233 TM3 M => F 1.594↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 7.39x38 384 TM7 L => A 1.175↑ pIC50 (Binding - Radioligand competition/displacement) exendin(9-39) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 7.39x38 384 TM7 L => V Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 1.47x47 152 TM1 Y => A 17.378↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Coopman K et al (2011) Graaf Cd et al (2016)
glp1r_human 7.40x39 385 TM7 F => A 134.896↓ pEC50 (Functional - ERK activation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 2.60x60 190 TM2 R => A 34.674↓ pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2013) Yang D et al (2016)
glp1r_human 5.37x38 307 TM5 L => A 1.996↑ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Koole C et al (2012) Yang D et al (2016)
glp1r_human 218 ECL1 L => A 12.882↓ pEC50 (Functional - cAMP accumulation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 2.67x67 197 TM2 K => I Abolished effect EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 211 ECL1 Q => A 3.311↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.34x33 379 TM7 L => A 58.884↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 374 ECL3 H => A 1.514↓ pEC50 (Functional - Ca2+ accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.35x34 380 TM7 R => D >21.877↓ EC50 (Functional - cAMP accumulation) GLP-1-(Gly10His) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 7.34x33 379 TM7 L => A 2.344↓ pIC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 5.34x35 304 TM5 N => A 3.162↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 7.41x40 386 TM7 T => A 181.97↓ pEC50 (Functional - ERK activation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 220 ECL1 Y => A 1.202↓ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 5.37x38 307 TM5 L => A 1.585↓ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 4.63x63 287 TM4 V => A 1.585↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 2.60x60 190 TM2 R => K Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 7.39x38 384 TM7 L => A 3.981↓ pEC50 (Functional - cAMP accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 2.67x67 197 TM2 K => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 6.60x60 371 TM6 M => A 1.046↑ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 2.68x68 198 TM2 D => A 89.2↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 7.57x57 402 TM7 Y => A 1.479↓ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2013) Yang D et al (2016)
glp1r_human 205 ECL1 Y => A 3.236↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 4.68x68 292 TM4 E => A 125.893↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 128 N-term E => A 1.96↓ EC50 (Functional - cAMP accumulation) GLP-1-(Ala8Gly) Patterson JT et al (2013) Graaf Cd et al (2016)
glp1r_human 7.42x41 387 TM7 E => D 13.768↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 212 ECL1 H => A 1.148↓ pEC50 (Functional - cAMP accumulation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 202 ECL1 K => A 3.236↑ pEC50 (Functional - ERK activation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 123 N-term L => A 1.727↓ EC50 (Functional - cAMP accumulation) exendin 4 Underwood CR et al (2010) Graaf Cd et al (2016)
glp1r_human 7.35x34 380 TM7 R => D 9.434↑ IC50 (Binding - Radioligand competition/displacement) GLP-1-(Asp15Lys) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 7.35x34 380 TM7 R => A 4570.882↓ pEC50 (Functional - ERK activation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 301 ECL2 S => A 1.0 pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 7.41x40 386 TM7 T => A 1.23↓ pEC50 (Functional - Ca2+ accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.42x41 387 TM7 E => D 1.284↑ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(15-36) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 4.64x64 288 TM4 K => A 3.981↓ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(1-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 214 ECL1 W => A 4.082↑ pEC50 (Functional - ERK activation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.34x33 379 TM7 L => E 317.303↓ EC50 (Functional - cAMP accumulation) GLP-1-(Asp15Glu) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 3.50x50 247 TM3 E => A 1.513↑ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Wootten D et al (2013) Yang D et al (2016)
glp1r_human 68 N-term E => K 1.773↓ EC50 (Functional - cAMP accumulation) glucagon-(Ser22Glu) Day JW et al (2011) Graaf Cd et al (2016)
glp1r_human 3.43x43 240 TM3 N => A 1.513↑ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Wootten D et al (2013) Yang D et al (2016)
glp1r_human 7.33x32 378 TM7 T => A 3.546↑ pEC50 (Functional - Ca2+ accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 6.53x53 364 TM6 E => D 1.449↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 2.67x67 197 TM2 K => A 3.02↓ pK(d) (Binding - Radioligand saturation) exendin(9-39) Coopman K et al (2011) Yang D et al (2016)
glp1r_human 4.60x60 284 TM4 W => A 1348.963↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Coopman K et al (2011) Graaf Cd et al (2016)
glp1r_human 376 ECL3 R => A 1.024↑ pEC50 (Functional - Ca2+ accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 222 ECL1 D => A 1.905↑ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 211 ECL1 Q => D 4.6↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 204 ECL1 M => A 691.831↓ pEC50 (Functional - ERK activation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 69 N-term Y => A Abolished effect IC50 (Binding - Radioligand competition/displacement) exendin 4 Underwood CR et al (2010) Graaf Cd et al (2016)
glp1r_human 7.34x33 379 TM7 L => E 1.0 EC50 (Functional - cAMP accumulation) GLP-1-(Gly10Lys) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 7.35x34 380 TM7 R => D 1.414↓ IC50 (Binding - Radioligand competition/displacement) GLP-1-(Asp15Glu) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 4.66x66 290 TM4 L => A 1.995↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 2.65x65 195 TM2 F => L 1.1↑ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Rye Underwood C et al (2011) Graaf Cd et al (2016)
glp1r_human 3.44x44 241 TM3 Y => A 1.552↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Rye Underwood C et al (2011) Graaf Cd et al (2016)
glp1r_human 3.37x37 234 TM3 Q => A Abolished effect IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 4.66x66 290 TM4 L => A 1.259↓ pK(i) (Binding - Radioligand competition/displacement) exendin(9-39) Koole C et al (2012) Yang D et al (2016)
glp1r_human 45.52x52 298 ECL2 T => A 2.513↑ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 5.35x36 305 TM5 Y => A 1.148↓ pIC50 (Binding - Radioligand competition/displacement) exendin(9-39) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 127 N-term E => Q 1.079↓ IC50 (Binding - Radioligand competition/displacement) exendin 4 Underwood CR et al (2010) Graaf Cd et al (2016)
glp1r_human 68 N-term E => A 1.9↓ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Underwood CR et al (2010) Yang D et al (2016)
glp1r_human 6.53x53 364 TM6 E => A 74.131↓ pK(d) (Binding - Radioligand saturation) exendin(9-39) Coopman K et al (2011) Yang D et al (2016)
glp1r_human 2.62x62 192 TM2 L => S 1.101↑ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-37) Rye Underwood C et al (2011) Graaf Cd et al (2016)
glp1r_human 207 ECL1 T => A 1.949↑ pEC50 (Functional - ERK activation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 6.53x53 364 TM6 E => A 57.544↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Coopman K et al (2011) Yang D et al (2016)
glp1r_human 223 ECL1 S => A 3.802↓ pEC50 (Functional - cAMP accumulation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 5.35x36 305 TM5 Y => A 39.811↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 7.36x35 381 TM7 F => E 1.0 EC50 (Functional - cAMP accumulation) GLP-1-(Gly10Lys) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 7.40x39 385 TM7 F => A 3.236↓ pIC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Dods RL et al (2015) Yang D et al (2016)
glp1r_human 7.34x33 379 TM7 L => E >11.75↓ EC50 (Functional - cAMP accumulation) GLP-1-(Gly10Glu) Moon MJ et al (2015) Yang D et al (2016)
glp1r_human 222 ECL1 D => A 1.905↑ pEC50 (Functional - cAMP accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 5.35x36 305 TM5 Y => A 2.512↓ pEC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(1-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 6.53x53 364 TM6 E => Q 2.0↑ IC50 (Binding - Radioligand competition/displacement) exendin(9-39) Yang D et al (2016) Yang D et al (2016)
glp1r_human 374 ECL3 H => A 1.326↑ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-37) Yang D et al (2016) Yang D et al (2016)
glp1r_human 5.35x36 305 TM5 Y => A 1.996↑ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(1-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 204 ECL1 M => A 5.495↓ pEC50 (Functional - cAMP accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 128 N-term E => A 1.529↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Patterson JT et al (2013) Graaf Cd et al (2016)
glp1r_human 7.39x38 384 TM7 L => A 1.698↓ pEC50 (Functional - ERK activation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 5.35x36 305 TM5 Y => A 79.433↓ pK(i) (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 372 ECL3 D => A 63.096↓ pEC50 (Functional - cAMP accumulation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 6.56x56 367 TM6 F => A 71.9↓ EC50 (Functional - cAMP accumulation) glucagon-like peptide 1-(7-36) Yang D et al (2016) Graaf Cd et al (2016)
glp1r_human 294 ECL2 E => A 1.259↓ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(1-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 212 ECL1 H => A 1.148↑ pEC50 (Functional - Ca2+ accumulation) glucagon-like peptide 1-(7-36) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.57x57 402 TM7 Y => A 1.778↓ pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2013) Yang D et al (2016)
glp1r_human 4.68x68 292 TM4 E => A 3.981↓ pEC50 (Functional - ERK activation) glucagon-like peptide 1-(7-36) Koole C et al (2012) Yang D et al (2016)
glp1r_human 213 ECL1 Q => A 1.202↑ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 223 ECL1 S => A 2.188↓ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 7.40x39 385 TM7 F => A 1.66↓ pK(i) (Binding - Radioligand competition/displacement) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 8.47x47 406 H8 N => A 1.479↓ pK(i) (Binding - Radioligand competition/displacement) Oxyntomodulin(30-37) Wootten D et al (2013) Yang D et al (2016)
glp1r_human 220 ECL1 Y => A 1.202↑ pEC50 (Functional - cAMP accumulation) exendin 4 Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 219 ECL1 S => A 8.333↑ pEC50 (Functional - ERK activation) Oxyntomodulin(30-37) Wootten D et al (2016) 10.5281/zenodo.60790
glp1r_human 6.53x53 364 TM6 E => Q 10.638↑ IC50 (Binding - Radioligand competition/displacement) glucagon-like peptide 1-(9-36) Yang D et al (2016)