Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
p2ry2_human 5.38x39 198 TM5 Y => A 1.038↑ IC50 (Ca2+ accumulaion) PSB-416 Hillmann P et al (2009)
p2ry2_human 177 ECL2 R => A 1.419↓ IC50 (Ca2+ accumulaion) PSB-416 Hillmann P et al (2009)
p2ry2_human 7.25x24 278 TM7 C => S ~558.621↓ EC50 (Ca2+ accumulaion) Ap4A Hillmann P et al (2009)
p2ry2_human 3.33x33 114 TM3 Y => A 1.585↑ EC50 (Ca2+ accumulaion) UTP Hillmann P et al (2009)
p2ry2_human 272 ECL3 R => A ~3463.687↓ EC50 (Ca2+ accumulaion) Ip4U Hillmann P et al (2009)
p2ry2_human 272 ECL3 R => A Abolished IC50 (Ca2+ accumulaion) PSB-416 Hillmann P et al (2009)
p2ry2_human 7.43x42 296 TM7 S => A >2068.966↓ EC50 (Ca2+ accumulaion) Ap4A Hillmann P et al (2009)
p2ry2_human 5.38x39 198 TM5 Y => A 1.343↓ EC50 (Ca2+ accumulaion) UTP Hillmann P et al (2009)
p2ry2_human 4.54x54 162 TM4 L => M N/A N/A Brockhoff A et al (2010)
p2ry2_human 177 ECL2 R => A 7.365↓ EC50 (Ca2+ accumulaion) Ap4A Hillmann P et al (2009)
p2ry2_human 7.43x42 296 TM7 S => A >3131.524↓ EC50 (Ca2+ accumulaion) ATP Hillmann P et al (2009)
p2ry2_human 5.34x35 194 TM5 R => H 1.621↑ IC50 (Ca2+ accumulaion) Reactive Blue 2 Hillmann P et al (2009)
p2ry2_human 1.39x39 40 TM1 Y => A N/A N/A Raouf R et al (2004)
p2ry2_human 180 ECL2 R => A 1.078↓ IC50 (Ca2+ accumulaion) PSB-416 Hillmann P et al (2009)
p2ry2_human 3.37x37 118 TM3 Y => A 1.032↑ IC50 (Ca2+ accumulaion) Reactive Blue 2 Hillmann P et al (2009)
p2ry2_human 5.38x39 198 TM5 Y => A 2.31↓ EC50 (Ca2+ accumulaion) Ap4A Hillmann P et al (2009)
p2ry2_human 5.38x39 198 TM5 Y => A 1.253↓ EC50 (Ca2+ accumulaion) ATP Hillmann P et al (2009)
p2ry2_human 3.37x37 118 TM3 Y => A 3.121↓ EC50 (Ca2+ accumulaion) ATP Hillmann P et al (2009)
p2ry2_human 7.25x24 278 TM7 C => S 25.995↓ EC50 (Ca2+ accumulaion) UTP Hillmann P et al (2009)
p2ry2_human 3.33x33 114 TM3 Y => A 1.018↓ EC50 (Ca2+ accumulaion) Ap4A Hillmann P et al (2009)
p2ry2_human 4.56x56 164 TM4 C => A N/A N/A Raouf R et al (2004)
p2ry2_human 3.33x33 114 TM3 Y => A 2.096↑ EC50 (Ca2+ accumulaion) ATP Hillmann P et al (2009)
p2ry2_human 8.55x55 318 H8 R => A N/A N/A Yan Z et al (2005)
p2ry2_human 272 ECL3 R => A ~4431.138↓ EC50 (Ca2+ accumulaion) Ap4A Hillmann P et al (2009)
p2ry2_human 177 ECL2 R => A 1.178↑ EC50 (Ca2+ accumulaion) UTP Hillmann P et al (2009)
p2ry2_human 7.43x42 296 TM7 S => A Abolished IC50 (Ca2+ accumulaion) Reactive Blue 2 Hillmann P et al (2009)
p2ry2_human 3.37x37 118 TM3 Y => A 1.295↓ EC50 (Ca2+ accumulaion) Ip4U Hillmann P et al (2009)
p2ry2_human 5.34x35 194 TM5 R => H 1.159↓ EC50 (Ca2+ accumulaion) ATP Hillmann P et al (2009)
p2ry2_human 272 ECL3 R => A Abolished IC50 (Ca2+ accumulaion) Reactive Blue 2 Hillmann P et al (2009)
p2ry2_human 3.37x37 118 TM3 Y => A 1.023↓ IC50 (Ca2+ accumulaion) PSB-416 Hillmann P et al (2009)
p2ry2_human 3.33x33 114 TM3 Y => A 1.894↑ EC50 (Ca2+ accumulaion) Ip4U Hillmann P et al (2009)
p2ry2_human 5.34x35 194 TM5 R => H 1.276↓ EC50 (Ca2+ accumulaion) Ap4A Hillmann P et al (2009)
p2ry2_human 15 N-term T => A N/A N/A Raouf R et al (2004)
p2ry2_human 7.25x24 278 TM7 C => S 6.369↑ IC50 (Ca2+ accumulaion) PSB-416 Hillmann P et al (2009)
p2ry2_human 5.38x39 198 TM5 Y => A 2.062↓ EC50 (Ca2+ accumulaion) Ip4U Hillmann P et al (2009)
p2ry2_human 180 ECL2 R => A 3.756↓ EC50 (Ca2+ accumulaion) ATP Hillmann P et al (2009)
p2ry2_human 8.55x55 318 H8 R => K N/A N/A Yan Z et al (2005)
p2ry2_human 7.43x42 296 TM7 S => A >2678.571↓ EC50 (Ca2+ accumulaion) Ip4U Hillmann P et al (2009)
p2ry2_human 177 ECL2 R => A 3.196↓ EC50 (Ca2+ accumulaion) Ip4U Hillmann P et al (2009)
p2ry2_human 6.55x55 265 TM6 R => W N/A N/A Cattaneo M et al (2005)
p2ry2_human 7.43x42 296 TM7 S => A Abolished IC50 (Ca2+ accumulaion) PSB-416 Hillmann P et al (2009)
p2ry2_human 5.34x35 194 TM5 R => H 1.929↓ EC50 (Ca2+ accumulaion) Ip4U Hillmann P et al (2009)
p2ry2_human 272 ECL3 R => A 349.153↓ EC50 (Ca2+ accumulaion) UTP Hillmann P et al (2009)
p2ry2_human 5.38x39 198 TM5 Y => A 5.741↓ IC50 (Ca2+ accumulaion) Reactive Blue 2 Hillmann P et al (2009)
p2ry2_human 3.33x33 114 TM3 Y => A >54.054↓ IC50 (Ca2+ accumulaion) Reactive Blue 2 Hillmann P et al (2009)
p2ry2_human 7.25x24 278 TM7 C => S 1.543↑ IC50 (Ca2+ accumulaion) Reactive Blue 2 Hillmann P et al (2009)
p2ry2_human 177 ECL2 R => A 1.816↓ IC50 (Ca2+ accumulaion) Reactive Blue 2 Hillmann P et al (2009)
p2ry2_human 180 ECL2 R => A 1.135↓ IC50 (Ca2+ accumulaion) Reactive Blue 2 Hillmann P et al (2009)
p2ry2_human 7.43x42 296 TM7 S => A >3731.343↓ EC50 (Ca2+ accumulaion) UTP Hillmann P et al (2009)
p2ry2_human 5.34x35 194 TM5 R => H 1.505↓ EC50 (Ca2+ accumulaion) UTP Hillmann P et al (2009)
p2ry2_human 3.37x37 118 TM3 Y => A 2.379↓ EC50 (Ca2+ accumulaion) Ap4A Hillmann P et al (2009)
p2ry2_human 272 ECL3 R => A 185.42↓ EC50 (Ca2+ accumulaion) ATP Hillmann P et al (2009)
p2ry2_human 180 ECL2 R => A 2.533↓ EC50 (Ca2+ accumulaion) Ap4A Hillmann P et al (2009)
p2ry2_human 180 ECL2 R => A 2.341↓ EC50 (Ca2+ accumulaion) Ip4U Hillmann P et al (2009)
p2ry2_human 180 ECL2 R => A 2.339↓ EC50 (Ca2+ accumulaion) UTP Hillmann P et al (2009)
p2ry2_human 5.34x35 194 TM5 R => H 1.244↑ IC50 (Ca2+ accumulaion) PSB-416 Hillmann P et al (2009)
p2ry2_human 3.37x37 118 TM3 Y => A 1.953↓ EC50 (Ca2+ accumulaion) UTP Hillmann P et al (2009)
p2ry2_human 3.33x33 114 TM3 Y => A 1.134↓ IC50 (Ca2+ accumulaion) PSB-416 Hillmann P et al (2009)
p2ry2_human 177 ECL2 R => A 2.9↓ EC50 (Ca2+ accumulaion) ATP Hillmann P et al (2009)
p2ry2_human 7.25x24 278 TM7 C => S 10.438↓ EC50 (Ca2+ accumulaion) ATP Hillmann P et al (2009)
p2ry2_human 7.25x24 278 TM7 C => S ~2410.714↓ EC50 (Ca2+ accumulaion) Ip4U Hillmann P et al (2009)


Residue

Diagrams

ICL1 L K T W ICL1ECL1 G D H W P F ECL1ICL2 P L R S L R W G ICL2ECL2 T T S A R G G R V T C H D T S A P E L ECL2ICL3 S G G L P R ICL3ECL3 R S L D L ECL3N-term M A A D L G P W N D T I N G T W D G D E L G Y R C R F N E D N-termC-term P T G P S P A T P A R R R L G L R R S D R T D M Q R I E D V L G S S E D S R R T E S T P A G S E N T K D I R L C-term F K Y V L L P V S Y G V V C V P G L C L N A V A L Y I F L C R N A S T T Y M F H L A V S D A L Y A A S L P L L V Y Y Y A R S T V L C K L V R F L F Y T N L Y C S I L F L T C I S V H R C L G V L R R A R Y A R R V A G A V W V L V L A C Q A P V L Y F V F S R F V A Y S S V M L G L L F A V P F A V I L V C Y V L M A R R L L K P A Y G T A K R K S V R T I A V V L A V F A L C F L P F H V T R T L Y Y S F S C H T L N A I N M A Y K V T R P L A S A N S C L D P V L Y F L A G Q R A R D L V R F A K P
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
A N L C L G P V C V V G Y S V P L L V Y 1 F H L A V S D A L Y A A S L P L L V Y Y 2 C T L F L I S C Y L N T Y F L F R V L K 3 A R R V A G A V W V L V L A C Q A P V L 4 Y C V L I V A F P V A F L L G L M V S S Y 5 I A V V L A V F L A C F L P F H V T R T L 6 V P D L C S N A S A L P R T V K Y A M 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
P2Y2 receptor
TM1
1x39 1.39x39 Y40
TM3
3x33 3.33x33 Y114
3x37 3.37x37 Y118
TM4
4x54 4.54x54 L162
4x56 4.56x56 C164
TM5
5x35 5.34x35 R194
5x39 5.38x39 Y198
TM6
6x55 6.55x55 R265
TM7
7x24 7.25x24 C278
7x42 7.43x42 S296
H8
8x55 8.55x55 R318