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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review
sctr_human 5.34x35 293 TM5 S => C 7.75↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 5.64x64 323 TM5 K => I N/A N/A Chan KY et al (2001)
sctr_human 284 ECL2 G => C 170.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 6.59x59 361 TM6 S => C 2.5↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 45.52x52 287 ECL2 D => C 2.083↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 3.27x27 213 TM3 A => C 4.5↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 6.37x37 339 TM6 R => I 7.519↑ EC50 (Functional - cAMP accumulation) secretin Chan KY et al (2001) 10.5281/zenodo.60790
sctr_human 6.37x37 339 TM6 R => A 5.988↑ EC50 (Functional - cAMP accumulation) secretin Chan KY et al (2001) 10.5281/zenodo.60790
sctr_human 364 ECL3 D => C 3.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 7.39x38 370 TM7 L => C 10.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 289 ECL2 N => C 4.917↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 363 ECL3 E => C 5.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 6.37x37 339 TM6 R => A N/A N/A Chan KY et al (2001)
sctr_human 288 ECL2 I => C 25.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 6.40x40 342 TM6 R => A 5.0↑ EC50 (Functional - cAMP accumulation) secretin Chan KY et al (2001) 10.5281/zenodo.60790
sctr_human 330 ICL3 R => I N/A N/A Chan KY et al (2001)
sctr_human 290 ECL2 A => C 2.833↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 362 ECL3 P => C 20.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 5.35x36 294 TM5 I => C 10.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 3.34x34 220 TM3 V => C 2.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 7.38x37 369 TM7 Q => C 2.5↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 283 ECL2 V => C 2.25↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 6.59x59 361 TM6 S => C 10.25↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 3.30x30 216 TM3 K => C 15.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 7.42x41 373 TM7 E => C 5.667↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 7.40x39 371 TM7 F => C 1.5↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 7.38x37 369 TM7 Q => C 4.167↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 3.35x35 221 TM3 L => C 1.0 EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 7.39x38 370 TM7 L => C 5.167↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 7.41x40 372 TM7 F => C 10.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 6.37x37 339 TM6 R => I N/A N/A Chan KY et al (2001)
sctr_human 45.51x51 286 ECL2 W => C Abolished effect EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 6.40x40 342 TM6 R => I 2.468↓ K(d) (Binding - Radioligand saturation) secretin Chan KY et al (2001) 10.5281/zenodo.60790
sctr_human 6.40x40 342 TM6 R => A N/A N/A Chan KY et al (2001)
sctr_human 4.68x68 281 TM4 E => C 2.75↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 330 ICL3 R => I 1.318↑ K(d) (Binding - Radioligand saturation) secretin Chan KY et al (2001) 10.5281/zenodo.60790
sctr_human 7.37x36 368 TM7 I => C 4.167↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 6.56x56 358 TM6 F => C 19.25↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 3.28x28 214 TM3 G => C 4.0↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 211 ECL1 H => C 105.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 6.57x57 359 TM6 A => C 6.333↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 7.41x40 372 TM7 F => C 9.167↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 363 ECL3 E => C 3.333↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 3.37x37 223 TM3 Q => C 6.833↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 3.31x31 217 TM3 L => C 5.917↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 3.28x28 214 TM3 G => C 4.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 45.51x51 286 ECL2 W => C Abolished effect K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 5.36x37 295 TM5 W => C 170.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 5.32x33 291 TM5 N => C 5.417↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 5.33x34 292 TM5 A => C 3.5↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 4.67x67 280 TM4 L => C 3.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 282 ECL2 D => C Abolished effect EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 3.35x35 221 TM3 L => C 5.75↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 4.66x66 279 TM4 F => C 7.5↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 5.38x381 297 TM5 I => C 4.583↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 288 ECL2 I => C 6.583↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 3.33x33 219 TM3 M => C 15.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 3.37x37 223 TM3 Q => C 60.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 7.34x33 365 TM7 A => C 4.333↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 5.35x36 294 TM5 I => C 7.667↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 3.26x26 212 TM3 R => C Abolished effect K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 6.57x57 359 TM6 A => C 3.5↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 6.58x58 360 TM6 F => C 8.333↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 6.40x40 342 TM6 R => A 2.305↓ K(d) (Binding - Radioligand saturation) secretin Chan KY et al (2001) 10.5281/zenodo.60790
sctr_human 4.66x66 279 TM4 F => C 2.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 6.37x37 339 TM6 R => A 3.525↓ K(d) (Binding - Radioligand saturation) secretin Chan KY et al (2001) 10.5281/zenodo.60790
sctr_human 282 ECL2 D => C Abolished effect K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 6.40x40 342 TM6 R => I 1.633↓ EC50 (Functional - cAMP accumulation) secretin Chan KY et al (2001) 10.5281/zenodo.60790
sctr_human 3.32x32 218 TM3 V => C 5.5↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 45.52x52 287 ECL2 D => C 40.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 7.36x35 367 TM7 E => C 15.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 7.36x35 367 TM7 E => C 4.417↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 3.27x27 213 TM3 A => C 5.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 200 ECL1 F => Y N/A N/A Nachtergael I et al (2003)
sctr_human 5.37x38 296 TM5 W => C 5.333↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 5.64x64 323 TM5 K => I 3.704↑ K(d) (Binding - Radioligand saturation) secretin Chan KY et al (2001) 10.5281/zenodo.60790
sctr_human 3.34x34 220 TM3 V => C 7.083↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 5.64x64 323 TM5 K => I 5.667↓ EC50 (Functional - cAMP accumulation) secretin Chan KY et al (2001) 10.5281/zenodo.60790
sctr_human 3.36x36 222 TM3 F => C 75.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 6.40x40 342 TM6 R => I N/A N/A Chan KY et al (2001)
sctr_human 3.33x33 219 TM3 M => C 2.917↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 5.38x381 297 TM5 I => C 2.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 6.37x37 339 TM6 R => I 1.901↓ K(d) (Binding - Radioligand saturation) secretin Chan KY et al (2001) 10.5281/zenodo.60790
sctr_human 289 ECL2 N => C 15.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 284 ECL2 G => C Abolished effect K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 5.34x35 293 TM5 S => C 5.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 4.68x68 281 TM4 E => C 220.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 211 ECL1 H => C Abolished effect K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 6.58x58 360 TM6 F => C 5.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 5.33x34 292 TM5 A => C 4.583↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 5.37x38 296 TM5 W => C 2.5↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 7.40x39 371 TM7 F => C 3.083↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 364 ECL3 D => C 7.667↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 362 ECL3 P => C 4.25↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 7.42x41 373 TM7 E => C 25.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 7.37x36 368 TM7 I => C 5.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 6.56x56 358 TM6 F => C 160.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 283 ECL2 V => C 10.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 209 ECL1 D => C 2.25↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 7.34x33 365 TM7 A => C 3.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 7.43x42 374 TM7 L => C 4.083↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 3.26x26 212 TM3 R => C 205.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 4.67x67 280 TM4 L => C 5.667↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 6.37x37 339 TM6 R => E N/A N/A Chan KY et al (2001)
sctr_human 7.43x42 374 TM7 L => C 50.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 209 ECL1 D => C 15.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 7.35x34 366 TM7 M => C 15.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 3.30x30 216 TM3 K => C 4.5↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 210 ECL1 A => C 110.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 3.32x32 218 TM3 V => C 2.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 5.32x33 291 TM5 N => C 1.5↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 3.31x31 217 TM3 L => C 1.0 EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 290 ECL2 A => C 5.0↓ EC50 (Functional - cAMP accumulation) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 7.35x34 366 TM7 M => C 6.0↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 3.36x36 222 TM3 F => C 16.417↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 330 ICL3 R => I 1.0 EC50 (Functional - cAMP accumulation) secretin Chan KY et al (2001) 10.5281/zenodo.60790
sctr_human 210 ECL1 A => C 3.25↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)
sctr_human 5.36x37 295 TM5 W => C 24.083↓ K(i) (Binding - Radioligand competition/displacement) secretin Dong M et al (2012) Hollenstein K et al (2014)


Residue

Diagrams

ICL1 R R L H ICL1ECL1 F S S D D V T Y C D A H ECL1ICL2 S F F S E R ICL2ECL2 D V G C W D I N A ECL2ICL3 Q E T R G ICL3ECL3 P E D ECL3N-term M R P H L S P P L Q Q L L L P V L L A C A A H S T G A L P R L C D V L Q V L W E E Q D Q C L Q E L S R E Q T G D L G T E Q P V P G C E G M W D N I S C W P S S V P G R M V E V E C P R F L R M L T S R N G S L F R N C T Q D G W S E T F P R P N L A C G V N V N D S N-termC-term S F S N S T K A S H L E Q S Q G T C R T S I I C-term S N E K R H S Y L L K L K V M Y T V G Y S S S L V M L L V A L G I L C A F C T R N Y I H M H L F V S F I L R A L S N F I K D A V L R A G C K L V M V L F Q Y C I M A N Y S W L L V E G L Y L H T L L A I K Y L Q G F V A F G W G S P A I F V A L W A I A R H F L E N A S I W W I I R G P V I L S I L I N F I L F I N I L R I L M R K L R T N E V S H Y K R L A R S T L L L I P L F G I H Y I V F A F S A M E I Q L F F E L A L G S F Q G L V V A V L Y C F L N G E V Q K W H L L H P V Q L E K W Q Q R E F P V A
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
L L M V L S S S Y G V T Y M V K L K L L 1 M H L F V S F I L R A L S N F I K D A V 2 V L L W S Y N A M I C Y Q F L V M V L K 3 Y L Q G F V A G F W G S P A I F V A L W A 4 F L I F N I L I S L I V P G R I I W W I S 5 L L L I P L F G I H Y I V F A F S 6 V A V V L G Q F S G L A L E F F L Q I 7
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Residue Table


GPCRdb(A)
GPCRdb(B)
secretin receptor
TM3
3x22 3.26x26 R212
3x23 3.27x27 A213
3x24 3.28x28 G214
3x26 3.30x30 K216
3x27 3.31x31 L217
3x28 3.32x32 V218
3x29 3.33x33 M219
3x30 3.34x34 V220
3x31 3.35x35 L221
3x32 3.36x36 F222
3x33 3.37x37 Q223
TM4
4x66 4.66x66 F279
4x67 4.67x67 L280
4x68 4.68x68 E281
TM5
5x37 5.32x33 N291
5x38 5.33x34 A292
5x39 5.34x35 S293
5x40 5.35x36 I294
5x41 5.36x37 W295
5x42 5.37x38 W296
5x421 5.38x381 I297
5x68 5.64x64 K323
TM6
6x32 6.37x37 R339
6x35 6.40x40 R342
6x51 6.56x56 F358
6x52 6.57x57 A359
6x53 6.58x58 F360
6x54 6.59x59 S361
TM7
7x29 7.34x33 A365
7x30 7.35x34 M366
7x31 7.36x35 E367
7x32 7.37x36 I368
7x33 7.38x37 Q369
7x34 7.39x38 L370
7x35 7.40x39 F371
7x36 7.41x40 F372
7x37 7.42x41 E373
7x38 7.43x42 L374