MC2 receptor (acthr_cavpo)

FAMILY

Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC2 receptor

GENE

MC2R

ORGANISM

Guinea pig (Cavia porcellus)

ALT. NAMES

Adrenocorticotropic hormone receptor, ACTH receptor, ACTH-R, Adrenocorticotropin receptor, Melanocortin receptor 2, MC2-R

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
K
H
I
I
H
A
S
G
N
10
                   
V
N
G
T
A
R
N
N
S
D
20
            TM1  
C
P
H
V
A
L
P
E
E
I
30
                   
F
F
I
I
S
I
T
G
V
L
40
                   
E
N
L
I
I
I
L
A
V
I
50
    ICL1 TM2  
K
N
K
N
L
Q
F
P
M
Y
60
                   
F
F
I
C
S
L
A
I
S
D
70
                   
M
L
G
S
L
Y
K
I
L
E
80
                   
S
I
L
I
M
F
R
N
M
G
90
ECL1   TM3    
Y
F
K
P
H
G
S
F
E
T
100
                   
T
T
D
D
I
I
D
T
M
F
110
                   
I
L
S
L
L
G
S
I
F
S
120
                   
L
L
A
I
A
V
D
R
Y
I
130
        ICL2    
T
I
F
H
A
L
Q
Y
H
S
140
    TM4          
I
V
T
M
H
R
T
I
A
V
150
                   
L
S
I
I
W
T
F
C
I
G
160
                   
S
G
I
T
M
V
L
F
S
H
170
TM5              
H
V
P
T
V
L
T
F
T
S
180
                   
L
F
P
L
M
L
V
F
I
L
190
                   
C
L
Y
V
H
M
F
L
M
A
200
                   
R
S
H
A
R
N
I
S
T
L
210
ICL3 TM6      
P
R
G
N
M
R
G
A
I
T
220
                   
L
T
I
L
L
G
V
F
I
F
230
                   
C
W
A
P
F
I
L
H
I
L
240
          ECL3 TM7
L
V
T
F
C
P
N
N
P
Y
250
               
C
T
C
Y
I
S
L
F
H
V
260
                   
N
G
M
L
I
M
C
N
A
V
270
                   
I
D
P
F
I
Y
A
F
R
S
280
H8                
P
E
L
R
S
A
F
R
R
M
290
        C-term
I
S
Y
S
K
C
L

LINKS

DIAGRAMS

ICL1 K N L Q ICL1ECL1 Y F K P H ECL1ICL2 A L Q Y H S I V ICL2ECL2 H ECL2ICL3 T L P R G ICL3ECL3 P N ECL3N-term M K H I I H A S G N V N G T A R N N S D C P H V A L N-termC-term K C L C-term P E E I F F I I S I T G V L E N L I I I L A V I K N F P M Y F F I C S L A I S D M L G S L Y K I L E S I L I M F R N M G G S F E T T T D D I I D T M F I L S L L G S I F S L L A I A V D R Y I T I F H T M H R T I A V L S I I W T F C I G S G I T M V L F S H V P T V L T F T S L F P L M L V F I L C L Y V H M F L M A R S H A R N I S N M R G A I T L T I L L G V F I F C W A P F I L H I L L V T F C N P Y C T C Y I S L F H V N G M L I M C N A V I D P F I Y A F R S P E F R R S L R S A M I S Y
Pick color:
 
 
 
 
 
 
 
 
 
 
 
 




Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

L N E L V G T I S I I F F I E E P 1 C S L A I S D M L G S L Y K I L E S I L 2 A L L S F I S G L L S L I F M T D I I D 3 T I A V L S I I W T F C I G S G I T M V 4 Y L C L I F V L M L P F L S T F T L V T 5 T I L L G V F I F C W A P F I L H I L L 6 F P D I V A N C M I L M G N V H F L S 7
Pick color:
 
 
 
 
 
 
 
 
 
 
 
 




Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

ENDOGENOUS LIGANDS

No endogenous ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available