MC2 receptor (acthr_pig)

FAMILY

Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC2 receptor

GENE

MC2R

ORGANISM

Pig (Sus scrofa)

ALT. NAMES

Adrenocorticotropic hormone receptor, ACTH receptor, ACTH-R, Adrenocorticotropin receptor, Melanocortin receptor 2, MC2-R

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
K
H
I
T
D
L
Y
E
S
10
                   
V
N
S
T
M
S
N
K
S
D
20
            TM1  
C
P
P
V
V
L
P
E
E
V
30
                   
F
F
T
I
S
V
I
G
V
L
40
                   
E
N
L
I
V
L
L
A
V
I
50
    ICL1 TM2  
K
N
K
N
L
Q
S
P
M
Y
60
                   
F
F
I
C
S
L
A
I
S
D
70
                   
M
L
G
S
L
Y
K
I
L
E
80
                   
N
I
L
I
I
F
R
N
M
G
90
ECL1   TM3    
Y
L
E
P
R
G
G
F
E
S
100
                   
T
A
D
D
V
V
D
S
L
F
110
                   
I
L
S
L
L
G
S
I
C
S
120
                   
L
S
A
I
A
A
D
R
Y
I
130
        ICL2    
T
I
F
H
A
L
Q
Y
Q
R
140
    TM4          
L
V
T
P
R
R
A
A
V
V
150
                   
L
L
I
I
W
A
C
C
I
G
160
                   
S
G
I
T
I
V
T
F
S
H
170
TM5              
H
V
P
A
V
I
A
F
T
A
180
                   
L
F
P
L
M
L
V
F
I
L
190
                   
C
L
Y
G
H
M
F
L
L
A
200
      ICL3 TM6
R
S
H
A
R
R
V
S
T
L
210
                   
P
R
A
N
M
K
G
A
I
T
220
                   
L
T
V
L
L
G
V
F
I
F
230
                   
C
W
A
P
F
V
L
H
I
L
240
          ECL3  
L
M
T
F
C
P
A
D
P
Y
250
            TM7  
C
A
C
Y
L
A
L
F
Q
V
260
                   
N
A
V
L
I
M
C
N
A
I
270
                   
I
D
P
F
I
Y
A
F
R
S
280
H8                
P
E
L
R
D
A
F
K
K
M
290
        C-term
I
I
C
K
R
Y
P

LINKS

DIAGRAMS

L N E L V G I V S I T F F V E E P 1 C S L A I S D M L G S L Y K I L E N I L 2 A S L S C I S G L L S L I F L S D V V D 3 A A V V L L I I W A C C I G S G I T I V 4 Y L C L I F V L M L P F L A T F A I V A 5 T V L L G V F I F C W A P F V L H I L L 6 F P D I I A N C M I L V A N V Q F L 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

ICL1 K N L Q ICL1ECL1 N M G Y L E P R ECL1ICL2 A L Q Y Q R L V ICL2ECL2 F S H ECL2ICL3 A R R V ICL3ECL3 P A D P Y C A C Y L A ECL3N-term M K H I T D L Y E S V N S T M S N K S D C P P V V L N-termC-term R Y P C-term P E E V F F T I S V I G V L E N L I V L L A V I K N S P M Y F F I C S L A I S D M L G S L Y K I L E N I L I I F R G G F E S T A D D V V D S L F I L S L L G S I C S L S A I A A D R Y I T I F H T P R R A A V V L L I I W A C C I G S G I T I V T H V P A V I A F T A L F P L M L V F I L C L Y G H M F L L A R S H S T L P R A N M K G A I T L T V L L G V F I F C W A P F V L H I L L M T F C L F Q V N A V L I M C N A I I D P F I Y A F R S P E F K K K L R D A M I I C
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

ENDOGENOUS LIGANDS

ACTH

HOMOLOGY MODELS

No homology models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available