C5a1 receptor (c5ar1_macmu)

FAMILY

Class A (Rhodopsin) Peptide receptors Complement peptide receptors C5a1 receptor

GENE

C5AR1 (C5AR, C5R1)

ORGANISM

Rhesus macaque (Macaca mulatta)

ALT. NAMES

C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin chemotactic receptor, C5a-R, C5aR, CD88

SOURCE

SWISSPROT

SEQUENCE

N-term        
T
P
D
Y
G
H
Y
D
D
K
10
                   
D
T
L
D
A
N
T
P
V
D
20
            TM1  
K
T
S
N
T
L
R
V
P
D
30
                   
I
L
A
L
V
I
F
A
V
V
40
                   
F
L
V
G
V
L
R
N
A
L
50
                   
V
V
W
V
T
A
F
E
A
K
60
ICL1 TM2      
R
T
I
N
A
I
W
F
L
N
70
                   
L
A
V
A
D
F
L
S
C
L
80
                   
A
L
P
I
L
F
T
S
I
V
90
    ECL1   TM3
Q
H
H
H
W
P
F
G
G
A
100
                   
A
C
R
I
L
P
S
L
I
L
110
                   
L
N
M
Y
A
S
I
L
L
L
120
                   
A
T
I
S
A
D
R
F
L
L
130
      ICL2      
V
F
N
P
I
W
C
Q
N
F
140
  TM4            
R
G
A
G
L
A
W
I
A
C
150
                   
A
V
A
W
G
L
A
L
L
L
160
                   
T
I
P
S
F
L
Y
R
V
V
170
ECL2            
R
E
E
Y
F
P
P
K
V
L
180
              TM5
C
G
V
D
H
G
H
D
K
R
190
                   
R
E
R
A
V
A
I
A
R
L
200
                   
V
L
G
F
V
W
P
L
L
T
210
                   
L
T
M
C
Y
T
F
L
L
L
220
          ICL3  
R
T
W
S
R
R
A
T
R
S
230
TM6              
T
K
T
L
K
V
V
V
A
V
240
                   
V
A
S
F
F
I
F
W
L
P
250
                   
Y
Q
V
T
G
M
M
M
S
F
260
  ECL3 TM7    
L
E
P
S
S
P
T
F
L
L
270
                   
L
K
K
L
D
S
L
C
I
S
280
                   
F
A
Y
I
N
C
C
I
N
P
290
            H8    
I
I
Y
V
V
A
G
Q
G
F
300
                   
Q
G
R
L
R
K
S
L
P
S
310
C-term        
L
L
R
N
V
L
T
E
E
S
320
                   
M
V
R
E
S
K
S
F
T
R
330
                   
S
T
V
D
T
M
A
Q
K
T
340

LINKS

DIAGRAMS

A N R L V G V L F V V A F I V L A L I D 1 L N L A V A D F L S C L A L P I L F T S 2 T A L L L I S A Y M N L L I L S P L I R 3 A W I A C A V A W G L A L L L T I P S 4 Y C M T L T L L P W V F G L V L R A I A V 5 V A V V A S F F I F W L P Y Q V T G M M 6 I P N I C C N I Y A F S I C L S D L K 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

ICL1 A K R ICL1ECL1 H H W P F ECL1ICL2 P I W C Q N F R ICL2ECL2 V V R E E Y F P P K V L C G V D H G H ECL2ICL3 R A T R S ICL3ECL3 E P S ECL3N-term T P D Y G H Y D D K D T L D A N T P V D K T S N T L N-termC-term S L P S L L R N V L T E E S M V R E S K S F T R S T V D T M A Q K T C-term R V P D I L A L V I F A V V F L V G V L R N A L V V W V T A F E T I N A I W F L N L A V A D F L S C L A L P I L F T S I V Q H G G A A C R I L P S L I L L N M Y A S I L L L A T I S A D R F L L V F N G A G L A W I A C A V A W G L A L L L T I P S F L Y R D K R R E R A V A I A R L V L G F V W P L L T L T M C Y T F L L L R T W S R T K T L K V V V A V V A S F F I F W L P Y Q V T G M M M S F L S P T F L L L K K L D S L C I S F A Y I N C C I N P I I Y V V A G Q G L R K F Q G R
Pick color:
 
 
 
 
 
 
 
 
 
 
 
 




Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

ENDOGENOUS LIGANDS

C5a,

C3a,

C5a des-Arg,

ribosomal protein S19

HOMOLOGY MODELS

No homology models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available