GPR25 (gpr25_mouse)

FAMILY

Class A (Rhodopsin) Orphan receptors Class A orphans GPR25

GENE

Gpr25 (Gm1300)

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

Probable G-protein coupled receptor 25

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
Q
S
T
E
P
W
S
P
S
10
                   
W
G
T
L
S
W
D
Y
S
G
20
                   
S
G
S
L
D
Q
V
E
L
C
30
        TM1      
P
A
W
N
L
P
Y
G
H
A
40
                   
I
I
P
A
L
Y
L
A
A
F
50
                   
A
V
G
L
P
G
N
A
F
V
60
                   
V
W
L
L
S
R
Q
R
G
P
70
ICL1 TM2      
R
R
L
V
D
T
F
V
L
H
80
                   
L
A
A
A
D
L
G
F
V
L
90
                   
T
L
P
L
W
A
A
A
E
A
100
    ECL1   TM3
R
G
G
L
W
P
F
G
D
G
110
                   
L
C
K
V
S
S
F
A
L
A
120
                   
V
T
R
C
A
G
A
L
L
L
130
                   
A
G
M
S
V
D
R
Y
L
A
140
      ICL2      
V
G
R
P
L
S
A
R
P
L
150
  TM4            
R
S
A
R
C
V
R
A
V
C
160
                   
G
A
A
W
A
A
A
F
L
A
170
                   
G
L
P
A
L
L
Y
R
G
L
180
ECL2            
Q
P
S
L
D
G
V
G
S
Q
190
              TM5
C
A
E
E
P
W
E
A
L
Q
200
                   
G
V
G
L
L
L
L
L
L
T
210
                   
F
A
L
P
L
A
V
T
L
I
220
                   
C
Y
W
R
V
S
R
R
L
P
230
  ICL3 TM6    
R
V
G
R
A
R
S
N
S
L
240
                   
R
I
I
F
T
V
E
S
V
F
250
                   
V
G
C
W
L
P
F
G
V
L
260
                   
R
S
L
F
H
L
A
R
L
Q
270
ECL3 TM7      
A
L
P
L
P
C
S
L
L
L
280
                   
A
L
R
W
G
L
T
V
T
T
290
                   
C
L
A
F
V
N
S
S
A
N
300
              H8  
P
V
I
Y
L
L
L
D
R
S
310
                   
F
R
A
R
A
R
F
G
L
C
320
    C-term    
A
R
A
G
R
Q
V
R
R
I
330
                   
S
S
A
S
S
L
S
R
D
D
340
                   
S
S
V
F
R
G
R
S
P
K
350
               
V
N
S
A
S
A
T
W

LINKS

Guide To Pharmacology

UniProt

DIAGRAMS

ICL1 R G P R ICL1ECL1 G L W P F ECL1ICL2 P L S A R P L R ICL2ECL2 G L Q P S L D G V G S Q C A E E P W E ECL2ICL3 V G ICL3ECL3 A L P L ECL3N-term M Q S T E P W S P S W G T L S W D Y S G S G S L D Q V E L C P A W N N-termC-term A G R Q V R R I S S A S S L S R D D S S V F R G R S P K V N S A S A T W C-term L P Y G H A I I P A L Y L A A F A V G L P G N A F V V W L L S R Q R L V D T F V L H L A A A D L G F V L T L P L W A A A E A R G G D G L C K V S S F A L A V T R C A G A L L L A G M S V D R Y L A V G R S A R C V R A V C G A A W A A A F L A G L P A L L Y R A L Q G V G L L L L L L T F A L P L A V T L I C Y W R V S R R L P R R A R S N S L R I I F T V E S V F V G C W L P F G V L R S L F H L A R L Q P C S L L L A L R W G L T V T T C L A F V N S S A N P V I Y L L L D R S A R F R F R A R G L C A
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

A N G P L G V A F A A L Y L A P I I A H 1 L H L A A A D L G F V L T L P L W A A A 2 G A L L L A G A C R T V A L A F S S V K 3 V R A V C G A A W A A A F L A G L P A L 4 Y C I L T V A L P L A F T L L L L L L G V 5 F T V E S V F V G C W L P F G V L R S L 6 V P N A S S N V F A L C T T V T L G W 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

ENDOGENOUS LIGANDS

No endogenous ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available