MRGPRX1 (mrgx1_mouse)

FAMILY

Class A (Rhodopsin) Orphan receptors Class A orphans MRGPRX1

GENE

Mrgprx1 (Mrgc11, Mrgprc11)

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

Mas-related G-protein coupled receptor member X1, Mas-related G-protein coupled receptor member C11, Sensory neuron-specific G-protein coupled receptor 1

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
D
P
T
I
S
S
H
D
T
10
                   
E
S
T
P
L
N
E
T
G
H
20
        TM1      
P
N
C
T
P
I
L
T
L
S
30
                   
F
L
V
L
I
T
T
L
V
G
40
                   
L
A
G
N
T
I
V
L
W
L
50
          ICL1 TM2
L
G
F
R
M
R
R
K
A
I
60
               
S
V
Y
I
L
N
L
A
L
A
70
                   
D
S
F
F
L
C
C
H
F
I
80
                   
D
S
L
L
R
I
I
D
F
Y
90
ECL1       TM3
G
L
Y
A
H
K
L
S
K
D
100
                   
I
L
G
N
A
A
I
I
P
Y
110
                   
I
S
G
L
S
I
L
S
A
I
120
                   
S
T
E
R
C
L
C
V
L
W
130
ICL2            
P
I
W
Y
H
C
H
R
P
R
140
TM4              
N
M
S
A
I
I
C
A
L
I
150
                   
W
V
L
S
F
L
M
G
I
L
160
          ECL2  
D
W
F
S
G
F
L
G
E
T
170
TM5              
H
H
H
L
W
K
N
V
D
F
180
                   
I
I
T
A
F
L
I
F
L
F
190
                   
M
L
L
S
G
S
S
L
A
L
200
            ICL3
L
L
R
I
L
C
G
P
R
R
210
  TM6            
K
P
L
S
R
L
Y
V
T
I
220
                   
A
L
T
V
M
V
Y
L
I
C
230
                   
G
L
P
L
G
L
Y
L
F
L
240
          ECL3  
L
Y
W
F
G
V
H
L
H
Y
250
TM7              
P
F
C
H
I
Y
Q
V
T
A
260
                   
V
L
S
C
V
N
S
S
A
N
270
                   
P
I
I
Y
F
L
V
G
S
F
280
  C-term      
R
Q
H
R
K
H
R
S
L
K
290
                   
R
V
L
K
R
A
L
E
D
T
300
                   
P
E
E
D
E
Y
T
D
S
H
310
                   
L
H
K
T
T
E
I
S
E
S
320
   
R
Y

LINKS

ChEMBL

UniProt

DIAGRAMS

ICL1 R R ICL1ECL1 D F Y G L Y A H K L ECL1ICL2 P I W Y H C H R ICL2ECL2 F L G E T ECL2ICL3 G P R R K ICL3ECL3 V H L H Y ECL3N-term M D P T I S S H D T E S T P L N E T G H P N C T N-termC-term Q H R K H R S L K R V L K R A L E D T P E E D E Y T D S H L H K T T E I S E S R Y C-term P I L T L S F L V L I T T L V G L A G N T I V L W L L G F R M K A I S V Y I L N L A L A D S F F L C C H F I D S L L R I I S K D I L G N A A I I P Y I S G L S I L S A I S T E R C L C V L W P R N M S A I I C A L I W V L S F L M G I L D W F S G H H H L W K N V D F I I T A F L I F L F M L L S G S S L A L L L R I L C P L S R L Y V T I A L T V M V Y L I C G L P L G L Y L F L L Y W F G P F C H I Y Q V T A V L S C V N S S A N P I I Y F L V G S F R
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

T N G A L G V L T T I L V L F S L T L I 1 L N L A L A D S F F L C C H F I D S L L 2 A S L I S L G S I Y P I I A A N G L I D 3 S A I I C A L I W V L S F L M G I L D W 4 S S G S L L M F L F I L F A T I I F D V 5 A L T V M V Y L I C G L P L G L Y L F L 6 I P N A S S N V C S L V A T V Q Y I H 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

ENDOGENOUS LIGANDS

No endogenous ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available