MRGPRX2 (mrgx2_rhibe)

FAMILY

Class A (Rhodopsin) Orphan receptors Class A orphans MRGPRX2

GENE

MRGPRX2 (MRGX2)

ORGANISM

Black snub-nosed monkey (Rhinopithecus bieti)

ALT. NAMES

Mas-related G-protein coupled receptor member X2

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
D
P
T
T
P
A
W
G
T
10
                   
E
S
T
T
M
N
G
N
D
Q
20
                   
A
L
P
L
L
C
G
K
E
T
30
TM1              
L
I
L
V
L
L
I
L
F
I
40
                   
A
L
V
G
L
V
G
N
A
F
50
                   
V
L
W
L
L
G
F
R
M
R
60
ICL1 TM2      
R
N
A
F
S
V
Y
V
L
S
70
                   
L
A
G
A
D
F
L
F
L
C
80
                   
F
P
M
I
N
C
L
E
Y
L
90
            ECL1
I
N
F
F
H
S
I
S
I
N
100
  TM3            
F
P
S
F
F
T
T
V
M
T
110
                   
C
A
Y
L
A
G
L
S
M
L
120
                   
S
A
I
S
T
E
R
C
L
S
130
      ICL2      
V
L
W
P
I
W
Y
R
C
R
140
  TM4            
R
P
R
H
L
S
A
V
L
C
150
                   
V
L
L
W
A
L
S
L
L
L
160
                   
S
I
L
E
G
K
F
C
G
L
170
ECL2   TM5    
L
F
S
D
G
D
S
G
W
C
180
                   
Q
T
F
D
F
I
T
A
A
W
190
                   
L
M
F
L
F
V
V
L
C
G
200
                   
S
S
L
A
L
L
V
R
I
L
210
    ICL3 TM6  
C
G
S
Q
G
L
P
L
T
R
220
                   
L
Y
L
T
I
L
L
T
V
L
230
                   
I
F
L
L
C
G
L
P
F
G
240
                   
I
Q
W
F
L
I
L
W
I
W
250
ECL3   TM7    
K
N
S
D
V
L
F
C
H
I
260
                   
H
P
V
S
V
V
L
S
S
F
270
                   
N
S
S
A
N
P
I
I
Y
F
280
                   
F
V
G
S
F
R
K
Q
W
R
290
C-term        
L
R
Q
P
V
L
K
L
A
L
300
                   
Q
R
A
L
Q
D
T
A
E
V
310
                   
D
H
S
E
G
C
F
S
Q
G
320
                   
T
L
E
M
S
G
S
S
L
V
330

LINKS

DIAGRAMS

ICL1 R R ICL1ECL1 I S I N F ECL1ICL2 P I W Y R C R R ICL2ECL2 G L L F S D G ECL2ICL3 S Q G L ICL3ECL3 K N S D V ECL3N-term M D P T T P A W G T E S T T M N G N D Q A L P L L C G K E N-termC-term R K Q W R L R Q P V L K L A L Q R A L Q D T A E V D H S E G C F S Q G T L E M S G S S L V C-term T L I L V L L I L F I A L V G L V G N A F V L W L L G F R M N A F S V Y V L S L A G A D F L F L C F P M I N C L E Y L I N F F H S P S F F T T V M T C A Y L A G L S M L S A I S T E R C L S V L W P R H L S A V L C V L L W A L S L L L S I L E G K F C D S G W C Q T F D F I T A A W L M F L F V V L C G S S L A L L V R I L C G P L T R L Y L T I L L T V L I F L L C G L P F G I Q W F L I L W I W L F C H I H P V S V V L S S F N S S A N P I I Y F F V G S F
Pick color:
 
 
 
 
 
 
 
 
 
 
 
 




Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

A N G V L G V L A I F L I L L V L I L T 1 L S L A G A D F L F L C F P M I N C L E 2 A S L M S L G A L Y A C T M V T T F F S 3 S A V L C V L L W A L S L L L S I L E G 4 S S G C L V V F L F M L W A A T I F D F 5 L L T V L I F L L C G L P F G I Q W F L 6 I P N A S S N F S S L V V S V P H I H 7
Pick color:
 
 
 
 
 
 
 
 
 
 
 
 




Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

ENDOGENOUS LIGANDS

No endogenous ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available