MC1 receptor (mshr_caphi)

FAMILY

Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC1 receptor

GENE

MC1R (MSHR)

ORGANISM

Goat (Capra hircus)

ALT. NAMES

Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
P
A
L
G
S
P
R
R
L
10
                   
L
G
S
L
N
C
T
P
P
A
20
                   
T
L
P
L
T
L
A
P
N
R
30
                   
T
G
P
Q
C
L
E
V
S
I
40
TM1              
P
D
G
L
F
L
S
L
G
L
50
                   
V
S
L
V
E
N
V
L
V
V
60
            ICL1
A
A
I
A
K
N
R
N
L
H
70
TM2              
S
P
M
Y
Y
F
I
C
C
L
80
                   
A
M
S
D
L
L
V
S
V
S
90
                   
N
V
L
E
T
A
V
M
L
L
100
        ECL1    
L
E
A
G
V
L
A
T
R
A
110
TM3              
A
V
V
Q
Q
L
D
N
V
I
120
                   
D
V
L
I
C
S
S
M
V
S
130
                   
S
L
C
F
L
G
A
I
A
V
140
                   
D
R
Y
I
S
I
F
Y
A
L
150
ICL2     TM4  
R
Y
H
S
V
V
T
L
P
R
160
                   
A
W
R
I
I
A
A
I
W
V
170
                   
A
S
I
L
T
S
V
L
S
I
180
    ECL2 TM5  
T
Y
Y
N
H
T
V
V
L
L
190
                   
C
L
V
G
F
F
I
A
M
L
200
                   
A
L
M
A
V
L
Y
V
H
M
210
                   
L
A
R
A
C
Q
H
A
R
G
220
            ICL3
I
A
R
L
Q
K
R
Q
R
P
230
    TM6          
I
H
Q
G
F
G
L
K
G
A
240
                   
A
T
L
T
I
L
L
G
V
F
250
                   
F
L
C
W
G
P
F
F
L
H
260
                   
L
S
L
I
V
L
C
P
Q
H
270
ECL3            
P
T
C
G
C
I
F
K
N
F
280
TM7              
N
L
F
L
A
L
I
I
C
N
290
                   
A
I
V
D
P
L
I
Y
A
F
300
  H8              
R
S
Q
E
L
R
K
T
L
Q
310
C-term  
E
V
L
Q
C
S
W

LINKS

DIAGRAMS

ICL1 R N L H ICL1ECL1 V L A T ECL1ICL2 A L R Y H S V V ICL2ECL2 Y N ECL2ICL3 R Q R P I H ICL3ECL3 P Q H P T C G C I F K ECL3N-term M P A L G S P R R L L G S L N C T P P A T L P L T L A P N R T G P Q C L E V S I N-termC-term L Q E V L Q C S W C-term P D G L F L S L G L V S L V E N V L V V A A I A K N S P M Y Y F I C C L A M S D L L V S V S N V L E T A V M L L L E A G R A A V V Q Q L D N V I D V L I C S S M V S S L C F L G A I A V D R Y I S I F Y T L P R A W R I I A A I W V A S I L T S V L S I T Y H T V V L L C L V G F F I A M L A L M A V L Y V H M L A R A C Q H A R G I A R L Q K Q G F G L K G A A T L T I L L G V F F L C W G P F F L H L S L I V L C N F N L F L A L I I C N A I V D P L I Y A F R S Q E L R K T
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

V N E V L S V L G L S L F L G D P 1 C C L A M S D L L V S V S N V L E T A V 2 A G L F C L S S V M S S C I L V D I V N 3 A W R I I A A I W V A S I L T S V L S I 4 Y L V A M L A L M A I F F G V L C L L V 5 T I L L G V F F L C W G P F F L H L S L 6 L P D V I A N C I I L A L F L N F N 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

ENDOGENOUS LIGANDS

No endogenous ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available