MC1 receptor (mshr_mampr)

FAMILY

Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC1 receptor

GENE

MC1R

ORGANISM

Siberian woolly mammoth (Mammuthus primigenius)

ALT. NAMES

Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
P
M
Q
G
A
Q
G
R
L
10
                   
R
G
S
L
N
A
T
P
P
T
20
                   
T
P
H
S
G
L
A
G
N
Q
30
                   
T
G
P
W
C
L
E
V
S
I
40
TM1              
P
D
E
L
F
L
S
L
G
L
50
                   
V
S
L
V
E
N
M
L
V
V
60
            ICL1
A
A
I
A
K
N
R
N
L
H
70
TM2              
S
P
M
Y
Y
F
I
C
C
L
80
                   
A
V
S
D
L
L
V
S
V
S
90
                   
N
V
L
E
T
A
V
M
L
L
100
        ECL1    
L
E
A
G
V
L
A
A
W
A
110
TM3              
G
V
V
Q
Q
L
D
N
A
I
120
                   
D
V
F
I
C
G
S
M
V
S
130
                   
S
L
C
F
L
G
A
I
A
V
140
                   
D
R
Y
I
T
I
F
Y
A
L
150
ICL2     TM4  
R
Y
H
S
I
V
T
L
P
R
160
                   
A
R
W
A
I
A
T
I
W
A
170
                   
A
S
V
V
C
S
T
L
F
I
180
    ECL2 TM5  
A
Y
Y
D
C
T
A
V
L
L
190
                   
C
L
V
S
F
F
L
A
L
V
200
                   
V
L
M
A
V
L
Y
M
H
M
210
                   
L
A
R
A
C
L
H
A
R
S
220
            ICL3
I
A
R
L
H
K
R
W
R
P
230
    TM6          
V
H
Q
G
L
G
L
K
G
A
240
                   
A
T
L
S
I
L
L
G
S
F
250
                   
F
L
C
W
G
P
F
F
L
H
260
                   
L
T
L
I
V
L
C
P
Q
H
270
ECL3            
P
T
C
S
C
V
F
K
N
F
280
TM7              
K
L
F
L
T
L
I
I
C
N
290
                   
S
I
V
D
P
L
I
Y
A
F
300
  H8              
R
S
Q
E
L
R
K
T
L
K
310
C-term  
E
V
L
L
C
S
W

LINKS

DIAGRAMS

ICL1 R N L H ICL1ECL1 V L A A ECL1ICL2 A L R Y H S I V ICL2ECL2 Y D ECL2ICL3 R W R P V H ICL3ECL3 P Q H P T C S C V F K ECL3N-term M P M Q G A Q G R L R G S L N A T P P T T P H S G L A G N Q T G P W C L E V S I N-termC-term L K E V L L C S W C-term P D E L F L S L G L V S L V E N M L V V A A I A K N S P M Y Y F I C C L A V S D L L V S V S N V L E T A V M L L L E A G W A G V V Q Q L D N A I D V F I C G S M V S S L C F L G A I A V D R Y I T I F Y T L P R A R W A I A T I W A A S V V C S T L F I A Y C T A V L L C L V S F F L A L V V L M A V L Y M H M L A R A C L H A R S I A R L H K Q G L G L K G A A T L S I L L G S F F L C W G P F F L H L T L I V L C N F K L F L T L I I C N S I V D P L I Y A F R S Q E L R K T
Pick color:
 
 
 
 
 
 
 
 
 
 
 
 




Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

M N E V L S V L G L S L F L E D P 1 C C L A V S D L L V S V S N V L E T A V 2 A G L F C L S S V M S G C I F V D I A N 3 A R W A I A T I W A A S V V C S T L F I 4 Y L V A M L V V L A L F F S V L C L L V 5 S I L L G S F F L C W G P F F L H L T L 6 L P D V I S N C I I L T L F L K F N 7
Pick color:
 
 
 
 
 
 
 
 
 
 
 
 




Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

ENDOGENOUS LIGANDS

No endogenous ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available