DP2 receptor (q56d28_cavpo)

FAMILY

Class A (Rhodopsin) Lipid receptors Prostanoid receptors DP2 receptor

GENE

CRTH2 (PTGDR2)

ORGANISM

Guinea pig (Cavia porcellus)

ALT. NAMES

Chemoattractant receptor-homologous molecule expressed on Th2 cells, Prostaglandin D2 receptor 2

SOURCE

TREMBL

SEQUENCE

N-term        
M
A
N
A
T
L
K
P
L
C
10
                   
P
V
L
K
D
M
S
L
L
G
20
                   
S
H
S
N
S
S
L
R
Y
M
30
TM1              
D
H
I
S
V
L
L
H
G
L
40
                   
A
A
L
L
G
L
V
E
N
G
50
                   
L
I
V
F
V
V
G
C
R
M
60
ICL1 TM2      
R
Q
T
V
V
T
T
W
A
L
70
                   
H
L
A
L
S
D
L
L
A
S
80
                   
A
A
L
P
F
F
T
Y
F
L
90
      ECL1      
A
V
G
H
S
W
E
L
G
T
100
TM3              
A
F
C
K
L
H
S
S
V
F
110
                   
F
L
N
M
F
A
S
G
F
L
120
                   
L
S
A
I
S
L
D
R
C
V
130
        ICL2    
R
V
V
H
P
V
W
A
Q
N
140
    TM4          
H
R
S
V
S
V
A
R
R
V
150
                   
C
A
V
L
W
A
L
A
L
L
160
                   
N
T
V
P
Y
F
V
F
R
D
170
ECL2            
T
I
L
R
R
D
G
R
T
M
180
                   
C
Y
Y
N
V
L
L
L
A
P
190
    TM5          
A
G
D
H
N
A
T
C
G
T
200
                   
R
Q
M
A
L
A
L
S
K
F
210
                   
L
L
A
F
A
L
P
L
G
I
220
                   
I
A
A
S
H
A
V
V
S
A
230
          ICL3  
R
L
Q
R
R
P
Q
G
G
V
240
  TM6            
R
P
G
R
F
V
R
L
V
A
250
                   
A
V
V
A
A
F
A
L
C
W
260
                   
G
P
Y
H
A
F
S
L
I
E
270
      ECL3      
A
R
A
H
A
V
P
S
L
R
280
TM7              
P
L
A
W
R
A
L
P
F
V
290
                   
S
S
L
A
F
I
N
S
V
V
300
                H8
N
P
L
L
Y
V
L
T
C
P
310
                   
D
V
G
R
K
L
R
R
S
L
320
                   
R
A
V
L
E
S
V
L
V
D
330
C-term        
D
G
E
L
G
S
R
Y
R
R
340
                   
R
G
G
S
S
S
P
A
V
A
350
                   
S
A
S
S
S
L
S
L
A
P
360
                   
A
T
H
Q
A
C
S
L
L
R
370
                   
W
L
R
G
S
R
G
T
G
S
380
                   
D
D
A
P
S
S
A
S
G
Q
390
 
G

LINKS

ChEMBL

UniProt

DIAGRAMS

ICL1 M R Q ICL1ECL1 H S W E L ECL1ICL2 P V W A Q N H R ICL2ECL2 D T I L R R D G R T M C Y Y N V L L L A P A G ECL2ICL3 P Q G G V R ICL3ECL3 H A V P S ECL3N-term M A N A T L K P L C P V L K D M S L L G S H S N S S L R Y M N-termC-term V L V D D G E L G S R Y R R R G G S S S P A V A S A S S S L S L A P A T H Q A C S L L R W L R G S R G T G S D D A P S S A S G Q G C-term D H I S V L L H G L A A L L G L V E N G L I V F V V G C R T V V T T W A L H L A L S D L L A S A A L P F F T Y F L A V G G T A F C K L H S S V F F L N M F A S G F L L S A I S L D R C V R V V H S V S V A R R V C A V L W A L A L L N T V P Y F V F R D H N A T C G T R Q M A L A L S K F L L A F A L P L G I I A A S H A V V S A R L Q R R P G R F V R L V A A V V A A F A L C W G P Y H A F S L I E A R A L R P L A W R A L P F V S S L A F I N S V V N P L L Y V L T C P D L R R V L E V G R K S L R A S
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G N E V L G L L A A L G H L L V S I H D 1 L H L A L S D L L A S A A L P F F T Y F 2 A S L L F G S A F M N L F F V S S H L K 3 A R R V C A V L W A L A L L N T V P Y 4 H S A A I I G L P L A F A L L F K S L A L 5 A A V V A A F A L C W G P Y H A F S L I 6 L P N V V S N I F A L S S V F P L A R 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

ENDOGENOUS LIGANDS

No endogenous ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available