V2 receptor (v2r_mouse)

FAMILY

Class A (Rhodopsin) Peptide receptors Vasopressin and oxytocin receptors V2 receptor

GENE

Avpr2 (V2r)

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

Vasopressin V2 receptor, V2R, AVPR V2, Antidiuretic hormone receptor, Renal-type arginine vasopressin receptor

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
I
L
V
S
T
T
S
A
V
10
                   
P
G
A
L
S
S
P
S
S
P
20
                   
S
N
S
S
Q
E
E
L
L
D
30
    TM1          
D
R
D
P
L
L
V
R
A
E
40
                   
L
A
L
L
S
T
I
F
V
A
50
                   
V
A
L
S
N
G
L
V
L
G
60
                   
A
L
I
R
R
G
R
R
G
R
70
ICL1 TM2      
W
A
P
M
H
V
F
I
S
H
80
                   
L
C
L
A
D
L
A
V
A
L
90
                   
F
Q
V
L
P
Q
L
A
W
D
100
      ECL1 TM3
A
T
D
R
F
H
G
P
D
A
110
                   
L
C
R
A
V
K
Y
L
Q
M
120
                   
V
G
M
Y
A
S
S
Y
M
I
130
                   
L
A
M
T
L
D
R
H
R
A
140
      ICL2      
I
C
R
P
M
L
A
Y
R
H
150
  TM4            
G
G
G
A
R
W
N
R
P
V
160
                   
L
V
A
W
A
F
S
L
L
L
170
                   
S
L
P
Q
L
F
I
F
A
Q
180
ECL2            
R
D
V
G
N
G
S
G
V
F
190
                   
D
C
W
A
R
F
A
E
P
W
200
TM5              
G
L
R
A
Y
V
T
W
I
A
210
                   
L
M
V
F
V
A
P
A
L
G
220
                   
I
A
A
C
Q
V
L
I
F
R
230
                   
E
I
H
A
S
L
V
P
G
P
240
      ICL3      
S
E
R
A
G
R
R
R
R
G
250
                   
H
R
T
G
S
P
S
E
G
A
260
TM6              
H
V
S
A
A
M
A
K
T
V
270
                   
R
M
T
L
V
I
V
I
V
Y
280
                   
V
L
C
W
A
P
F
F
L
V
290
                   
Q
L
W
A
A
W
D
P
E
A
300
ECL3 TM7      
P
L
E
R
P
P
F
V
L
L
310
                   
M
L
L
A
S
L
N
S
C
T
320
                H8
N
P
W
I
Y
A
S
F
S
S
330
                   
S
V
S
S
E
L
R
S
L
L
340
                   
C
C
A
Q
R
H
T
T
H
S
350
C-term        
L
G
P
Q
D
E
S
C
A
T
360
                   
A
S
S
S
L
M
K
D
T
P
370
 
S

LINKS

Guide To Pharmacology

UniProt

DIAGRAMS

ICL1 R W ICL1ECL1 R F H G ECL1ICL2 P M L A Y R H G ICL2ECL2 A Q R D V G N G S G V F D C W A R F A E P ECL2ICL3 A G R R R R G H R T G S P S E G ICL3ECL3 P E A P L E ECL3N-term M I L V S T T S A V P G A L S S P S S P S N S S Q E E L L D D R N-termC-term H T T H S L G P Q D E S C A T A S S S L M K D T P S C-term D P L L V R A E L A L L S T I F V A V A L S N G L V L G A L I R R G R R G A P M H V F I S H L C L A D L A V A L F Q V L P Q L A W D A T D P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R G G A R W N R P V L V A W A F S L L L S L P Q L F I F W G L R A Y V T W I A L M V F V A P A L G I A A C Q V L I F R E I H A S L V P G P S E R A H V S A A M A K T V R M T L V I V I V Y V L C W A P F F L V Q L W A A W D R P P F V L L M L L A S L N S C T N P W I Y A S F S S S L R S A Q R V S S E L L C C
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G N S L A V A V F I T S L L A L E A R V 1 S H L C L A D L A V A F L Q V L P Q L A W 2 A L I M Y S S A Y M G V M Q L Y K V A R 3 W N R P V L V A W A F S L L L S L P Q 4 Q C A A I G L A P A V F V M L A I W T V Y 5 L V I V I V Y V L C W A P F F L V Q L W 6 W P N T C S N L S A L L M L L V F P P 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

1 mutation data points available.

ENDOGENOUS LIGANDS

No endogenous ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available