C5a2 receptor (c5ar2_mouse)

FAMILY

Class A (Rhodopsin) Peptide receptors Complement peptide receptors C5a2 receptor

GENE

C5ar2 (C5l2, Gpr77)

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

C5a anaphylatoxin chemotactic receptor 2, Complement component 5a receptor 2, G-protein coupled receptor 77

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
M
N
H
T
T
S
E
Y
Y
10
                   
D
Y
E
Y
D
H
E
H
Y
S
20
                   
D
L
P
D
V
P
V
D
C
P
30
              TM1
A
G
T
C
F
T
S
D
V
Y
40
                   
L
I
V
L
L
V
L
Y
A
A
50
                   
V
F
L
V
G
V
P
G
N
T
60
                   
L
V
A
W
V
T
W
K
E
S
70
ICL1 TM2      
R
H
R
L
G
A
S
W
F
L
80
                   
H
L
T
M
A
D
L
L
C
C
90
                   
V
S
L
P
F
L
A
V
P
I
100
      ECL1      
A
Q
K
G
H
W
P
Y
G
A
110
TM3              
A
G
C
W
L
L
S
S
I
T
120
                   
I
L
S
M
Y
A
S
V
L
L
130
                   
L
T
G
L
S
G
D
L
F
L
140
        ICL2    
L
A
F
R
P
S
W
K
G
A
150
    TM4          
D
H
R
T
F
G
V
R
V
V
160
                   
Q
A
S
S
W
M
L
G
L
L
170
                   
L
T
V
P
S
A
V
Y
R
R
180
ECL2            
L
L
Q
E
H
Y
P
P
R
L
190
                   
V
C
G
I
D
Y
G
G
S
V
200
TM5              
S
A
E
V
A
I
T
T
V
R
210
                   
F
L
F
G
F
L
G
P
L
V
220
                   
F
M
A
G
C
H
G
I
L
Q
230
    ICL3 TM6  
R
Q
M
A
R
R
H
W
P
L
240
                   
G
T
A
V
V
V
G
F
F
I
250
                   
C
W
T
P
Y
H
V
L
R
V
260
          ECL3  
I
I
A
A
A
P
P
H
S
L
270
TM7              
L
L
A
R
V
L
E
A
E
P
280
                   
L
F
N
G
L
A
L
A
H
S
290
                   
A
L
N
P
I
M
F
L
Y
F
300
                   
G
R
K
Q
L
C
K
S
L
Q
310
C-term        
A
A
C
H
W
A
L
R
D
P
320
                   
Q
D
E
E
S
A
V
T
K
V
330
                   
S
I
S
T
S
H
E
M
V
S
340
       
E
M
P
V

LINKS

DIAGRAMS

ICL1 S R H ICL1ECL1 G H W P Y ECL1ICL2 P S W K G A D H ICL2ECL2 R L L Q E H Y P P R L V C G I D Y G G ECL2ICL3 M A ICL3ECL3 P P H ECL3N-term M M N H T T S E Y Y D Y E Y D H E H Y S D L P D V P V D C P A G T C F T S N-termC-term C K S L Q A A C H W A L R D P Q D E E S A V T K V S I S T S H E M V S E M P V C-term D V Y L I V L L V L Y A A V F L V G V P G N T L V A W V T W K E R L G A S W F L H L T M A D L L C C V S L P F L A V P I A Q K G A A G C W L L S S I T I L S M Y A S V L L L T G L S G D L F L L A F R R T F G V R V V Q A S S W M L G L L L T V P S A V Y R S V S A E V A I T T V R F L F G F L G P L V F M A G C H G I L Q R Q R R H W P L G T A V V V G F F I C W T P Y H V L R V I I A A A S L L L A R V L E A E P L F N G L A L A H S A L N P I M F L Y F G R K Q L
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

T N G P V G V L F V A A Y L V L L V I L 1 L H L T M A D L L C C V S L P F L A V P 2 G T L L L V S A Y M S L I T I S S L L W 3 V R V V Q A S S W M L G L L L T V P S 4 H C G A M F V L P G L F G F L F R V T T I 5 T A V V V G F F I C W T P Y H V L R V I 6 I P N L A S H A L A L G N F L P E A E 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

ENDOGENOUS LIGANDS

No endogenous ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available