FFA1 receptor (ffar1_rat)

FAMILY

Class A (Rhodopsin) Lipid receptors Free fatty acid receptors FFA1 receptor

GENE

Ffar1 (Gpr40)

ORGANISM

Rat (Rattus norvegicus)

ALT. NAMES

Free fatty acid receptor 1, G-protein coupled receptor 40

SOURCE

SWISSPROT

SEQUENCE

N-term TM1  
M
D
L
P
P
Q
L
S
F
A
10
                   
L
Y
V
S
A
F
A
L
G
F
20
                   
P
L
N
L
L
A
I
R
G
A
30
                   
V
S
H
A
K
L
R
L
T
P
40
TM2              
S
L
V
Y
T
L
H
L
A
C
50
                   
S
D
L
L
L
A
I
T
L
P
60
                   
L
K
A
V
E
A
L
A
S
G
70
ECL1 TM3      
V
W
P
L
P
L
P
F
C
P
80
                   
V
F
A
L
A
H
F
A
P
L
90
                   
Y
A
G
G
G
F
L
A
A
L
100
                   
S
A
G
R
Y
L
G
A
A
F
110
ICL2            
P
F
G
Y
Q
A
I
R
R
P
120
TM4              
C
Y
S
W
G
V
C
V
A
I
130
                   
W
A
L
V
L
C
H
L
G
L
140
            ECL2
A
L
G
L
E
A
P
R
G
W
150
                   
V
D
N
T
T
S
S
L
G
I
160
                   
N
I
P
V
N
G
S
P
V
C
170
        TM5      
L
E
A
W
D
P
D
S
A
R
180
                   
P
A
R
L
S
F
S
I
L
L
190
                   
F
F
L
P
L
V
I
T
A
F
200
                   
C
Y
V
G
C
L
R
A
L
V
210
  ICL3   TM6  
H
S
G
L
S
H
K
R
K
L
220
                   
R
A
A
W
V
A
G
G
A
L
230
                   
L
T
L
L
L
C
L
G
P
Y
240
                   
N
A
S
N
V
A
S
F
I
N
250
ECL3 TM7      
P
D
L
E
G
S
W
R
K
L
260
                   
G
L
I
T
G
A
W
S
V
V
270
                   
L
N
P
L
V
T
G
Y
L
G
280
H8                
T
G
P
G
Q
G
T
I
C
V
290
        C-term
T
R
T
P
R
G
T
I
Q
K
300

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

ICL1 L ICL1ECL1 G V W P L ECL1ICL2 P F G Y Q A I R ICL2ECL2 P R G W V D N T T S S L G I N I P V N G S P V C L E A W ECL2ICL3 S G L S H ICL3ECL3 P D L E ECL3N-term M D L N-termC-term R G T I Q K C-term P P Q L S F A L Y V S A F A L G F P L N L L A I R G A V S H A K L R T P S L V Y T L H L A C S D L L L A I T L P L K A V E A L A S P L P F C P V F A L A H F A P L Y A G G G F L A A L S A G R Y L G A A F R P C Y S W G V C V A I W A L V L C H L G L A L G L E A D P D S A R P A R L S F S I L L F F L P L V I T A F C Y V G C L R A L V H K R K L R A A W V A G G A L L T L L L C L G P Y N A S N V A S F I N G S W R K L G L I T G A W S V V L N P L V T G Y L G T G T I C P P G Q G V T R T
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

L N L P F G L A F A S V Y L A F S L Q P 1 L H L A C S D L L L A I T L P L K A V E 2 A A L F G G G A Y L P A F H A L A F V P 3 S W G V C V A I W A L V L C H L G L A L 4 Y C F A T I V L P L F F L L I S F S L R A 5 A G G A L L T L L L C L G P Y N A S N V A 6 L P N L V V S W A G T I L G L K R W S 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

ENDOGENOUS LIGANDS

No endogenous ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available