MRGPRD (mrgrd_mouse)

FAMILY

Class A (Rhodopsin) Orphan receptors Class A orphans MRGPRD

GENE

Mrgprd (Gm499, Mrgd)

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

Mas-related G-protein coupled receptor member D, Beta-alanine receptor, G-protein coupled receptor TGR7

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
N
S
T
L
D
S
S
P
A
10
                   
P
G
L
T
I
S
P
T
M
D
20
TM1              
L
V
T
W
I
Y
F
S
V
T
30
                   
F
L
A
M
A
T
C
V
G
G
40
                   
M
A
G
N
S
L
V
I
W
L
50
        ICL1    
L
S
C
N
G
M
Q
R
S
P
60
TM2              
F
C
V
Y
V
L
N
L
A
V
70
                   
A
D
F
L
F
L
F
C
M
A
80
                   
S
M
L
S
L
E
T
G
P
L
90
ECL1   TM3    
L
I
V
N
I
S
A
K
I
Y
100
                   
E
G
M
R
R
I
K
Y
F
A
110
                   
Y
T
A
G
L
S
L
L
T
A
120
                   
I
S
T
Q
R
C
L
S
V
L
130
  ICL2          
F
P
I
W
Y
K
C
H
R
P
140
TM4              
R
H
L
S
S
V
V
S
G
A
150
                   
L
W
A
L
A
F
L
M
N
F
160
            ECL2
L
A
S
F
F
C
V
Q
F
W
170
        TM5      
H
P
N
K
H
Q
C
F
K
V
180
                   
D
I
V
F
N
S
L
I
L
G
190
                   
I
F
M
P
V
M
I
L
T
S
200
                   
T
I
L
F
I
R
V
R
K
N
210
    ICL3 TM6  
S
L
M
Q
R
R
R
P
R
R
220
                   
L
Y
V
V
I
L
T
S
I
L
230
                   
V
F
L
T
C
S
L
P
L
G
240
                   
I
N
W
F
L
L
Y
W
V
D
250
ECL3   TM7    
V
K
R
D
V
R
L
L
Y
S
260
                   
C
V
S
R
F
S
S
S
L
S
270
                   
S
S
A
N
P
V
I
Y
F
L
280
  H8              
V
G
S
Q
K
S
H
R
L
Q
290
                   
E
S
L
G
A
V
L
G
R
A
300
C-term        
L
R
D
E
P
E
P
E
G
R
310
                   
E
T
P
S
T
C
T
N
D
G
320
 
V

LINKS

DIAGRAMS

S N G A M G G V C T A M A L F T V S F Y 1 L N L A V A D F L F L F C M A S M L S L 2 A T L L S L G A T Y A F Y K I R R M G E 3 S S V V S G A L W A L A F L M N F L A S 4 I T S T L I M V P M F I G L I L S N F V I 5 L T S I L V F L T C S L P L G I N W F L 6 V P N A S S S L S S S F R S V C S Y L 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

ICL1 G M Q R ICL1ECL1 P L L I V N I ECL1ICL2 P I W Y K C H R ICL2ECL2 V Q F W H P N K ECL2ICL3 M Q R ICL3ECL3 D V K R D V ECL3N-term M N S T L D S S P A P G L T I S P T N-termC-term G R A L R D E P E P E G R E T P S T C T N D G V C-term M D L V T W I Y F S V T F L A M A T C V G G M A G N S L V I W L L S C N S P F C V Y V L N L A V A D F L F L F C M A S M L S L E T G S A K I Y E G M R R I K Y F A Y T A G L S L L T A I S T Q R C L S V L F P R H L S S V V S G A L W A L A F L M N F L A S F F C H Q C F K V D I V F N S L I L G I F M P V M I L T S T I L F I R V R K N S L R R P R R L Y V V I L T S I L V F L T C S L P L G I N W F L L Y W V R L L Y S C V S R F S S S L S S S A N P V I Y F L V G S Q L Q E V L K S H R S L G A
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

ENDOGENOUS LIGANDS

β-alanine

HOMOLOGY MODELS

No homology models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available