Click on an area of the venn diagram or a receptor clade on the phylogenetic G-protein selectivity tree to display the respective receptor sets:
GPCR selectivity tree. Concentric circles illustrate the G protein-coupling selectivity of each GPCR: the four dots depict both primary and secondary G protein coupling (from inside to outside: Gαs, Gαi/o, Gαq/11, Gα12/13). Tree nodes can be highlighted and selected to retrieve clade-specific receptor sets, which can be used in dedicated segment specific sequence alignments.
We used the G protein transducer imformation from the GuideToPharmacology (IUPHAR):
Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Sharman JL, Campo B, Cavanagh DR, Alexander SPH, Davenport AP, Spedding M, Davies JA, NC-IUPHAR.
The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY.
Nucleic Acids Research, 2020, 48 (D1 - Database Issue), D1006–D1021. [PMID:31691834]