3VW7_refined

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

PAR1

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2020-09-02

MODEL

Download

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

PAR1 (sequence similarity: 100%) PDB: 3VW7

TEMPLATES

3VW7 (PAR1)
6VI4 (κ receptor)
6B73 (κ receptor)
5NDD (PAR2)
6WWZ (CCR6)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 87.5 8.2 4.3
Side-chains 86.8 6.9 6.2

Number of backbone templates: 5
Number of rotamer templates: 17

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 91 D PAR1 3VW7 PAR1 3VW7
N-term 92 A PAR1 3VW7 PAR1 3VW7
N-term 93 S PAR1 3VW7 PAR1 3VW7
N-term 94 G PAR1 3VW7 PAR1 3VW7
N-term 95 Y PAR1 3VW7 PAR1 3VW7
N-term 96 L PAR1 3VW7 PAR1 3VW7
N-term 97 T PAR1 3VW7 PAR1 3VW7
N-term 98 S PAR1 3VW7 PAR1 3VW7
TM1 99 S 1.29x29 PAR1 3VW7 PAR1 3VW7
TM1 100 W 1.30x30 PAR1 3VW7 PAR1 3VW7
TM1 101 L 1.31x31 PAR1 3VW7 PAR1 3VW7
TM1 102 T 1.32x32 PAR1 3VW7 PAR1 3VW7
TM1 103 L 1.33x33 PAR1 3VW7 PAR1 3VW7
TM1 104 F 1.34x34 PAR1 3VW7 PAR1 3VW7
TM1 105 V 1.35x35 PAR1 3VW7 PAR1 3VW7
TM1 106 P 1.36x36 PAR1 3VW7 PAR1 3VW7
TM1 107 S 1.37x37 PAR1 3VW7 PAR1 3VW7
TM1 108 V 1.38x38 PAR1 3VW7 PAR1 3VW7
TM1 109 Y 1.39x39 PAR1 3VW7 PAR1 3VW7
TM1 110 T 1.40x40 PAR1 3VW7 PAR1 3VW7
TM1 111 G 1.41x41 PAR1 3VW7 PAR1 3VW7
TM1 112 V 1.42x42 PAR1 3VW7 PAR1 3VW7
TM1 113 F 1.43x43 PAR1 3VW7 PAR1 3VW7
TM1 114 V 1.44x44 PAR1 3VW7 PAR1 3VW7
TM1 115 V 1.45x45 PAR1 3VW7 PAR1 3VW7
TM1 116 S 1.46x46 PAR1 3VW7 PAR1 3VW7
TM1 117 L 1.47x47 PAR1 3VW7 PAR1 3VW7
TM1 118 P 1.48x48 PAR1 3VW7 PAR1 3VW7
TM1 119 L 1.49x49 PAR1 3VW7 PAR1 3VW7
TM1 120 N 1.50x50 PAR1 3VW7 PAR1 3VW7
TM1 121 I 1.51x51 PAR1 3VW7 PAR1 3VW7
TM1 122 M 1.52x52 PAR1 3VW7 PAR1 3VW7
TM1 123 A 1.53x53 PAR1 3VW7 PAR1 3VW7
TM1 124 I 1.54x54 PAR1 3VW7 PAR1 3VW7
TM1 125 V 1.55x55 PAR1 3VW7 PAR1 3VW7
TM1 126 V 1.56x56 PAR1 3VW7 PAR1 3VW7
TM1 127 F 1.57x57 PAR1 3VW7 PAR1 3VW7
TM1 128 I 1.58x58 PAR1 3VW7 PAR1 3VW7
TM1 129 L 1.59x59 PAR1 3VW7 PAR1 3VW7
TM1 130 K 1.60x60 PAR1 3VW7 PAR1 3VW7
ICL1 131 M 12.48x48 - - - -
ICL1 132 K 12.49x49 κ receptor 6VI4 5-HT2B receptor 4NC3
ICL1 133 V 12.50x50 κ receptor 6VI4 - -
ICL1 134 K 12.51x51 - - - -
TM2 135 K 2.37x37 PAR1 3VW7 PAR1 3VW7
TM2 136 P 2.38x38 PAR1 3VW7 PAR1 3VW7
TM2 137 A 2.39x39 PAR1 3VW7 PAR1 3VW7
TM2 138 V 2.40x40 PAR1 3VW7 PAR1 3VW7
TM2 139 V 2.41x41 PAR1 3VW7 PAR1 3VW7
TM2 140 Y 2.42x42 PAR1 3VW7 PAR1 3VW7
TM2 141 M 2.43x43 PAR1 3VW7 PAR1 3VW7
TM2 142 L 2.44x44 PAR1 3VW7 PAR1 3VW7
TM2 143 H 2.45x45 PAR1 3VW7 PAR1 3VW7
TM2 144 L 2.46x46 PAR1 3VW7 PAR1 3VW7
TM2 145 A 2.47x47 PAR1 3VW7 PAR1 3VW7
TM2 146 T 2.48x48 PAR1 3VW7 PAR1 3VW7
TM2 147 A 2.49x49 PAR1 3VW7 PAR1 3VW7
TM2 148 D 2.50x50 PAR1 3VW7 PAR1 3VW7
TM2 149 V 2.51x51 PAR1 3VW7 PAR1 3VW7
TM2 150 L 2.52x52 PAR1 3VW7 PAR1 3VW7
TM2 151 F 2.53x53 PAR1 3VW7 PAR1 3VW7
TM2 152 V 2.54x54 PAR1 3VW7 PAR1 3VW7
TM2 153 S 2.55x55 PAR1 3VW7 PAR1 3VW7
TM2 154 V 2.56x56 PAR1 3VW7 PAR1 3VW7
TM2 155 L 2.57x57 PAR1 3VW7 PAR1 3VW7
TM2 156 P 2.58x58 PAR1 3VW7 PAR1 3VW7
TM2 157 F 2.59x59 PAR1 3VW7 PAR1 3VW7
TM2 158 K 2.60x60 PAR1 3VW7 PAR1 3VW7
TM2 159 I 2.61x61 PAR1 3VW7 PAR1 3VW7
TM2 160 S 2.62x62 PAR1 3VW7 PAR1 3VW7
TM2 161 Y 2.63x63 PAR1 3VW7 PAR1 3VW7
TM2 162 Y 2.64x64 PAR1 3VW7 PAR1 3VW7
TM2 163 F 2.65x65 PAR1 3VW7 PAR1 3VW7
TM2 164 S 2.66x66 PAR1 3VW7 PAR1 3VW7
ECL1 165 G PAR1 3VW7 PAR1 3VW7
ECL1 166 S PAR1 3VW7 PAR1 3VW7
ECL1 167 D 23.49x49 PAR1 3VW7 PAR1 3VW7
ECL1 168 W 23.50x50 PAR1 3VW7 PAR1 3VW7
ECL1 169 Q 23.51x51 PAR1 3VW7 PAR1 3VW7
ECL1 170 F 23.52x52 PAR1 3VW7 PAR1 3VW7
TM3 171 G 3.21x21 PAR1 3VW7 PAR1 3VW7
TM3 172 S 3.22x22 PAR1 3VW7 PAR1 3VW7
TM3 173 E 3.23x23 PAR1 3VW7 PAR1 3VW7
TM3 174 L 3.24x24 PAR1 3VW7 PAR1 3VW7
TM3 175 C 3.25x25 PAR1 3VW7 PAR1 3VW7
TM3 176 R 3.26x26 PAR1 3VW7 PAR1 3VW7
TM3 177 F 3.27x27 PAR1 3VW7 PAR1 3VW7
TM3 178 V 3.28x28 PAR1 3VW7 PAR1 3VW7
TM3 179 T 3.29x29 PAR1 3VW7 PAR1 3VW7
TM3 180 A 3.30x30 PAR1 3VW7 PAR1 3VW7
TM3 181 A 3.31x31 PAR1 3VW7 PAR1 3VW7
TM3 182 F 3.32x32 PAR1 3VW7 PAR1 3VW7
TM3 183 Y 3.33x33 PAR1 3VW7 PAR1 3VW7
TM3 184 C 3.34x34 PAR1 3VW7 PAR1 3VW7
TM3 185 N 3.35x35 PAR1 3VW7 PAR1 3VW7
TM3 186 M 3.36x36 PAR1 3VW7 PAR1 3VW7
TM3 187 Y 3.37x37 PAR1 3VW7 PAR1 3VW7
TM3 188 A 3.38x38 PAR1 3VW7 PAR1 3VW7
TM3 189 S 3.39x39 PAR1 3VW7 PAR1 3VW7
TM3 190 I 3.40x40 PAR1 3VW7 PAR1 3VW7
TM3 191 L 3.41x41 PAR1 3VW7 PAR1 3VW7
TM3 192 L 3.42x42 PAR1 3VW7 PAR1 3VW7
TM3 193 M 3.43x43 PAR1 3VW7 PAR1 3VW7
TM3 194 T 3.44x44 PAR1 3VW7 PAR1 3VW7
TM3 195 V 3.45x45 PAR1 3VW7 PAR1 3VW7
TM3 196 I 3.46x46 PAR1 3VW7 PAR1 3VW7
TM3 197 S 3.47x47 PAR1 3VW7 PAR1 3VW7
TM3 198 I 3.48x48 PAR1 3VW7 PAR1 3VW7
TM3 199 D 3.49x49 PAR1 3VW7 PAR1 3VW7
TM3 200 R 3.50x50 PAR1 3VW7 PAR1 3VW7
TM3 201 F 3.51x51 PAR1 3VW7 PAR1 3VW7
TM3 202 L 3.52x52 PAR1 3VW7 PAR1 3VW7
TM3 203 A 3.53x53 PAR1 3VW7 PAR1 3VW7
TM3 204 V 3.54x54 PAR1 3VW7 PAR1 3VW7
TM3 205 V 3.55x55 PAR1 3VW7 PAR1 3VW7
TM3 206 Y 3.56x56 PAR1 3VW7 PAR1 3VW7
ICL2 207 P 34.50x50 - - - -
ICL2 208 M 34.51x51 κ receptor 6B73 AT1 receptor 6OS2
ICL2 209 Q 34.52x52 κ receptor 6B73 CysLT1 receptor 6RZ5
ICL2 210 S 34.53x53 κ receptor 6B73 P2Y1 receptor 4XNW
ICL2 211 L 34.54x54 κ receptor 6B73 κ receptor 6B73
ICL2 212 S 34.55x55 κ receptor 6B73 β1-adrenoceptor 4AMJ
ICL2 213 W 34.56x56 κ receptor 6B73 CCR9 5LWE
ICL2 214 R 34.57x57 - - - -
TM4 215 T 4.38x38 PAR1 3VW7 PAR1 3VW7
TM4 216 L 4.39x39 PAR1 3VW7 PAR1 3VW7
TM4 217 G 4.40x40 PAR1 3VW7 PAR1 3VW7
TM4 218 R 4.41x41 PAR1 3VW7 PAR1 3VW7
TM4 219 A 4.42x42 PAR1 3VW7 PAR1 3VW7
TM4 220 S 4.43x43 PAR1 3VW7 PAR1 3VW7
TM4 221 F 4.44x44 PAR1 3VW7 PAR1 3VW7
TM4 222 T 4.45x45 PAR1 3VW7 PAR1 3VW7
TM4 223 C 4.46x46 PAR1 3VW7 PAR1 3VW7
TM4 224 L 4.47x47 PAR1 3VW7 PAR1 3VW7
TM4 225 A 4.48x48 PAR1 3VW7 PAR1 3VW7
TM4 226 I 4.49x49 PAR1 3VW7 PAR1 3VW7
TM4 227 W 4.50x50 PAR1 3VW7 PAR1 3VW7
TM4 228 A 4.51x51 PAR1 3VW7 PAR1 3VW7
TM4 229 L 4.52x52 PAR1 3VW7 PAR1 3VW7
TM4 230 A 4.53x53 PAR1 3VW7 PAR1 3VW7
TM4 231 I 4.54x54 PAR1 3VW7 PAR1 3VW7
TM4 232 A 4.55x55 PAR1 3VW7 PAR1 3VW7
TM4 233 G 4.56x56 PAR1 3VW7 PAR1 3VW7
TM4 234 V 4.57x57 PAR1 3VW7 PAR1 3VW7
TM4 235 V 4.58x59 PAR1 3VW7 PAR1 3VW7
TM4 236 P 4.59x60 PAR1 3VW7 PAR1 3VW7
TM4 237 L 4.60x61 PAR1 3VW7 PAR1 3VW7
TM4 238 L 4.61x62 PAR1 3VW7 PAR1 3VW7
TM4 239 L 4.62x63 PAR1 3VW7 PAR1 3VW7
TM4 240 K 4.63x64 PAR1 3VW7 PAR1 3VW7
ECL2 241 E PAR1 3VW7 PAR1 3VW7
ECL2 242 Q PAR1 3VW7 PAR1 3VW7
ECL2 243 T PAR1 3VW7 PAR1 3VW7
ECL2 244 I PAR1 3VW7 PAR1 3VW7
ECL2 245 Q PAR1 3VW7 PAR1 3VW7
ECL2 246 V PAR1 3VW7 PAR1 3VW7
ECL2 247 P PAR1 3VW7 PAR1 3VW7
ECL2 248 G PAR1 3VW7 PAR1 3VW7
ECL2 249 L PAR1 3VW7 PAR1 3VW7
ECL2 250 N PAR1 3VW7 - -
ECL2 251 I PAR1 3VW7 PAR1 3VW7
ECL2 252 T PAR1 3VW7 PAR1 3VW7
ECL2 253 T PAR1 3VW7 PAR1 3VW7
ECL2 254 C 45.50x50 PAR1 3VW7 PAR1 3VW7
ECL2 255 H 45.51x51 PAR1 3VW7 PAR1 3VW7
ECL2 256 D 45.52x52 PAR1 3VW7 PAR1 3VW7
ECL2 257 V PAR1 3VW7 PAR1 3VW7
ECL2 258 L PAR1 3VW7 PAR1 3VW7
ECL2 259 N PAR1 3VW7 - -
ECL2 260 E PAR1 3VW7 PAR1 3VW7
ECL2 261 T PAR1 3VW7 PAR1 3VW7
ECL2 262 L PAR1 3VW7 PAR1 3VW7
ECL2 263 L PAR1 3VW7 PAR1 3VW7
TM5 264 E 5.32x32 PAR1 3VW7 PAR1 3VW7
TM5 265 G 5.33x33 PAR1 3VW7 PAR1 3VW7
TM5 266 Y 5.34x34 PAR1 3VW7 PAR1 3VW7
TM5 267 Y 5.35x35 PAR1 3VW7 PAR1 3VW7
TM5 268 A 5.36x36 PAR1 3VW7 PAR1 3VW7
TM5 269 Y 5.37x37 PAR1 3VW7 PAR1 3VW7
TM5 270 Y 5.38x38 PAR1 3VW7 PAR1 3VW7
TM5 271 F 5.39x39 PAR1 3VW7 PAR1 3VW7
TM5 272 S 5.40x40 PAR1 3VW7 PAR1 3VW7
TM5 273 A 5.41x41 PAR1 3VW7 PAR1 3VW7
TM5 274 F 5.42x42 PAR1 3VW7 PAR1 3VW7
TM5 275 S 5.43x43 PAR1 3VW7 PAR1 3VW7
TM5 276 A 5.44x44 PAR1 3VW7 PAR1 3VW7
TM5 277 V 5.45x45 PAR1 3VW7 PAR1 3VW7
TM5 278 F 5.46x46 PAR1 3VW7 PAR1 3VW7
TM5 279 F 5.47x47 PAR1 3VW7 PAR1 3VW7
TM5 280 F 5.48x48 PAR1 3VW7 PAR1 3VW7
TM5 281 V 5.49x49 PAR1 3VW7 PAR1 3VW7
TM5 282 P 5.50x50 PAR1 3VW7 PAR1 3VW7
TM5 283 L 5.51x51 PAR1 3VW7 PAR1 3VW7
TM5 284 I 5.52x52 PAR1 3VW7 PAR1 3VW7
TM5 285 I 5.53x53 PAR1 3VW7 PAR1 3VW7
TM5 286 S 5.54x54 PAR1 3VW7 PAR1 3VW7
TM5 287 T 5.55x55 PAR1 3VW7 PAR1 3VW7
TM5 288 V 5.56x56 PAR1 3VW7 PAR1 3VW7
TM5 289 C 5.57x57 PAR1 3VW7 PAR1 3VW7
TM5 290 Y 5.58x58 PAR1 3VW7 PAR1 3VW7
TM5 291 V 5.59x59 PAR1 3VW7 PAR1 3VW7
TM5 292 S 5.60x60 PAR1 3VW7 PAR1 3VW7
TM5 293 I 5.61x61 PAR1 3VW7 PAR1 3VW7
TM5 294 I 5.62x62 PAR1 3VW7 PAR1 3VW7
TM5 295 R 5.63x63 PAR1 3VW7 PAR1 3VW7
TM5 296 C 5.64x64 PAR1 3VW7 PAR1 3VW7
TM5 297 L 5.65x65 PAR1 3VW7 PAR1 3VW7
TM5 298 S 5.66x66 PAR1 3VW7 PAR1 3VW7
TM5 299 S 5.67x67 PAR1 3VW7 PAR1 3VW7
ICL3 300 S - - - -
ICL3 301 A - - - -
ICL3 302 V - - - -
ICL3 303 A - - - -
TM6 304 N 6.26x27 PAR1 3VW7 PAR1 3VW7
TM6 305 R 6.27x28 PAR1 3VW7 PAR1 3VW7
TM6 306 S 6.28x29 PAR1 3VW7 PAR1 3VW7
TM6 307 K 6.29x30 PAR1 3VW7 PAR1 3VW7
TM6 308 K 6.30x31 PAR1 3VW7 PAR1 3VW7
TM6 309 S 6.31x32 PAR1 3VW7 PAR1 3VW7
TM6 310 R 6.32x33 PAR1 3VW7 PAR1 3VW7
TM6 311 A 6.33x34 PAR1 3VW7 PAR1 3VW7
TM6 312 L 6.34x35 PAR1 3VW7 PAR1 3VW7
TM6 313 F 6.35x36 PAR1 3VW7 PAR1 3VW7
TM6 314 L 6.36x37 PAR1 3VW7 PAR1 3VW7
TM6 315 S 6.37x38 PAR1 3VW7 PAR1 3VW7
TM6 316 A 6.38x39 PAR1 3VW7 PAR1 3VW7
TM6 317 A 6.39x40 PAR1 3VW7 PAR1 3VW7
TM6 318 V 6.40x41 PAR1 3VW7 PAR1 3VW7
TM6 319 F 6.41x42 PAR1 3VW7 PAR1 3VW7
TM6 320 C 6.42x43 PAR1 3VW7 PAR1 3VW7
TM6 321 I 6.43x44 PAR1 3VW7 PAR1 3VW7
TM6 322 F 6.44x45 PAR1 3VW7 PAR1 3VW7
TM6 323 I 6.45x46 PAR1 3VW7 PAR1 3VW7
TM6 324 I 6.46x461 PAR1 3VW7 PAR1 3VW7
TM6 325 C 6.47x47 PAR1 3VW7 PAR1 3VW7
TM6 326 F 6.48x48 PAR1 3VW7 PAR1 3VW7
TM6 327 G 6.49x49 PAR1 3VW7 PAR1 3VW7
TM6 328 P 6.50x50 PAR1 3VW7 PAR1 3VW7
TM6 329 T 6.51x51 PAR1 3VW7 PAR1 3VW7
TM6 330 N 6.52x52 PAR1 3VW7 PAR1 3VW7
TM6 331 V 6.53x53 PAR1 3VW7 PAR1 3VW7
TM6 332 L 6.54x54 PAR1 3VW7 PAR1 3VW7
TM6 333 L 6.55x55 PAR1 3VW7 PAR1 3VW7
TM6 334 I 6.56x56 PAR1 3VW7 PAR1 3VW7
TM6 335 A 6.57x57 PAR1 3VW7 PAR1 3VW7
TM6 336 H 6.58x58 PAR1 3VW7 PAR1 3VW7
TM6 337 Y 6.59x59 PAR1 3VW7 PAR1 3VW7
TM6 338 S 6.60x60 PAR1 3VW7 PAR1 3VW7
TM6 339 F 6.61x61 PAR1 3VW7 PAR1 3VW7
TM6 340 L 6.62x62 PAR1 3VW7 PAR1 3VW7
ECL3 341 S PAR1 3VW7 PAR1 3VW7
ECL3 342 H PAR1 3VW7 PAR1 3VW7
ECL3 343 T PAR1 3VW7 PAR1 3VW7
ECL3 344 S PAR1 3VW7 PAR1 3VW7
ECL3 345 T PAR1 3VW7 PAR1 3VW7
TM7 346 T 7.28x27 PAR1 3VW7 PAR1 3VW7
TM7 347 E 7.29x28 PAR1 3VW7 PAR1 3VW7
TM7 348 A 7.30x29 PAR1 3VW7 PAR1 3VW7
TM7 349 A 7.31x30 PAR1 3VW7 PAR1 3VW7
TM7 350 Y 7.32x31 PAR1 3VW7 PAR1 3VW7
TM7 351 F 7.33x32 PAR1 3VW7 PAR1 3VW7
TM7 352 A 7.34x33 PAR1 3VW7 PAR1 3VW7
TM7 353 Y 7.35x34 PAR1 3VW7 PAR1 3VW7
TM7 354 L 7.36x35 PAR1 3VW7 PAR1 3VW7
TM7 355 L 7.37x36 PAR1 3VW7 PAR1 3VW7
TM7 356 C 7.38x37 PAR1 3VW7 PAR1 3VW7
TM7 357 V 7.39x38 PAR1 3VW7 PAR1 3VW7
TM7 358 C 7.40x39 PAR1 3VW7 PAR1 3VW7
TM7 359 V 7.41x40 PAR1 3VW7 PAR1 3VW7
TM7 360 S 7.42x41 PAR1 3VW7 PAR1 3VW7
TM7 361 S 7.43x42 PAR1 3VW7 PAR1 3VW7
TM7 362 I 7.44x43 PAR1 3VW7 PAR1 3VW7
TM7 363 S 7.45x45 PAR1 3VW7 PAR1 3VW7
TM7 364 C 7.46x46 PAR1 3VW7 PAR1 3VW7
TM7 365 C 7.47x47 PAR1 3VW7 PAR1 3VW7
TM7 366 I 7.48x48 PAR1 3VW7 PAR1 3VW7
TM7 367 D 7.49x49 PAR1 3VW7 PAR1 3VW7
TM7 368 P 7.50x50 PAR1 3VW7 PAR1 3VW7
TM7 369 L 7.51x51 PAR1 3VW7 PAR1 3VW7
TM7 370 I 7.52x52 PAR1 3VW7 PAR1 3VW7
TM7 371 Y 7.53x53 PAR1 3VW7 PAR1 3VW7
TM7 372 Y 7.54x54 PAR1 3VW7 PAR1 3VW7
TM7 373 Y 7.55x55 PAR2 5NDD A2A receptor 4UHR
TM7 374 A 7.56x56 PAR2 5NDD CysLT2 receptor 6RZ6
H8 375 S 8.47x47 PAR2 5NDD PAR2 5NDD
H8 376 S 8.48x48 PAR2 5NDD GPR52 6LI1
H8 377 E 8.49x49 PAR2 5NDD MC4 receptor 6W25
H8 378 C 8.50x50 PAR2 5NDD - -
H8 379 Q 8.51x51 PAR2 5NDD AT2 receptor 6JOD
H8 380 R 8.52x52 PAR2 5NDD TP receptor 6IIV
H8 381 Y 8.53x53 PAR2 5NDD CCR5 5UIW
H8 382 V 8.54x54 PAR2 5NDD ghrelin receptor 6KO5
H8 383 Y 8.55x55 PAR2 5NDD - -
H8 384 S 8.56x56 PAR2 5NDD CysLT2 receptor 6RZ6
H8 385 I 8.57x57 PAR2 5NDD MC4 receptor 6W25
H8 386 L 8.58x58 PAR2 5NDD PAR2 5NDD
H8 387 C 8.59x59 CCR6 6WWZ MC4 receptor 6W25
H8 388 C 8.60x60 CCR6 6WWZ MC4 receptor 6W25
H8 389 K 8.61x61 CCR6 6WWZ - -
C-term 390 E - - - -
C-term 391 S - - - -
C-term 392 S - - - -
C-term 393 D - - - -
C-term 394 P - - - -