5NDD_refined

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2020-09-02

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

PAR2 (sequence similarity: 100%) PDB: 5NDD

TEMPLATES

5NDD (PAR2)
5NDZ (PAR2)
4XNW (P2Y1 receptor)
6JOD (AT2 receptor)
6IBB (succinate receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 90.6 5.5 3.9
Side-chains 87.4 7.1 5.5

Number of backbone templates: 5
Number of rotamer templates: 16

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 59 F PAR2 5NDD PAR2 5NDD
N-term 60 S PAR2 5NDD PAR2 5NDD
N-term 61 V PAR2 5NDD PAR2 5NDD
N-term 62 D PAR2 5NDD PAR2 5NDD
N-term 63 E PAR2 5NDD PAR2 5NDD
N-term 64 F PAR2 5NDD PAR2 5NDD
N-term 65 S PAR2 5NDD PAR2 5NDD
N-term 66 A PAR2 5NDD PAR2 5NDD
N-term 67 S PAR2 5NDD PAR2 5NDD
N-term 68 V PAR2 5NDD PAR2 5NDD
N-term 69 L PAR2 5NDD PAR2 5NDD
N-term 70 T PAR2 5NDD PAR2 5NDD
TM1 71 G 1.28x28 PAR2 5NDD PAR2 5NDD
TM1 72 K 1.29x29 PAR2 5NDD PAR2 5NDD
TM1 73 L 1.30x30 PAR2 5NDD PAR2 5NDD
TM1 74 T 1.31x31 PAR2 5NDD PAR2 5NDD
TM1 75 T 1.32x32 PAR2 5NDD PAR2 5NDD
TM1 76 V 1.33x33 PAR2 5NDD PAR2 5NDD
TM1 77 F 1.34x34 PAR2 5NDD PAR2 5NDD
TM1 78 L 1.35x35 PAR2 5NDD PAR2 5NDD
TM1 79 P 1.36x36 PAR2 5NDD PAR2 5NDD
TM1 80 I 1.37x37 PAR2 5NDD PAR2 5NDD
TM1 81 V 1.38x38 PAR2 5NDD PAR2 5NDD
TM1 82 Y 1.39x39 PAR2 5NDD PAR2 5NDD
TM1 83 T 1.40x40 PAR2 5NDD PAR2 5NDD
TM1 84 I 1.41x41 PAR2 5NDD PAR2 5NDD
TM1 85 V 1.42x42 PAR2 5NDD PAR2 5NDD
TM1 86 F 1.43x43 PAR2 5NDD PAR2 5NDD
TM1 87 V 1.44x44 PAR2 5NDD PAR2 5NDD
TM1 88 V 1.45x45 PAR2 5NDD PAR2 5NDD
TM1 89 G 1.46x46 PAR2 5NDD P2Y1 receptor 4XNW
TM1 90 L 1.47x47 PAR2 5NDD PAR2 5NDD
TM1 91 P 1.48x48 PAR2 5NDD PAR2 5NDD
TM1 92 S 1.49x49 PAR2 5NDD PAR2 5NDD
TM1 93 N 1.50x50 PAR2 5NDD PAR2 5NDD
TM1 94 G 1.51x51 PAR2 5NDD PAR2 5NDD
TM1 95 M 1.52x52 PAR2 5NDD PAR2 5NDD
TM1 96 A 1.53x53 PAR2 5NDD PAR2 5NDD
TM1 97 L 1.54x54 PAR2 5NDD PAR2 5NDD
TM1 98 W 1.55x55 PAR2 5NDD PAR2 5NDD
TM1 99 V 1.56x56 PAR2 5NDD PAR2 5NDD
TM1 100 F 1.57x57 PAR2 5NDD PAR2 5NDD
TM1 101 L 1.58x58 PAR2 5NDD PAR2 5NDD
TM1 102 F 1.59x59 PAR2 5NDD PAR2 5NDD
TM1 103 R 1.60x60 PAR2 5NDD PAR2 5NDD
ICL1 104 T PAR2 5NDD PAR2 5NDD
ICL1 105 K PAR2 5NDD PAR2 5NDD
ICL1 106 K PAR2 5NDD PAR2 5NDD
ICL1 107 K PAR2 5NDD PAR2 5NDD
TM2 108 H 2.37x37 PAR2 5NDD - -
TM2 109 P 2.38x38 PAR2 5NDD PAR2 5NDD
TM2 110 A 2.39x39 PAR2 5NDD PAR2 5NDD
TM2 111 V 2.40x40 PAR2 5NDD PAR2 5NDD
TM2 112 I 2.41x41 PAR2 5NDD PAR2 5NDD
TM2 113 Y 2.42x42 PAR2 5NDD PAR2 5NDD
TM2 114 M 2.43x43 PAR2 5NDD PAR2 5NDD
TM2 115 A 2.44x44 PAR2 5NDD PAR2 5NDD
TM2 116 N 2.45x45 PAR2 5NDD PAR2 5NDD
TM2 117 L 2.46x46 PAR2 5NDD PAR2 5NDD
TM2 118 A 2.47x47 PAR2 5NDD PAR2 5NDD
TM2 119 L 2.48x48 PAR2 5NDD PAR2 5NDD
TM2 120 A 2.49x49 PAR2 5NDD PAR2 5NDD
TM2 121 D 2.50x50 PAR2 5NDD PAR2 5NDD
TM2 122 L 2.51x51 PAR2 5NDD PAR2 5NDD
TM2 123 L 2.52x52 PAR2 5NDD PAR2 5NDD
TM2 124 S 2.53x53 PAR2 5NDD PAR2 5NDD
TM2 125 V 2.54x54 PAR2 5NDD PAR2 5NDD
TM2 126 I 2.55x55 PAR2 5NDD PAR2 5NDD
TM2 127 W 2.56x56 PAR2 5NDD PAR2 5NDD
TM2 128 F 2.57x57 PAR2 5NDD PAR2 5NDD
TM2 129 P 2.58x58 PAR2 5NDD PAR2 5NDD
TM2 130 L 2.59x59 PAR2 5NDD PAR2 5NDD
TM2 131 K 2.60x60 PAR2 5NDD PAR2 5NDD
TM2 132 I 2.61x61 PAR2 5NDD PAR2 5NDD
TM2 133 A 2.62x62 PAR2 5NDD PAR2 5NDD
TM2 134 Y 2.63x63 PAR2 5NDD PAR2 5NDD
TM2 135 H 2.64x64 PAR2 5NDD PAR2 5NDD
TM2 136 I 2.65x65 PAR2 5NDD PAR2 5NDD
TM2 137 H 2.66x66 PAR2 5NDD PAR2 5NDD
ECL1 138 G - - - -
ECL1 139 N PAR2 5NDZ PAR2 5NDZ
ECL1 140 N 23.49x49 PAR2 5NDZ PAR2 5NDZ
ECL1 141 W 23.50x50 PAR2 5NDZ PAR2 5NDZ
ECL1 142 I 23.51x51 PAR2 5NDZ PAR2 5NDZ
ECL1 143 Y 23.52x52 - - - -
TM3 144 G 3.21x21 PAR2 5NDD PAR2 5NDD
TM3 145 E 3.22x22 PAR2 5NDD PAR2 5NDD
TM3 146 A 3.23x23 PAR2 5NDD PAR2 5NDD
TM3 147 L 3.24x24 PAR2 5NDD PAR2 5NDD
TM3 148 C 3.25x25 PAR2 5NDD PAR2 5NDD
TM3 149 N 3.26x26 PAR2 5NDD PAR2 5NDD
TM3 150 V 3.27x27 PAR2 5NDD PAR2 5NDD
TM3 151 L 3.28x28 PAR2 5NDD PAR2 5NDD
TM3 152 I 3.29x29 PAR2 5NDD PAR2 5NDD
TM3 153 G 3.30x30 PAR2 5NDD PAR2 5NDD
TM3 154 F 3.31x31 PAR2 5NDD PAR2 5NDD
TM3 155 F 3.32x32 PAR2 5NDD PAR2 5NDD
TM3 156 Y 3.33x33 PAR2 5NDD PAR2 5NDD
TM3 157 G 3.34x34 PAR2 5NDD - -
TM3 158 N 3.35x35 PAR2 5NDD PAR2 5NDD
TM3 159 M 3.36x36 PAR2 5NDD PAR2 5NDD
TM3 160 Y 3.37x37 PAR2 5NDD PAR2 5NDD
TM3 161 C 3.38x38 PAR2 5NDD PAR2 5NDD
TM3 162 S 3.39x39 PAR2 5NDD PAR2 5NDD
TM3 163 I 3.40x40 PAR2 5NDD PAR2 5NDD
TM3 164 L 3.41x41 PAR2 5NDD PAR2 5NDD
TM3 165 F 3.42x42 PAR2 5NDD PAR2 5NDD
TM3 166 M 3.43x43 PAR2 5NDD PAR1 3VW7
TM3 167 T 3.44x44 PAR2 5NDD PAR2 5NDD
TM3 168 C 3.45x45 PAR2 5NDD PAR2 5NDD
TM3 169 L 3.46x46 PAR2 5NDD PAR2 5NDD
TM3 170 S 3.47x47 PAR2 5NDD PAR2 5NDD
TM3 171 V 3.48x48 PAR2 5NDD PAR2 5NDD
TM3 172 Q 3.49x49 PAR2 5NDD PAR2 5NDD
TM3 173 R 3.50x50 PAR2 5NDD PAR2 5NDD
TM3 174 Y 3.51x51 PAR2 5NDD P2Y1 receptor 4XNW
TM3 175 W 3.52x52 PAR2 5NDD PAR2 5NDD
TM3 176 V 3.53x53 PAR2 5NDD Rhodopsin 1GZM
TM3 177 I 3.54x54 PAR2 5NDD PAR2 5NDD
TM3 178 V 3.55x55 PAR2 5NDD PAR2 5NDD
TM3 179 N 3.56x56 PAR2 5NDD PAR2 5NDD
ICL2 180 P 34.50x50 - - - -
ICL2 181 M 34.51x51 P2Y1 receptor 4XNW AT1 receptor 6OS2
ICL2 182 G 34.52x52 P2Y1 receptor 4XNW FFA1 receptor 5TZY
ICL2 183 H 34.53x53 P2Y1 receptor 4XNW - -
ICL2 184 S 34.54x54 P2Y1 receptor 4XNW 5-HT1B receptor 4IAQ
ICL2 185 R 34.55x55 P2Y1 receptor 4XNW C5a1 receptor 5O9H
ICL2 186 K 34.56x56 - - - -
TM4 187 K 4.38x38 PAR2 5NDD PAR2 5NDD
TM4 188 A 4.39x39 PAR2 5NDD PAR2 5NDD
TM4 189 N 4.40x40 PAR2 5NDD PAR2 5NDD
TM4 190 I 4.41x41 PAR2 5NDD PAR2 5NDD
TM4 191 A 4.42x42 PAR2 5NDD PAR2 5NDD
TM4 192 I 4.43x43 PAR2 5NDD PAR2 5NDD
TM4 193 G 4.44x44 PAR2 5NDD PAR2 5NDD
TM4 194 I 4.45x45 PAR2 5NDD PAR2 5NDD
TM4 195 S 4.46x46 PAR2 5NDD PAR2 5NDD
TM4 196 L 4.47x47 PAR2 5NDD PAR2 5NDD
TM4 197 A 4.48x48 PAR2 5NDD PAR2 5NDD
TM4 198 I 4.49x49 PAR2 5NDD PAR2 5NDD
TM4 199 W 4.50x50 PAR2 5NDD PAR2 5NDD
TM4 200 L 4.51x51 PAR2 5NDD PAR2 5NDD
TM4 201 L 4.52x52 PAR2 5NDD PAR2 5NDD
TM4 202 I 4.53x53 PAR2 5NDD PAR2 5NDD
TM4 203 L 4.54x54 PAR2 5NDD PAR2 5NDD
TM4 204 L 4.55x55 PAR2 5NDD PAR2 5NDD
TM4 205 V 4.56x56 PAR2 5NDD PAR2 5NDD
TM4 206 T 4.57x57 PAR2 5NDD PAR2 5NDD
TM4 207 I 4.58x59 PAR2 5NDD PAR2 5NDD
TM4 208 P 4.59x60 PAR2 5NDD PAR2 5NDD
TM4 209 L 4.60x61 PAR2 5NDD PAR2 5NDD
TM4 210 Y 4.61x62 PAR2 5NDD PAR2 5NDD
TM4 211 V 4.62x63 PAR2 5NDD PAR2 5NDD
ECL2 212 V PAR2 5NDD PAR2 5NDD
ECL2 213 K PAR2 5NDD PAR2 5NDD
ECL2 214 Q PAR2 5NDD PAR2 5NDD
ECL2 215 T PAR2 5NDD PAR2 5NDD
ECL2 216 I PAR2 5NDD PAR2 5NDD
ECL2 217 F PAR2 5NDD PAR2 5NDD
ECL2 218 I PAR2 5NDD PAR2 5NDD
ECL2 219 P PAR2 5NDD PAR2 5NDD
ECL2 220 A PAR2 5NDD PAR2 5NDD
ECL2 221 L PAR2 5NDD PAR2 5NDD
ECL2 222 N PAR2 5NDD - -
ECL2 223 I PAR2 5NDD PAR2 5NDD
ECL2 224 T PAR2 5NDD PAR2 5NDD
ECL2 225 T PAR2 5NDD PAR2 5NDD
ECL2 226 C 45.50x50 PAR2 5NDD PAR2 5NDD
ECL2 227 H 45.51x51 PAR2 5NDD PAR2 5NDD
ECL2 228 D 45.52x52 PAR2 5NDD PAR2 5NDD
ECL2 229 V PAR2 5NDD PAR2 5NDD
ECL2 230 L PAR2 5NDD PAR2 5NDD
ECL2 231 P PAR2 5NDD PAR2 5NDD
ECL2 232 E PAR2 5NDD PAR2 5NDD
ECL2 233 Q PAR2 5NDD PAR2 5NDD
ECL2 234 L PAR2 5NDD PAR2 5NDD
TM5 235 L 5.31x32 PAR2 5NDD PAR2 5NDD
TM5 236 V 5.32x33 PAR2 5NDD PAR2 5NDD
TM5 237 G 5.33x34 PAR2 5NDD PAR2 5NDD
TM5 238 D 5.34x35 PAR2 5NDD PAR2 5NDD
TM5 239 M 5.35x36 PAR2 5NDD PAR2 5NDD
TM5 240 F 5.36x37 PAR2 5NDD PAR2 5NDD
TM5 241 N 5.37x38 PAR2 5NDD PAR2 5NDD
TM5 242 Y 5.38x39 PAR2 5NDD PAR2 5NDD
TM5 243 F 5.39x40 PAR2 5NDD PAR2 5NDD
TM5 244 L 5.40x41 PAR2 5NDD PAR2 5NDD
TM5 245 S 5.41x42 PAR2 5NDD PAR2 5NDD
TM5 246 L 5.42x43 PAR2 5NDD PAR2 5NDD
TM5 247 A 5.43x44 PAR2 5NDD PAR2 5NDD
TM5 248 I 5.44x45 PAR2 5NDD PAR2 5NDD
TM5 249 G 5.45x46 PAR2 5NDD PAR2 5NDD
TM5 250 V 5.46x461 PAR2 5NDD PAR2 5NDD
TM5 251 F 5.47x47 PAR2 5NDD PAR2 5NDD
TM5 252 L 5.48x48 PAR2 5NDD PAR2 5NDD
TM5 253 F 5.49x49 PAR2 5NDD PAR2 5NDD
TM5 254 P 5.50x50 PAR2 5NDD PAR2 5NDD
TM5 255 A 5.51x51 PAR2 5NDD PAR2 5NDD
TM5 256 F 5.52x52 PAR2 5NDD PAR2 5NDD
TM5 257 L 5.53x53 PAR2 5NDD PAR2 5NDD
TM5 258 T 5.54x54 PAR2 5NDD PAR2 5NDD
TM5 259 A 5.55x55 PAR2 5NDD PAR2 5NDD
TM5 260 S 5.56x56 PAR2 5NDD PAR2 5NDD
TM5 261 A 5.57x57 PAR2 5NDD PAR2 5NDD
TM5 262 Y 5.58x58 PAR2 5NDD PAR2 5NDD
TM5 263 V 5.59x59 PAR2 5NDD PAR2 5NDD
TM5 264 L 5.60x60 PAR2 5NDD PAR2 5NDD
TM5 265 M 5.61x61 PAR2 5NDD PAR2 5NDD
TM5 266 I 5.62x62 PAR2 5NDD PAR2 5NDD
TM5 267 R 5.63x63 PAR2 5NDD PAR2 5NDD
TM5 268 M 5.64x64 PAR2 5NDD MC4 receptor 6W25
TM5 269 L 5.65x65 PAR2 5NDD PAR2 5NDD
TM5 270 R 5.66x66 P2Y1 receptor 4XNW δ receptor 4N6H
TM5 271 S 5.67x67 P2Y1 receptor 4XNW μ receptor 5C1M
TM5 272 S 5.68x68 P2Y1 receptor 4XNW PAR1 3VW7
ICL3 273 A - - - -
ICL3 274 M - - - -
ICL3 275 D - - - -
TM6 276 E 6.24x25 AT2 receptor 6JOD μ receptor 6DDF
TM6 277 N 6.25x26 AT2 receptor 6JOD AT2 receptor 6JOD
TM6 278 S 6.26x27 PAR2 5NDD PAR2 5NDD
TM6 279 E 6.27x28 PAR2 5NDD PAR2 5NDD
TM6 280 K 6.28x29 PAR2 5NDD PAR2 5NDD
TM6 281 K 6.29x30 PAR2 5NDD PAR2 5NDD
TM6 282 R 6.30x31 PAR2 5NDD PAR2 5NDD
TM6 283 K 6.31x32 PAR2 5NDD PAR2 5NDD
TM6 284 R 6.32x33 PAR2 5NDD PAR2 5NDD
TM6 285 A 6.33x34 PAR2 5NDD PAR2 5NDD
TM6 286 I 6.34x35 PAR2 5NDD PAR2 5NDD
TM6 287 K 6.35x36 PAR2 5NDD PAR2 5NDD
TM6 288 L 6.36x37 PAR2 5NDD PAR2 5NDD
TM6 289 I 6.37x38 PAR2 5NDD CysLT2 receptor 6RZ6
TM6 290 V 6.38x39 PAR2 5NDD PAR2 5NDD
TM6 291 T 6.39x40 PAR2 5NDD PAR2 5NDD
TM6 292 V 6.40x41 PAR2 5NDD PAR2 5NDD
TM6 293 L 6.41x42 PAR2 5NDD P2Y1 receptor 4XNW
TM6 294 A 6.42x43 PAR2 5NDD PAR2 5NDD
TM6 295 M 6.43x44 PAR2 5NDD PAR2 5NDD
TM6 296 Y 6.44x45 PAR2 5NDD PAR2 5NDD
TM6 297 L 6.45x46 PAR2 5NDD PAR2 5NDD
TM6 298 I 6.46x461 PAR2 5NDD PAR2 5NDD
TM6 299 C 6.47x47 PAR2 5NDD PAR2 5NDD
TM6 300 F 6.48x48 PAR2 5NDD PAR2 5NDD
TM6 301 T 6.49x49 PAR2 5NDD PAR2 5NDD
TM6 302 P 6.50x50 PAR2 5NDD PAR2 5NDD
TM6 303 S 6.51x51 PAR2 5NDD PAR2 5NDD
TM6 304 N 6.52x52 PAR2 5NDD PAR2 5NDD
TM6 305 L 6.53x53 PAR2 5NDD PAR2 5NDD
TM6 306 L 6.54x54 PAR2 5NDD PAR2 5NDD
TM6 307 L 6.55x55 PAR2 5NDD PAR2 5NDD
TM6 308 V 6.56x56 PAR2 5NDD PAR2 5NDD
TM6 309 V 6.57x57 PAR2 5NDD PAR2 5NDD
TM6 310 H 6.58x58 PAR2 5NDD PAR2 5NDD
TM6 311 Y 6.59x59 PAR2 5NDD PAR2 5NDD
TM6 312 F 6.60x60 PAR2 5NDD PAR2 5NDD
TM6 313 L 6.61x61 PAR2 5NDD PAR2 5NDD
TM6 314 I 6.62x62 PAR2 5NDD PAR2 5NDD
ECL3 315 K PAR2 5NDD PAR2 5NDD
ECL3 316 S PAR2 5NDD PAR2 5NDD
ECL3 317 Q PAR2 5NDD PAR2 5NDD
ECL3 318 G PAR2 5NDD PAR2 5NDD
ECL3 319 Q PAR2 5NDD PAR2 5NDD
ECL3 320 S PAR2 5NDD PAR2 5NDD
ECL3 321 H PAR2 5NDD PAR2 5NDD
TM7 322 V 7.31x30 PAR2 5NDD PAR2 5NDD
TM7 323 Y 7.32x31 PAR2 5NDD PAR2 5NDD
TM7 324 A 7.33x32 PAR2 5NDD PAR2 5NDD
TM7 325 L 7.34x33 PAR2 5NDD PAR2 5NDD
TM7 326 Y 7.35x34 PAR2 5NDD PAR2 5NDD
TM7 327 I 7.36x35 PAR2 5NDD PAR2 5NDD
TM7 328 V 7.37x36 PAR2 5NDD PAR2 5NDD
TM7 329 A 7.38x37 PAR2 5NDD PAR2 5NDD
TM7 330 L 7.39x38 PAR2 5NDD PAR2 5NDD
TM7 331 C 7.40x39 PAR2 5NDD PAR2 5NDD
TM7 332 L 7.41x40 PAR2 5NDD PAR2 5NDD
TM7 333 S 7.42x41 PAR2 5NDD PAR2 5NDD
TM7 334 T 7.43x42 PAR2 5NDD PAR2 5NDD
TM7 335 L 7.44x43 PAR2 5NDD PAR2 5NDD
TM7 336 N 7.45x45 PAR2 5NDD PAR2 5NDD
TM7 337 S 7.46x46 PAR2 5NDD PAR2 5NDD
TM7 338 C 7.47x47 PAR2 5NDD PAR2 5NDD
TM7 339 I 7.48x48 PAR2 5NDD PAR2 5NDD
TM7 340 D 7.49x49 PAR2 5NDD PAR2 5NDD
TM7 341 P 7.50x50 PAR2 5NDD PAR2 5NDD
TM7 342 F 7.51x51 PAR2 5NDD PAR2 5NDD
TM7 343 V 7.52x52 PAR2 5NDD PAR2 5NDD
TM7 344 Y 7.53x53 PAR2 5NDD PAR2 5NDD
TM7 345 Y 7.54x54 PAR2 5NDD PAR2 5NDD
TM7 346 F 7.55x55 PAR2 5NDD PAR2 5NDD
TM7 347 V 7.56x56 PAR2 5NDD PAR2 5NDD
H8 348 S 8.47x47 PAR2 5NDD PAR2 5NDD
H8 349 H 8.48x48 PAR2 5NDD PAR2 5NDD
H8 350 D 8.49x49 PAR2 5NDD PAR2 5NDD
H8 351 F 8.50x50 PAR2 5NDD PAR2 5NDD
H8 352 R 8.51x51 PAR2 5NDD PAR2 5NDD
H8 353 D 8.52x52 PAR2 5NDD PAR2 5NDD
H8 354 H 8.53x53 PAR2 5NDD PAR2 5NDD
H8 355 A 8.54x54 PAR2 5NDD PAR2 5NDD
H8 356 K 8.55x55 PAR2 5NDD PAR2 5NDD
H8 357 N 8.56x56 PAR2 5NDD PAR2 5NDD
H8 358 A 8.57x57 PAR2 5NDD PAR2 5NDD
H8 359 L 8.58x58 PAR2 5NDD PAR2 5NDD
H8 360 L 8.59x59 succinate receptor 6IBB apelin receptor 5VBL
H8 361 C 8.60x60 succinate receptor 6IBB MC4 receptor 6W25
H8 362 R 8.61x61 succinate receptor 6IBB - -
C-term 363 S - - - -
C-term 364 V - - - -
C-term 365 R - - - -
C-term 366 T - - - -
C-term 367 V - - - -