ACKR1 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

ACKR1

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2020-10-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

MC4 receptor (sequence similarity: 25%) PDB: 6W25
Align

TEMPLATES

6LFO (CXCR2)
6LFL (CXCR2)
6W25 (MC4 receptor)
5UIW (CCR5)
3ODU (CXCR4)
4XNW (P2Y1 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 74.8 13.3 11.9
Side-chains 11.2 59.0 29.9

Number of backbone templates: 6
Number of rotamer templates: 43

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 50 P CXCR2 6LFO CXCR2 6LFO
N-term 51 C CXCR2 6LFO CXCR2 6LFO
N-term 52 H CXCR2 6LFO CXCR2 6LFO
N-term 53 S CXCR2 6LFO CXCR2 6LFO
N-term 54 C CXCR2 6LFO CXCR2 6LFO
TM1 55 N 1.29x29 CXCR2 6LFO CXCR4 3OE0
TM1 56 L 1.30x30 CXCR2 6LFO PAR2 5NDD
TM1 57 L 1.31x31 CXCR2 6LFO FPR2/ALX 6LW5
TM1 58 D 1.32x32 CXCR2 6LFO C5a1 receptor 5O9H
TM1 59 D 1.33x33 CXCR2 6LFO AT2 receptor 5UNH
TM1 60 S 1.34x34 CXCR2 6LFO EP4 receptor 5YWY
TM1 61 A 1.35x35 MC4 receptor 6W25 - -
TM1 62 L 1.36x36 MC4 receptor 6W25 C5a1 receptor 5O9H
TM1 63 P 1.37x37 MC4 receptor 6W25 CCR9 5LWE
TM1 64 F 1.38x38 MC4 receptor 6W25 succinate receptor 6RNK
TM1 65 F 1.39x39 MC4 receptor 6W25 MC4 receptor 6W25
TM1 66 I 1.40x40 MC4 receptor 6W25 P2Y1 receptor 4XNW
TM1 67 L 1.41x41 MC4 receptor 6W25 CXCR2 6LFL
TM1 68 T 1.42x42 MC4 receptor 6W25 FPR2/ALX 6LW5
TM1 69 S 1.43x43 MC4 receptor 6W25 DP2 receptor 6D27
TM1 70 V 1.44x44 MC4 receptor 6W25 MC4 receptor 6W25
TM1 71 L 1.45x45 MC4 receptor 6W25 CXCR2 6LFL
TM1 72 G 1.46x46 MC4 receptor 6W25 CXCR4 3ODU
TM1 73 I 1.47x47 MC4 receptor 6W25 CXCR4 3ODU
TM1 74 L 1.48x48 MC4 receptor 6W25 MC4 receptor 6W25
TM1 75 A 1.49x49 MC4 receptor 6W25 PAF receptor 5ZKQ
TM1 76 S 1.50x50 MC4 receptor 6W25 - -
TM1 77 S 1.51x51 MC4 receptor 6W25 CXCR2 6LFL
TM1 78 T 1.52x52 MC4 receptor 6W25 ETB receptor 5X93
TM1 79 V 1.53x53 MC4 receptor 6W25 MC4 receptor 6W25
TM1 80 L 1.54x54 MC4 receptor 6W25 DP2 receptor 6D27
TM1 81 F 1.55x55 MC4 receptor 6W25 US28 5WB1
TM1 82 M 1.56x56 MC4 receptor 6W25 P2Y1 receptor 4XNW
TM1 83 L 1.57x57 MC4 receptor 6W25 CCR5 5UIW
TM1 84 F 1.58x58 MC4 receptor 6W25 apelin receptor 5VBL
TM1 85 R 1.59x59 MC4 receptor 6W25 μ receptor 5C1M
TM1 86 P 1.60x60 MC4 receptor 6W25 - -
ICL1 87 L - - - -
ICL1 88 F - - - -
ICL1 89 R - - - -
ICL1 90 W - - - -
ICL1 91 Q - - - -
ICL1 92 L - - - -
TM2 93 C 2.37x37 MC4 receptor 6W25 US28 5WB1
TM2 94 P 2.38x38 MC4 receptor 6W25 MC4 receptor 6W25
TM2 95 G 2.39x39 MC4 receptor 6W25 US28 5WB1
TM2 96 W 2.40x40 MC4 receptor 6W25 - -
TM2 97 P 2.41x41 MC4 receptor 6W25 - -
TM2 98 V 2.42x42 MC4 receptor 6W25 - -
TM2 99 L 2.43x43 MC4 receptor 6W25 CXCR2 6LFL
TM2 100 A 2.44x44 MC4 receptor 6W25 PAR2 5NDD
TM2 101 Q 2.45x45 MC4 receptor 6W25 - -
TM2 102 L 2.46x46 MC4 receptor 6W25 MC4 receptor 6W25
TM2 103 A 2.47x47 MC4 receptor 6W25 MC4 receptor 6W25
TM2 104 V 2.48x48 MC4 receptor 6W25 MC4 receptor 6W25
TM2 105 G 2.49x49 MC4 receptor 6W25 ETB receptor 5X93
TM2 106 S 2.50x50 MC4 receptor 6W25 - -
TM2 107 A 2.51x51 MC4 receptor 6W25 μ receptor 5C1M
TM2 108 L 2.52x52 MC4 receptor 6W25 MC4 receptor 6W25
TM2 109 F 2.53x53 MC4 receptor 6W25 CXCR2 6LFL
TM2 110 S 2.54x54 MC4 receptor 6W25 MC4 receptor 6W25
TM2 111 I 2.55x55 MC4 receptor 6W25 CXCR4 3ODU
TM2 112 V 2.56x56 MC4 receptor 6W25 5-HT1B receptor 4IAQ
TM2 113 V 2.57x57 MC4 receptor 6W25 CCR5 5UIW
TM2 114 P 2.58x58 MC4 receptor 6W25 CXCR2 6LFL
TM2 115 V 2.59x59 MC4 receptor 6W25 NTS1 receptor 4BUO
TM2 116 L 2.60x60 MC4 receptor 6W25 C5a1 receptor 5O9H
TM2 117 A 2.61x61 MC4 receptor 6W25 CXCR2 6LFL
TM2 118 P 2.62x62 MC4 receptor 6W25 - -
TM2 119 G 2.63x63 MC4 receptor 6W25 - -
TM2 120 L 2.64x64 MC4 receptor 6W25 US28 5WB1
TM2 121 G 2.65x65 MC4 receptor 6W25 - -
TM2 122 S 2.66x66 MC4 receptor 6W25 PAR1 3VW7
ECL1 123 T - - - -
ECL1 124 R - - - -
ECL1 125 S - - - -
ECL1 126 S - - - -
ECL1 127 A - - - -
TM3 128 L 3.24x24 MC4 receptor 6W25 CXCR2 6LFL
TM3 129 C 3.25x25 MC4 receptor 6W25 CXCR2 6LFL
TM3 130 S 3.26x26 MC4 receptor 6W25 C5a1 receptor 5O9H
TM3 131 L 3.27x27 MC4 receptor 6W25 FPR2/ALX 6LW5
TM3 132 G 3.28x28 MC4 receptor 6W25 - -
TM3 133 Y 3.29x29 MC4 receptor 6W25 NTS1 receptor 4BUO
TM3 134 C 3.30x30 MC4 receptor 6W25 PAF receptor 5ZKQ
TM3 135 V 3.31x31 MC4 receptor 6W25 MC4 receptor 6W25
TM3 136 W 3.32x32 MC4 receptor 6W25 - -
TM3 137 Y 3.33x33 MC4 receptor 6W25 US28 5WB1
TM3 138 G 3.34x34 MC4 receptor 6W25 - -
TM3 139 S 3.35x35 MC4 receptor 6W25 MC4 receptor 6W25
TM3 140 A 3.36x36 MC4 receptor 6W25 A1 receptor 5N2S
TM3 141 F 3.37x37 MC4 receptor 6W25 FPR2/ALX 6LW5
TM3 142 A 3.38x38 MC4 receptor 6W25 MC4 receptor 6W25
TM3 143 Q 3.39x39 MC4 receptor 6W25 - -
TM3 144 A 3.40x40 MC4 receptor 6W25 apelin receptor 5VBL
TM3 145 L 3.41x41 MC4 receptor 6W25 CXCR2 6LFO
TM3 146 L 3.42x42 MC4 receptor 6W25 CXCR2 6LFL
TM3 147 L 3.43x43 MC4 receptor 6W25 MC4 receptor 6W25
TM3 148 G 3.44x44 MC4 receptor 6W25 FPR2/ALX 6LW5
TM3 149 C 3.45x45 MC4 receptor 6W25 CXCR2 6LFL
TM3 150 H 3.46x46 MC4 receptor 6W25 - -
TM3 151 A 3.47x47 MC4 receptor 6W25 MC4 receptor 6W25
TM3 152 S 3.48x48 MC4 receptor 6W25 TP receptor 6IIV
TM3 153 L 3.49x49 MC4 receptor 6W25 - -
TM3 154 G 3.50x50 MC4 receptor 6W25 - -
TM3 155 H 3.51x51 MC4 receptor 6W25 LPA1 receptor 4Z35
TM3 156 R 3.52x52 MC4 receptor 6W25 ETB receptor 5X93
TM3 157 L 3.53x53 MC4 receptor 6W25 C5a1 receptor 5O9H
TM3 158 G 3.54x54 MC4 receptor 6W25 - -
TM3 159 A 3.55x55 MC4 receptor 6W25 CCR9 5LWE
TM3 160 G 3.56x56 MC4 receptor 6W25 - -
ICL2 161 Q - - - -
TM4 162 V 4.38x38 MC4 receptor 6W25 - -
TM4 163 P 4.39x39 MC4 receptor 6W25 μ receptor 5C1M
TM4 164 G 4.40x40 MC4 receptor 6W25 C5a1 receptor 5O9H
TM4 165 L 4.41x41 MC4 receptor 6W25 CXCR2 6LFL
TM4 166 T 4.42x42 MC4 receptor 6W25 ETB receptor 5X93
TM4 167 L 4.43x43 MC4 receptor 6W25 OX1 receptor 6TO7
TM4 168 G 4.44x44 MC4 receptor 6W25 PAR2 5NDD
TM4 169 L 4.45x45 MC4 receptor 6W25 C5a1 receptor 5O9H
TM4 170 T 4.46x46 MC4 receptor 6W25 apelin receptor 5VBL
TM4 171 V 4.47x47 MC4 receptor 6W25 CXCR4 3ODU
TM4 172 G 4.48x48 MC4 receptor 6W25 CXCR4 3ODU
TM4 173 I 4.49x49 MC4 receptor 6W25 MC4 receptor 6W25
TM4 174 W 4.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM4 175 G 4.51x51 MC4 receptor 6W25 CXCR2 6LFL
TM4 176 V 4.52x52 MC4 receptor 6W25 CCR5 5UIW
TM4 177 A 4.53x53 MC4 receptor 6W25 CXCR4 3ODU
TM4 178 A 4.54x54 MC4 receptor 6W25 CCR9 5LWE
TM4 179 L 4.55x55 MC4 receptor 6W25 CXCR2 6LFL
TM4 180 L 4.56x56 MC4 receptor 6W25 CXCR2 6LFL
TM4 181 T 4.57x57 CXCR2 6LFL CXCR4 3ODU
TM4 182 L 4.58x59 CXCR2 6LFL CXCR2 6LFL
TM4 183 P 4.59x60 MC4 receptor 6W25 CXCR2 6LFL
TM4 184 V 4.60x61 MC4 receptor 6W25 CXCR2 6LFL
TM4 185 T 4.61x62 MC4 receptor 6W25 - -
TM4 186 L 4.62x63 MC4 receptor 6W25 CXCR2 6LFL
TM4 187 A 4.63x64 MC4 receptor 6W25 MT1 receptor 6ME2
TM4 188 S 4.64x65 CXCR2 6LFL NK1 receptor 6HLP
ECL2 189 G - - - -
ECL2 190 A - - - -
ECL2 191 S - - - -
ECL2 192 G - - - -
ECL2 193 G - - - -
ECL2 194 L - - - -
ECL2 195 C 45.50x50 CXCR2 6LFL CXCR2 6LFL
ECL2 196 T 45.51x51 CXCR2 6LFL FPR2/ALX 6LW5
ECL2 197 L 45.52x52 CXCR2 6LFL CCR7 6QZH
ECL2 198 I - - - -
ECL2 199 Y CCR5 5UIW - -
ECL2 200 S CCR5 5UIW - -
ECL2 201 T CCR5 5UIW - -
ECL2 202 E - - - -
TM5 203 L 5.35x35 CXCR2 6LFL AT1 receptor 4ZUD
TM5 204 K 5.36x36 MC4 receptor 6W25 - -
TM5 205 A 5.37x37 MC4 receptor 6W25 DP2 receptor 6D27
TM5 206 L 5.38x38 MC4 receptor 6W25 CXCR2 6LFL
TM5 207 Q 5.39x39 MC4 receptor 6W25 CCR5 5UIW
TM5 208 A 5.40x40 MC4 receptor 6W25 C5a1 receptor 5O9H
TM5 209 T 5.41x41 MC4 receptor 6W25 Y1 receptor 5ZBH
TM5 210 H 5.42x42 MC4 receptor 6W25 - -
TM5 211 T 5.43x43 MC4 receptor 6W25 P2Y1 receptor 4XNW
TM5 212 V 5.44x44 MC4 receptor 6W25 CCR5 5UIW
TM5 213 A 5.45x45 MC4 receptor 6W25 - -
TM5 214 C 5.46x46 MC4 receptor 6W25 D4 receptor 6IQL
TM5 215 L 5.47x47 MC4 receptor 6W25 CXCR4 3ODU
TM5 216 A 5.48x48 MC4 receptor 6W25 CB2 receptor 5ZTY
TM5 217 I 5.49x49 MC4 receptor 6W25 US28 5WB1
TM5 218 F 5.50x50 MC4 receptor 6W25 - -
TM5 219 V 5.51x51 MC4 receptor 6W25 μ receptor 5C1M
TM5 220 L 5.52x52 MC4 receptor 6W25 CXCR2 6LFL
TM5 221 L 5.53x53 MC4 receptor 6W25 MC4 receptor 6W25
TM5 222 P 5.54x54 MC4 receptor 6W25 - -
TM5 223 L 5.55x55 MC4 receptor 6W25 CXCR2 6LFL
TM5 224 G 5.56x56 MC4 receptor 6W25 P2Y1 receptor 4XNW
TM5 225 L 5.57x57 MC4 receptor 6W25 MC4 receptor 6W25
TM5 226 F 5.58x58 MC4 receptor 6W25 FFA1 receptor 5TZY
TM5 227 G 5.59x59 MC4 receptor 6W25 CXCR2 6LFL
TM5 228 A 5.60x60 MC4 receptor 6W25 DP2 receptor 6D27
TM5 229 K 5.61x61 MC4 receptor 6W25 - -
TM5 230 G 5.62x62 MC4 receptor 6W25 ghrelin receptor 6KO5
TM5 231 L 5.63x63 MC4 receptor 6W25 MC4 receptor 6W25
TM5 232 K 5.64x64 MC4 receptor 6W25 CXCR4 3ODU
ICL3 233 K - - - -
ICL3 234 A - - - -
ICL3 235 L - - - -
ICL3 236 G - - - -
ICL3 237 M - - - -
ICL3 238 G - - - -
TM6 239 P 6.34x34 MC4 receptor 6W25 - -
TM6 240 G 6.35x35 MC4 receptor 6W25 - -
TM6 241 P 6.36x36 MC4 receptor 6W25 CXCR4 3OE0
TM6 242 W 6.37x37 MC4 receptor 6W25 - -
TM6 243 M 6.38x38 MC4 receptor 6W25 AT1 receptor 4ZUD
TM6 244 N 6.39x39 MC4 receptor 6W25 - -
TM6 245 I 6.40x40 MC4 receptor 6W25 P2Y1 receptor 4XNW
TM6 246 L 6.41x41 MC4 receptor 6W25 CCR9 5LWE
TM6 247 W 6.42x42 MC4 receptor 6W25 - -
TM6 248 A 6.43x43 MC4 receptor 6W25 CXCR4 3ODU
TM6 249 W 6.44x44 MC4 receptor 6W25 α2C-adrenoceptor 6KUW
TM6 250 F 6.45x45 MC4 receptor 6W25 CXCR4 3ODU
TM6 251 I 6.46x46 MC4 receptor 6W25 C5a1 receptor 5O9H
TM6 252 F 6.47x47 MC4 receptor 6W25 C5a1 receptor 5O9H
TM6 253 W 6.48x48 MC4 receptor 6W25 MC4 receptor 6W25
TM6 254 W 6.49x49 MC4 receptor 6W25 - -
TM6 255 P 6.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM6 256 H 6.51x51 MC4 receptor 6W25 AT1 receptor 4ZUD
TM6 257 G 6.52x52 MC4 receptor 6W25 - -
TM6 258 V 6.53x53 MC4 receptor 6W25 C5a1 receptor 5O9H
TM6 259 V 6.54x54 MC4 receptor 6W25 CXCR2 6LFL
TM6 260 L 6.55x55 MC4 receptor 6W25 MC4 receptor 6W25
TM6 261 G 6.56x56 MC4 receptor 6W25 - -
TM6 262 L 6.57x57 MC4 receptor 6W25 FPR2/ALX 6LW5
TM6 263 D 6.58x58 MC4 receptor 6W25 CXCR2 6LFL
TM6 264 F 6.59x59 MC4 receptor 6W25 A2A receptor 4UHR
TM6 265 L 6.60x60 MC4 receptor 6W25 CXCR2 6LFL
TM6 266 V 6.61x61 MC4 receptor 6W25 LPA6 receptor 5XSZ
TM6 267 R 6.62x62 CXCR4 3ODU CXCR2 6LFL
TM6 268 S 6.63x63 CXCR4 3ODU - -
TM6 269 K 6.64x64 CXCR4 3ODU US28 5WB1
ECL3 270 L - - - -
ECL3 271 L P2Y1 receptor 4XNW - -
ECL3 272 L P2Y1 receptor 4XNW - -
ECL3 273 L P2Y1 receptor 4XNW - -
ECL3 274 S - - - -
TM7 275 T 7.24x23 CXCR2 6LFO CXCR2 6LFO
TM7 276 C 7.25x24 CXCR2 6LFO CXCR2 6LFO
TM7 277 L 7.26x25 CXCR2 6LFO - -
TM7 278 A 7.27x26 CXCR2 6LFO LPA6 receptor 5XSZ
TM7 279 Q 7.28x27 CXCR2 6LFO succinate receptor 6RNK
TM7 280 Q 7.29x28 CXCR2 6LFO PAF receptor 5ZKQ
TM7 281 A 7.30x29 CXCR2 6LFO CCR9 5LWE
TM7 282 L 7.31x30 CXCR2 6LFO C5a1 receptor 5O9H
TM7 283 D 7.32x31 CXCR2 6LFO CXCR2 6LFO
TM7 284 L 7.33x32 CXCR2 6LFO AT2 receptor 6JOD
TM7 285 L 7.34x33 MC4 receptor 6W25 C5a1 receptor 5O9H
TM7 286 L 7.35x34 MC4 receptor 6W25 CXCR2 6LFL
TM7 287 N 7.36x35 MC4 receptor 6W25 MC4 receptor 6W25
TM7 288 L 7.37x36 MC4 receptor 6W25 MC4 receptor 6W25
TM7 289 A 7.38x37 MC4 receptor 6W25 PAR2 5NDD
TM7 290 E 7.39x38 MC4 receptor 6W25 CXCR2 6LFL
TM7 291 A 7.40x39 MC4 receptor 6W25 CXCR4 3ODU
TM7 292 L 7.41x40 MC4 receptor 6W25 MC4 receptor 6W25
TM7 293 A 7.42x41 MC4 receptor 6W25 CXCR2 6LFL
TM7 294 I 7.43x42 MC4 receptor 6W25 CXCR2 6LFL
TM7 295 L 7.44x43 MC4 receptor 6W25 CXCR2 6LFL
TM7 296 H 7.45x45 MC4 receptor 6W25 CXCR2 6LFL
TM7 297 C 7.46x46 MC4 receptor 6W25 CXCR4 3ODU
TM7 298 V 7.47x47 MC4 receptor 6W25 DP2 receptor 6D27
TM7 299 A 7.48x48 MC4 receptor 6W25 DP2 receptor 6D27
TM7 300 T 7.49x49 MC4 receptor 6W25 - -
TM7 301 P 7.50x50 MC4 receptor 6W25 MC4 receptor 6W25
TM7 302 L 7.51x51 MC4 receptor 6W25 MC4 receptor 6W25
TM7 303 L 7.52x52 MC4 receptor 6W25 FPR2/ALX 6LW5
TM7 304 L 7.53x53 MC4 receptor 6W25 ETB receptor 5X93
TM7 305 A 7.54x54 MC4 receptor 6W25 MC4 receptor 6W25
TM7 306 L 7.55x55 MC4 receptor 6W25 MC4 receptor 6W25
TM7 307 F 7.56x56 MC4 receptor 6W25 apelin receptor 5VBL
H8 308 C 8.47x47 MC4 receptor 6W25 P2Y12 receptor 4NTJ
H8 309 H 8.48x48 MC4 receptor 6W25 PAR2 5NDD
H8 310 Q 8.49x49 MC4 receptor 6W25 Rhodopsin 4ZWJ
H8 311 A 8.50x50 MC4 receptor 6W25 - -
H8 312 T 8.51x51 MC4 receptor 6W25 GPBA receptor 7CFN
H8 313 R 8.52x52 MC4 receptor 6W25 CCR9 5LWE
H8 314 T 8.53x53 MC4 receptor 6W25 MC4 receptor 6W25
H8 315 L 8.54x54 MC4 receptor 6W25 CXCR2 6LFL
H8 316 L 8.55x55 MC4 receptor 6W25 CXCR2 6LFL
H8 317 P 8.56x56 MC4 receptor 6W25 - -
H8 318 S 8.57x57 MC4 receptor 6W25 FPR2/ALX 6LW5
H8 319 L 8.58x58 MC4 receptor 6W25 CXCR2 6LFL
H8 320 P 8.59x59 MC4 receptor 6W25 - -
H8 321 L 8.60x60 MC4 receptor 6W25 - -
H8 322 P 8.61x61 MC4 receptor 6W25 - -
C-term 323 E - - - -
C-term 324 G - - - -
C-term 325 W - - - -
C-term 326 S - - - -
C-term 327 S - - - -