ACKR2 homology model
PROTEIN CLASS
Class A (Rhodopsin)
RECEPTOR
SPECIES
Homo sapiens
STATE
Intermediate
VERSION
2021-01-08
MODEL
TEMPLATES
5UIW (CCR5)
6MEO (CCR5)
3VW7 (PAR1)
6WWZ (CCR6)
6LW5 (FPR2/ALX)
5T1A (CCR2)
4ZUD (AT1 receptor)
None
6MEO (CCR5)
3VW7 (PAR1)
6WWZ (CCR6)
6LW5 (FPR2/ALX)
5T1A (CCR2)
4ZUD (AT1 receptor)
None
| Main template (%) | Additional templates (%) | No template - freely modelled (%) | |
|---|---|---|---|
| Backbone | 74.4 | 19.2 | 6.4 |
| Side-chains | 18.2 | 66.3 | 15.5 |
Number of backbone templates: 7
Number of rotamer templates: 40
| Segment | Seq.num. | AA | GPCRdb# | Backbone | PDB | Rotamer | PDB |
|---|---|---|---|---|---|---|---|
| N-term | 36 | C | CCR5 | 5UIW | CCR5 | 5UIW | |
| N-term | 37 | R | CCR5 | 5UIW | CCR5 | 5UIW | |
| N-term | 38 | K | CCR5 | 5UIW | CCR5 | 5UIW | |
| N-term | 39 | D | CCR5 | 5UIW | CCR5 | 5UIW | |
| N-term | 40 | A | CCR5 | 5UIW | CCR5 | 5UIW | |
| TM1 | 41 | V | 1.27x27 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM1 | 42 | V | 1.28x28 | CCR5 | 5UIW | - | - |
| TM1 | 43 | S | 1.29x29 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 44 | F | 1.30x30 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM1 | 45 | G | 1.31x31 | PAR1 | 3VW7 | CCR2 | 5T1A |
| TM1 | 46 | K | 1.32x32 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM1 | 47 | V | 1.33x33 | PAR1 | 3VW7 | P2Y12 receptor | 4NTJ |
| TM1 | 48 | F | 1.34x34 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 49 | L | 1.35x35 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM1 | 50 | P | 1.36x36 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 51 | V | 1.37x37 | PAR1 | 3VW7 | MC4 receptor | 6W25 |
| TM1 | 52 | F | 1.38x38 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM1 | 53 | Y | 1.39x39 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 54 | S | 1.40x40 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM1 | 55 | L | 1.41x41 | PAR1 | 3VW7 | P2Y1 receptor | 4XNW |
| TM1 | 56 | I | 1.42x42 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM1 | 57 | F | 1.43x43 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 58 | V | 1.44x44 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 59 | L | 1.45x45 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM1 | 60 | G | 1.46x46 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM1 | 61 | L | 1.47x47 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 62 | S | 1.48x48 | PAR1 | 3VW7 | Y1 receptor | 5ZBH |
| TM1 | 63 | G | 1.49x49 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM1 | 64 | N | 1.50x50 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 65 | L | 1.51x51 | PAR1 | 3VW7 | GPR52 | 6LI1 |
| TM1 | 66 | L | 1.52x52 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM1 | 67 | L | 1.53x53 | PAR1 | 3VW7 | Y1 receptor | 5ZBH |
| TM1 | 68 | L | 1.54x54 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ4 |
| TM1 | 69 | M | 1.55x55 | PAR1 | 3VW7 | 5-HT2C receptor | 6BQH |
| TM1 | 70 | V | 1.56x56 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 71 | L | 1.57x57 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ4 |
| TM1 | 72 | L | 1.58x58 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM1 | 73 | R | 1.59x59 | PAR1 | 3VW7 | apelin receptor | 5VBL |
| TM1 | 74 | Y | 1.60x60 | PAR1 | 3VW7 | CCR5 | 5UIW |
| ICL1 | 75 | V | 12.48x48 | - | - | - | - |
| ICL1 | 76 | P | 12.49x49 | CCR6 | 6WWZ | - | - |
| ICL1 | 77 | R | 12.50x50 | CCR6 | 6WWZ | - | - |
| ICL1 | 78 | R | 12.51x51 | - | - | - | - |
| TM2 | 79 | R | 2.37x37 | PAR1 | 3VW7 | apelin receptor | 5VBL |
| TM2 | 80 | M | 2.38x38 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM2 | 81 | V | 2.39x39 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM2 | 82 | E | 2.40x40 | PAR1 | 3VW7 | - | - |
| TM2 | 83 | I | 2.41x41 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM2 | 84 | Y | 2.42x42 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 85 | L | 2.43x43 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM2 | 86 | L | 2.44x44 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 87 | N | 2.45x45 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM2 | 88 | L | 2.46x46 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 89 | A | 2.47x47 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 90 | I | 2.48x48 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM2 | 91 | S | 2.49x49 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM2 | 92 | N | 2.50x50 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM2 | 93 | L | 2.51x51 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM2 | 94 | L | 2.52x52 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 95 | F | 2.53x53 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 96 | L | 2.54x54 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM2 | 97 | V | 2.55x55 | PAR1 | 3VW7 | MC4 receptor | 6W25 |
| TM2 | 98 | T | 2.56x56 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM2 | 99 | L | 2.57x57 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 100 | P | 2.58x58 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 101 | F | 2.59x59 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 102 | W | 2.60x60 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM2 | 103 | G | 2.61x61 | PAR1 | 3VW7 | NOP receptor | 5DHG |
| TM2 | 104 | I | 2.62x62 | PAR1 | 3VW7 | MC4 receptor | 6W25 |
| TM2 | 105 | S | 2.63x63 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM2 | 106 | V | 2.64x64 | PAR1 | 3VW7 | - | - |
| TM2 | 107 | A | 2.65x65 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM2 | 108 | W | 2.66x66 | PAR1 | 3VW7 | BLT1 receptor | 5X33 |
| ECL1 | 109 | H | 23.49x49 | - | - | - | - |
| ECL1 | 110 | W | 23.50x50 | CCR5 | 5UIW | CCR5 | 5UIW |
| ECL1 | 111 | V | 23.51x51 | CCR5 | 5UIW | CCR2 | 5T1A |
| ECL1 | 112 | F | 23.52x52 | - | - | - | - |
| TM3 | 113 | G | 3.21x21 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 114 | S | 3.22x22 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 115 | F | 3.23x23 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ4 |
| TM3 | 116 | L | 3.24x24 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 117 | C | 3.25x25 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 118 | K | 3.26x26 | PAR1 | 3VW7 | P2Y1 receptor | 4XNW |
| TM3 | 119 | M | 3.27x27 | PAR1 | 3VW7 | A1 receptor | 5UEN |
| TM3 | 120 | V | 3.28x28 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 121 | S | 3.29x29 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM3 | 122 | T | 3.30x30 | PAR1 | 3VW7 | D3 receptor | 3PBL |
| TM3 | 123 | L | 3.31x31 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM3 | 124 | Y | 3.32x32 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM3 | 125 | T | 3.33x33 | PAR1 | 3VW7 | CXCR4 | 3ODU |
| TM3 | 126 | I | 3.34x34 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM3 | 127 | N | 3.35x35 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 128 | F | 3.36x36 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM3 | 129 | Y | 3.37x37 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 130 | S | 3.38x38 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM3 | 131 | G | 3.39x39 | PAR1 | 3VW7 | FFA1 receptor | 5TZY |
| TM3 | 132 | I | 3.40x40 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 133 | F | 3.41x41 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ4 |
| TM3 | 134 | F | 3.42x42 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM3 | 135 | I | 3.43x43 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM3 | 136 | S | 3.44x44 | PAR1 | 3VW7 | DP2 receptor | 6D27 |
| TM3 | 137 | C | 3.45x45 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM3 | 138 | M | 3.46x46 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ4 |
| TM3 | 139 | S | 3.47x47 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 140 | L | 3.48x48 | PAR1 | 3VW7 | CXCR4 | 3ODU |
| TM3 | 141 | D | 3.49x49 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 142 | K | 3.50x50 | PAR1 | 3VW7 | - | - |
| TM3 | 143 | Y | 3.51x51 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM3 | 144 | L | 3.52x52 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 145 | E | 3.53x53 | PAR1 | 3VW7 | PAR2 | 5NDD |
| TM3 | 146 | I | 3.54x54 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM3 | 147 | V | 3.55x55 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 148 | H | 3.56x56 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| ICL2 | 149 | A | 34.50x50 | - | - | - | - |
| ICL2 | 150 | Q | 34.51x51 | CCR5 | 5UIW | - | - |
| ICL2 | 151 | P | 34.52x52 | CCR5 | 5UIW | - | - |
| ICL2 | 152 | Y | 34.53x53 | CCR5 | 5UIW | MC4 receptor | 6W25 |
| ICL2 | 153 | H | 34.54x54 | CCR5 | 5UIW | MC4 receptor | 6W25 |
| ICL2 | 154 | R | 34.55x55 | CCR5 | 5UIW | CCR6 | 6WWZ |
| ICL2 | 155 | L | 34.56x56 | CCR5 | 5UIW | LPA6 receptor | 5XSZ |
| ICL2 | 156 | R | 34.57x57 | - | - | - | - |
| TM4 | 157 | T | 4.38x38 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM4 | 158 | R | 4.39x39 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM4 | 159 | A | 4.40x40 | PAR1 | 3VW7 | 5-HT2B receptor | 4IB4 |
| TM4 | 160 | K | 4.41x41 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ5 |
| TM4 | 161 | S | 4.42x42 | PAR1 | 3VW7 | FFA1 receptor | 5TZY |
| TM4 | 162 | L | 4.43x43 | PAR1 | 3VW7 | OX2 receptor | 6TPN |
| TM4 | 163 | L | 4.44x44 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM4 | 164 | L | 4.45x45 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM4 | 165 | A | 4.46x46 | PAR1 | 3VW7 | - | - |
| TM4 | 166 | T | 4.47x47 | PAR1 | 3VW7 | 5-HT2B receptor | 4IB4 |
| TM4 | 167 | I | 4.48x48 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM4 | 168 | V | 4.49x49 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM4 | 169 | W | 4.50x50 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM4 | 170 | A | 4.51x51 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM4 | 171 | V | 4.52x52 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM4 | 172 | S | 4.53x53 | PAR1 | 3VW7 | 5-HT2B receptor | 4IB4 |
| TM4 | 173 | L | 4.54x54 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM4 | 174 | A | 4.55x55 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM4 | 175 | V | 4.56x56 | PAR1 | 3VW7 | PAR2 | 5NDD |
| TM4 | 176 | S | 4.57x57 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM4 | 177 | I | 4.58x59 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM4 | 178 | P | 4.59x60 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM4 | 179 | D | 4.60x61 | PAR1 | 3VW7 | CXCR4 | 3ODU |
| TM4 | 180 | M | 4.61x62 | PAR1 | 3VW7 | apelin receptor | 5VBL |
| TM4 | 181 | V | 4.62x63 | PAR1 | 3VW7 | PAR2 | 5NDD |
| TM4 | 182 | F | 4.63x64 | PAR1 | 3VW7 | - | - |
| TM4 | 183 | V | 4.64x65 | CCR5 | 5UIW | ghrelin receptor | 6KO5 |
| ECL2 | 184 | Q | - | - | - | - | |
| ECL2 | 185 | T | FPR2/ALX | 6LW5 | FPR2/ALX | 6LW5 | |
| ECL2 | 186 | H | FPR2/ALX | 6LW5 | - | - | |
| ECL2 | 187 | E | FPR2/ALX | 6LW5 | - | - | |
| ECL2 | 188 | N | FPR2/ALX | 6LW5 | - | - | |
| ECL2 | 189 | P | FPR2/ALX | 6LW5 | FPR2/ALX | 6LW5 | |
| ECL2 | 190 | K | FPR2/ALX | 6LW5 | - | - | |
| ECL2 | 191 | G | FPR2/ALX | 6LW5 | FPR2/ALX | 6LW5 | |
| ECL2 | 192 | V | FPR2/ALX | 6LW5 | - | - | |
| ECL2 | 193 | W | FPR2/ALX | 6LW5 | - | - | |
| ECL2 | 194 | N | - | - | - | - | |
| ECL2 | 195 | C | 45.50x50 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| ECL2 | 196 | H | 45.51x51 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| ECL2 | 197 | A | 45.52x52 | PAR1 | 3VW7 | BLT1 receptor | 5X33 |
| ECL2 | 198 | D | - | - | - | - | |
| ECL2 | 199 | F | CCR5 | 5UIW | CCR5 | 5UIW | |
| ECL2 | 200 | G | CCR5 | 5UIW | - | - | |
| ECL2 | 201 | G | CCR5 | 5UIW | - | - | |
| ECL2 | 202 | H | - | - | - | - | |
| TM5 | 203 | G | 5.31x32 | PAR1 | 3VW7 | - | - |
| TM5 | 204 | T | 5.32x33 | PAR1 | 3VW7 | NTS1 receptor | 4BUO |
| TM5 | 205 | I | 5.33x34 | PAR1 | 3VW7 | OX2 receptor | 5WS3 |
| TM5 | 206 | W | 5.34x35 | PAR1 | 3VW7 | P2Y12 receptor | 4NTJ |
| TM5 | 207 | K | 5.35x36 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM5 | 208 | L | 5.36x37 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ4 |
| TM5 | 209 | F | 5.37x38 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM5 | 210 | L | 5.38x39 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ4 |
| TM5 | 211 | R | 5.39x40 | PAR1 | 3VW7 | FFA1 receptor | 5TZY |
| TM5 | 212 | F | 5.40x41 | PAR1 | 3VW7 | FFA1 receptor | 5TZY |
| TM5 | 213 | Q | 5.41x42 | PAR1 | 3VW7 | CXCR4 | 3ODU |
| TM5 | 214 | Q | 5.42x43 | PAR1 | 3VW7 | CCR7 | 6QZH |
| TM5 | 215 | N | 5.43x44 | PAR1 | 3VW7 | CCR2 | 5T1A |
| TM5 | 216 | L | 5.44x45 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM5 | 217 | L | 5.45x46 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM5 | 218 | G | 5.46x461 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM5 | 219 | F | 5.47x47 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM5 | 220 | L | 5.48x48 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM5 | 221 | L | 5.49x49 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM5 | 222 | P | 5.50x50 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM5 | 223 | L | 5.51x51 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM5 | 224 | L | 5.52x52 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM5 | 225 | A | 5.53x53 | PAR1 | 3VW7 | CCR7 | 6QZH |
| TM5 | 226 | M | 5.54x54 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM5 | 227 | I | 5.55x55 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ4 |
| TM5 | 228 | F | 5.56x56 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM5 | 229 | F | 5.57x57 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM5 | 230 | Y | 5.58x58 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM5 | 231 | S | 5.59x59 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM5 | 232 | R | 5.60x60 | PAR1 | 3VW7 | US28 | 5WB1 |
| TM5 | 233 | I | 5.61x61 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM5 | 234 | G | 5.62x62 | PAR1 | 3VW7 | ghrelin receptor | 6KO5 |
| TM5 | 235 | C | 5.63x63 | PAR1 | 3VW7 | ETB receptor | 5X93 |
| TM5 | 236 | V | 5.64x64 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM5 | 237 | L | 5.65x65 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM5 | 238 | V | 5.66x66 | PAR1 | 3VW7 | CCR6 | 6WWZ |
| TM5 | 239 | R | 5.67x67 | PAR1 | 3VW7 | - | - |
| TM5 | 240 | L | 5.68x68 | CCR5 | 6MEO | - | - |
| ICL3 | 241 | R | - | - | - | - | |
| ICL3 | 242 | P | - | - | - | - | |
| TM6 | 243 | A | 6.28x28 | PAR1 | 3VW7 | α2C-adrenoceptor | 6KUW |
| TM6 | 244 | G | 6.29x29 | PAR1 | 3VW7 | - | - |
| TM6 | 245 | Q | 6.30x30 | PAR1 | 3VW7 | - | - |
| TM6 | 246 | G | 6.31x31 | PAR1 | 3VW7 | US28 | 5WB1 |
| TM6 | 247 | R | 6.32x32 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM6 | 248 | A | 6.33x33 | PAR1 | 3VW7 | 5-HT2B receptor | 4IB4 |
| TM6 | 249 | L | 6.34x34 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM6 | 250 | K | 6.35x35 | PAR1 | 3VW7 | CCR7 | 6QZH |
| TM6 | 251 | I | 6.36x36 | PAR1 | 3VW7 | AT1 receptor | 4ZUD |
| TM6 | 252 | A | 6.37x37 | PAR1 | 3VW7 | AT2 receptor | 6JOD |
| TM6 | 253 | A | 6.38x38 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM6 | 254 | A | 6.39x39 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM6 | 255 | L | 6.40x40 | PAR1 | 3VW7 | MC4 receptor | 6W25 |
| TM6 | 256 | V | 6.41x41 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM6 | 257 | V | 6.42x42 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM6 | 258 | A | 6.43x43 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ4 |
| TM6 | 259 | F | 6.44x44 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM6 | 260 | F | 6.45x45 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM6 | 261 | V | 6.46x46 | CCR5 | 5UIW | succinate receptor | 6RNK |
| TM6 | 262 | L | 6.47x47 | CCR5 | 5UIW | succinate receptor | 6RNK |
| TM6 | 263 | W | 6.48x48 | PAR1 | 3VW7 | 5-HT2B receptor | 4IB4 |
| TM6 | 264 | F | 6.49x49 | PAR1 | 3VW7 | CCR9 | 5LWE |
| TM6 | 265 | P | 6.50x50 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM6 | 266 | Y | 6.51x51 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM6 | 267 | N | 6.52x52 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM6 | 268 | L | 6.53x53 | PAR1 | 3VW7 | PAR2 | 5NDD |
| TM6 | 269 | T | 6.54x54 | PAR1 | 3VW7 | 5-HT2B receptor | 4IB4 |
| TM6 | 270 | L | 6.55x55 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM6 | 271 | F | 6.56x56 | PAR1 | 3VW7 | AT1 receptor | 4ZUD |
| TM6 | 272 | L | 6.57x57 | PAR1 | 3VW7 | GPR52 | 6LI1 |
| TM6 | 273 | H | 6.58x58 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM6 | 274 | T | 6.59x59 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM6 | 275 | L | 6.60x60 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM6 | 276 | L | 6.61x61 | PAR1 | 3VW7 | PAR2 | 5NDD |
| TM6 | 277 | D | 6.62x62 | PAR1 | 3VW7 | - | - |
| TM6 | 278 | L | 6.63x63 | CCR2 | 5T1A | PAF receptor | 5ZKQ |
| TM6 | 279 | Q | 6.64x64 | CCR2 | 5T1A | - | - |
| ECL3 | 280 | V | - | - | - | - | |
| ECL3 | 281 | F | AT1 receptor | 4ZUD | - | - | |
| ECL3 | 282 | G | - | - | - | - | |
| TM7 | 283 | N | 7.24x23 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM7 | 284 | C | 7.25x24 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM7 | 285 | E | 7.26x25 | CCR5 | 5UIW | CCR7 | 6QZH |
| TM7 | 286 | V | 7.27x26 | CCR5 | 5UIW | CCR9 | 5LWE |
| TM7 | 287 | S | 7.28x27 | PAR1 | 3VW7 | TP receptor | 6IIV |
| TM7 | 288 | Q | 7.29x28 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM7 | 289 | H | 7.30x29 | PAR1 | 3VW7 | CXCR2 | 6LFL |
| TM7 | 290 | L | 7.31x30 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM7 | 291 | D | 7.32x31 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM7 | 292 | Y | 7.33x32 | PAR1 | 3VW7 | P2Y12 receptor | 4NTJ |
| TM7 | 293 | A | 7.34x33 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM7 | 294 | L | 7.35x34 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM7 | 295 | Q | 7.36x35 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM7 | 296 | V | 7.37x36 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM7 | 297 | T | 7.38x37 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM7 | 298 | E | 7.39x38 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM7 | 299 | S | 7.40x39 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ4 |
| TM7 | 300 | I | 7.41x40 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM7 | 301 | A | 7.42x41 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM7 | 302 | F | 7.43x42 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM7 | 303 | L | 7.44x43 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM7 | 304 | H | 7.45x45 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM7 | 305 | C | 7.46x46 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM7 | 306 | C | 7.47x47 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM7 | 307 | F | 7.48x48 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM7 | 308 | S | 7.49x49 | PAR1 | 3VW7 | - | - |
| TM7 | 309 | P | 7.50x50 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM7 | 310 | I | 7.51x51 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM7 | 311 | L | 7.52x52 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM7 | 312 | Y | 7.53x53 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM7 | 313 | A | 7.54x54 | PAR1 | 3VW7 | MC4 receptor | 6W25 |
| TM7 | 314 | F | 7.55x55 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM7 | 315 | S | 7.56x56 | CCR5 | 5UIW | GPR52 | 6LI1 |
| H8 | 316 | S | 8.47x47 | CCR5 | 5UIW | PAR2 | 5NDD |
| H8 | 317 | H | 8.48x48 | CCR5 | 5UIW | PAR2 | 5NDD |
| H8 | 318 | R | 8.49x49 | CCR5 | 5UIW | CCR9 | 5LWE |
| H8 | 319 | F | 8.50x50 | CCR5 | 5UIW | CysLT2 receptor | 6RZ6 |
| H8 | 320 | R | 8.51x51 | CCR5 | 5UIW | succinate receptor | 6RNK |
| H8 | 321 | Q | 8.52x52 | CCR5 | 5UIW | AT2 receptor | 6JOD |
| H8 | 322 | Y | 8.53x53 | CCR5 | 5UIW | CCR5 | 5UIW |
| H8 | 323 | L | 8.54x54 | CCR5 | 5UIW | CysLT2 receptor | 6RZ6 |
| H8 | 324 | K | 8.55x55 | CCR5 | 5UIW | PAR2 | 5NDD |
| H8 | 325 | A | 8.56x56 | CCR5 | 5UIW | OX2 receptor | 5WS3 |
| H8 | 326 | F | 8.57x57 | CCR5 | 5UIW | CCR5 | 5UIW |
| H8 | 327 | L | 8.58x58 | CCR5 | 5UIW | CysLT2 receptor | 6RZ6 |
| C-term | 328 | A | - | - | - | - | |
| C-term | 329 | A | - | - | - | - | |
| C-term | 330 | V | - | - | - | - | |
| C-term | 331 | L | - | - | - | - | |
| C-term | 332 | G | - | - | - | - |