ACKR2 homology model
PROTEIN CLASS
Class A (Rhodopsin)
RECEPTOR
SPECIES
Homo sapiens
STATE
Intermediate
VERSION
2020-09-02
MODEL
TEMPLATES
5UIW (CCR5)
6MEO (CCR5)
3VW7 (PAR1)
6WWZ (CCR6)
5X33 (BLT1 receptor)
5T1A (CCR2)
4ZUD (AT1 receptor)
None
6MEO (CCR5)
3VW7 (PAR1)
6WWZ (CCR6)
5X33 (BLT1 receptor)
5T1A (CCR2)
4ZUD (AT1 receptor)
None
| Main template (%) | Additional templates (%) | No template - freely modelled (%) | |
|---|---|---|---|
| Backbone | 73.7 | 19.9 | 6.4 |
| Side-chains | 18.2 | 65.3 | 16.5 |
Number of backbone templates: 7
Number of rotamer templates: 38
| Segment | Seq.num. | AA | GPCRdb# | Backbone | PDB | Rotamer | PDB |
|---|---|---|---|---|---|---|---|
| N-term | 36 | C | CCR5 | 5UIW | CCR5 | 5UIW | |
| N-term | 37 | R | CCR5 | 5UIW | CCR5 | 5UIW | |
| N-term | 38 | K | CCR5 | 5UIW | CCR5 | 5UIW | |
| N-term | 39 | D | CCR5 | 5UIW | CCR5 | 5UIW | |
| N-term | 40 | A | CCR5 | 5UIW | CCR5 | 5UIW | |
| TM1 | 41 | V | 1.27x27 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM1 | 42 | V | 1.28x28 | CCR5 | 5UIW | - | - |
| TM1 | 43 | S | 1.29x29 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 44 | F | 1.30x30 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM1 | 45 | G | 1.31x31 | PAR1 | 3VW7 | CCR2 | 5T1A |
| TM1 | 46 | K | 1.32x32 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM1 | 47 | V | 1.33x33 | PAR1 | 3VW7 | P2Y12 receptor | 4NTJ |
| TM1 | 48 | F | 1.34x34 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 49 | L | 1.35x35 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM1 | 50 | P | 1.36x36 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 51 | V | 1.37x37 | PAR1 | 3VW7 | MC4 receptor | 6W25 |
| TM1 | 52 | F | 1.38x38 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM1 | 53 | Y | 1.39x39 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 54 | S | 1.40x40 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM1 | 55 | L | 1.41x41 | PAR1 | 3VW7 | P2Y1 receptor | 4XNW |
| TM1 | 56 | I | 1.42x42 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM1 | 57 | F | 1.43x43 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 58 | V | 1.44x44 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 59 | L | 1.45x45 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM1 | 60 | G | 1.46x46 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM1 | 61 | L | 1.47x47 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 62 | S | 1.48x48 | PAR1 | 3VW7 | Y1 receptor | 5ZBH |
| TM1 | 63 | G | 1.49x49 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM1 | 64 | N | 1.50x50 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 65 | L | 1.51x51 | PAR1 | 3VW7 | TP receptor | 6IIV |
| TM1 | 66 | L | 1.52x52 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM1 | 67 | L | 1.53x53 | PAR1 | 3VW7 | Y1 receptor | 5ZBH |
| TM1 | 68 | L | 1.54x54 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ4 |
| TM1 | 69 | M | 1.55x55 | PAR1 | 3VW7 | 5-HT2C receptor | 6BQH |
| TM1 | 70 | V | 1.56x56 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM1 | 71 | L | 1.57x57 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ4 |
| TM1 | 72 | L | 1.58x58 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM1 | 73 | R | 1.59x59 | PAR1 | 3VW7 | apelin receptor | 5VBL |
| TM1 | 74 | Y | 1.60x60 | PAR1 | 3VW7 | CCR5 | 5UIW |
| ICL1 | 75 | V | 12.48x48 | - | - | - | - |
| ICL1 | 76 | P | 12.49x49 | CCR6 | 6WWZ | - | - |
| ICL1 | 77 | R | 12.50x50 | CCR6 | 6WWZ | - | - |
| ICL1 | 78 | R | 12.51x51 | - | - | - | - |
| TM2 | 79 | R | 2.37x37 | PAR1 | 3VW7 | apelin receptor | 5VBL |
| TM2 | 80 | M | 2.38x38 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM2 | 81 | V | 2.39x39 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM2 | 82 | E | 2.40x40 | PAR1 | 3VW7 | - | - |
| TM2 | 83 | I | 2.41x41 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM2 | 84 | Y | 2.42x42 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 85 | L | 2.43x43 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM2 | 86 | L | 2.44x44 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 87 | N | 2.45x45 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM2 | 88 | L | 2.46x46 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 89 | A | 2.47x47 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 90 | I | 2.48x48 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM2 | 91 | S | 2.49x49 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM2 | 92 | N | 2.50x50 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM2 | 93 | L | 2.51x51 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM2 | 94 | L | 2.52x52 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 95 | F | 2.53x53 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 96 | L | 2.54x54 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM2 | 97 | V | 2.55x55 | PAR1 | 3VW7 | MC4 receptor | 6W25 |
| TM2 | 98 | T | 2.56x56 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM2 | 99 | L | 2.57x57 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 100 | P | 2.58x58 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 101 | F | 2.59x59 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM2 | 102 | W | 2.60x60 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM2 | 103 | G | 2.61x61 | PAR1 | 3VW7 | NOP receptor | 5DHG |
| TM2 | 104 | I | 2.62x62 | PAR1 | 3VW7 | MC4 receptor | 6W25 |
| TM2 | 105 | S | 2.63x63 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM2 | 106 | V | 2.64x64 | PAR1 | 3VW7 | - | - |
| TM2 | 107 | A | 2.65x65 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM2 | 108 | W | 2.66x66 | PAR1 | 3VW7 | BLT1 receptor | 5X33 |
| ECL1 | 109 | H | 23.49x49 | - | - | - | - |
| ECL1 | 110 | W | 23.50x50 | CCR5 | 5UIW | CCR5 | 5UIW |
| ECL1 | 111 | V | 23.51x51 | CCR5 | 5UIW | CCR2 | 5T1A |
| ECL1 | 112 | F | 23.52x52 | - | - | - | - |
| TM3 | 113 | G | 3.21x21 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 114 | S | 3.22x22 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 115 | F | 3.23x23 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ4 |
| TM3 | 116 | L | 3.24x24 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 117 | C | 3.25x25 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 118 | K | 3.26x26 | PAR1 | 3VW7 | P2Y1 receptor | 4XNW |
| TM3 | 119 | M | 3.27x27 | PAR1 | 3VW7 | A1 receptor | 5UEN |
| TM3 | 120 | V | 3.28x28 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 121 | S | 3.29x29 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM3 | 122 | T | 3.30x30 | PAR1 | 3VW7 | D3 receptor | 3PBL |
| TM3 | 123 | L | 3.31x31 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM3 | 124 | Y | 3.32x32 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM3 | 125 | T | 3.33x33 | PAR1 | 3VW7 | CXCR4 | 3ODU |
| TM3 | 126 | I | 3.34x34 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM3 | 127 | N | 3.35x35 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 128 | F | 3.36x36 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM3 | 129 | Y | 3.37x37 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 130 | S | 3.38x38 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM3 | 131 | G | 3.39x39 | PAR1 | 3VW7 | FFA1 receptor | 5TZY |
| TM3 | 132 | I | 3.40x40 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 133 | F | 3.41x41 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ4 |
| TM3 | 134 | F | 3.42x42 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM3 | 135 | I | 3.43x43 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM3 | 136 | S | 3.44x44 | PAR1 | 3VW7 | DP2 receptor | 6D27 |
| TM3 | 137 | C | 3.45x45 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM3 | 138 | M | 3.46x46 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ4 |
| TM3 | 139 | S | 3.47x47 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 140 | L | 3.48x48 | PAR1 | 3VW7 | CXCR4 | 3ODU |
| TM3 | 141 | D | 3.49x49 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 142 | K | 3.50x50 | PAR1 | 3VW7 | - | - |
| TM3 | 143 | Y | 3.51x51 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM3 | 144 | L | 3.52x52 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 145 | E | 3.53x53 | PAR1 | 3VW7 | PAR2 | 5NDD |
| TM3 | 146 | I | 3.54x54 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM3 | 147 | V | 3.55x55 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM3 | 148 | H | 3.56x56 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| ICL2 | 149 | A | 34.50x50 | - | - | - | - |
| ICL2 | 150 | Q | 34.51x51 | CCR5 | 5UIW | - | - |
| ICL2 | 151 | P | 34.52x52 | CCR5 | 5UIW | - | - |
| ICL2 | 152 | Y | 34.53x53 | CCR5 | 5UIW | MC4 receptor | 6W25 |
| ICL2 | 153 | H | 34.54x54 | CCR5 | 5UIW | MC4 receptor | 6W25 |
| ICL2 | 154 | R | 34.55x55 | CCR5 | 5UIW | CCR6 | 6WWZ |
| ICL2 | 155 | L | 34.56x56 | CCR5 | 5UIW | LPA6 receptor | 5XSZ |
| ICL2 | 156 | R | 34.57x57 | - | - | - | - |
| TM4 | 157 | T | 4.38x38 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM4 | 158 | R | 4.39x39 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM4 | 159 | A | 4.40x40 | PAR1 | 3VW7 | 5-HT2B receptor | 4IB4 |
| TM4 | 160 | K | 4.41x41 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ5 |
| TM4 | 161 | S | 4.42x42 | PAR1 | 3VW7 | FFA1 receptor | 5TZY |
| TM4 | 162 | L | 4.43x43 | PAR1 | 3VW7 | OX2 receptor | 6TPN |
| TM4 | 163 | L | 4.44x44 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM4 | 164 | L | 4.45x45 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM4 | 165 | A | 4.46x46 | PAR1 | 3VW7 | - | - |
| TM4 | 166 | T | 4.47x47 | PAR1 | 3VW7 | 5-HT2B receptor | 4IB4 |
| TM4 | 167 | I | 4.48x48 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM4 | 168 | V | 4.49x49 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM4 | 169 | W | 4.50x50 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM4 | 170 | A | 4.51x51 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM4 | 171 | V | 4.52x52 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM4 | 172 | S | 4.53x53 | PAR1 | 3VW7 | 5-HT2B receptor | 4IB4 |
| TM4 | 173 | L | 4.54x54 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM4 | 174 | A | 4.55x55 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM4 | 175 | V | 4.56x56 | PAR1 | 3VW7 | PAR2 | 5NDD |
| TM4 | 176 | S | 4.57x57 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM4 | 177 | I | 4.58x59 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM4 | 178 | P | 4.59x60 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM4 | 179 | D | 4.60x61 | PAR1 | 3VW7 | CXCR4 | 3ODU |
| TM4 | 180 | M | 4.61x62 | PAR1 | 3VW7 | apelin receptor | 5VBL |
| TM4 | 181 | V | 4.62x63 | PAR1 | 3VW7 | PAR2 | 5NDD |
| TM4 | 182 | F | 4.63x64 | PAR1 | 3VW7 | DP2 receptor | 6D27 |
| TM4 | 183 | V | 4.64x65 | CCR5 | 5UIW | ghrelin receptor | 6KO5 |
| ECL2 | 184 | Q | - | - | - | - | |
| ECL2 | 185 | T | BLT1 receptor | 5X33 | - | - | |
| ECL2 | 186 | H | BLT1 receptor | 5X33 | - | - | |
| ECL2 | 187 | E | BLT1 receptor | 5X33 | - | - | |
| ECL2 | 188 | N | BLT1 receptor | 5X33 | - | - | |
| ECL2 | 189 | P | BLT1 receptor | 5X33 | - | - | |
| ECL2 | 190 | K | BLT1 receptor | 5X33 | - | - | |
| ECL2 | 191 | G | BLT1 receptor | 5X33 | - | - | |
| ECL2 | 192 | V | BLT1 receptor | 5X33 | - | - | |
| ECL2 | 193 | W | BLT1 receptor | 5X33 | - | - | |
| ECL2 | 194 | N | - | - | - | - | |
| ECL2 | 195 | C | 45.50x50 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| ECL2 | 196 | H | 45.51x51 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| ECL2 | 197 | A | 45.52x52 | PAR1 | 3VW7 | BLT1 receptor | 5X33 |
| ECL2 | 198 | D | - | - | - | - | |
| ECL2 | 199 | F | CCR5 | 5UIW | CCR5 | 5UIW | |
| ECL2 | 200 | G | CCR5 | 5UIW | - | - | |
| ECL2 | 201 | G | CCR5 | 5UIW | - | - | |
| ECL2 | 202 | H | - | - | - | - | |
| TM5 | 203 | G | 5.31x32 | PAR1 | 3VW7 | - | - |
| TM5 | 204 | T | 5.32x33 | PAR1 | 3VW7 | NTS1 receptor | 4BUO |
| TM5 | 205 | I | 5.33x34 | PAR1 | 3VW7 | OX2 receptor | 5WS3 |
| TM5 | 206 | W | 5.34x35 | PAR1 | 3VW7 | P2Y12 receptor | 4NTJ |
| TM5 | 207 | K | 5.35x36 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM5 | 208 | L | 5.36x37 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ4 |
| TM5 | 209 | F | 5.37x38 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM5 | 210 | L | 5.38x39 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ4 |
| TM5 | 211 | R | 5.39x40 | PAR1 | 3VW7 | FFA1 receptor | 5TZY |
| TM5 | 212 | F | 5.40x41 | PAR1 | 3VW7 | FFA1 receptor | 5TZY |
| TM5 | 213 | Q | 5.41x42 | PAR1 | 3VW7 | CXCR4 | 3ODU |
| TM5 | 214 | Q | 5.42x43 | PAR1 | 3VW7 | CCR7 | 6QZH |
| TM5 | 215 | N | 5.43x44 | PAR1 | 3VW7 | CCR2 | 5T1A |
| TM5 | 216 | L | 5.44x45 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM5 | 217 | L | 5.45x46 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM5 | 218 | G | 5.46x461 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM5 | 219 | F | 5.47x47 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM5 | 220 | L | 5.48x48 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM5 | 221 | L | 5.49x49 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM5 | 222 | P | 5.50x50 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM5 | 223 | L | 5.51x51 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM5 | 224 | L | 5.52x52 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM5 | 225 | A | 5.53x53 | PAR1 | 3VW7 | CCR7 | 6QZH |
| TM5 | 226 | M | 5.54x54 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM5 | 227 | I | 5.55x55 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ4 |
| TM5 | 228 | F | 5.56x56 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM5 | 229 | F | 5.57x57 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM5 | 230 | Y | 5.58x58 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM5 | 231 | S | 5.59x59 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM5 | 232 | R | 5.60x60 | PAR1 | 3VW7 | US28 | 5WB1 |
| TM5 | 233 | I | 5.61x61 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM5 | 234 | G | 5.62x62 | PAR1 | 3VW7 | ghrelin receptor | 6KO5 |
| TM5 | 235 | C | 5.63x63 | PAR1 | 3VW7 | ETB receptor | 5X93 |
| TM5 | 236 | V | 5.64x64 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM5 | 237 | L | 5.65x65 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM5 | 238 | V | 5.66x66 | PAR1 | 3VW7 | CCR6 | 6WWZ |
| TM5 | 239 | R | 5.67x67 | PAR1 | 3VW7 | FFA1 receptor | 4PHU |
| TM5 | 240 | L | 5.68x68 | CCR5 | 6MEO | - | - |
| ICL3 | 241 | R | - | - | - | - | |
| ICL3 | 242 | P | CCR6 | 6WWZ | - | - | |
| ICL3 | 243 | A | CCR6 | 6WWZ | - | - | |
| ICL3 | 244 | G | - | - | - | - | |
| TM6 | 245 | Q | 6.30x30 | PAR1 | 3VW7 | - | - |
| TM6 | 246 | G | 6.31x31 | PAR1 | 3VW7 | US28 | 5WB1 |
| TM6 | 247 | R | 6.32x32 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM6 | 248 | A | 6.33x33 | PAR1 | 3VW7 | 5-HT2B receptor | 4IB4 |
| TM6 | 249 | L | 6.34x34 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM6 | 250 | K | 6.35x35 | PAR1 | 3VW7 | CCR7 | 6QZH |
| TM6 | 251 | I | 6.36x36 | PAR1 | 3VW7 | AT1 receptor | 4ZUD |
| TM6 | 252 | A | 6.37x37 | PAR1 | 3VW7 | AT2 receptor | 6JOD |
| TM6 | 253 | A | 6.38x38 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM6 | 254 | A | 6.39x39 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM6 | 255 | L | 6.40x40 | PAR1 | 3VW7 | MC4 receptor | 6W25 |
| TM6 | 256 | V | 6.41x41 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM6 | 257 | V | 6.42x42 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM6 | 258 | A | 6.43x43 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ4 |
| TM6 | 259 | F | 6.44x44 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM6 | 260 | F | 6.45x45 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM6 | 261 | V | 6.46x46 | CCR5 | 5UIW | succinate receptor | 6RNK |
| TM6 | 262 | L | 6.47x47 | CCR5 | 5UIW | succinate receptor | 6RNK |
| TM6 | 263 | W | 6.48x48 | PAR1 | 3VW7 | 5-HT2B receptor | 4IB4 |
| TM6 | 264 | F | 6.49x49 | PAR1 | 3VW7 | CCR9 | 5LWE |
| TM6 | 265 | P | 6.50x50 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM6 | 266 | Y | 6.51x51 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM6 | 267 | N | 6.52x52 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM6 | 268 | L | 6.53x53 | PAR1 | 3VW7 | PAR2 | 5NDD |
| TM6 | 269 | T | 6.54x54 | PAR1 | 3VW7 | 5-HT2B receptor | 4IB4 |
| TM6 | 270 | L | 6.55x55 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM6 | 271 | F | 6.56x56 | PAR1 | 3VW7 | AT1 receptor | 4ZUD |
| TM6 | 272 | L | 6.57x57 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM6 | 273 | H | 6.58x58 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM6 | 274 | T | 6.59x59 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM6 | 275 | L | 6.60x60 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM6 | 276 | L | 6.61x61 | PAR1 | 3VW7 | PAR2 | 5NDD |
| TM6 | 277 | D | 6.62x62 | PAR1 | 3VW7 | - | - |
| TM6 | 278 | L | 6.63x63 | CCR2 | 5T1A | PAF receptor | 5ZKQ |
| TM6 | 279 | Q | 6.64x64 | CCR2 | 5T1A | - | - |
| ECL3 | 280 | V | - | - | - | - | |
| ECL3 | 281 | F | AT1 receptor | 4ZUD | - | - | |
| ECL3 | 282 | G | - | - | - | - | |
| TM7 | 283 | N | 7.24x23 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM7 | 284 | C | 7.25x24 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM7 | 285 | E | 7.26x25 | CCR5 | 5UIW | CCR7 | 6QZH |
| TM7 | 286 | V | 7.27x26 | CCR5 | 5UIW | CCR9 | 5LWE |
| TM7 | 287 | S | 7.28x27 | PAR1 | 3VW7 | TP receptor | 6IIV |
| TM7 | 288 | Q | 7.29x28 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM7 | 289 | H | 7.30x29 | PAR1 | 3VW7 | - | - |
| TM7 | 290 | L | 7.31x30 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM7 | 291 | D | 7.32x31 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM7 | 292 | Y | 7.33x32 | PAR1 | 3VW7 | P2Y12 receptor | 4NTJ |
| TM7 | 293 | A | 7.34x33 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM7 | 294 | L | 7.35x34 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM7 | 295 | Q | 7.36x35 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM7 | 296 | V | 7.37x36 | PAR1 | 3VW7 | PAF receptor | 5ZKQ |
| TM7 | 297 | T | 7.38x37 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM7 | 298 | E | 7.39x38 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM7 | 299 | S | 7.40x39 | PAR1 | 3VW7 | CysLT1 receptor | 6RZ4 |
| TM7 | 300 | I | 7.41x40 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM7 | 301 | A | 7.42x41 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM7 | 302 | F | 7.43x42 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM7 | 303 | L | 7.44x43 | PAR1 | 3VW7 | succinate receptor | 6RNK |
| TM7 | 304 | H | 7.45x45 | PAR1 | 3VW7 | CCR5 | 5UIW |
| TM7 | 305 | C | 7.46x46 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM7 | 306 | C | 7.47x47 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM7 | 307 | F | 7.48x48 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM7 | 308 | S | 7.49x49 | PAR1 | 3VW7 | - | - |
| TM7 | 309 | P | 7.50x50 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM7 | 310 | I | 7.51x51 | PAR1 | 3VW7 | LPA6 receptor | 5XSZ |
| TM7 | 311 | L | 7.52x52 | PAR1 | 3VW7 | CysLT2 receptor | 6RZ6 |
| TM7 | 312 | Y | 7.53x53 | PAR1 | 3VW7 | PAR1 | 3VW7 |
| TM7 | 313 | A | 7.54x54 | PAR1 | 3VW7 | MC4 receptor | 6W25 |
| TM7 | 314 | F | 7.55x55 | CCR5 | 5UIW | CCR5 | 5UIW |
| TM7 | 315 | S | 7.56x56 | CCR5 | 5UIW | 5-HT1B receptor | 4IAQ |
| H8 | 316 | S | 8.47x47 | CCR5 | 5UIW | PAR2 | 5NDD |
| H8 | 317 | H | 8.48x48 | CCR5 | 5UIW | PAR2 | 5NDD |
| H8 | 318 | R | 8.49x49 | CCR5 | 5UIW | CCR9 | 5LWE |
| H8 | 319 | F | 8.50x50 | CCR5 | 5UIW | CysLT2 receptor | 6RZ6 |
| H8 | 320 | R | 8.51x51 | CCR5 | 5UIW | succinate receptor | 6RNK |
| H8 | 321 | Q | 8.52x52 | CCR5 | 5UIW | AT2 receptor | 6JOD |
| H8 | 322 | Y | 8.53x53 | CCR5 | 5UIW | CCR5 | 5UIW |
| H8 | 323 | L | 8.54x54 | CCR5 | 5UIW | CysLT2 receptor | 6RZ6 |
| H8 | 324 | K | 8.55x55 | CCR5 | 5UIW | PAR2 | 5NDD |
| H8 | 325 | A | 8.56x56 | CCR5 | 5UIW | OX2 receptor | 5WS3 |
| H8 | 326 | F | 8.57x57 | CCR5 | 5UIW | CCR5 | 5UIW |
| H8 | 327 | L | 8.58x58 | CCR5 | 5UIW | CysLT2 receptor | 6RZ6 |
| C-term | 328 | A | - | - | - | - | |
| C-term | 329 | A | - | - | - | - | |
| C-term | 330 | V | - | - | - | - | |
| C-term | 331 | L | - | - | - | - | |
| C-term | 332 | G | - | - | - | - |