ADGRD2 homology model

PROTEIN CLASS

Class B2 (Adhesion)

RECEPTOR

ADGRD2

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2022-06-19

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

GLP-1 receptor (sequence similarity: 12%) PDB: 5NX2
Align

TEMPLATES

7WU2 (ADGRD1)
5NX2 (GLP-1 receptor)
6PB1 (CRF2 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 76.4 13.3 10.3
Side-chains 21.0 41.0 38.0

Number of backbone templates: 3
Number of rotamer templates: 20

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 646 Y - ADGRD1 7WU2 ADGRD1 7WU2
N-term 647 E - ADGRD1 7WU2 ADGRD1 7WU2
N-term 648 V - ADGRD1 7WU2 ADGRD1 7WU2
N-term 649 Q - ADGRD1 7WU2 ADGRD1 7WU2
N-term 650 R - ADGRD1 7WU2 ADGRD1 7WU2
TM1 651 G 1.32x32 ADGRD1 7WU2 - -
TM1 652 P 1.33x33 GLP-1 receptor 5NX2 - -
TM1 653 E 1.34x34 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 654 E 1.35x35 GLP-1 receptor 5NX2 - -
TM1 655 E 1.36x36 GLP-1 receptor 5NX2 - -
TM1 656 S 1.37x37 GLP-1 receptor 5NX2 glucagon receptor 5YQZ
TM1 657 L 1.38x38 GLP-1 receptor 5NX2 ADGRL3 7SF7
TM1 658 L 1.39x39 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 659 R 1.40x40 GLP-1 receptor 5NX2 - -
TM1 660 T 1.41x41 GLP-1 receptor 5NX2 VPAC1 receptor 6VN7
TM1 661 L 1.42x42 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 662 S 1.43x43 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM1 663 F 1.44x44 GLP-1 receptor 5NX2 - -
TM1 664 V 1.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 665 G 1.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 666 C 1.47x47 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM1 667 G 1.48x48 GLP-1 receptor 5NX2 ADGRG4 7WUJ
TM1 668 V 1.49x49 GLP-1 receptor 5NX2 ADGRG3 7D77
TM1 669 S 1.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 670 F 1.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 671 C 1.52x52 GLP-1 receptor 5NX2 - -
TM1 672 A 1.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 673 L 1.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 674 T 1.55x55 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM1 675 T 1.56x56 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM1 676 T 1.57x57 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM1 677 F 1.58x58 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 678 L 1.59x59 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 679 L 1.60x60 GLP-1 receptor 5NX2 ADGRG3 7D77
TM1 680 F 1.61x61 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM1 681 L 1.62x62 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 682 V 1.63x63 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM1 683 A 1.64x64 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM1 684 G 1.65x65 ADGRD1 7WU2 - -
TM1 685 V 1.66x66 ADGRD1 7WU2 - -
TM1 686 P 1.67x67 ADGRD1 7WU2 - -
ICL1 687 K - - - - -
TM2 688 S 2.44x44 GLP-1 receptor 5NX2 - -
TM2 689 E 2.45x45 GLP-1 receptor 5NX2 - -
TM2 690 R 2.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 691 T 2.47x47 GLP-1 receptor 5NX2 - -
TM2 692 T 2.48x48 GLP-1 receptor 5NX2 ADGRL3 7SF7
TM2 693 V 2.49x49 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 694 H 2.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 695 K 2.51x51 GLP-1 receptor 5NX2 ADGRL3 7SF7
TM2 696 N 2.52x52 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 697 L 2.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 698 T 2.54x54 GLP-1 receptor 5NX2 - -
TM2 699 F 2.55x55 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM2 700 S 2.56x56 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 701 L 2.57x57 GLP-1 receptor 5NX2 ADGRL3 7SF7
TM2 702 A 2.58x58 GLP-1 receptor 5NX2 - -
TM2 703 S 2.59x59 GLP-1 receptor 5NX2 - -
TM2 704 A 2.60x60 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM2 705 E 2.61x61 GLP-1 receptor 5NX2 ADGRL3 7SF7
TM2 706 G 2.62x62 GLP-1 receptor 5NX2 GHRH receptor 7V9M
TM2 707 F 2.63x63 GLP-1 receptor 5NX2 - -
TM2 708 L 2.64x64 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM2 709 M 2.65x65 GLP-1 receptor 5NX2 - -
TM2 710 T 2.66x66 GLP-1 receptor 5NX2 - -
TM2 711 S 2.67x67 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM2 712 E 2.68x68 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 713 W 2.69x69 GLP-1 receptor 5NX2 ADGRG4 7WUJ
TM2 714 A 2.70x70 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL1 715 K - - - - -
ECL1 716 A - - - - -
ECL1 717 N - - - - -
ECL1 718 E - - - - -
TM3 719 V 3.27x27 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM3 720 A 3.28x28 GLP-1 receptor 5NX2 ADGRL3 7SF7
TM3 721 C 3.29x29 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 722 V 3.30x30 GLP-1 receptor 5NX2 - -
TM3 723 A 3.31x31 GLP-1 receptor 5NX2 ADGRF1 7WU3
TM3 724 V 3.32x32 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 725 T 3.33x33 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM3 726 V 3.34x34 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM3 727 A 3.35x35 GLP-1 receptor 5NX2 ADGRG4 7WUJ
TM3 728 M 3.36x36 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 729 H 3.37x37 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM3 730 F 3.38x38 GLP-1 receptor 5NX2 ADGRL3 7SF7
TM3 731 L 3.39x39 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM3 732 F 3.40x40 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM3 733 L 3.41x41 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM3 734 V 3.42x42 GLP-1 receptor 5NX2 ADGRG4 7WUJ
TM3 735 A 3.43x43 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM3 736 F 3.44x44 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM3 737 S 3.45x45 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 738 W 3.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 739 M 3.47x47 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM3 740 L 3.48x48 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 741 V 3.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 742 E 3.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 743 G 3.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 744 L 3.52x52 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM3 745 L 3.53x53 GLP-1 receptor 5NX2 ADGRF1 7WU3
TM3 746 L 3.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 747 W 3.55x55 GLP-1 receptor 5NX2 - -
TM3 748 R 3.56x56 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 749 K 3.57x57 GLP-1 receptor 5NX2 - -
TM3 750 V 3.58x58 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM3 751 V 3.59x59 GLP-1 receptor 5NX2 ADGRL3 7SF7
TM3 752 A 3.60x60 GLP-1 receptor 5NX2 - -
ICL2 753 V - - - - -
ICL2 754 S - ADGRD1 7WU2 - -
ICL2 755 M - ADGRD1 7WU2 - -
ICL2 756 H - ADGRD1 7WU2 - -
ICL2 757 P - ADGRD1 7WU2 - -
ICL2 758 G - ADGRD1 7WU2 - -
ICL2 759 P - - - - -
TM4 760 G 4.41x42 GLP-1 receptor 5NX2 - -
TM4 761 M 4.42x43 GLP-1 receptor 5NX2 ADGRF1 7WU3
TM4 762 R 4.43x44 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 763 L 4.44x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 764 Y 4.45x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 765 H 4.46x47 GLP-1 receptor 5NX2 - -
TM4 766 A 4.47x48 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM4 767 T 4.48x49 GLP-1 receptor 5NX2 - -
TM4 768 G 4.49x491 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 769 W 4.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 770 G 4.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 771 V 4.52x52 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 772 P 4.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 773 V 4.54x54 GLP-1 receptor 5NX2 GLP-2 receptor 7D68
TM4 774 G 4.55x55 GLP-1 receptor 5NX2 - -
TM4 775 I 4.56x56 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM4 776 V 4.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 777 A 4.58x58 GLP-1 receptor 5NX2 ADGRL3 7SF7
TM4 778 V 4.59x59 GLP-1 receptor 5NX2 ADGRL3 7SF7
TM4 779 T 4.60x60 GLP-1 receptor 5NX2 ADGRG4 7WUJ
TM4 780 L 4.61x61 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM4 781 A 4.62x62 GLP-1 receptor 5NX2 ADGRL3 7SF7
TM4 782 M 4.63x63 GLP-1 receptor 5NX2 - -
TM4 783 L 4.64x64 GLP-1 receptor 5NX2 - -
ECL2 784 P - - - - -
ECL2 785 H - ADGRD1 7WU2 - -
ECL2 786 D - ADGRD1 7WU2 - -
ECL2 787 Y - ADGRD1 7WU2 ADGRD1 7WU2
ECL2 788 V - ADGRD1 7WU2 - -
ECL2 789 A - ADGRD1 7WU2 - -
ECL2 790 P - ADGRD1 7WU2 - -
ECL2 791 G - ADGRD1 7WU2 - -
ECL2 792 H - - - - -
ECL2 793 C 45.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 794 W 45.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 795 L 45.52x52 GLP-1 receptor 5NX2 ADGRL3 7SF7
ECL2 796 N - - - - -
ECL2 797 V - ADGRD1 7WU2 - -
ECL2 798 H - ADGRD1 7WU2 - -
ECL2 799 T - - - - -
TM5 800 N 5.34x34 GLP-1 receptor 5NX2 - -
TM5 801 A 5.35x35 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM5 802 I 5.36x36 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM5 803 W 5.37x37 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 804 A 5.38x38 ADGRD1 7WU2 ADGRD1 7WU2
TM5 805 F 5.39x39 ADGRD1 7WU2 ADGRD1 7WU2
TM5 806 V 5.40x40 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM5 807 G 5.41x41 GLP-1 receptor 5NX2 ADGRL3 7SF7
TM5 808 P 5.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 809 V 5.43x43 GLP-1 receptor 5NX2 CT receptor 6NIY
TM5 810 L 5.44x44 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 811 F 5.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 812 V 5.46x46 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM5 813 L 5.47x47 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM5 814 T 5.48x48 GLP-1 receptor 5NX2 GLP-2 receptor 7D68
TM5 815 A 5.49x49 GLP-1 receptor 5NX2 - -
TM5 816 N 5.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 817 T 5.51x51 GLP-1 receptor 5NX2 - -
TM5 818 C 5.52x52 GLP-1 receptor 5NX2 - -
TM5 819 I 5.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 820 L 5.54x54 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM5 821 A 5.55x55 GLP-1 receptor 5NX2 ADGRG3 7D77
TM5 822 R 5.56x56 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 823 V 5.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 824 V 5.58x58 GLP-1 receptor 5NX2 ADGRG3 7D77
TM5 825 M 5.59x59 GLP-1 receptor 5NX2 - -
TM5 826 I 5.60x60 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 827 T 5.61x61 GLP-1 receptor 5NX2 - -
TM5 828 V 5.62x62 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 829 S 5.63x63 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 830 S 5.64x64 GLP-1 receptor 5NX2 - -
TM5 831 A 5.65x65 GLP-1 receptor 5NX2 - -
TM5 832 R 5.66x66 ADGRD1 7WU2 ADGRG3 7D77
TM5 833 R 5.67x67 ADGRD1 7WU2 - -
TM5 834 R 5.68x68 ADGRD1 7WU2 GIP receptor 7RA3
TM5 835 A 5.69x69 ADGRD1 7WU2 - -
TM5 836 R 5.70x70 ADGRD1 7WU2 - -
ICL3 837 M - - - - -
ICL3 838 L - - - - -
ICL3 839 S - - - - -
ICL3 840 P - - - - -
ICL3 841 Q - - - - -
ICL3 852 I - - - - -
ICL3 853 W - - - - -
ICL3 854 A - - - - -
ICL3 855 T - - - - -
ICL3 856 V - - - - -
TM6 857 K 6.34x34 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 858 P 6.35x35 GLP-1 receptor 5NX2 - -
TM6 859 V 6.36x36 GLP-1 receptor 5NX2 - -
TM6 860 L 6.37x37 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM6 861 V 6.38x38 GLP-1 receptor 5NX2 ADGRF1 7WU3
TM6 862 L 6.39x39 GLP-1 receptor 5NX2 ADGRG4 7WUJ
TM6 863 L 6.40x40 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 864 P 6.41x41 GLP-1 receptor 5NX2 - -
TM6 865 V 6.42x42 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM6 866 L 6.43x43 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 867 G 6.44x44 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 868 L 6.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 869 T 6.46x46 GLP-1 receptor 5NX2 ADGRG4 7WUJ
TM6 870 W 6.47x47 GLP-1 receptor 5NX2 - -
TM6 871 L 6.48x48 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 872 A 6.49x49 GLP-1 receptor 5NX2 - -
TM6 873 G 6.50x50 GLP-1 receptor 5NX2 ADGRF1 7WU3
TM6 874 I 6.51x51 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM6 875 L 6.52x52 GLP-1 receptor 5NX2 - -
TM6 876 V 6.53x53 GLP-1 receptor 5NX2 - -
TM6 877 H 6.54x54 GLP-1 receptor 5NX2 - -
TM6 878 L 6.55x55 GLP-1 receptor 5NX2 ADGRG3 7D77
ECL3 879 S - - - - -
ECL3 880 P - - - - -
TM7 881 A 7.37x36 GLP-1 receptor 5NX2 ADGRF1 7WU3
TM7 882 W 7.38x37 GLP-1 receptor 5NX2 ADGRF1 7WU3
TM7 883 A 7.39x38 GLP-1 receptor 5NX2 ADGRL3 7SF7
TM7 884 Y 7.40x39 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM7 885 A 7.41x40 GLP-1 receptor 5NX2 - -
TM7 886 A 7.42x41 GLP-1 receptor 5NX2 - -
TM7 887 V 7.43x42 GLP-1 receptor 5NX2 - -
TM7 888 G 7.44x43 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM7 889 L 7.45x44 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM7 890 N 7.46x45 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM7 891 S 7.47x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 892 I 7.48x47 GLP-1 receptor 5NX2 - -
TM7 893 Q 7.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 894 G 7.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 895 L 7.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 896 Y 7.52x52 GLP-1 receptor 5NX2 - -
TM7 897 I 7.53x53 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM7 898 F 7.54x54 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM7 899 L 7.55x55 GLP-1 receptor 5NX2 ADGRD1 7WU2
TM7 900 V 7.56x56 GLP-1 receptor 5NX2 - -
TM7 901 Y 7.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 902 A 7.58x58 GLP-1 receptor 5NX2 - -
TM7 903 A 7.59x59 GLP-1 receptor 5NX2 - -
TM7 904 C 7.60x60 GLP-1 receptor 5NX2 CT receptor 6NIY
H8 905 N 8.47x47 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 906 E 8.48x48 GLP-1 receptor 5NX2 - -
H8 907 E 8.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 908 V 8.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 909 R 8.51x51 GLP-1 receptor 5NX2 ADGRD1 7WU2
H8 910 S 8.52x52 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
H8 911 A 8.53x53 GLP-1 receptor 5NX2 ADGRD1 7WU2
H8 912 L 8.54x54 GLP-1 receptor 5NX2 ADGRF1 7WU3
H8 913 Q 8.55x55 GLP-1 receptor 5NX2 secretin receptor 6WZG
H8 914 R 8.56x56 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
H8 915 M 8.57x57 GLP-1 receptor 5NX2 PTH2 receptor 7F16
H8 916 A 8.58x58 CRF2 receptor 6PB1 - -
H8 917 E 8.59x59 CRF2 receptor 6PB1 GLP-1 receptor 7DUQ
H8 918 K 8.60x60 CRF2 receptor 6PB1 - -
H8 919 K 8.61x61 CRF2 receptor 6PB1 - -
H8 920 V 8.62x62 CRF2 receptor 6PB1 - -
H8 921 A 8.63x63 CRF2 receptor 6PB1 - -
C-term 922 E - - - - -
C-term 923 V - - - - -
C-term 924 L - - - - -
C-term 925 R - - - - -
C-term 926 A - - - - -