ADGRE1 homology model

PROTEIN CLASS

Class B2 (Adhesion)

RECEPTOR

ADGRE1

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2020-09-02

MODEL

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PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

GLP-1 receptor (sequence similarity: 33%) PDB: 5NX2
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TEMPLATES

5UZ7 (CT receptor)
6NIY (CT receptor)
5NX2 (GLP-1 receptor)
5VAI (GLP-1 receptor)
6M1H (PAC1 receptor)
6WZG (secretin receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 79.2 5.3 15.5
Side-chains 19.4 21.5 59.2

Number of backbone templates: 6
Number of rotamer templates: 14

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 585 A - - - -
N-term 586 N - - - -
N-term 587 L - - - -
N-term 588 A - - - -
N-term 589 V - - - -
TM1 590 I 1.27x27 CT receptor 5UZ7 - -
TM1 591 M 1.28x28 CT receptor 5UZ7 - -
TM1 592 A 1.29x29 CT receptor 5UZ7 - -
TM1 593 S 1.30x30 CT receptor 5UZ7 - -
TM1 594 G 1.31x31 CT receptor 5UZ7 - -
TM1 595 E 1.32x32 CT receptor 5UZ7 PTH1 receptor 6FJ3
TM1 596 L 1.33x33 GLP-1 receptor 5NX2 - -
TM1 597 T 1.34x34 GLP-1 receptor 5NX2 - -
TM1 598 M 1.35x35 GLP-1 receptor 5NX2 glucagon receptor 6WPW
TM1 599 D 1.36x36 GLP-1 receptor 5NX2 - -
TM1 600 F 1.37x37 GLP-1 receptor 5NX2 - -
TM1 601 S 1.38x38 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM1 602 L 1.39x39 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 603 Y 1.40x40 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 604 I 1.41x41 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 605 I 1.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 606 S 1.43x43 GLP-1 receptor 5NX2 - -
TM1 607 H 1.44x44 GLP-1 receptor 5NX2 - -
TM1 608 V 1.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 609 G 1.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 610 I 1.47x47 GLP-1 receptor 5NX2 - -
TM1 611 I 1.48x48 GLP-1 receptor 5NX2 - -
TM1 612 I 1.49x49 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM1 613 S 1.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 614 L 1.51x51 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM1 615 V 1.52x52 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM1 616 C 1.53x53 GLP-1 receptor 5NX2 - -
TM1 617 L 1.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 618 V 1.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 619 L 1.56x56 GLP-1 receptor 5NX2 PAC1 receptor 6M1I
TM1 620 A 1.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 621 I 1.58x58 GLP-1 receptor 5NX2 - -
TM1 622 A 1.59x59 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 623 T 1.60x60 GLP-1 receptor 5NX2 - -
TM1 624 F 1.61x61 GLP-1 receptor 5NX2 CT receptor 6NIY
TM1 625 L 1.62x62 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 626 L 1.63x63 GLP-1 receptor 5NX2 - -
TM1 627 C 1.64x64 GLP-1 receptor 5NX2 - -
ICL1 628 R GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ICL1 629 S GLP-1 receptor 5NX2 - -
ICL1 630 I GLP-1 receptor 5NX2 - -
ICL1 631 R GLP-1 receptor 5NX2 - -
TM2 632 N 2.44x44 GLP-1 receptor 5NX2 - -
TM2 633 H 2.45x45 GLP-1 receptor 5NX2 - -
TM2 634 N 2.46x46 GLP-1 receptor 5NX2 - -
TM2 635 T 2.47x47 GLP-1 receptor 5NX2 - -
TM2 636 Y 2.48x48 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 637 L 2.49x49 GLP-1 receptor 5NX2 CT receptor 6NIY
TM2 638 H 2.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 639 L 2.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 640 H 2.52x52 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM2 641 L 2.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 642 C 2.54x54 GLP-1 receptor 5NX2 - -
TM2 643 V 2.55x55 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM2 644 C 2.56x56 GLP-1 receptor 5NX2 - -
TM2 645 L 2.57x57 GLP-1 receptor 5NX2 - -
TM2 646 L 2.58x58 GLP-1 receptor 5NX2 - -
TM2 647 L 2.59x59 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 648 A 2.60x60 GLP-1 receptor 5NX2 - -
TM2 649 K 2.61x61 GLP-1 receptor 5NX2 - -
TM2 650 T 2.62x62 GLP-1 receptor 5NX2 - -
TM2 651 L 2.63x63 GLP-1 receptor 5NX2 - -
TM2 652 F 2.64x64 GLP-1 receptor 5NX2 - -
TM2 653 L 2.65x65 GLP-1 receptor 5NX2 glucagon receptor 5XEZ
TM2 654 A 2.66x66 GLP-1 receptor 5NX2 - -
TM2 655 G 2.67x67 GLP-1 receptor 5NX2 - -
TM2 656 I 2.68x68 GLP-1 receptor 5NX2 - -
TM2 657 H 2.69x69 GLP-1 receptor 5NX2 - -
TM2 658 K 2.70x70 GLP-1 receptor 5NX2 - -
ECL1 659 T - - - -
ECL1 660 D - - - -
ECL1 661 N - - - -
ECL1 662 K - - - -
TM3 663 M 3.27x27 GLP-1 receptor 5NX2 - -
TM3 664 G 3.28x28 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM3 665 C 3.29x29 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 666 A 3.30x30 GLP-1 receptor 5NX2 - -
TM3 667 I 3.31x31 GLP-1 receptor 5NX2 CT receptor 6NIY
TM3 668 I 3.32x32 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM3 669 A 3.33x33 GLP-1 receptor 5NX2 glucagon receptor 5XEZ
TM3 670 G 3.34x34 GLP-1 receptor 5NX2 - -
TM3 671 F 3.35x35 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 672 L 3.36x36 GLP-1 receptor 5NX2 - -
TM3 673 H 3.37x37 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM3 674 Y 3.38x38 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 675 L 3.39x39 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM3 676 F 3.40x40 GLP-1 receptor 5NX2 - -
TM3 677 L 3.41x41 GLP-1 receptor 5NX2 - -
TM3 678 A 3.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 679 C 3.43x43 GLP-1 receptor 5NX2 - -
TM3 680 F 3.44x44 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM3 681 F 3.45x45 GLP-1 receptor 5NX2 CT receptor 6NIY
TM3 682 W 3.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 683 M 3.47x47 GLP-1 receptor 5NX2 CT receptor 6NIY
TM3 684 L 3.48x48 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 685 V 3.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 686 E 3.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 687 A 3.51x51 GLP-1 receptor 5NX2 - -
TM3 688 V 3.52x52 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 689 I 3.53x53 GLP-1 receptor 5NX2 - -
TM3 690 L 3.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 691 F 3.55x55 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM3 692 L 3.56x56 GLP-1 receptor 5NX2 - -
TM3 693 M 3.57x57 GLP-1 receptor 5NX2 - -
TM3 694 V 3.58x58 GLP-1 receptor 5NX2 - -
TM3 695 R 3.59x59 GLP-1 receptor 5NX2 - -
TM3 696 N 3.60x60 GLP-1 receptor 5NX2 - -
ICL2 697 L - - - -
ICL2 698 K - - - -
ICL2 699 V - - - -
ICL2 700 V - - - -
ICL2 701 N - - - -
ICL2 702 Y - - - -
ICL2 703 F - - - -
ICL2 704 S - - - -
TM4 705 S 4.37x38 GLP-1 receptor 5VAI GLP-1 receptor 5VAI
TM4 706 R 4.38x39 GLP-1 receptor 5NX2 - -
TM4 707 N 4.39x40 GLP-1 receptor 5NX2 - -
TM4 708 I 4.40x41 GLP-1 receptor 5NX2 - -
TM4 709 K 4.41x42 GLP-1 receptor 5NX2 - -
TM4 710 M 4.42x43 GLP-1 receptor 5NX2 - -
TM4 711 L 4.43x44 GLP-1 receptor 5NX2 - -
TM4 712 H 4.44x45 GLP-1 receptor 5NX2 - -
TM4 713 I 4.45x46 GLP-1 receptor 5NX2 - -
TM4 714 C 4.46x47 GLP-1 receptor 5NX2 - -
TM4 715 A 4.47x48 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 716 F 4.48x49 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 717 G 4.49x491 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 718 Y 4.50x50 GLP-1 receptor 5NX2 - -
TM4 719 G 4.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 720 L 4.52x52 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM4 721 P 4.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 722 M 4.54x54 GLP-1 receptor 5NX2 glucagon receptor 5XEZ
TM4 723 L 4.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 724 V 4.56x56 GLP-1 receptor 5NX2 - -
TM4 725 V 4.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 726 V 4.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 727 I 4.59x59 GLP-1 receptor 5NX2 CT receptor 6NIY
TM4 728 S 4.60x60 GLP-1 receptor 5NX2 - -
TM4 729 A 4.61x61 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 730 S 4.62x62 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM4 731 V 4.63x63 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 732 Q 4.64x64 GLP-1 receptor 5NX2 - -
TM4 733 P 4.65x65 GLP-1 receptor 5NX2 - -
TM4 734 Q 4.66x66 GLP-1 receptor 5NX2 - -
TM4 735 G 4.67x67 GLP-1 receptor 5NX2 - -
TM4 736 Y 4.68x68 CT receptor 6NIY calcitonin receptor-like receptor 6UUS
ECL2 737 G - - - -
ECL2 738 M - - - -
ECL2 739 H - - - -
ECL2 740 N - - - -
ECL2 741 R - - - -
ECL2 742 C 45.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 743 W 45.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 744 L 45.52x52 GLP-1 receptor 5NX2 CT receptor 6NIY
ECL2 745 N - - - -
ECL2 746 T - - - -
TM5 747 E 5.32x32 - - - -
TM5 748 T 5.33x33 GLP-1 receptor 5NX2 - -
TM5 749 G 5.34x34 GLP-1 receptor 5NX2 PTH1 receptor 6NBI
TM5 750 F 5.35x35 GLP-1 receptor 5NX2 - -
TM5 751 I 5.36x36 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 752 W 5.37x37 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 753 S 5.38x38 GLP-1 receptor 5NX2 - -
TM5 754 F 5.39x39 GLP-1 receptor 5NX2 - -
TM5 755 L 5.40x40 GLP-1 receptor 5NX2 - -
TM5 756 G 5.41x41 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 757 P 5.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 758 V 5.43x43 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 759 C 5.44x44 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM5 760 T 5.45x45 GLP-1 receptor 5NX2 - -
TM5 761 V 5.46x46 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM5 762 I 5.47x47 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 763 V 5.48x48 GLP-1 receptor 5NX2 CT receptor 6NIY
TM5 764 I 5.49x49 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 765 N 5.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 766 S 5.51x51 GLP-1 receptor 5NX2 - -
TM5 767 L 5.52x52 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 768 L 5.53x53 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 769 L 5.54x54 GLP-1 receptor 5NX2 CT receptor 6NIY
TM5 770 T 5.55x55 GLP-1 receptor 5NX2 - -
TM5 771 W 5.56x56 GLP-1 receptor 5NX2 - -
TM5 772 T 5.57x57 GLP-1 receptor 5NX2 - -
TM5 773 L 5.58x58 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 774 W 5.59x59 GLP-1 receptor 5NX2 - -
TM5 775 I 5.60x60 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 776 L 5.61x61 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 777 R 5.62x62 GLP-1 receptor 5NX2 - -
TM5 778 Q 5.63x63 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM5 779 R 5.64x64 GLP-1 receptor 5NX2 - -
TM5 780 L 5.65x65 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ICL3 781 S - - - -
ICL3 782 S - - - -
ICL3 783 V - - - -
ICL3 784 N - - - -
ICL3 785 A - - - -
ICL3 787 V - - - -
ICL3 788 S - - - -
ICL3 789 T - - - -
ICL3 790 L - - - -
ICL3 791 K - - - -
TM6 792 D 6.34x34 GLP-1 receptor 5NX2 - -
TM6 793 T 6.35x35 GLP-1 receptor 5NX2 - -
TM6 794 R 6.36x36 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM6 795 L 6.37x37 GLP-1 receptor 5NX2 - -
TM6 796 L 6.38x38 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 797 T 6.39x39 GLP-1 receptor 5NX2 - -
TM6 798 F 6.40x40 GLP-1 receptor 5NX2 - -
TM6 799 K 6.41x41 GLP-1 receptor 5NX2 - -
TM6 800 A 6.42x42 GLP-1 receptor 5NX2 - -
TM6 801 F 6.43x43 GLP-1 receptor 5NX2 - -
TM6 802 A 6.44x44 GLP-1 receptor 5NX2 - -
TM6 803 Q 6.45x45 GLP-1 receptor 5NX2 - -
TM6 804 L 6.46x46 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM6 805 F 6.47x47 GLP-1 receptor 5NX2 - -
TM6 806 I 6.48x48 GLP-1 receptor 5NX2 - -
TM6 807 L 6.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 808 G 6.50x50 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM6 809 C 6.51x51 GLP-1 receptor 5NX2 - -
TM6 810 S 6.52x52 GLP-1 receptor 5NX2 - -
TM6 811 W 6.53x53 GLP-1 receptor 5NX2 - -
TM6 812 V 6.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 813 L 6.55x55 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM6 814 G 6.56x56 GLP-1 receptor 5NX2 - -
TM6 815 I 6.57x57 GLP-1 receptor 5NX2 - -
TM6 816 F 6.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 817 Q 6.59x59 PAC1 receptor 6M1H - -
ECL3 818 I - - - -
ECL3 819 G - - - -
ECL3 820 P - - - -
ECL3 821 V - - - -
TM7 822 A 7.35x34 GLP-1 receptor 5NX2 - -
TM7 823 G 7.36x35 GLP-1 receptor 5NX2 - -
TM7 824 V 7.37x36 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM7 825 M 7.38x37 GLP-1 receptor 5NX2 - -
TM7 826 A 7.39x38 GLP-1 receptor 5NX2 - -
TM7 827 Y 7.40x39 GLP-1 receptor 5NX2 CT receptor 6NIY
TM7 828 L 7.41x40 GLP-1 receptor 5NX2 - -
TM7 829 F 7.42x41 GLP-1 receptor 5NX2 - -
TM7 830 T 7.43x42 GLP-1 receptor 5NX2 - -
TM7 831 I 7.44x43 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM7 832 I 7.45x44 GLP-1 receptor 5NX2 - -
TM7 833 N 7.46x45 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM7 834 S 7.47x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 835 L 7.48x47 GLP-1 receptor 5NX2 - -
TM7 836 Q 7.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 837 G 7.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 838 A 7.51x51 GLP-1 receptor 5NX2 - -
TM7 839 F 7.52x52 GLP-1 receptor 5NX2 CT receptor 6NIY
TM7 840 I 7.53x53 GLP-1 receptor 5NX2 - -
TM7 841 F 7.54x54 GLP-1 receptor 5NX2 - -
TM7 842 L 7.55x55 GLP-1 receptor 5NX2 - -
TM7 843 I 7.56x56 GLP-1 receptor 5NX2 CT receptor 6NIY
TM7 844 H 7.57x57 GLP-1 receptor 5NX2 - -
TM7 845 C 7.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 846 L 7.59x59 GLP-1 receptor 5NX2 - -
TM7 847 L 7.60x60 GLP-1 receptor 5NX2 secretin receptor 6WZG
H8 848 N 8.47x47 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 849 G 8.48x48 GLP-1 receptor 5NX2 secretin receptor 6WZG
H8 850 Q 8.49x49 GLP-1 receptor 5NX2 - -
H8 851 V 8.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 852 R 8.51x51 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
H8 853 E 8.52x52 GLP-1 receptor 5NX2 - -
H8 854 E 8.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 855 Y 8.54x54 GLP-1 receptor 5NX2 - -
H8 856 K 8.55x55 GLP-1 receptor 5NX2 CT receptor 6NIY
H8 857 R 8.56x56 GLP-1 receptor 5NX2 CT receptor 6NIY
H8 858 W 8.57x57 GLP-1 receptor 5NX2 - -
H8 859 I 8.58x58 secretin receptor 6WZG - -
H8 860 T 8.59x59 secretin receptor 6WZG - -
H8 861 G 8.60x60 secretin receptor 6WZG - -
H8 862 K 8.61x61 secretin receptor 6WZG - -
H8 863 T 8.62x62 secretin receptor 6WZG PTH1 receptor 6NBI
H8 864 K 8.63x63 secretin receptor 6WZG - -
C-term 865 P - - - -
C-term 866 S - - - -
C-term 867 S - - - -
C-term 868 Q - - - -
C-term 869 S - - - -