ADGRE5 homology model

PROTEIN CLASS

Class B2 (Adhesion)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2020-10-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

GLP-1 receptor (sequence similarity: 34%) PDB: 5NX2

TEMPLATES

6VN7 (VPAC1 receptor)
5NX2 (GLP-1 receptor)
6X19 (GLP-1 receptor)
6X1A (GLP-1 receptor)
6WZG (secretin receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 81.5 5.3 13.2
Side-chains 22.4 19.9 57.7

Number of backbone templates: 5
Number of rotamer templates: 13

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 530 L - - - -
N-term 531 S - - - -
N-term 532 S - - - -
N-term 533 F - - - -
N-term 534 A - - - -
TM1 535 I 1.27x27 VPAC1 receptor 6VN7 - -
TM1 536 L 1.28x28 VPAC1 receptor 6VN7 VPAC1 receptor 6VN7
TM1 537 M 1.29x29 VPAC1 receptor 6VN7 - -
TM1 538 A 1.30x30 VPAC1 receptor 6VN7 - -
TM1 539 H 1.31x31 VPAC1 receptor 6VN7 - -
TM1 540 Y 1.32x32 VPAC1 receptor 6VN7 - -
TM1 541 D 1.33x33 GLP-1 receptor 5NX2 - -
TM1 542 V 1.34x34 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM1 543 E 1.35x35 GLP-1 receptor 5NX2 - -
TM1 544 D 1.36x36 GLP-1 receptor 5NX2 - -
TM1 545 W 1.37x37 GLP-1 receptor 5NX2 - -
TM1 546 K 1.38x38 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM1 547 L 1.39x39 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 548 T 1.40x40 GLP-1 receptor 5NX2 - -
TM1 549 L 1.41x41 GLP-1 receptor 5NX2 - -
TM1 550 I 1.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 551 T 1.43x43 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM1 552 R 1.44x44 GLP-1 receptor 5NX2 - -
TM1 553 V 1.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 554 G 1.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 555 L 1.47x47 GLP-1 receptor 5NX2 - -
TM1 556 A 1.48x48 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 557 L 1.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 558 S 1.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 559 L 1.51x51 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM1 560 F 1.52x52 GLP-1 receptor 5NX2 CT receptor 6NIY
TM1 561 C 1.53x53 GLP-1 receptor 5NX2 - -
TM1 562 L 1.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 563 L 1.55x55 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM1 564 L 1.56x56 GLP-1 receptor 5NX2 PAC1 receptor 6M1I
TM1 565 C 1.57x57 GLP-1 receptor 5NX2 - -
TM1 566 I 1.58x58 GLP-1 receptor 5NX2 - -
TM1 567 L 1.59x59 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 568 T 1.60x60 GLP-1 receptor 5NX2 - -
TM1 569 F 1.61x61 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 570 L 1.62x62 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 571 L 1.63x63 GLP-1 receptor 5NX2 VPAC1 receptor 6VN7
TM1 572 V 1.64x64 GLP-1 receptor 5NX2 - -
ICL1 573 R GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ICL1 574 P GLP-1 receptor 5NX2 - -
ICL1 575 I GLP-1 receptor 5NX2 - -
ICL1 576 Q GLP-1 receptor 5NX2 - -
TM2 577 G 2.44x44 GLP-1 receptor 5NX2 - -
TM2 578 S 2.45x45 GLP-1 receptor 5NX2 - -
TM2 579 R 2.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 580 T 2.47x47 GLP-1 receptor 5NX2 - -
TM2 581 T 2.48x48 GLP-1 receptor 5NX2 CT receptor 6NIY
TM2 582 I 2.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 583 H 2.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 584 L 2.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 585 H 2.52x52 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM2 586 L 2.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 587 C 2.54x54 GLP-1 receptor 5NX2 - -
TM2 588 I 2.55x55 GLP-1 receptor 5NX2 VPAC1 receptor 6VN7
TM2 589 C 2.56x56 GLP-1 receptor 5NX2 - -
TM2 590 L 2.57x57 GLP-1 receptor 5NX2 - -
TM2 591 F 2.58x58 GLP-1 receptor 5NX2 - -
TM2 592 V 2.59x59 GLP-1 receptor 5NX2 - -
TM2 593 G 2.60x60 GLP-1 receptor 5NX2 - -
TM2 594 S 2.61x61 GLP-1 receptor 5NX2 CT receptor 6NIY
TM2 595 T 2.62x62 GLP-1 receptor 5NX2 - -
TM2 596 I 2.63x63 GLP-1 receptor 5NX2 CT receptor 6NIY
TM2 597 F 2.64x64 GLP-1 receptor 5NX2 - -
TM2 598 L 2.65x65 GLP-1 receptor 5NX2 glucagon receptor 5XEZ
TM2 599 A 2.66x66 GLP-1 receptor 5NX2 - -
TM2 600 G 2.67x67 GLP-1 receptor 5NX2 - -
TM2 601 I 2.68x68 GLP-1 receptor 5NX2 - -
TM2 602 E 2.69x69 GLP-1 receptor 5NX2 - -
TM2 603 N 2.70x70 GLP-1 receptor 5NX2 - -
ECL1 604 E - - - -
ECL1 605 G - - - -
ECL1 606 G - - - -
ECL1 607 Q - - - -
ECL1 608 V - - - -
ECL1 609 G - - - -
TM3 610 L 3.27x27 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 611 R 3.28x28 GLP-1 receptor 5NX2 - -
TM3 612 C 3.29x29 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 613 R 3.30x30 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 614 L 3.31x31 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 615 V 3.32x32 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 616 A 3.33x33 GLP-1 receptor 5NX2 glucagon receptor 5XEZ
TM3 617 G 3.34x34 GLP-1 receptor 5NX2 - -
TM3 618 L 3.35x35 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM3 619 L 3.36x36 GLP-1 receptor 5NX2 - -
TM3 620 H 3.37x37 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM3 621 Y 3.38x38 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 622 C 3.39x39 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 623 F 3.40x40 GLP-1 receptor 5NX2 - -
TM3 624 L 3.41x41 GLP-1 receptor 5NX2 - -
TM3 625 A 3.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 626 A 3.43x43 GLP-1 receptor 5NX2 - -
TM3 627 F 3.44x44 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM3 628 C 3.45x45 GLP-1 receptor 5NX2 glucagon receptor 5XEZ
TM3 629 W 3.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 630 M 3.47x47 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM3 631 S 3.48x48 GLP-1 receptor 5NX2 - -
TM3 632 L 3.49x49 GLP-1 receptor 5NX2 - -
TM3 633 E 3.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 634 G 3.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 635 L 3.52x52 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM3 636 E 3.53x53 GLP-1 receptor 5NX2 - -
TM3 637 L 3.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 638 Y 3.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 639 F 3.56x56 GLP-1 receptor 5NX2 - -
TM3 640 L 3.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 641 V 3.58x58 GLP-1 receptor 5NX2 - -
TM3 642 V 3.59x59 GLP-1 receptor 5NX2 PAC1 receptor 6LPB
TM3 643 R 3.60x60 GLP-1 receptor 5NX2 - -
ICL2 644 V GLP-1 receptor 5NX2 - -
ICL2 645 F GLP-1 receptor 5NX2 - -
ICL2 646 Q GLP-1 receptor 5NX2 - -
ICL2 647 G GLP-1 receptor 5NX2 - -
TM4 648 Q 4.38x39 GLP-1 receptor 5NX2 - -
TM4 649 G 4.39x40 GLP-1 receptor 5NX2 - -
TM4 650 L 4.40x41 GLP-1 receptor 5NX2 - -
TM4 651 S 4.41x42 GLP-1 receptor 5NX2 - -
TM4 652 T 4.42x43 GLP-1 receptor 5NX2 - -
TM4 653 R 4.43x44 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 654 W 4.44x45 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM4 655 L 4.45x46 GLP-1 receptor 5NX2 - -
TM4 656 C 4.46x47 GLP-1 receptor 5NX2 - -
TM4 657 L 4.47x48 GLP-1 receptor 5NX2 VPAC1 receptor 6VN7
TM4 658 I 4.48x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 659 G 4.49x491 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 660 Y 4.50x50 GLP-1 receptor 5NX2 - -
TM4 661 G 4.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 662 V 4.52x52 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 663 P 4.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 664 L 4.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 665 L 4.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 666 I 4.56x56 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM4 667 V 4.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 668 G 4.58x58 GLP-1 receptor 5NX2 - -
TM4 669 V 4.59x59 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM4 670 S 4.60x60 GLP-1 receptor 5NX2 - -
TM4 671 A 4.61x61 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 672 A 4.62x62 GLP-1 receptor 5NX2 - -
TM4 673 I 4.63x63 GLP-1 receptor 5NX2 - -
TM4 674 Y 4.64x64 GLP-1 receptor 5NX2 - -
TM4 675 S 4.65x65 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM4 676 K 4.66x66 GLP-1 receptor 5NX2 - -
TM4 677 G 4.67x67 GLP-1 receptor 5NX2 - -
TM4 678 Y 4.68x68 GLP-1 receptor 6X19 calcitonin receptor-like receptor 6UUS
ECL2 679 G - - - -
ECL2 680 R - - - -
ECL2 681 P - - - -
ECL2 682 R - - - -
ECL2 683 Y - - - -
ECL2 684 C 45.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 685 W 45.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 686 L 45.52x52 GLP-1 receptor 5NX2 CT receptor 6NIY
ECL2 687 D - - - -
ECL2 688 F - - - -
TM5 689 E 5.32x32 - - - -
TM5 690 Q 5.33x33 GLP-1 receptor 5NX2 - -
TM5 691 G 5.34x34 GLP-1 receptor 5NX2 - -
TM5 692 F 5.35x35 GLP-1 receptor 5NX2 - -
TM5 693 L 5.36x36 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM5 694 W 5.37x37 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 695 S 5.38x38 GLP-1 receptor 5NX2 - -
TM5 696 F 5.39x39 GLP-1 receptor 5NX2 - -
TM5 697 L 5.40x40 GLP-1 receptor 5NX2 - -
TM5 698 G 5.41x41 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 699 P 5.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 700 V 5.43x43 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 701 T 5.44x44 GLP-1 receptor 5NX2 - -
TM5 702 F 5.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 703 I 5.46x46 GLP-1 receptor 5NX2 - -
TM5 704 I 5.47x47 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 705 L 5.48x48 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 706 C 5.49x49 GLP-1 receptor 5NX2 - -
TM5 707 N 5.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 708 A 5.51x51 GLP-1 receptor 5NX2 - -
TM5 709 V 5.52x52 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM5 710 I 5.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 711 F 5.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 712 V 5.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 713 T 5.56x56 GLP-1 receptor 5NX2 - -
TM5 714 T 5.57x57 GLP-1 receptor 5NX2 - -
TM5 715 V 5.58x58 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM5 716 W 5.59x59 GLP-1 receptor 5NX2 - -
TM5 717 K 5.60x60 GLP-1 receptor 5NX2 - -
TM5 718 L 5.61x61 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 719 T 5.62x62 GLP-1 receptor 5NX2 - -
TM5 720 Q 5.63x63 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM5 721 K 5.64x64 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 722 F 5.65x65 GLP-1 receptor 5NX2 - -
ICL3 723 S - - - -
ICL3 724 E - - - -
ICL3 725 I - - - -
ICL3 726 N - - - -
ICL3 727 P - - - -
ICL3 729 M - - - -
ICL3 730 K - - - -
ICL3 731 K - - - -
ICL3 732 L - - - -
ICL3 733 K - - - -
TM6 734 K 6.34x34 GLP-1 receptor 5NX2 - -
TM6 735 A 6.35x35 GLP-1 receptor 5NX2 GLP-1 receptor 5VEW
TM6 736 R 6.36x36 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM6 737 A 6.37x37 GLP-1 receptor 5NX2 - -
TM6 738 L 6.38x38 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 739 T 6.39x39 GLP-1 receptor 5NX2 - -
TM6 740 I 6.40x40 GLP-1 receptor 5NX2 - -
TM6 741 T 6.41x41 GLP-1 receptor 5NX2 - -
TM6 742 A 6.42x42 GLP-1 receptor 5NX2 - -
TM6 743 I 6.43x43 GLP-1 receptor 5NX2 - -
TM6 744 A 6.44x44 GLP-1 receptor 5NX2 - -
TM6 745 Q 6.45x45 GLP-1 receptor 5NX2 - -
TM6 746 L 6.46x46 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM6 747 F 6.47x47 GLP-1 receptor 5NX2 - -
TM6 748 L 6.48x48 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 749 L 6.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 750 G 6.50x50 GLP-1 receptor 5NX2 PAC1 receptor 6M1I
TM6 751 C 6.51x51 GLP-1 receptor 5NX2 - -
TM6 752 T 6.52x52 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM6 753 W 6.53x53 GLP-1 receptor 5NX2 - -
TM6 754 V 6.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 755 F 6.55x55 GLP-1 receptor 5NX2 - -
TM6 756 G 6.56x56 GLP-1 receptor 5NX2 - -
TM6 757 L 6.57x57 GLP-1 receptor 5NX2 - -
TM6 758 F 6.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 759 I 6.59x59 GLP-1 receptor 6X1A - -
TM6 760 F 6.60x60 GLP-1 receptor 6X1A - -
ECL3 761 D - - - -
ECL3 762 D - - - -
ECL3 763 R - - - -
TM7 764 S 7.35x34 GLP-1 receptor 5NX2 - -
TM7 765 L 7.36x35 GLP-1 receptor 5NX2 - -
TM7 766 V 7.37x36 GLP-1 receptor 5NX2 VPAC1 receptor 6VN7
TM7 767 L 7.38x37 GLP-1 receptor 5NX2 - -
TM7 768 T 7.39x38 GLP-1 receptor 5NX2 - -
TM7 769 Y 7.40x39 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM7 770 V 7.41x40 GLP-1 receptor 5NX2 CT receptor 6NIY
TM7 771 F 7.42x41 GLP-1 receptor 5NX2 - -
TM7 772 T 7.43x42 GLP-1 receptor 5NX2 - -
TM7 773 I 7.44x43 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM7 774 L 7.45x44 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM7 775 N 7.46x45 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM7 776 C 7.47x46 GLP-1 receptor 5NX2 - -
TM7 777 L 7.48x47 GLP-1 receptor 5NX2 - -
TM7 778 Q 7.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 779 G 7.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 780 A 7.51x51 GLP-1 receptor 5NX2 - -
TM7 781 F 7.52x52 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM7 782 L 7.53x53 GLP-1 receptor 5NX2 - -
TM7 783 Y 7.54x54 GLP-1 receptor 5NX2 - -
TM7 784 L 7.55x55 GLP-1 receptor 5NX2 - -
TM7 785 L 7.56x56 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 786 H 7.57x57 GLP-1 receptor 5NX2 - -
TM7 787 C 7.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 788 L 7.59x59 GLP-1 receptor 5NX2 - -
TM7 789 L 7.60x60 GLP-1 receptor 5NX2 secretin receptor 6WZG
H8 790 N 8.47x47 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 791 K 8.48x48 GLP-1 receptor 5NX2 glucagon receptor 5XEZ
H8 792 K 8.49x49 GLP-1 receptor 5NX2 - -
H8 793 V 8.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 794 R 8.51x51 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
H8 795 E 8.52x52 GLP-1 receptor 5NX2 - -
H8 796 E 8.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 797 Y 8.54x54 GLP-1 receptor 5NX2 - -
H8 798 R 8.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 799 K 8.56x56 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 800 W 8.57x57 GLP-1 receptor 5NX2 - -
H8 801 A 8.58x58 secretin receptor 6WZG - -
H8 802 C 8.59x59 secretin receptor 6WZG - -
H8 803 L 8.60x60 secretin receptor 6WZG - -
H8 804 V 8.61x61 secretin receptor 6WZG - -
H8 805 A 8.62x62 secretin receptor 6WZG - -
H8 806 G 8.63x63 secretin receptor 6WZG - -
C-term 807 G - - - -
C-term 808 S - - - -
C-term 809 K - - - -
C-term 810 Y - - - -
C-term 811 S - - - -