ADGRF1 homology model

PROTEIN CLASS

Class B2 (Adhesion)

RECEPTOR

ADGRF1

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2021-09-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

GLP-1 receptor (sequence similarity: 11%) PDB: 5NX2
Align

TEMPLATES

5NX2 (GLP-1 receptor)
7D77 (ADGRG3)
7JHJ (BILF1)
6PB0 (CRF1 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 74.7 8.3 17.0
Side-chains 14.9 33.6 51.6

Number of backbone templates: 4
Number of rotamer templates: 16

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 575 P - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
N-term 576 F - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
N-term 577 V - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
N-term 578 P - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
N-term 579 S - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 580 T 1.34x34 GLP-1 receptor 5NX2 - -
TM1 581 I 1.35x35 GLP-1 receptor 5NX2 GIP receptor 7DTY
TM1 582 F 1.36x36 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM1 583 P 1.37x37 GLP-1 receptor 5NX2 - -
TM1 584 V 1.38x38 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM1 585 V 1.39x39 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM1 586 K 1.40x40 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM1 587 W 1.41x41 GLP-1 receptor 5NX2 - -
TM1 588 I 1.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 589 T 1.43x43 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM1 590 Y 1.44x44 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM1 591 V 1.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 592 G 1.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 593 L 1.47x47 GLP-1 receptor 5NX2 BILF1 7JHJ
TM1 594 G 1.48x48 GLP-1 receptor 5NX2 ADGRG3 7D77
TM1 595 I 1.49x49 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM1 596 S 1.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 597 I 1.51x51 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM1 598 G 1.52x52 GLP-1 receptor 5NX2 glucagon receptor 5YQZ
TM1 599 S 1.53x53 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM1 600 L 1.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 601 I 1.55x55 GLP-1 receptor 5NX2 - -
TM1 602 L 1.56x56 GLP-1 receptor 5NX2 PAC1 receptor 6M1I
TM1 603 C 1.57x57 GLP-1 receptor 5NX2 - -
TM1 604 L 1.58x58 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM1 605 I 1.59x59 GLP-1 receptor 5NX2 ADGRG3 7D77
TM1 606 I 1.60x60 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 607 E 1.61x61 GLP-1 receptor 5NX2 - -
TM1 608 A 1.62x62 GLP-1 receptor 5NX2 ADGRG3 7D77
TM1 609 L 1.63x63 GLP-1 receptor 5NX2 VPAC1 receptor 6VN7
TM1 610 F 1.64x64 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 611 W 1.65x65 ADGRG3 7D77 - -
ICL1 612 K 12.48x48 - - - -
ICL1 613 Q 12.49x49 ADGRG3 7D77 - -
ICL1 614 I 12.50x50 ADGRG3 7D77 CRF1 receptor 4Z9G
ICL1 615 K 12.51x51 ADGRG3 7D77 ADGRG3 7D77
ICL1 616 K - - - - -
ICL1 617 S - - - - -
TM2 618 Q 2.44x44 GLP-1 receptor 5NX2 - -
TM2 619 T 2.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 620 S 2.46x46 GLP-1 receptor 5NX2 - -
TM2 621 H 2.47x47 GLP-1 receptor 5NX2 - -
TM2 622 T 2.48x48 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM2 623 R 2.49x49 GLP-1 receptor 5NX2 - -
TM2 624 R 2.50x50 GLP-1 receptor 5NX2 - -
TM2 625 I 2.51x51 GLP-1 receptor 5NX2 GIP receptor 7DTY
TM2 626 C 2.52x52 GLP-1 receptor 5NX2 - -
TM2 627 M 2.53x53 GLP-1 receptor 5NX2 CT receptor 6NIY
TM2 628 V 2.54x54 GLP-1 receptor 5NX2 - -
TM2 629 N 2.55x55 GLP-1 receptor 5NX2 - -
TM2 630 I 2.56x56 GLP-1 receptor 5NX2 - -
TM2 631 A 2.57x57 GLP-1 receptor 5NX2 - -
TM2 632 L 2.58x58 GLP-1 receptor 5NX2 BILF1 7JHJ
TM2 633 S 2.59x59 GLP-1 receptor 5NX2 - -
TM2 634 L 2.60x60 GLP-1 receptor 5NX2 ADGRG3 7D77
TM2 635 L 2.61x61 GLP-1 receptor 5NX2 - -
TM2 636 I 2.62x62 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM2 637 A 2.63x63 GLP-1 receptor 5NX2 ADGRG3 7D77
TM2 638 D 2.64x64 GLP-1 receptor 5NX2 - -
TM2 639 V 2.65x65 GLP-1 receptor 5NX2 - -
TM2 640 W 2.66x66 GLP-1 receptor 5NX2 - -
TM2 641 F 2.67x67 GLP-1 receptor 5NX2 - -
TM2 642 I 2.68x68 GLP-1 receptor 5NX2 - -
TM2 643 V 2.69x69 GLP-1 receptor 5NX2 CT receptor 6NIY
TM2 644 G 2.70x70 GLP-1 receptor 5NX2 - -
ECL1 645 A - - - - -
ECL1 646 T - - - - -
ECL1 647 V - - - - -
ECL1 648 D - - - - -
ECL1 649 T - - - - -
ECL1 650 T - - - - -
ECL1 651 V - - - - -
ECL1 652 N - - - - -
TM3 653 P 3.25x25 ADGRG3 7D77 - -
TM3 654 S 3.26x26 ADGRG3 7D77 - -
TM3 655 G 3.27x27 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM3 656 V 3.28x28 GLP-1 receptor 5NX2 - -
TM3 657 C 3.29x29 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 658 T 3.30x30 GLP-1 receptor 5NX2 - -
TM3 659 A 3.31x31 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 660 A 3.32x32 GLP-1 receptor 5NX2 VPAC1 receptor 6VN7
TM3 661 V 3.33x33 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM3 662 F 3.34x34 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM3 663 F 3.35x35 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 664 T 3.36x36 GLP-1 receptor 5NX2 GIP receptor 7DTY
TM3 665 H 3.37x37 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 666 F 3.38x38 GLP-1 receptor 5NX2 GHRH receptor 7CZ5
TM3 667 F 3.39x39 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 668 Y 3.40x40 GLP-1 receptor 5NX2 - -
TM3 669 L 3.41x41 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 670 S 3.42x42 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM3 671 L 3.43x43 GLP-1 receptor 5NX2 - -
TM3 672 F 3.44x44 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 673 F 3.45x45 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM3 674 W 3.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 675 M 3.47x47 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 676 L 3.48x48 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 677 M 3.49x49 GLP-1 receptor 5NX2 - -
TM3 678 L 3.50x50 GLP-1 receptor 5NX2 - -
TM3 679 G 3.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 680 I 3.52x52 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM3 681 L 3.53x53 GLP-1 receptor 5NX2 - -
TM3 682 L 3.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 683 A 3.55x55 GLP-1 receptor 5NX2 - -
TM3 684 Y 3.56x56 GLP-1 receptor 5NX2 - -
TM3 685 R 3.57x57 GLP-1 receptor 5NX2 - -
TM3 686 I 3.58x58 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM3 687 I 3.59x59 GLP-1 receptor 5NX2 - -
TM3 688 L 3.60x60 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
ICL2 689 V - - - - -
ICL2 690 F - - - - -
ICL2 691 H - - - - -
ICL2 692 H - - - - -
ICL2 693 M - - - - -
ICL2 694 A - - - - -
ICL2 695 Q - - - - -
ICL2 696 H - - - - -
ICL2 697 L - - - - -
TM4 698 M 4.41x42 GLP-1 receptor 5NX2 - -
TM4 699 M 4.42x43 GLP-1 receptor 5NX2 - -
TM4 700 A 4.43x44 GLP-1 receptor 5NX2 - -
TM4 701 V 4.44x45 GLP-1 receptor 5NX2 - -
TM4 702 G 4.45x46 GLP-1 receptor 5NX2 - -
TM4 703 F 4.46x47 GLP-1 receptor 5NX2 - -
TM4 704 C 4.47x48 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM4 705 L 4.48x49 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM4 706 G 4.49x491 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 707 Y 4.50x50 GLP-1 receptor 5NX2 - -
TM4 708 G 4.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 709 C 4.52x52 GLP-1 receptor 5NX2 - -
TM4 710 P 4.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 711 L 4.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 712 I 4.55x55 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM4 713 I 4.56x56 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM4 714 S 4.57x57 GLP-1 receptor 5NX2 - -
TM4 715 V 4.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 716 I 4.59x59 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM4 717 T 4.60x60 GLP-1 receptor 5NX2 ADGRG3 7D77
TM4 718 I 4.61x61 GLP-1 receptor 5NX2 - -
TM4 719 A 4.62x62 GLP-1 receptor 5NX2 - -
TM4 720 V 4.63x63 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 721 T 4.64x64 GLP-1 receptor 5NX2 - -
ECL2 722 Q - - - - -
ECL2 723 P - BILF1 7JHJ - -
ECL2 724 S - BILF1 7JHJ - -
ECL2 725 N - BILF1 7JHJ - -
ECL2 726 T - BILF1 7JHJ - -
ECL2 727 Y - BILF1 7JHJ - -
ECL2 728 K - BILF1 7JHJ - -
ECL2 729 R - BILF1 7JHJ - -
ECL2 730 K - BILF1 7JHJ - -
ECL2 731 D - BILF1 7JHJ - -
ECL2 732 V - - - - -
ECL2 733 C 45.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 734 W 45.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 735 L 45.52x52 GLP-1 receptor 5NX2 CT receptor 6NIY
ECL2 736 N - - - - -
ECL2 737 W - - - - -
ECL2 738 S - - - - -
ECL2 739 N - - - - -
ECL2 740 G - - - - -
TM5 741 S 5.33x33 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM5 742 K 5.34x34 GLP-1 receptor 5NX2 GIP receptor 7DTY
TM5 743 P 5.35x35 GLP-1 receptor 5NX2 - -
TM5 744 L 5.36x36 GLP-1 receptor 5NX2 ADGRG3 7D77
TM5 745 L 5.37x37 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM5 746 A 5.38x38 BILF1 7JHJ - -
TM5 747 F 5.39x39 BILF1 7JHJ - -
TM5 748 V 5.40x40 GLP-1 receptor 5NX2 - -
TM5 749 V 5.41x41 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM5 750 P 5.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 751 A 5.43x43 GLP-1 receptor 5NX2 - -
TM5 752 L 5.44x44 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 753 A 5.45x45 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM5 754 I 5.46x46 GLP-1 receptor 5NX2 - -
TM5 755 V 5.47x47 GLP-1 receptor 5NX2 GHRH receptor 7CZ5
TM5 756 A 5.48x48 GLP-1 receptor 5NX2 - -
TM5 757 V 5.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 758 N 5.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 759 F 5.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 760 V 5.52x52 GLP-1 receptor 5NX2 ADGRG3 7D77
TM5 761 V 5.53x53 GLP-1 receptor 5NX2 ADGRG3 7D77
TM5 762 V 5.54x54 GLP-1 receptor 5NX2 - -
TM5 763 L 5.55x55 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM5 764 L 5.56x56 GLP-1 receptor 5NX2 ADGRG3 7D77
TM5 765 V 5.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 766 L 5.58x58 GLP-1 receptor 5NX2 GIP receptor 7DTY
TM5 767 T 5.59x59 GLP-1 receptor 5NX2 - -
TM5 768 K 5.60x60 GLP-1 receptor 5NX2 ADGRG3 7D77
TM5 769 L 5.61x61 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM5 770 W 5.62x62 GLP-1 receptor 5NX2 - -
TM5 771 R 5.63x63 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 772 P 5.64x64 GLP-1 receptor 5NX2 - -
TM5 773 T 5.65x65 GLP-1 receptor 5NX2 - -
TM5 774 V 5.66x66 ADGRG3 7D77 - -
ICL3 775 G - - - - -
ICL3 776 E - - - - -
ICL3 777 R - - - - -
ICL3 778 L - - - - -
ICL3 779 S - - - - -
ICL3 780 R - - - - -
ICL3 781 D - - - - -
ICL3 782 D - - - - -
ICL3 783 K - - - - -
ICL3 784 A - - - - -
TM6 785 T 6.34x34 GLP-1 receptor 5NX2 - -
TM6 786 I 6.35x35 GLP-1 receptor 5NX2 - -
TM6 787 I 6.36x36 GLP-1 receptor 5NX2 - -
TM6 788 R 6.37x37 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 789 V 6.38x38 GLP-1 receptor 5NX2 - -
TM6 790 G 6.39x39 GLP-1 receptor 5NX2 - -
TM6 791 K 6.40x40 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 792 S 6.41x41 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 793 L 6.42x42 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 794 L 6.43x43 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 795 I 6.44x44 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM6 796 L 6.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 797 T 6.46x46 GLP-1 receptor 5NX2 - -
TM6 798 P 6.47x47 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM6 799 L 6.48x48 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 800 L 6.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 801 G 6.50x50 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 802 L 6.51x51 GLP-1 receptor 5NX2 - -
TM6 803 T 6.52x52 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 804 W 6.53x53 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 805 G 6.54x54 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 806 F 6.55x55 GLP-1 receptor 5NX2 - -
TM6 807 G 6.56x56 GLP-1 receptor 5NX2 - -
TM6 808 I 6.57x57 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 809 G 6.58x58 GLP-1 receptor 5NX2 - -
ECL3 810 T - - - - -
ECL3 811 I - - - - -
ECL3 812 V - - - - -
ECL3 813 D - - - - -
ECL3 814 S - - - - -
ECL3 815 Q - - - - -
TM7 816 N 7.35x34 GLP-1 receptor 5NX2 - -
TM7 817 L 7.36x35 GLP-1 receptor 5NX2 GLP-2 receptor 7D68
TM7 818 A 7.37x36 GLP-1 receptor 5NX2 GIP receptor 7DTY
TM7 819 W 7.38x37 GLP-1 receptor 5NX2 - -
TM7 820 H 7.39x38 GLP-1 receptor 5NX2 - -
TM7 821 V 7.40x39 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM7 822 I 7.41x40 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 823 F 7.42x41 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 824 A 7.43x42 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 825 L 7.44x43 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 826 L 7.45x44 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM7 827 N 7.46x45 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 828 A 7.47x46 GLP-1 receptor 5NX2 BILF1 7JHJ
TM7 829 F 7.48x47 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 830 Q 7.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 831 G 7.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 832 F 7.51x51 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM7 833 F 7.52x52 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 834 I 7.53x53 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 835 L 7.54x54 GLP-1 receptor 5NX2 - -
TM7 836 C 7.55x55 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 837 F 7.56x56 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM7 838 G 7.57x57 GLP-1 receptor 5NX2 - -
TM7 839 I 7.58x58 GLP-1 receptor 5NX2 - -
TM7 840 L 7.59x59 GLP-1 receptor 5NX2 - -
TM7 841 L 7.60x60 GLP-1 receptor 5NX2 ADGRG3 7D77
ICL4 842 D - - - - -
H8 843 S 8.48x48 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
H8 844 K 8.49x49 GLP-1 receptor 5NX2 - -
H8 845 L 8.50x50 GLP-1 receptor 5NX2 - -
H8 846 R 8.51x51 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
H8 847 Q 8.52x52 GLP-1 receptor 5NX2 - -
H8 848 L 8.53x53 GLP-1 receptor 5NX2 - -
H8 849 L 8.54x54 GLP-1 receptor 5NX2 VPAC1 receptor 6VN7
H8 850 F 8.55x55 GLP-1 receptor 5NX2 - -
H8 851 N 8.56x56 GLP-1 receptor 5NX2 BILF1 7JHJ
H8 852 K 8.57x57 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
H8 853 L 8.58x58 CRF1 receptor 6PB0 - -
H8 854 S 8.59x59 CRF1 receptor 6PB0 PTH1 receptor 6FJ3
H8 855 A 8.60x60 CRF1 receptor 6PB0 - -
H8 856 L 8.61x61 CRF1 receptor 6PB0 - -
H8 857 S 8.62x62 CRF1 receptor 6PB0 - -
H8 858 S 8.63x63 CRF1 receptor 6PB0 - -
C-term 859 W - - - - -
C-term 860 K - - - - -
C-term 861 Q - - - - -
C-term 862 T - - - - -
C-term 863 E - - - - -