ADGRF4 homology model

PROTEIN CLASS

Class B2 (Adhesion)

RECEPTOR

ADGRF4

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2021-09-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

GLP-1 receptor (sequence similarity: 15%) PDB: 5NX2
Align

TEMPLATES

5NX2 (GLP-1 receptor)
7D77 (ADGRG3)
7JHJ (BILF1)
6PB0 (CRF1 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 75.6 6.6 17.8
Side-chains 13.9 34.1 51.9

Number of backbone templates: 4
Number of rotamer templates: 15

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 391 M - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
N-term 392 S - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
N-term 393 S - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
N-term 394 K - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
N-term 395 S - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 396 M 1.34x34 GLP-1 receptor 5NX2 VPAC1 receptor 6VN7
TM1 397 T 1.35x35 GLP-1 receptor 5NX2 ADGRG3 7D77
TM1 398 D 1.36x36 GLP-1 receptor 5NX2 - -
TM1 399 K 1.37x37 GLP-1 receptor 5NX2 - -
TM1 400 V 1.38x38 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM1 401 L 1.39x39 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 402 D 1.40x40 GLP-1 receptor 5NX2 - -
TM1 403 Y 1.41x41 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM1 404 I 1.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 405 T 1.43x43 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM1 406 C 1.44x44 GLP-1 receptor 5NX2 - -
TM1 407 I 1.45x45 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM1 408 G 1.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 409 L 1.47x47 GLP-1 receptor 5NX2 BILF1 7JHJ
TM1 410 S 1.48x48 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM1 411 V 1.49x49 GLP-1 receptor 5NX2 ADGRG3 7D77
TM1 412 S 1.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 413 I 1.51x51 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM1 414 L 1.52x52 GLP-1 receptor 5NX2 BILF1 7JHJ
TM1 415 S 1.53x53 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM1 416 L 1.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 417 V 1.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 418 L 1.56x56 GLP-1 receptor 5NX2 PAC1 receptor 6M1I
TM1 419 C 1.57x57 GLP-1 receptor 5NX2 - -
TM1 420 L 1.58x58 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM1 421 I 1.59x59 GLP-1 receptor 5NX2 ADGRG3 7D77
TM1 422 I 1.60x60 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 423 E 1.61x61 GLP-1 receptor 5NX2 - -
TM1 424 A 1.62x62 GLP-1 receptor 5NX2 ADGRG3 7D77
TM1 425 T 1.63x63 GLP-1 receptor 5NX2 - -
TM1 426 V 1.64x64 GLP-1 receptor 5NX2 - -
ICL1 427 W - - - - -
ICL1 428 S - - - - -
ICL1 429 R - - - - -
ICL1 430 V - - - - -
ICL1 431 V - - - - -
ICL1 432 V - - - - -
ICL1 433 T - - - - -
TM2 434 E 2.44x44 GLP-1 receptor 5NX2 ADGRG3 7D77
TM2 435 I 2.45x45 GLP-1 receptor 5NX2 - -
TM2 436 S 2.46x46 GLP-1 receptor 5NX2 - -
TM2 437 Y 2.47x47 GLP-1 receptor 5NX2 - -
TM2 438 M 2.48x48 GLP-1 receptor 5NX2 - -
TM2 439 R 2.49x49 GLP-1 receptor 5NX2 - -
TM2 440 H 2.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 441 V 2.51x51 GLP-1 receptor 5NX2 ADGRG3 7D77
TM2 442 C 2.52x52 GLP-1 receptor 5NX2 - -
TM2 443 I 2.53x53 GLP-1 receptor 5NX2 - -
TM2 444 V 2.54x54 GLP-1 receptor 5NX2 - -
TM2 445 N 2.55x55 GLP-1 receptor 5NX2 - -
TM2 446 I 2.56x56 GLP-1 receptor 5NX2 - -
TM2 447 A 2.57x57 GLP-1 receptor 5NX2 - -
TM2 448 V 2.58x58 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM2 449 S 2.59x59 GLP-1 receptor 5NX2 - -
TM2 450 L 2.60x60 GLP-1 receptor 5NX2 ADGRG3 7D77
TM2 451 L 2.61x61 GLP-1 receptor 5NX2 - -
TM2 452 T 2.62x62 GLP-1 receptor 5NX2 - -
TM2 453 A 2.63x63 GLP-1 receptor 5NX2 ADGRG3 7D77
TM2 454 N 2.64x64 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM2 455 V 2.65x65 GLP-1 receptor 5NX2 - -
TM2 456 W 2.66x66 GLP-1 receptor 5NX2 - -
TM2 457 F 2.67x67 GLP-1 receptor 5NX2 - -
TM2 458 I 2.68x68 GLP-1 receptor 5NX2 - -
TM2 459 I 2.69x69 GLP-1 receptor 5NX2 - -
TM2 460 G 2.70x70 GLP-1 receptor 5NX2 - -
ECL1 461 S - - - - -
ECL1 462 H - - - - -
ECL1 463 F - - - - -
ECL1 464 N - - - - -
ECL1 465 I - - - - -
ECL1 466 K - - - - -
ECL1 467 A - - - - -
ECL1 468 Q - - - - -
TM3 469 D 3.25x25 ADGRG3 7D77 - -
TM3 470 Y 3.26x26 ADGRG3 7D77 PTH1 receptor 6FJ3
TM3 471 N 3.27x27 GLP-1 receptor 5NX2 - -
TM3 472 M 3.28x28 GLP-1 receptor 5NX2 - -
TM3 473 C 3.29x29 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 474 V 3.30x30 GLP-1 receptor 5NX2 - -
TM3 475 A 3.31x31 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 476 V 3.32x32 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 477 T 3.33x33 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM3 478 F 3.34x34 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM3 479 F 3.35x35 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 480 S 3.36x36 GLP-1 receptor 5NX2 GHRH receptor 7CZ5
TM3 481 H 3.37x37 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 482 F 3.38x38 GLP-1 receptor 5NX2 GHRH receptor 7CZ5
TM3 483 F 3.39x39 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 484 Y 3.40x40 GLP-1 receptor 5NX2 - -
TM3 485 L 3.41x41 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 486 S 3.42x42 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM3 487 L 3.43x43 GLP-1 receptor 5NX2 - -
TM3 488 F 3.44x44 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 489 F 3.45x45 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM3 490 W 3.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 491 M 3.47x47 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 492 L 3.48x48 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 493 F 3.49x49 GLP-1 receptor 5NX2 - -
TM3 494 K 3.50x50 GLP-1 receptor 5NX2 - -
TM3 495 A 3.51x51 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 496 L 3.52x52 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM3 497 L 3.53x53 GLP-1 receptor 5NX2 - -
TM3 498 I 3.54x54 GLP-1 receptor 5NX2 - -
TM3 499 I 3.55x55 GLP-1 receptor 5NX2 - -
TM3 500 Y 3.56x56 GLP-1 receptor 5NX2 - -
TM3 501 G 3.57x57 GLP-1 receptor 5NX2 - -
TM3 502 I 3.58x58 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM3 503 L 3.59x59 GLP-1 receptor 5NX2 - -
TM3 504 V 3.60x60 GLP-1 receptor 5NX2 CT receptor 6NIY
ICL2 505 I - - - - -
ICL2 506 F - - - - -
ICL2 507 R - - - - -
ICL2 508 R - - - - -
ICL2 509 M - - - - -
ICL2 510 M - - - - -
ICL2 511 K - - - - -
ICL2 512 S - - - - -
TM4 513 R 4.40x41 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM4 514 M 4.41x42 GLP-1 receptor 5NX2 - -
TM4 515 M 4.42x43 GLP-1 receptor 5NX2 - -
TM4 516 V 4.43x44 GLP-1 receptor 5NX2 - -
TM4 517 I 4.44x45 GLP-1 receptor 5NX2 - -
TM4 518 G 4.45x46 GLP-1 receptor 5NX2 - -
TM4 519 F 4.46x47 GLP-1 receptor 5NX2 - -
TM4 520 A 4.47x48 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 521 I 4.48x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 522 G 4.49x491 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 523 Y 4.50x50 GLP-1 receptor 5NX2 - -
TM4 524 G 4.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 525 C 4.52x52 GLP-1 receptor 5NX2 - -
TM4 526 P 4.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 527 L 4.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 528 I 4.55x55 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM4 529 I 4.56x56 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM4 530 A 4.57x57 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM4 531 V 4.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 532 T 4.59x59 GLP-1 receptor 5NX2 GHRH receptor 7CZ5
TM4 533 T 4.60x60 GLP-1 receptor 5NX2 ADGRG3 7D77
TM4 534 V 4.61x61 GLP-1 receptor 5NX2 GIP receptor 7DTY
TM4 535 A 4.62x62 GLP-1 receptor 5NX2 - -
TM4 536 I 4.63x63 GLP-1 receptor 5NX2 - -
TM4 537 T 4.64x64 GLP-1 receptor 5NX2 - -
ECL2 538 E - - - - -
ECL2 539 P - BILF1 7JHJ - -
ECL2 540 E - BILF1 7JHJ - -
ECL2 541 K - BILF1 7JHJ - -
ECL2 542 G - BILF1 7JHJ - -
ECL2 543 Y - BILF1 7JHJ - -
ECL2 544 M - BILF1 7JHJ - -
ECL2 545 R - BILF1 7JHJ - -
ECL2 546 P - BILF1 7JHJ BILF1 7JHJ
ECL2 547 E - BILF1 7JHJ - -
ECL2 548 A - - - - -
ECL2 549 C 45.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 550 W 45.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 551 L 45.52x52 GLP-1 receptor 5NX2 CT receptor 6NIY
ECL2 552 N - - - - -
ECL2 553 W - - - - -
ECL2 554 D - - - - -
ECL2 555 N - - - - -
TM5 556 T 5.33x33 GLP-1 receptor 5NX2 - -
TM5 557 K 5.34x34 GLP-1 receptor 5NX2 GIP receptor 7DTY
TM5 558 A 5.35x35 GLP-1 receptor 5NX2 ADGRG3 7D77
TM5 559 L 5.36x36 GLP-1 receptor 5NX2 ADGRG3 7D77
TM5 560 L 5.37x37 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM5 561 A 5.38x38 BILF1 7JHJ - -
TM5 562 F 5.39x39 BILF1 7JHJ - -
TM5 563 A 5.40x40 GLP-1 receptor 5NX2 BILF1 7JHJ
TM5 564 I 5.41x41 GLP-1 receptor 5NX2 - -
TM5 565 P 5.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 566 A 5.43x43 GLP-1 receptor 5NX2 - -
TM5 567 F 5.44x44 GLP-1 receptor 5NX2 glucagon receptor 5YQZ
TM5 568 V 5.45x45 GLP-1 receptor 5NX2 - -
TM5 569 I 5.46x46 GLP-1 receptor 5NX2 - -
TM5 570 V 5.47x47 GLP-1 receptor 5NX2 GHRH receptor 7CZ5
TM5 571 A 5.48x48 GLP-1 receptor 5NX2 - -
TM5 572 V 5.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 573 N 5.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 574 L 5.51x51 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM5 575 I 5.52x52 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM5 576 V 5.53x53 GLP-1 receptor 5NX2 ADGRG3 7D77
TM5 577 V 5.54x54 GLP-1 receptor 5NX2 - -
TM5 578 L 5.55x55 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM5 579 V 5.56x56 GLP-1 receptor 5NX2 - -
TM5 580 V 5.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 581 A 5.58x58 GLP-1 receptor 5NX2 - -
TM5 582 V 5.59x59 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM5 583 N 5.60x60 GLP-1 receptor 5NX2 - -
TM5 584 T 5.61x61 GLP-1 receptor 5NX2 - -
TM5 585 Q 5.62x62 GLP-1 receptor 5NX2 - -
TM5 586 R 5.63x63 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 587 P 5.64x64 GLP-1 receptor 5NX2 - -
TM5 588 S 5.65x65 GLP-1 receptor 5NX2 ADGRG3 7D77
ICL3 589 I - - - - -
ICL3 590 G - - - - -
ICL3 591 S - - - - -
ICL3 592 S - - - - -
ICL3 593 K - - - - -
ICL3 594 S - - - - -
ICL3 595 Q - - - - -
ICL3 596 D - - - - -
ICL3 597 V - - - - -
ICL3 598 V - - - - -
TM6 599 I 6.34x34 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 600 I 6.35x35 GLP-1 receptor 5NX2 - -
TM6 601 M 6.36x36 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM6 602 R 6.37x37 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 603 I 6.38x38 GLP-1 receptor 5NX2 - -
TM6 604 S 6.39x39 GLP-1 receptor 5NX2 GHRH receptor 7CZ5
TM6 605 K 6.40x40 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 606 N 6.41x41 GLP-1 receptor 5NX2 BILF1 7JHJ
TM6 607 V 6.42x42 GLP-1 receptor 5NX2 BILF1 7JHJ
TM6 608 A 6.43x43 GLP-1 receptor 5NX2 - -
TM6 609 I 6.44x44 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM6 610 L 6.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 611 T 6.46x46 GLP-1 receptor 5NX2 - -
TM6 612 P 6.47x47 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM6 613 L 6.48x48 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 614 L 6.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 615 G 6.50x50 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 616 L 6.51x51 GLP-1 receptor 5NX2 - -
TM6 617 T 6.52x52 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 618 W 6.53x53 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 619 G 6.54x54 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 620 F 6.55x55 GLP-1 receptor 5NX2 - -
TM6 621 G 6.56x56 GLP-1 receptor 5NX2 - -
TM6 622 I 6.57x57 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 623 A 6.58x58 GLP-1 receptor 5NX2 - -
ECL3 624 T - - - - -
ECL3 625 L - - - - -
ECL3 626 I - - - - -
ECL3 627 E - - - - -
ECL3 628 G - - - - -
ECL3 629 T - - - - -
TM7 630 S 7.35x34 GLP-1 receptor 5NX2 - -
TM7 631 L 7.36x35 GLP-1 receptor 5NX2 GLP-2 receptor 7D68
TM7 632 T 7.37x36 GLP-1 receptor 5NX2 - -
TM7 633 F 7.38x37 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM7 634 H 7.39x38 GLP-1 receptor 5NX2 - -
TM7 635 I 7.40x39 GLP-1 receptor 5NX2 - -
TM7 636 I 7.41x40 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 637 F 7.42x41 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 638 A 7.43x42 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 639 L 7.44x43 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 640 L 7.45x44 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM7 641 N 7.46x45 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 642 A 7.47x46 GLP-1 receptor 5NX2 BILF1 7JHJ
TM7 643 F 7.48x47 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 644 Q 7.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 645 G 7.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 646 F 7.51x51 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM7 647 F 7.52x52 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 648 I 7.53x53 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 649 L 7.54x54 GLP-1 receptor 5NX2 - -
TM7 650 L 7.55x55 GLP-1 receptor 5NX2 GLP-2 receptor 7D68
TM7 651 F 7.56x56 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM7 652 G 7.57x57 GLP-1 receptor 5NX2 - -
TM7 653 T 7.58x58 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 654 I 7.59x59 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 655 M 7.60x60 GLP-1 receptor 5NX2 - -
ICL4 656 D - - - - -
H8 657 H 8.48x48 GLP-1 receptor 5NX2 - -
H8 658 K 8.49x49 GLP-1 receptor 5NX2 - -
H8 659 I 8.50x50 GLP-1 receptor 5NX2 - -
H8 660 R 8.51x51 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
H8 661 D 8.52x52 GLP-1 receptor 5NX2 BILF1 7JHJ
H8 662 A 8.53x53 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
H8 663 L 8.54x54 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
H8 664 R 8.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 665 M 8.56x56 GLP-1 receptor 5NX2 - -
H8 666 R 8.57x57 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
H8 667 M 8.58x58 CRF1 receptor 6PB0 - -
H8 668 S 8.59x59 CRF1 receptor 6PB0 PTH1 receptor 6FJ3
H8 669 S 8.60x60 CRF1 receptor 6PB0 PAC1 receptor 6P9Y
H8 670 L 8.61x61 CRF1 receptor 6PB0 - -
H8 671 K 8.62x62 CRF1 receptor 6PB0 PAC1 receptor 6M1I
H8 672 G 8.63x63 CRF1 receptor 6PB0 - -
C-term 673 K - - - - -
C-term 674 S - - - - -
C-term 675 R - - - - -
C-term 676 A - - - - -
C-term 677 A - - - - -