ADGRG1 homology model

PROTEIN CLASS

Class B2 (Adhesion)

RECEPTOR

ADGRG1

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2022-06-19

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

NGL is a WebGL based 3D viewer powered by MMTF.

MAIN TEMPLATE

GLP-1 receptor (sequence similarity: 16%) PDB: 5NX2
Align

TEMPLATES

7SF8 (ADGRG1)
5NX2 (GLP-1 receptor)
7WUJ (ADGRG4)
6NIY (CT receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 74.7 5.8 19.5
Side-chains 15.5 60.6 23.8

Number of backbone templates: 4
Number of rotamer templates: 8

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 391 S - ADGRG1 7SF8 ADGRG1 7SF8
N-term 392 S - ADGRG1 7SF8 ADGRG1 7SF8
N-term 393 V - ADGRG1 7SF8 ADGRG1 7SF8
N-term 394 E - ADGRG1 7SF8 ADGRG1 7SF8
N-term 395 V - ADGRG1 7SF8 ADGRG1 7SF8
TM1 396 D 1.32x32 ADGRG1 7SF8 ADGRG1 7SF8
TM1 397 A 1.33x33 GLP-1 receptor 5NX2 - -
TM1 398 V 1.34x34 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 399 H 1.35x35 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 400 K 1.36x36 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 401 H 1.37x37 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 402 Y 1.38x38 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 403 L 1.39x39 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 404 S 1.40x40 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 405 L 1.41x41 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 406 L 1.42x42 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 407 S 1.43x43 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 408 Y 1.44x44 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 409 V 1.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 410 G 1.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 411 C 1.47x47 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 412 V 1.48x48 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 413 V 1.49x49 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 414 S 1.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 415 A 1.51x51 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 416 L 1.52x52 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 417 A 1.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 418 C 1.54x54 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 419 L 1.55x55 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 420 V 1.56x56 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 421 T 1.57x57 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 422 I 1.58x58 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 423 A 1.59x59 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 424 A 1.60x60 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 425 Y 1.61x61 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM1 426 L 1.62x62 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 427 C 1.63x63 GLP-1 receptor 5NX2 - -
TM1 428 S 1.64x64 GLP-1 receptor 5NX2 - -
ICL1 429 R - - - - -
ICL1 430 V - - - - -
ICL1 431 P - - - - -
ICL1 432 L - - - - -
ICL1 433 P - - - - -
ICL1 434 C - - - - -
ICL1 435 R - - - - -
ICL1 436 R - - - - -
ICL1 437 K - - - - -
ICL1 438 P - - - - -
ICL1 439 R - - - - -
TM2 440 D 2.44x44 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 441 Y 2.45x45 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 442 T 2.46x46 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 443 I 2.47x47 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 444 K 2.48x48 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 445 V 2.49x49 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 446 H 2.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 447 M 2.51x51 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 448 N 2.52x52 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 449 L 2.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 450 L 2.54x54 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 451 L 2.55x55 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 452 A 2.56x56 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 453 V 2.57x57 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 454 F 2.58x58 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 455 L 2.59x59 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 456 L 2.60x60 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 457 D 2.61x61 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 458 T 2.62x62 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 459 S 2.63x63 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 460 F 2.64x64 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 461 L 2.65x65 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 462 L 2.66x66 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 463 S 2.67x67 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 464 E 2.68x68 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 465 P 2.69x69 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 466 V 2.70x70 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 467 A 2.71x71 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM2 468 L 2.72x72 GLP-1 receptor 5NX2 ADGRG1 7SF8
ECL1 469 T - - - - -
ECL1 470 G - - - - -
TM3 471 S 3.25x25 ADGRG4 7WUJ ADGRG1 7SF8
TM3 472 E 3.26x26 ADGRG4 7WUJ ADGRG1 7SF8
TM3 473 A 3.27x27 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 474 G 3.28x28 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 475 C 3.29x29 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 476 R 3.30x30 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 477 A 3.31x31 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 478 S 3.32x32 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 479 A 3.33x33 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 480 I 3.34x34 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 481 F 3.35x35 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 482 L 3.36x36 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 483 H 3.37x37 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 484 F 3.38x38 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 485 S 3.39x39 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 486 L 3.40x40 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 487 L 3.41x41 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 488 T 3.42x42 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 489 C 3.43x43 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 490 L 3.44x44 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 491 S 3.45x45 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 492 W 3.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 493 M 3.47x47 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 494 G 3.48x48 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 495 L 3.49x49 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 496 E 3.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 497 G 3.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 498 Y 3.52x52 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 499 N 3.53x53 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 500 L 3.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 501 Y 3.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 502 R 3.56x56 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 503 L 3.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 504 V 3.58x58 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 505 V 3.59x59 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM3 506 E 3.60x60 GLP-1 receptor 5NX2 - -
ICL2 507 V - - - - -
ICL2 508 F - ADGRG4 7WUJ ADGRG4 7WUJ
ICL2 509 G - ADGRG4 7WUJ - -
ICL2 510 T - ADGRG4 7WUJ - -
ICL2 511 Y - ADGRG4 7WUJ ADGRG4 7WUJ
ICL2 512 V - ADGRG4 7WUJ - -
ICL2 513 P - - - - -
TM4 514 G 4.40x41 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM4 515 Y 4.41x42 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM4 516 L 4.42x43 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM4 517 L 4.43x44 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM4 518 K 4.44x45 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM4 519 L 4.45x46 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM4 520 S 4.46x47 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM4 521 A 4.47x48 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM4 522 M 4.48x49 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM4 523 G 4.49x491 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 524 W 4.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 525 G 4.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 526 F 4.52x52 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM4 527 P 4.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 528 I 4.54x54 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM4 529 F 4.55x55 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM4 530 L 4.56x56 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM4 531 V 4.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 532 T 4.58x58 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM4 533 L 4.59x59 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM4 534 V 4.60x60 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM4 535 A 4.61x61 GLP-1 receptor 5NX2 ADGRL3 7SF7
TM4 536 L 4.62x62 GLP-1 receptor 5NX2 - -
TM4 537 V 4.63x63 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 538 D 4.64x64 GLP-1 receptor 5NX2 - -
ECL2 539 V - - - - -
ECL2 540 D - - - - -
ECL2 541 N - - - - -
ECL2 542 Y - - - - -
ECL2 543 G - - - - -
ECL2 544 P - - - - -
ECL2 545 I - - - - -
ECL2 546 I - - - - -
ECL2 547 L - - - - -
ECL2 548 A - - - - -
ECL2 549 V - - - - -
ECL2 550 H - - - - -
ECL2 551 R - - - - -
ECL2 552 T - - - - -
ECL2 553 P - - - - -
ECL2 554 E - - - - -
ECL2 555 G - - - - -
ECL2 556 V - - - - -
ECL2 557 I - - - - -
ECL2 558 Y - - - - -
ECL2 559 P - - - - -
ECL2 560 S - - - - -
ECL2 561 M - - - - -
ECL2 562 C 45.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 563 W 45.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 564 I 45.52x52 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
ECL2 565 R - - - - -
TM5 566 D 5.31x32 - - - -
TM5 567 S 5.32x33 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM5 568 L 5.33x34 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 569 V 5.34x35 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 570 S 5.35x36 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 571 Y 5.36x37 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 572 I 5.37x38 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 573 T 5.38x381 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 574 N 5.39x39 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 575 L 5.40x40 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 576 G 5.41x41 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 577 L 5.42x42 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 578 F 5.43x43 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 579 S 5.44x44 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 580 L 5.45x45 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 581 V 5.46x46 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 582 F 5.47x47 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 583 L 5.48x48 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 584 F 5.49x49 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 585 N 5.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 586 M 5.51x51 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 587 A 5.52x52 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 588 M 5.53x53 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 589 L 5.54x54 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 590 A 5.55x55 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 591 T 5.56x56 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 592 M 5.57x57 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 593 V 5.58x58 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 594 V 5.59x59 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 595 Q 5.60x60 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 596 I 5.61x61 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 597 L 5.62x62 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM5 598 R 5.63x63 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 599 L 5.64x64 GLP-1 receptor 5NX2 ADGRG3 7D77
TM5 600 R 5.65x65 GLP-1 receptor 5NX2 - -
ICL3 601 P - - - - -
ICL3 602 H - - - - -
ICL3 603 T - - - - -
ICL3 604 Q - - - - -
ICL3 605 K - - - - -
ICL3 606 W - - - - -
ICL3 607 S - - - - -
TM6 608 H 6.38x38 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM6 609 V 6.39x39 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM6 610 L 6.40x40 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM6 611 T 6.41x41 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM6 612 L 6.42x42 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM6 613 L 6.43x43 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 614 G 6.44x44 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM6 615 L 6.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 616 S 6.46x46 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM6 617 L 6.47x47 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM6 618 V 6.48x48 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM6 619 L 6.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 620 G 6.50x50 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM6 621 L 6.51x51 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM6 622 P 6.52x52 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM6 623 W 6.53x53 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM6 624 A 6.54x54 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM6 625 L 6.55x55 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM6 626 I 6.56x56 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM6 627 F 6.57x57 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM6 628 F 6.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 629 S 6.59x59 ADGRG1 7SF8 ADGRG1 7SF8
ECL3 630 F - - - - -
ECL3 631 A - - - - -
TM7 632 S 7.31x30 CT receptor 6NIY - -
TM7 633 G 7.32x31 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 634 T 7.33x32 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 635 F 7.34x33 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM7 636 Q 7.35x34 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM7 637 L 7.36x35 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM7 638 V 7.37x36 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM7 639 V 7.38x37 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM7 640 L 7.39x38 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 641 Y 7.40x39 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM7 642 L 7.41x40 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM7 643 F 7.42x41 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM7 644 S 7.43x42 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM7 645 I 7.44x43 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM7 646 I 7.45x44 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM7 647 T 7.46x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 648 S 7.47x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 649 F 7.48x47 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 650 Q 7.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 651 G 7.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 652 F 7.51x51 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM7 653 L 7.52x52 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM7 654 I 7.53x53 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM7 655 F 7.54x54 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM7 656 I 7.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 657 W 7.56x56 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM7 658 Y 7.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 659 W 7.58x58 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM7 660 S 7.59x59 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM7 661 M 7.60x60 GLP-1 receptor 5NX2 ADGRG1 7SF8
TM7 662 R 7.61x61 ADGRG1 7SF8 - -
C-term 663 L - - - - -
C-term 664 Q - - - - -
C-term 665 A - - - - -
C-term 666 R - - - - -
C-term 667 G - - - - -