ADGRG2 homology model

PROTEIN CLASS

Class B2 (Adhesion)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2020-10-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

GLP-1 receptor (sequence similarity: 30%) PDB: 5NX2

TEMPLATES

5UZ7 (CT receptor)
5NX2 (GLP-1 receptor)
6PB1 (CRF2 receptor)
6M1H (PAC1 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 74.5 4.8 20.7
Side-chains 16.0 23.1 60.9

Number of backbone templates: 4
Number of rotamer templates: 15

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 611 V - - - -
N-term 612 L - - - -
N-term 613 L - - - -
N-term 614 D - - - -
N-term 615 L - - - -
TM1 616 S 1.27x27 CT receptor 5UZ7 VPAC1 receptor 6VN7
TM1 617 R 1.28x28 CT receptor 5UZ7 - -
TM1 618 T 1.29x29 CT receptor 5UZ7 CT receptor 5UZ7
TM1 619 S 1.30x30 CT receptor 5UZ7 - -
TM1 620 V 1.31x31 CT receptor 5UZ7 - -
TM1 621 L 1.32x32 CT receptor 5UZ7 - -
TM1 622 P 1.33x33 GLP-1 receptor 5NX2 - -
TM1 623 A 1.34x34 GLP-1 receptor 5NX2 - -
TM1 624 Q 1.35x35 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 625 M 1.36x36 GLP-1 receptor 5NX2 - -
TM1 626 M 1.37x37 GLP-1 receptor 5NX2 - -
TM1 627 A 1.38x38 GLP-1 receptor 5NX2 - -
TM1 628 L 1.39x39 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 629 T 1.40x40 GLP-1 receptor 5NX2 - -
TM1 630 F 1.41x41 GLP-1 receptor 5NX2 - -
TM1 631 I 1.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 632 T 1.43x43 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM1 633 Y 1.44x44 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 634 I 1.45x45 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM1 635 G 1.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 636 C 1.47x47 GLP-1 receptor 5NX2 - -
TM1 637 G 1.48x48 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM1 638 L 1.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 639 S 1.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 640 S 1.51x51 GLP-1 receptor 5NX2 - -
TM1 641 I 1.52x52 GLP-1 receptor 5NX2 - -
TM1 642 F 1.53x53 GLP-1 receptor 5NX2 - -
TM1 643 L 1.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 644 S 1.55x55 GLP-1 receptor 5NX2 - -
TM1 645 V 1.56x56 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM1 646 T 1.57x57 GLP-1 receptor 5NX2 - -
TM1 647 L 1.58x58 GLP-1 receptor 5NX2 CT receptor 6NIY
TM1 648 V 1.59x59 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM1 649 T 1.60x60 GLP-1 receptor 5NX2 - -
TM1 650 Y 1.61x61 GLP-1 receptor 5NX2 - -
TM1 651 I 1.62x62 GLP-1 receptor 5NX2 - -
TM1 652 A 1.63x63 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 653 F 1.64x64 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ICL1 654 E - - - -
ICL1 655 K - - - -
ICL1 656 I - - - -
ICL1 657 R - - - -
ICL1 658 R - - - -
TM2 659 D 2.44x44 GLP-1 receptor 5NX2 - -
TM2 660 Y 2.45x45 GLP-1 receptor 5NX2 - -
TM2 661 P 2.46x46 GLP-1 receptor 5NX2 - -
TM2 662 S 2.47x47 GLP-1 receptor 5NX2 - -
TM2 663 K 2.48x48 GLP-1 receptor 5NX2 - -
TM2 664 I 2.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 665 L 2.50x50 GLP-1 receptor 5NX2 - -
TM2 666 I 2.51x51 GLP-1 receptor 5NX2 - -
TM2 667 Q 2.52x52 GLP-1 receptor 5NX2 - -
TM2 668 L 2.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 669 C 2.54x54 GLP-1 receptor 5NX2 - -
TM2 670 A 2.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 671 A 2.56x56 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM2 672 L 2.57x57 GLP-1 receptor 5NX2 - -
TM2 673 L 2.58x58 GLP-1 receptor 5NX2 - -
TM2 674 L 2.59x59 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 675 L 2.60x60 GLP-1 receptor 5NX2 - -
TM2 676 N 2.61x61 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM2 677 L 2.62x62 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 678 V 2.63x63 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM2 679 F 2.64x64 GLP-1 receptor 5NX2 - -
TM2 680 L 2.65x65 GLP-1 receptor 5NX2 glucagon receptor 5XEZ
TM2 681 L 2.66x66 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM2 682 D 2.67x67 GLP-1 receptor 5NX2 - -
TM2 683 S 2.68x68 GLP-1 receptor 5NX2 - -
TM2 684 W 2.69x69 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM2 685 I 2.70x70 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
ECL1 686 A - - - -
ECL1 687 L - - - -
ECL1 688 Y - - - -
ECL1 689 K - - - -
ECL1 690 M - - - -
ECL1 691 Q - - - -
TM3 692 G 3.27x27 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM3 693 L 3.28x28 GLP-1 receptor 5NX2 - -
TM3 694 C 3.29x29 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 695 I 3.30x30 GLP-1 receptor 5NX2 - -
TM3 696 S 3.31x31 GLP-1 receptor 5NX2 - -
TM3 697 V 3.32x32 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 698 A 3.33x33 GLP-1 receptor 5NX2 glucagon receptor 5XEZ
TM3 699 V 3.34x34 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM3 700 F 3.35x35 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 701 L 3.36x36 GLP-1 receptor 5NX2 - -
TM3 702 H 3.37x37 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM3 703 Y 3.38x38 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 704 F 3.39x39 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM3 705 L 3.40x40 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM3 706 L 3.41x41 GLP-1 receptor 5NX2 - -
TM3 707 V 3.42x42 GLP-1 receptor 5NX2 - -
TM3 708 S 3.43x43 GLP-1 receptor 5NX2 - -
TM3 709 F 3.44x44 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM3 710 T 3.45x45 GLP-1 receptor 5NX2 - -
TM3 711 W 3.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 712 M 3.47x47 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM3 713 G 3.48x48 GLP-1 receptor 5NX2 - -
TM3 714 L 3.49x49 GLP-1 receptor 5NX2 - -
TM3 715 E 3.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 716 A 3.51x51 GLP-1 receptor 5NX2 - -
TM3 717 F 3.52x52 GLP-1 receptor 5NX2 - -
TM3 718 H 3.53x53 GLP-1 receptor 5NX2 - -
TM3 719 M 3.54x54 GLP-1 receptor 5NX2 - -
TM3 720 Y 3.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 721 L 3.56x56 GLP-1 receptor 5NX2 - -
TM3 722 A 3.57x57 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM3 723 L 3.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 724 V 3.59x59 GLP-1 receptor 5NX2 PAC1 receptor 6LPB
TM3 725 K 3.60x60 GLP-1 receptor 5NX2 - -
ICL2 726 V - - - -
ICL2 727 F - - - -
ICL2 728 N - - - -
ICL2 729 T - - - -
ICL2 730 Y - - - -
ICL2 731 I - - - -
ICL2 732 R - - - -
TM4 733 K 4.40x41 GLP-1 receptor 5NX2 secretin receptor 6WI9
TM4 734 Y 4.41x42 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM4 735 I 4.42x43 GLP-1 receptor 5NX2 - -
TM4 736 L 4.43x44 GLP-1 receptor 5NX2 - -
TM4 737 K 4.44x45 GLP-1 receptor 5NX2 - -
TM4 738 F 4.45x46 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM4 739 C 4.46x47 GLP-1 receptor 5NX2 - -
TM4 740 I 4.47x48 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM4 741 V 4.48x49 GLP-1 receptor 5NX2 - -
TM4 742 G 4.49x491 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 743 W 4.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 744 G 4.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 745 V 4.52x52 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 746 P 4.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 747 A 4.54x54 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 748 V 4.55x55 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM4 749 V 4.56x56 GLP-1 receptor 5NX2 - -
TM4 750 V 4.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 751 T 4.58x58 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM4 752 I 4.59x59 GLP-1 receptor 5NX2 CT receptor 6NIY
TM4 753 I 4.60x60 GLP-1 receptor 5NX2 - -
TM4 754 L 4.61x61 GLP-1 receptor 5NX2 - -
TM4 755 T 4.62x62 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM4 756 I 4.63x63 GLP-1 receptor 5NX2 - -
TM4 757 S 4.64x64 GLP-1 receptor 5NX2 - -
TM4 758 P 4.65x65 GLP-1 receptor 5NX2 - -
TM4 759 D 4.66x66 GLP-1 receptor 5NX2 - -
TM4 760 N 4.67x67 GLP-1 receptor 5NX2 - -
TM4 761 Y 4.68x68 CRF2 receptor 6PB1 calcitonin receptor-like receptor 6UUS
ECL2 762 G - - - -
ECL2 763 L - - - -
ECL2 764 G - - - -
ECL2 765 S - - - -
ECL2 766 Y - - - -
ECL2 767 G - - - -
ECL2 768 K - - - -
ECL2 769 F - - - -
ECL2 770 P - - - -
ECL2 771 N - - - -
ECL2 772 G - - - -
ECL2 773 S - - - -
ECL2 774 P - - - -
ECL2 775 D - - - -
ECL2 776 D - - - -
ECL2 777 F - - - -
ECL2 778 C 45.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 779 W 45.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 780 I 45.52x52 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
ECL2 781 N - - - -
ECL2 782 N - - - -
TM5 783 N 5.32x32 - - - -
TM5 784 A 5.33x33 GLP-1 receptor 5NX2 - -
TM5 785 V 5.34x34 GLP-1 receptor 5NX2 - -
TM5 786 F 5.35x35 GLP-1 receptor 5NX2 - -
TM5 787 Y 5.36x36 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 788 I 5.37x37 GLP-1 receptor 5NX2 - -
TM5 789 T 5.38x38 GLP-1 receptor 5NX2 - -
TM5 790 V 5.39x39 GLP-1 receptor 5NX2 - -
TM5 791 V 5.40x40 GLP-1 receptor 5NX2 - -
TM5 792 G 5.41x41 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM5 793 Y 5.42x42 GLP-1 receptor 5NX2 - -
TM5 794 F 5.43x43 GLP-1 receptor 5NX2 - -
TM5 795 C 5.44x44 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM5 796 V 5.45x45 GLP-1 receptor 5NX2 - -
TM5 797 I 5.46x46 GLP-1 receptor 5NX2 - -
TM5 798 F 5.47x47 GLP-1 receptor 5NX2 - -
TM5 799 L 5.48x48 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM5 800 L 5.49x49 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM5 801 N 5.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 802 V 5.51x51 GLP-1 receptor 5NX2 - -
TM5 803 S 5.52x52 GLP-1 receptor 5NX2 - -
TM5 804 M 5.53x53 GLP-1 receptor 5NX2 - -
TM5 805 F 5.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 806 I 5.55x55 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM5 807 V 5.56x56 GLP-1 receptor 5NX2 - -
TM5 808 V 5.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 809 L 5.58x58 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 810 V 5.59x59 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM5 811 Q 5.60x60 GLP-1 receptor 5NX2 - -
TM5 812 L 5.61x61 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM5 813 C 5.62x62 GLP-1 receptor 5NX2 - -
TM5 814 R 5.63x63 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 815 I 5.64x64 GLP-1 receptor 5NX2 - -
TM5 816 K 5.65x65 GLP-1 receptor 5NX2 - -
ICL3 817 K - - - -
ICL3 818 K - - - -
ICL3 819 K - - - -
ICL3 820 Q - - - -
ICL3 821 L - - - -
ICL3 822 G - - - -
ICL3 823 A - - - -
ICL3 824 Q - - - -
ICL3 825 R - - - -
ICL3 826 K - - - -
TM6 827 T 6.34x34 GLP-1 receptor 5NX2 - -
TM6 828 S 6.35x35 GLP-1 receptor 5NX2 - -
TM6 829 I 6.36x36 GLP-1 receptor 5NX2 - -
TM6 830 Q 6.37x37 GLP-1 receptor 5NX2 - -
TM6 831 D 6.38x38 GLP-1 receptor 5NX2 - -
TM6 832 L 6.39x39 GLP-1 receptor 5NX2 PTH1 receptor 6NBI
TM6 833 R 6.40x40 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM6 834 S 6.41x41 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 835 I 6.42x42 GLP-1 receptor 5NX2 - -
TM6 836 A 6.43x43 GLP-1 receptor 5NX2 - -
TM6 837 G 6.44x44 GLP-1 receptor 5NX2 - -
TM6 838 L 6.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 839 T 6.46x46 GLP-1 receptor 5NX2 - -
TM6 840 F 6.47x47 GLP-1 receptor 5NX2 - -
TM6 841 L 6.48x48 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 842 L 6.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 843 G 6.50x50 GLP-1 receptor 5NX2 PAC1 receptor 6M1I
TM6 844 I 6.51x51 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM6 845 T 6.52x52 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM6 846 W 6.53x53 GLP-1 receptor 5NX2 - -
TM6 847 G 6.54x54 GLP-1 receptor 5NX2 - -
TM6 848 F 6.55x55 GLP-1 receptor 5NX2 - -
TM6 849 A 6.56x56 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM6 850 F 6.57x57 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM6 851 F 6.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 852 A 6.59x59 PAC1 receptor 6M1H - -
ECL3 853 W - - - -
ECL3 854 G - - - -
ECL3 855 P - - - -
ECL3 856 V - - - -
TM7 857 N 7.35x34 GLP-1 receptor 5NX2 - -
TM7 858 V 7.36x35 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM7 859 T 7.37x36 GLP-1 receptor 5NX2 - -
TM7 860 F 7.38x37 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM7 861 M 7.39x38 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM7 862 Y 7.40x39 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM7 863 L 7.41x40 GLP-1 receptor 5NX2 - -
TM7 864 F 7.42x41 GLP-1 receptor 5NX2 - -
TM7 865 A 7.43x42 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM7 866 I 7.44x43 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM7 867 F 7.45x44 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 868 N 7.46x45 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM7 869 T 7.47x46 GLP-1 receptor 5NX2 - -
TM7 870 L 7.48x47 GLP-1 receptor 5NX2 - -
TM7 871 Q 7.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 872 G 7.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 873 F 7.51x51 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM7 874 F 7.52x52 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM7 875 I 7.53x53 GLP-1 receptor 5NX2 - -
TM7 876 F 7.54x54 GLP-1 receptor 5NX2 - -
TM7 877 I 7.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 878 F 7.56x56 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM7 879 Y 7.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 880 C 7.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 881 V 7.59x59 GLP-1 receptor 5NX2 - -
TM7 882 A 7.60x60 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 883 K 8.47x47 GLP-1 receptor 5NX2 - -
H8 884 E 8.48x48 GLP-1 receptor 5NX2 - -
H8 885 N 8.49x49 GLP-1 receptor 5NX2 - -
H8 886 V 8.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 887 R 8.51x51 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
H8 888 K 8.52x52 GLP-1 receptor 5NX2 - -
H8 889 Q 8.53x53 GLP-1 receptor 5NX2 - -
H8 890 W 8.54x54 GLP-1 receptor 5NX2 - -
H8 891 R 8.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 892 R 8.56x56 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
H8 893 Y 8.57x57 GLP-1 receptor 5NX2 - -
H8 894 L 8.58x58 CRF2 receptor 6PB1 - -
H8 895 C 8.59x59 CRF2 receptor 6PB1 - -
H8 896 C 8.60x60 CRF2 receptor 6PB1 - -
H8 897 G 8.61x61 CRF2 receptor 6PB1 - -
H8 898 K 8.62x62 CRF2 receptor 6PB1 PAC1 receptor 6M1I
H8 899 L 8.63x63 CRF2 receptor 6PB1 secretin receptor 6WI9
C-term 900 R - - - -
C-term 901 L - - - -
C-term 902 A - - - -
C-term 903 E - - - -
C-term 904 N - - - -