ADGRG5 homology model

PROTEIN CLASS

Class B2 (Adhesion)

RECEPTOR

ADGRG5

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2020-09-02

MODEL

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PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

GLP-1 receptor (sequence similarity: 31%) PDB: 5NX2
Align

TEMPLATES

6NBI (PTH1 receptor)
6FJ3 (PTH1 receptor)
5NX2 (GLP-1 receptor)
6WZG (secretin receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 78.2 5.1 16.7
Side-chains 18.1 23.5 58.4

Number of backbone templates: 4
Number of rotamer templates: 14

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
TM1 236 S 1.27x27 PTH1 receptor 6NBI - -
TM1 237 P 1.28x28 PTH1 receptor 6NBI - -
TM1 238 A 1.29x29 PTH1 receptor 6NBI - -
TM1 239 L 1.30x30 PTH1 receptor 6NBI - -
TM1 240 V 1.31x31 PTH1 receptor 6NBI - -
TM1 241 P 1.32x32 PTH1 receptor 6NBI GLP-1 receptor 5VAI
TM1 242 A 1.33x33 GLP-1 receptor 5NX2 - -
TM1 243 E 1.34x34 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 244 L 1.35x35 GLP-1 receptor 5NX2 - -
TM1 245 L 1.36x36 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 246 A 1.37x37 GLP-1 receptor 5NX2 - -
TM1 247 P 1.38x38 GLP-1 receptor 5NX2 - -
TM1 248 L 1.39x39 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 249 T 1.40x40 GLP-1 receptor 5NX2 - -
TM1 250 Y 1.41x41 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM1 251 I 1.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 252 S 1.43x43 GLP-1 receptor 5NX2 - -
TM1 253 L 1.44x44 GLP-1 receptor 5NX2 - -
TM1 254 V 1.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 255 G 1.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 256 C 1.47x47 GLP-1 receptor 5NX2 - -
TM1 257 S 1.48x48 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM1 258 I 1.49x49 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM1 259 S 1.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 260 I 1.51x51 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM1 261 V 1.52x52 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM1 262 A 1.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 263 S 1.54x54 GLP-1 receptor 5NX2 - -
TM1 264 L 1.55x55 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM1 265 I 1.56x56 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 266 T 1.57x57 GLP-1 receptor 5NX2 - -
TM1 267 V 1.58x58 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM1 268 L 1.59x59 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM1 269 L 1.60x60 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM1 270 H 1.61x61 GLP-1 receptor 5NX2 - -
TM1 271 F 1.62x62 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM1 272 H 1.63x63 GLP-1 receptor 5NX2 - -
TM1 273 F 1.64x64 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ICL1 274 R GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ICL1 275 K GLP-1 receptor 5NX2 - -
ICL1 276 Q GLP-1 receptor 5NX2 - -
ICL1 277 S GLP-1 receptor 5NX2 - -
TM2 278 D 2.44x44 GLP-1 receptor 5NX2 - -
TM2 279 S 2.45x45 GLP-1 receptor 5NX2 - -
TM2 280 L 2.46x46 GLP-1 receptor 5NX2 - -
TM2 281 T 2.47x47 GLP-1 receptor 5NX2 - -
TM2 282 R 2.48x48 GLP-1 receptor 5NX2 - -
TM2 283 I 2.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 284 H 2.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 285 M 2.51x51 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM2 286 N 2.52x52 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 287 L 2.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 288 H 2.54x54 GLP-1 receptor 5NX2 - -
TM2 289 A 2.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 290 S 2.56x56 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 291 V 2.57x57 GLP-1 receptor 5NX2 - -
TM2 292 L 2.58x58 GLP-1 receptor 5NX2 - -
TM2 293 L 2.59x59 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 294 L 2.60x60 GLP-1 receptor 5NX2 - -
TM2 295 N 2.61x61 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM2 296 I 2.62x62 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM2 297 A 2.63x63 GLP-1 receptor 5NX2 glucagon receptor 5EE7
TM2 298 F 2.64x64 GLP-1 receptor 5NX2 - -
TM2 299 L 2.65x65 GLP-1 receptor 5NX2 glucagon receptor 5XEZ
TM2 300 L 2.66x66 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM2 301 S 2.67x67 GLP-1 receptor 5NX2 - -
TM2 302 P 2.68x68 GLP-1 receptor 5NX2 - -
TM2 303 A 2.69x69 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 304 F 2.70x70 GLP-1 receptor 5NX2 - -
ECL1 305 A - - - -
ECL1 306 M - - - -
ECL1 307 S - - - -
ECL1 308 P - - - -
ECL1 309 V - - - -
ECL1 310 P - - - -
ECL1 311 G - - - -
TM3 312 S 3.27x27 GLP-1 receptor 5NX2 - -
TM3 313 A 3.28x28 GLP-1 receptor 5NX2 GLP-1 receptor 5VEW
TM3 314 C 3.29x29 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 315 T 3.30x30 GLP-1 receptor 5NX2 - -
TM3 316 A 3.31x31 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM3 317 L 3.32x32 GLP-1 receptor 5NX2 CT receptor 6NIY
TM3 318 A 3.33x33 GLP-1 receptor 5NX2 glucagon receptor 5XEZ
TM3 319 A 3.34x34 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM3 320 A 3.35x35 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM3 321 L 3.36x36 GLP-1 receptor 5NX2 - -
TM3 322 H 3.37x37 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM3 323 Y 3.38x38 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 324 A 3.39x39 GLP-1 receptor 5NX2 - -
TM3 325 L 3.40x40 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM3 326 L 3.41x41 GLP-1 receptor 5NX2 - -
TM3 327 S 3.42x42 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM3 328 C 3.43x43 GLP-1 receptor 5NX2 - -
TM3 329 L 3.44x44 GLP-1 receptor 5NX2 - -
TM3 330 T 3.45x45 GLP-1 receptor 5NX2 - -
TM3 331 W 3.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 332 M 3.47x47 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM3 333 A 3.48x48 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM3 334 I 3.49x49 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM3 335 E 3.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 336 G 3.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 337 F 3.52x52 GLP-1 receptor 5NX2 - -
TM3 338 N 3.53x53 GLP-1 receptor 5NX2 - -
TM3 339 L 3.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 340 Y 3.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 341 L 3.56x56 GLP-1 receptor 5NX2 - -
TM3 342 L 3.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 343 L 3.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 344 G 3.59x59 GLP-1 receptor 5NX2 glucagon receptor 5XEZ
TM3 345 R 3.60x60 GLP-1 receptor 5NX2 - -
ICL2 346 V GLP-1 receptor 5NX2 - -
ICL2 347 Y GLP-1 receptor 5NX2 - -
ICL2 348 N GLP-1 receptor 5NX2 - -
ICL2 349 I GLP-1 receptor 5NX2 - -
TM4 350 Y 4.37x38 PTH1 receptor 6FJ3 - -
TM4 351 I 4.38x39 GLP-1 receptor 5NX2 - -
TM4 352 R 4.39x40 GLP-1 receptor 5NX2 PAC1 receptor 6M1I
TM4 353 R 4.40x41 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM4 354 Y 4.41x42 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 355 V 4.42x43 GLP-1 receptor 5NX2 - -
TM4 356 F 4.43x44 GLP-1 receptor 5NX2 - -
TM4 357 K 4.44x45 GLP-1 receptor 5NX2 - -
TM4 358 L 4.45x46 GLP-1 receptor 5NX2 - -
TM4 359 G 4.46x47 GLP-1 receptor 5NX2 - -
TM4 360 V 4.47x48 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM4 361 L 4.48x49 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM4 362 G 4.49x491 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 363 W 4.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 364 G 4.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 365 A 4.52x52 GLP-1 receptor 5NX2 PAC1 receptor 6M1I
TM4 366 P 4.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 367 A 4.54x54 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 368 L 4.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 369 L 4.56x56 GLP-1 receptor 5NX2 - -
TM4 370 V 4.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 371 L 4.58x58 GLP-1 receptor 5NX2 - -
TM4 372 L 4.59x59 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 373 S 4.60x60 GLP-1 receptor 5NX2 - -
TM4 374 L 4.61x61 GLP-1 receptor 5NX2 - -
TM4 375 S 4.62x62 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM4 376 V 4.63x63 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 377 K 4.64x64 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 378 S 4.65x65 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM4 379 S 4.66x66 GLP-1 receptor 5NX2 - -
TM4 380 V 4.67x67 GLP-1 receptor 5NX2 - -
TM4 381 Y 4.68x68 PTH1 receptor 6FJ3 - -
ECL2 382 G - - - -
ECL2 383 P - - - -
ECL2 384 C - - - -
ECL2 385 T - - - -
ECL2 386 I - - - -
ECL2 387 P - - - -
ECL2 388 V - - - -
ECL2 389 F - - - -
ECL2 390 D - - - -
ECL2 391 S - - - -
ECL2 392 W - - - -
ECL2 393 E - - - -
ECL2 394 N - - - -
ECL2 395 G - - - -
ECL2 396 T - - - -
ECL2 397 G - - - -
ECL2 398 F - - - -
ECL2 399 Q - - - -
ECL2 400 N - - - -
ECL2 401 M - - - -
ECL2 402 S - - - -
ECL2 403 I - - - -
ECL2 404 C 45.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 405 W 45.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 406 V 45.52x52 GLP-1 receptor 5NX2 - -
ECL2 407 R - - - -
ECL2 408 S - - - -
TM5 409 P 5.32x32 - - - -
TM5 410 V 5.33x33 GLP-1 receptor 5NX2 - -
TM5 411 V 5.34x34 GLP-1 receptor 5NX2 - -
TM5 412 H 5.35x35 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM5 413 S 5.36x36 GLP-1 receptor 5NX2 - -
TM5 414 V 5.37x37 GLP-1 receptor 5NX2 - -
TM5 415 L 5.38x38 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 416 V 5.39x39 GLP-1 receptor 5NX2 - -
TM5 417 M 5.40x40 GLP-1 receptor 5NX2 - -
TM5 418 G 5.41x41 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 419 Y 5.42x42 GLP-1 receptor 5NX2 - -
TM5 420 G 5.43x43 GLP-1 receptor 5NX2 - -
TM5 421 G 5.44x44 GLP-1 receptor 5NX2 - -
TM5 422 L 5.45x45 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 423 T 5.46x46 GLP-1 receptor 5NX2 - -
TM5 424 S 5.47x47 GLP-1 receptor 5NX2 - -
TM5 425 L 5.48x48 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 426 F 5.49x49 GLP-1 receptor 5NX2 - -
TM5 427 N 5.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 428 L 5.51x51 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM5 429 V 5.52x52 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM5 430 V 5.53x53 GLP-1 receptor 5NX2 - -
TM5 431 L 5.54x54 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM5 432 A 5.55x55 GLP-1 receptor 5NX2 - -
TM5 433 W 5.56x56 GLP-1 receptor 5NX2 - -
TM5 434 A 5.57x57 GLP-1 receptor 5NX2 - -
TM5 435 L 5.58x58 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 436 W 5.59x59 GLP-1 receptor 5NX2 - -
TM5 437 T 5.60x60 GLP-1 receptor 5NX2 - -
TM5 438 L 5.61x61 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 439 R 5.62x62 GLP-1 receptor 5NX2 - -
TM5 440 R 5.63x63 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 441 L 5.64x64 GLP-1 receptor 5NX2 - -
TM5 442 R 5.65x65 GLP-1 receptor 5NX2 - -
ICL3 443 E - - - -
ICL3 444 R - - - -
ICL3 445 A - - - -
ICL3 446 D - - - -
ICL3 447 A - - - -
ICL3 448 P - - - -
ICL3 449 S - - - -
ICL3 450 V - - - -
TM6 451 R 6.34x34 GLP-1 receptor 5NX2 - -
TM6 452 A 6.35x35 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM6 453 C 6.36x36 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 454 H 6.37x37 GLP-1 receptor 5NX2 - -
TM6 455 D 6.38x38 GLP-1 receptor 5NX2 - -
TM6 456 T 6.39x39 GLP-1 receptor 5NX2 - -
TM6 457 V 6.40x40 GLP-1 receptor 5NX2 - -
TM6 458 T 6.41x41 GLP-1 receptor 5NX2 - -
TM6 459 V 6.42x42 GLP-1 receptor 5NX2 - -
TM6 460 L 6.43x43 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 461 G 6.44x44 GLP-1 receptor 5NX2 - -
TM6 462 L 6.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 463 T 6.46x46 GLP-1 receptor 5NX2 - -
TM6 464 V 6.47x47 GLP-1 receptor 5NX2 - -
TM6 465 L 6.48x48 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 466 L 6.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 467 G 6.50x50 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM6 468 T 6.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 469 T 6.52x52 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM6 470 W 6.53x53 GLP-1 receptor 5NX2 - -
TM6 471 A 6.54x54 GLP-1 receptor 5NX2 - -
TM6 472 L 6.55x55 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM6 473 A 6.56x56 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM6 474 F 6.57x57 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM6 475 F 6.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 476 S 6.59x59 PTH1 receptor 6FJ3 PAC1 receptor 6M1H
ECL3 477 F - - - -
ECL3 478 G - - - -
ECL3 479 V - - - -
ECL3 480 F - - - -
TM7 481 L 7.35x34 GLP-1 receptor 5NX2 - -
TM7 482 L 7.36x35 GLP-1 receptor 5NX2 - -
TM7 483 P 7.37x36 GLP-1 receptor 5NX2 - -
TM7 484 Q 7.38x37 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM7 485 L 7.39x38 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 486 F 7.40x39 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 487 L 7.41x40 GLP-1 receptor 5NX2 - -
TM7 488 F 7.42x41 GLP-1 receptor 5NX2 - -
TM7 489 T 7.43x42 GLP-1 receptor 5NX2 - -
TM7 490 I 7.44x43 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM7 491 L 7.45x44 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM7 492 N 7.46x45 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM7 493 S 7.47x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 494 L 7.48x47 GLP-1 receptor 5NX2 - -
TM7 495 Y 7.49x49 GLP-1 receptor 5NX2 - -
TM7 496 G 7.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 497 F 7.51x51 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM7 498 F 7.52x52 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM7 499 L 7.53x53 GLP-1 receptor 5NX2 - -
TM7 500 F 7.54x54 GLP-1 receptor 5NX2 - -
TM7 501 L 7.55x55 GLP-1 receptor 5NX2 - -
TM7 502 W 7.56x56 GLP-1 receptor 5NX2 - -
TM7 503 F 7.57x57 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM7 504 C 7.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 505 S 7.59x59 GLP-1 receptor 5NX2 - -
TM7 506 Q 7.60x60 GLP-1 receptor 5NX2 - -
H8 507 R 8.47x47 GLP-1 receptor 5NX2 - -
H8 508 C 8.48x48 GLP-1 receptor 5NX2 - -
H8 509 R 8.49x49 GLP-1 receptor 5NX2 - -
H8 510 S 8.50x50 GLP-1 receptor 5NX2 - -
H8 511 E 8.51x51 GLP-1 receptor 5NX2 - -
H8 512 A 8.52x52 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
H8 513 E 8.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 514 A 8.54x54 GLP-1 receptor 5NX2 - -
H8 515 K 8.55x55 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
H8 516 A 8.56x56 GLP-1 receptor 5NX2 - -
H8 517 Q 8.57x57 GLP-1 receptor 5NX2 CT receptor 6NIY
H8 518 I 8.58x58 secretin receptor 6WZG - -
H8 519 E 8.59x59 secretin receptor 6WZG GLP-1 receptor 5VAI
H8 520 A 8.60x60 secretin receptor 6WZG - -
H8 521 F 8.61x61 secretin receptor 6WZG CT receptor 6NIY
H8 522 S 8.62x62 secretin receptor 6WZG - -
H8 523 S 8.63x63 secretin receptor 6WZG - -
C-term 524 S - - - -
C-term 525 Q - - - -
C-term 526 T - - - -
C-term 527 T - - - -
C-term 528 Q - - - -