ADGRG6 homology model

PROTEIN CLASS

Class B2 (Adhesion)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2020-09-02

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

GLP-1 receptor (sequence similarity: 31%) PDB: 5NX2

TEMPLATES

5UZ7 (CT receptor)
5NX2 (GLP-1 receptor)
6PB1 (CRF2 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 74.4 4.4 21.2
Side-chains 15.4 21.2 63.5

Number of backbone templates: 3
Number of rotamer templates: 11

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 847 M - - - -
N-term 848 D - - - -
N-term 849 L - - - -
N-term 850 P - - - -
N-term 851 R - - - -
TM1 852 S 1.27x27 CT receptor 5UZ7 - -
TM1 853 A 1.28x28 CT receptor 5UZ7 - -
TM1 854 S 1.29x29 CT receptor 5UZ7 - -
TM1 855 Q 1.30x30 CT receptor 5UZ7 - -
TM1 856 L 1.31x31 CT receptor 5UZ7 - -
TM1 857 D 1.32x32 CT receptor 5UZ7 - -
TM1 858 A 1.33x33 GLP-1 receptor 5NX2 - -
TM1 859 R 1.34x34 GLP-1 receptor 5NX2 - -
TM1 860 N 1.35x35 GLP-1 receptor 5NX2 CT receptor 6NIY
TM1 861 T 1.36x36 GLP-1 receptor 5NX2 - -
TM1 862 K 1.37x37 GLP-1 receptor 5NX2 - -
TM1 863 V 1.38x38 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM1 864 L 1.39x39 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 865 T 1.40x40 GLP-1 receptor 5NX2 - -
TM1 866 F 1.41x41 GLP-1 receptor 5NX2 - -
TM1 867 I 1.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 868 S 1.43x43 GLP-1 receptor 5NX2 - -
TM1 869 Y 1.44x44 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 870 I 1.45x45 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM1 871 G 1.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 872 C 1.47x47 GLP-1 receptor 5NX2 - -
TM1 873 G 1.48x48 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM1 874 I 1.49x49 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM1 875 S 1.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 876 A 1.51x51 GLP-1 receptor 5NX2 - -
TM1 877 I 1.52x52 GLP-1 receptor 5NX2 - -
TM1 878 F 1.53x53 GLP-1 receptor 5NX2 - -
TM1 879 S 1.54x54 GLP-1 receptor 5NX2 - -
TM1 880 A 1.55x55 GLP-1 receptor 5NX2 - -
TM1 881 A 1.56x56 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 882 T 1.57x57 GLP-1 receptor 5NX2 - -
TM1 883 L 1.58x58 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM1 884 L 1.59x59 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 885 T 1.60x60 GLP-1 receptor 5NX2 - -
TM1 886 Y 1.61x61 GLP-1 receptor 5NX2 - -
TM1 887 V 1.62x62 GLP-1 receptor 5NX2 CT receptor 6NIY
TM1 888 A 1.63x63 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 889 F 1.64x64 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ICL1 890 E 12.48x48 - - - -
ICL1 891 K 12.49x49 - - - -
ICL1 892 L 12.50x50 - - - -
ICL1 893 R 12.51x51 - - - -
TM2 894 R 2.43x43 - - - -
TM2 895 D 2.44x44 GLP-1 receptor 5NX2 - -
TM2 896 Y 2.45x45 GLP-1 receptor 5NX2 - -
TM2 897 P 2.46x46 GLP-1 receptor 5NX2 - -
TM2 898 S 2.47x47 GLP-1 receptor 5NX2 - -
TM2 899 K 2.48x48 GLP-1 receptor 5NX2 - -
TM2 900 I 2.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 901 L 2.50x50 GLP-1 receptor 5NX2 - -
TM2 902 M 2.51x51 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM2 903 N 2.52x52 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 904 L 2.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 905 S 2.54x54 GLP-1 receptor 5NX2 - -
TM2 906 T 2.55x55 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM2 907 A 2.56x56 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM2 908 L 2.57x57 GLP-1 receptor 5NX2 - -
TM2 909 L 2.58x58 GLP-1 receptor 5NX2 - -
TM2 910 F 2.59x59 GLP-1 receptor 5NX2 - -
TM2 911 L 2.60x60 GLP-1 receptor 5NX2 - -
TM2 912 N 2.61x61 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM2 913 L 2.62x62 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 914 L 2.63x63 GLP-1 receptor 5NX2 - -
TM2 915 F 2.64x64 GLP-1 receptor 5NX2 - -
TM2 916 L 2.65x65 GLP-1 receptor 5NX2 glucagon receptor 5XEZ
TM2 917 L 2.66x66 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM2 918 D 2.67x67 GLP-1 receptor 5NX2 - -
TM2 919 G 2.68x68 GLP-1 receptor 5NX2 - -
TM2 920 W 2.69x69 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM2 921 I 2.70x70 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
ECL1 922 T - - - -
ECL1 923 S - - - -
ECL1 924 F - - - -
ECL1 925 N - - - -
ECL1 926 V - - - -
ECL1 927 D - - - -
TM3 928 G 3.27x27 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM3 929 L 3.28x28 GLP-1 receptor 5NX2 - -
TM3 930 C 3.29x29 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 931 I 3.30x30 GLP-1 receptor 5NX2 - -
TM3 932 A 3.31x31 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM3 933 V 3.32x32 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 934 A 3.33x33 GLP-1 receptor 5NX2 glucagon receptor 5XEZ
TM3 935 V 3.34x34 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM3 936 L 3.35x35 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM3 937 L 3.36x36 GLP-1 receptor 5NX2 - -
TM3 938 H 3.37x37 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM3 939 F 3.38x38 GLP-1 receptor 5NX2 - -
TM3 940 F 3.39x39 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM3 941 L 3.40x40 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM3 942 L 3.41x41 GLP-1 receptor 5NX2 - -
TM3 943 A 3.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 944 T 3.43x43 GLP-1 receptor 5NX2 - -
TM3 945 F 3.44x44 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM3 946 T 3.45x45 GLP-1 receptor 5NX2 - -
TM3 947 W 3.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 948 M 3.47x47 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM3 949 G 3.48x48 GLP-1 receptor 5NX2 - -
TM3 950 L 3.49x49 GLP-1 receptor 5NX2 - -
TM3 951 E 3.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 952 A 3.51x51 GLP-1 receptor 5NX2 - -
TM3 953 I 3.52x52 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM3 954 H 3.53x53 GLP-1 receptor 5NX2 - -
TM3 955 M 3.54x54 GLP-1 receptor 5NX2 - -
TM3 956 Y 3.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 957 I 3.56x56 GLP-1 receptor 5NX2 - -
TM3 958 A 3.57x57 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM3 959 L 3.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 960 V 3.59x59 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM3 961 K 3.60x60 GLP-1 receptor 5NX2 - -
ICL2 962 V - - - -
ICL2 963 F - - - -
ICL2 964 N - - - -
ICL2 965 T - - - -
ICL2 966 Y - - - -
ICL2 967 I - - - -
ICL2 968 R - - - -
ICL2 969 R - - - -
TM4 970 Y 4.41x42 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 971 I 4.42x43 GLP-1 receptor 5NX2 - -
TM4 972 L 4.43x44 GLP-1 receptor 5NX2 - -
TM4 973 K 4.44x45 GLP-1 receptor 5NX2 - -
TM4 974 F 4.45x46 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM4 975 C 4.46x47 GLP-1 receptor 5NX2 - -
TM4 976 I 4.47x48 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM4 977 I 4.48x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 978 G 4.49x491 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 979 W 4.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 980 G 4.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 981 L 4.52x52 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM4 982 P 4.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 983 A 4.54x54 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 984 L 4.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 985 V 4.56x56 GLP-1 receptor 5NX2 - -
TM4 986 V 4.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 987 S 4.58x58 GLP-1 receptor 5NX2 - -
TM4 988 V 4.59x59 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM4 989 V 4.60x60 GLP-1 receptor 5NX2 - -
TM4 990 L 4.61x61 GLP-1 receptor 5NX2 - -
TM4 991 A 4.62x62 GLP-1 receptor 5NX2 - -
TM4 992 S 4.63x63 GLP-1 receptor 5NX2 - -
TM4 993 R 4.64x64 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 994 N 4.65x65 GLP-1 receptor 5NX2 - -
TM4 995 N 4.66x66 GLP-1 receptor 5NX2 - -
TM4 996 N 4.67x67 GLP-1 receptor 5NX2 - -
TM4 997 E 4.68x68 CRF2 receptor 6PB1 CRF2 receptor 6PB1
ECL2 998 V - - - -
ECL2 999 Y - - - -
ECL2 1000 G - - - -
ECL2 1001 K - - - -
ECL2 1002 E - - - -
ECL2 1003 S - - - -
ECL2 1004 Y - - - -
ECL2 1005 G - - - -
ECL2 1006 K - - - -
ECL2 1007 E - - - -
ECL2 1008 K - - - -
ECL2 1009 G - - - -
ECL2 1010 D - - - -
ECL2 1011 E - - - -
ECL2 1012 F - - - -
ECL2 1013 C 45.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 1014 W 45.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 1015 I 45.52x52 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
ECL2 1016 Q - - - -
ECL2 1017 D - - - -
TM5 1018 P 5.32x32 - - - -
TM5 1019 V 5.33x33 GLP-1 receptor 5NX2 - -
TM5 1020 I 5.34x34 GLP-1 receptor 5NX2 - -
TM5 1021 F 5.35x35 GLP-1 receptor 5NX2 - -
TM5 1022 Y 5.36x36 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 1023 V 5.37x37 GLP-1 receptor 5NX2 - -
TM5 1024 T 5.38x38 GLP-1 receptor 5NX2 - -
TM5 1025 C 5.39x39 GLP-1 receptor 5NX2 - -
TM5 1026 A 5.40x40 GLP-1 receptor 5NX2 - -
TM5 1027 G 5.41x41 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM5 1028 Y 5.42x42 GLP-1 receptor 5NX2 - -
TM5 1029 F 5.43x43 GLP-1 receptor 5NX2 - -
TM5 1030 G 5.44x44 GLP-1 receptor 5NX2 - -
TM5 1031 V 5.45x45 GLP-1 receptor 5NX2 - -
TM5 1032 M 5.46x46 GLP-1 receptor 5NX2 - -
TM5 1033 F 5.47x47 GLP-1 receptor 5NX2 - -
TM5 1034 F 5.48x48 GLP-1 receptor 5NX2 - -
TM5 1035 L 5.49x49 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM5 1036 N 5.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 1037 I 5.51x51 GLP-1 receptor 5NX2 - -
TM5 1038 A 5.52x52 GLP-1 receptor 5NX2 - -
TM5 1039 M 5.53x53 GLP-1 receptor 5NX2 - -
TM5 1040 F 5.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 1041 I 5.55x55 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 1042 V 5.56x56 GLP-1 receptor 5NX2 - -
TM5 1043 V 5.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 1044 M 5.58x58 GLP-1 receptor 5NX2 - -
TM5 1045 V 5.59x59 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM5 1046 Q 5.60x60 GLP-1 receptor 5NX2 - -
TM5 1047 I 5.61x61 GLP-1 receptor 5NX2 - -
TM5 1048 C 5.62x62 GLP-1 receptor 5NX2 - -
TM5 1049 G 5.63x63 GLP-1 receptor 5NX2 - -
TM5 1050 R 5.64x64 GLP-1 receptor 5NX2 - -
TM5 1051 N 5.65x65 GLP-1 receptor 5NX2 - -
ICL3 1052 G - - - -
ICL3 1053 K - - - -
ICL3 1054 R - - - -
ICL3 1055 S - - - -
ICL3 1056 N - - - -
ICL3 1057 R - - - -
ICL3 1058 T - - - -
ICL3 1059 L - - - -
ICL3 1060 R - - - -
ICL3 1061 E - - - -
TM6 1062 E 6.34x34 GLP-1 receptor 5NX2 - -
TM6 1063 V 6.35x35 GLP-1 receptor 5NX2 - -
TM6 1064 L 6.36x36 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM6 1065 R 6.37x37 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 1066 N 6.38x38 GLP-1 receptor 5NX2 - -
TM6 1067 L 6.39x39 GLP-1 receptor 5NX2 PTH1 receptor 6NBI
TM6 1068 R 6.40x40 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM6 1069 S 6.41x41 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 1070 V 6.42x42 GLP-1 receptor 5NX2 - -
TM6 1071 V 6.43x43 GLP-1 receptor 5NX2 - -
TM6 1072 S 6.44x44 GLP-1 receptor 5NX2 - -
TM6 1073 L 6.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 1074 T 6.46x46 GLP-1 receptor 5NX2 - -
TM6 1075 F 6.47x47 GLP-1 receptor 5NX2 - -
TM6 1076 L 6.48x48 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 1077 L 6.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 1078 G 6.50x50 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM6 1079 M 6.51x51 GLP-1 receptor 5NX2 - -
TM6 1080 T 6.52x52 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM6 1081 W 6.53x53 GLP-1 receptor 5NX2 - -
TM6 1082 G 6.54x54 GLP-1 receptor 5NX2 - -
TM6 1083 F 6.55x55 GLP-1 receptor 5NX2 - -
TM6 1084 A 6.56x56 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM6 1085 F 6.57x57 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM6 1086 F 6.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL3 1087 A - - - -
ECL3 1088 W - - - -
ECL3 1089 G - - - -
ECL3 1090 P - - - -
ECL3 1091 L - - - -
TM7 1092 N 7.35x34 GLP-1 receptor 5NX2 - -
TM7 1093 I 7.36x35 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM7 1094 P 7.37x36 GLP-1 receptor 5NX2 - -
TM7 1095 F 7.38x37 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM7 1096 M 7.39x38 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM7 1097 Y 7.40x39 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM7 1098 L 7.41x40 GLP-1 receptor 5NX2 - -
TM7 1099 F 7.42x41 GLP-1 receptor 5NX2 - -
TM7 1100 S 7.43x42 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM7 1101 I 7.44x43 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM7 1102 F 7.45x44 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 1103 N 7.46x45 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM7 1104 S 7.47x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 1105 L 7.48x47 GLP-1 receptor 5NX2 - -
TM7 1106 Q 7.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 1107 G 7.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 1108 L 7.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 1109 F 7.52x52 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM7 1110 I 7.53x53 GLP-1 receptor 5NX2 - -
TM7 1111 F 7.54x54 GLP-1 receptor 5NX2 - -
TM7 1112 I 7.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 1113 F 7.56x56 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM7 1114 H 7.57x57 GLP-1 receptor 5NX2 - -
TM7 1115 C 7.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 1116 A 7.59x59 GLP-1 receptor 5NX2 - -
TM7 1117 M 7.60x60 GLP-1 receptor 5NX2 - -
H8 1118 K 8.47x47 GLP-1 receptor 5NX2 - -
H8 1119 E 8.48x48 GLP-1 receptor 5NX2 - -
H8 1120 N 8.49x49 GLP-1 receptor 5NX2 - -
H8 1121 V 8.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 1122 Q 8.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 1123 K 8.52x52 GLP-1 receptor 5NX2 - -
H8 1124 Q 8.53x53 GLP-1 receptor 5NX2 - -
H8 1125 W 8.54x54 GLP-1 receptor 5NX2 - -
H8 1126 R 8.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 1127 Q 8.56x56 GLP-1 receptor 5NX2 - -
H8 1128 H 8.57x57 GLP-1 receptor 5NX2 - -
H8 1129 L 8.58x58 CRF2 receptor 6PB1 - -
H8 1130 C 8.59x59 CRF2 receptor 6PB1 - -
H8 1131 C 8.60x60 CRF2 receptor 6PB1 - -
H8 1132 G 8.61x61 CRF2 receptor 6PB1 - -
H8 1133 R 8.62x62 CRF2 receptor 6PB1 glucagon receptor 6WPW
H8 1134 F 8.63x63 CRF2 receptor 6PB1 - -
C-term 1135 R - - - -
C-term 1136 L - - - -
C-term 1137 A - - - -
C-term 1138 D - - - -
C-term 1139 N - - - -