ADGRL2 homology model

PROTEIN CLASS

Class B2 (Adhesion)

RECEPTOR

ADGRL2

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2020-09-02

MODEL

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PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

GLP-1 receptor (sequence similarity: 30%) PDB: 5NX2
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TEMPLATES

5UZ7 (CT receptor)
5NX2 (GLP-1 receptor)
6WI9 (secretin receptor)
6WZG (secretin receptor)
4Z9G (CRF1 receptor)
6M1H (PAC1 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 79.9 6.5 13.6
Side-chains 19.4 23.7 57.0

Number of backbone templates: 6
Number of rotamer templates: 14

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 830 L - - - -
N-term 831 M - - - -
N-term 832 A - - - -
N-term 833 H - - - -
N-term 834 R - - - -
TM1 835 E 1.27x27 CT receptor 5UZ7 - -
TM1 836 I 1.28x28 CT receptor 5UZ7 - -
TM1 837 A 1.29x29 CT receptor 5UZ7 - -
TM1 838 Y 1.30x30 CT receptor 5UZ7 - -
TM1 839 K 1.31x31 CT receptor 5UZ7 secretin receptor 6WZG
TM1 840 D 1.32x32 CT receptor 5UZ7 - -
TM1 841 G 1.33x33 GLP-1 receptor 5NX2 - -
TM1 842 V 1.34x34 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM1 843 H 1.35x35 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM1 844 E 1.36x36 GLP-1 receptor 5NX2 - -
TM1 845 L 1.37x37 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 846 L 1.38x38 GLP-1 receptor 5NX2 - -
TM1 847 L 1.39x39 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 848 T 1.40x40 GLP-1 receptor 5NX2 - -
TM1 849 V 1.41x41 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM1 850 I 1.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 851 T 1.43x43 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM1 852 W 1.44x44 GLP-1 receptor 5NX2 - -
TM1 853 V 1.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 854 G 1.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 855 I 1.47x47 GLP-1 receptor 5NX2 - -
TM1 856 V 1.48x48 GLP-1 receptor 5NX2 - -
TM1 857 I 1.49x49 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM1 858 S 1.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 859 L 1.51x51 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM1 860 V 1.52x52 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM1 861 C 1.53x53 GLP-1 receptor 5NX2 - -
TM1 862 L 1.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 863 A 1.55x55 GLP-1 receptor 5NX2 - -
TM1 864 I 1.56x56 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 865 C 1.57x57 GLP-1 receptor 5NX2 - -
TM1 866 I 1.58x58 GLP-1 receptor 5NX2 - -
TM1 867 F 1.59x59 GLP-1 receptor 5NX2 - -
TM1 868 T 1.60x60 GLP-1 receptor 5NX2 - -
TM1 869 F 1.61x61 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM1 870 C 1.62x62 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM1 871 F 1.63x63 GLP-1 receptor 5NX2 CT receptor 6NIY
TM1 872 F 1.64x64 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ICL1 873 R GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ICL1 874 G GLP-1 receptor 5NX2 - -
ICL1 875 L GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ICL1 876 Q GLP-1 receptor 5NX2 - -
TM2 877 S 2.44x44 GLP-1 receptor 5NX2 - -
TM2 878 D 2.45x45 GLP-1 receptor 5NX2 - -
TM2 879 R 2.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 880 N 2.47x47 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 881 T 2.48x48 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM2 882 I 2.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 883 H 2.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 884 K 2.51x51 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM2 885 N 2.52x52 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 886 L 2.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 887 C 2.54x54 GLP-1 receptor 5NX2 - -
TM2 888 I 2.55x55 GLP-1 receptor 5NX2 - -
TM2 889 N 2.56x56 GLP-1 receptor 5NX2 - -
TM2 890 L 2.57x57 GLP-1 receptor 5NX2 - -
TM2 891 F 2.58x58 GLP-1 receptor 5NX2 - -
TM2 892 I 2.59x59 GLP-1 receptor 5NX2 - -
TM2 893 A 2.60x60 GLP-1 receptor 5NX2 - -
TM2 894 E 2.61x61 GLP-1 receptor 5NX2 - -
TM2 895 F 2.62x62 GLP-1 receptor 5NX2 - -
TM2 896 I 2.63x63 GLP-1 receptor 5NX2 CT receptor 6NIY
TM2 897 F 2.64x64 GLP-1 receptor 5NX2 - -
TM2 898 L 2.65x65 GLP-1 receptor 5NX2 glucagon receptor 5XEZ
TM2 899 I 2.66x66 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 900 G 2.67x67 GLP-1 receptor 5NX2 - -
TM2 901 I 2.68x68 GLP-1 receptor 5NX2 - -
TM2 902 D 2.69x69 GLP-1 receptor 5NX2 - -
TM2 903 K 2.70x70 GLP-1 receptor 5NX2 - -
ECL1 904 T - - - -
ECL1 905 K - - - -
ECL1 906 Y - - - -
ECL1 907 A - - - -
TM3 908 I 3.27x27 GLP-1 receptor 5NX2 - -
TM3 909 A 3.28x28 GLP-1 receptor 5NX2 GLP-1 receptor 5VEW
TM3 910 C 3.29x29 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 911 P 3.30x30 GLP-1 receptor 5NX2 - -
TM3 912 I 3.31x31 GLP-1 receptor 5NX2 CT receptor 6NIY
TM3 913 F 3.32x32 GLP-1 receptor 5NX2 - -
TM3 914 A 3.33x33 GLP-1 receptor 5NX2 glucagon receptor 5XEZ
TM3 915 G 3.34x34 GLP-1 receptor 5NX2 - -
TM3 916 L 3.35x35 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM3 917 L 3.36x36 GLP-1 receptor 5NX2 - -
TM3 918 H 3.37x37 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM3 919 F 3.38x38 GLP-1 receptor 5NX2 - -
TM3 920 F 3.39x39 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM3 921 F 3.40x40 GLP-1 receptor 5NX2 - -
TM3 922 L 3.41x41 GLP-1 receptor 5NX2 - -
TM3 923 A 3.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 924 A 3.43x43 GLP-1 receptor 5NX2 - -
TM3 925 F 3.44x44 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM3 926 A 3.45x45 GLP-1 receptor 5NX2 - -
TM3 927 W 3.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 928 M 3.47x47 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM3 929 C 3.48x48 GLP-1 receptor 5NX2 - -
TM3 930 L 3.49x49 GLP-1 receptor 5NX2 - -
TM3 931 E 3.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 932 G 3.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 933 V 3.52x52 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 934 Q 3.53x53 GLP-1 receptor 5NX2 - -
TM3 935 L 3.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 936 Y 3.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 937 L 3.56x56 GLP-1 receptor 5NX2 - -
TM3 938 M 3.57x57 GLP-1 receptor 5NX2 - -
TM3 939 L 3.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 940 V 3.59x59 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM3 941 E 3.60x60 GLP-1 receptor 5NX2 - -
ICL2 942 V - - - -
ICL2 943 F secretin receptor 6WI9 secretin receptor 6WI9
ICL2 944 E secretin receptor 6WI9 - -
ICL2 945 S secretin receptor 6WI9 secretin receptor 6WI9
ICL2 946 E secretin receptor 6WI9 secretin receptor 6WI9
ICL2 947 Y - - - -
TM4 948 S 4.40x41 GLP-1 receptor 5NX2 glucagon receptor 5EE7
TM4 949 R 4.41x42 GLP-1 receptor 5NX2 CT receptor 6NIY
TM4 950 K 4.42x43 GLP-1 receptor 5NX2 CRF1 receptor 6P9X
TM4 951 K 4.43x44 GLP-1 receptor 5NX2 GLP-1 receptor 5VAI
TM4 952 Y 4.44x45 GLP-1 receptor 5NX2 - -
TM4 953 Y 4.45x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 954 Y 4.46x47 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM4 955 V 4.47x48 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM4 956 A 4.48x49 GLP-1 receptor 5NX2 - -
TM4 957 G 4.49x491 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 958 Y 4.50x50 GLP-1 receptor 5NX2 - -
TM4 959 L 4.51x51 GLP-1 receptor 5NX2 - -
TM4 960 F 4.52x52 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM4 961 P 4.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 962 A 4.54x54 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 963 T 4.55x55 GLP-1 receptor 5NX2 - -
TM4 964 V 4.56x56 GLP-1 receptor 5NX2 - -
TM4 965 V 4.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 966 G 4.58x58 GLP-1 receptor 5NX2 - -
TM4 967 V 4.59x59 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM4 968 S 4.60x60 GLP-1 receptor 5NX2 - -
TM4 969 A 4.61x61 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 970 A 4.62x62 GLP-1 receptor 5NX2 - -
TM4 971 I 4.63x63 GLP-1 receptor 5NX2 - -
TM4 972 D 4.64x64 GLP-1 receptor 5NX2 - -
TM4 973 Y 4.65x65 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 974 K 4.66x66 GLP-1 receptor 5NX2 - -
TM4 975 S 4.67x67 GLP-1 receptor 5NX2 - -
TM4 976 Y 4.68x68 CRF1 receptor 4Z9G calcitonin receptor-like receptor 6UUS
ECL2 977 G - - - -
ECL2 978 T - - - -
ECL2 979 E - - - -
ECL2 980 K - - - -
ECL2 981 A - - - -
ECL2 982 C 45.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 983 W 45.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 984 L 45.52x52 GLP-1 receptor 5NX2 CT receptor 6NIY
ECL2 985 H - - - -
ECL2 986 V - - - -
TM5 987 D 5.32x32 - - - -
TM5 988 N 5.33x33 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 989 Y 5.34x34 GLP-1 receptor 5NX2 - -
TM5 990 F 5.35x35 GLP-1 receptor 5NX2 - -
TM5 991 I 5.36x36 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 992 W 5.37x37 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 993 S 5.38x38 GLP-1 receptor 5NX2 - -
TM5 994 F 5.39x39 GLP-1 receptor 5NX2 - -
TM5 995 I 5.40x40 GLP-1 receptor 5NX2 - -
TM5 996 G 5.41x41 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 997 P 5.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 998 V 5.43x43 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 999 T 5.44x44 GLP-1 receptor 5NX2 - -
TM5 1000 F 5.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 1001 I 5.46x46 GLP-1 receptor 5NX2 - -
TM5 1002 I 5.47x47 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 1003 L 5.48x48 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 1004 L 5.49x49 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM5 1005 N 5.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 1006 I 5.51x51 GLP-1 receptor 5NX2 - -
TM5 1007 I 5.52x52 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 1008 F 5.53x53 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM5 1009 L 5.54x54 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM5 1010 V 5.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 1011 I 5.56x56 GLP-1 receptor 5NX2 - -
TM5 1012 T 5.57x57 GLP-1 receptor 5NX2 - -
TM5 1013 L 5.58x58 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 1014 C 5.59x59 GLP-1 receptor 5NX2 GLP-1 receptor 5VAI
TM5 1015 K 5.60x60 GLP-1 receptor 5NX2 - -
TM5 1016 M 5.61x61 GLP-1 receptor 5NX2 - -
TM5 1017 V 5.62x62 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 1018 K 5.63x63 GLP-1 receptor 5NX2 - -
TM5 1019 H 5.64x64 GLP-1 receptor 5NX2 - -
TM5 1020 S 5.65x65 GLP-1 receptor 5NX2 - -
ICL3 1021 N - - - -
ICL3 1022 T - - - -
ICL3 1023 L - - - -
ICL3 1024 K - - - -
ICL3 1025 P - - - -
ICL3 1027 S - - - -
ICL3 1028 S - - - -
ICL3 1029 R - - - -
ICL3 1030 L - - - -
ICL3 1031 E - - - -
TM6 1032 N 6.34x34 GLP-1 receptor 5NX2 - -
TM6 1033 I 6.35x35 GLP-1 receptor 5NX2 - -
TM6 1034 K 6.36x36 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM6 1035 S 6.37x37 GLP-1 receptor 5NX2 - -
TM6 1036 W 6.38x38 GLP-1 receptor 5NX2 - -
TM6 1037 V 6.39x39 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM6 1038 L 6.40x40 GLP-1 receptor 5NX2 - -
TM6 1039 G 6.41x41 GLP-1 receptor 5NX2 - -
TM6 1040 A 6.42x42 GLP-1 receptor 5NX2 - -
TM6 1041 F 6.43x43 GLP-1 receptor 5NX2 - -
TM6 1042 A 6.44x44 GLP-1 receptor 5NX2 - -
TM6 1043 L 6.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 1044 L 6.46x46 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM6 1045 C 6.47x47 GLP-1 receptor 5NX2 - -
TM6 1046 L 6.48x48 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 1047 L 6.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 1048 G 6.50x50 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM6 1049 L 6.51x51 GLP-1 receptor 5NX2 - -
TM6 1050 T 6.52x52 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM6 1051 W 6.53x53 GLP-1 receptor 5NX2 - -
TM6 1052 S 6.54x54 GLP-1 receptor 5NX2 - -
TM6 1053 F 6.55x55 GLP-1 receptor 5NX2 - -
TM6 1054 G 6.56x56 GLP-1 receptor 5NX2 - -
TM6 1055 L 6.57x57 GLP-1 receptor 5NX2 - -
TM6 1056 L 6.58x58 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM6 1057 F 6.59x59 PAC1 receptor 6M1H - -
ECL3 1058 I - - - -
ECL3 1059 N - - - -
ECL3 1060 E - - - -
ECL3 1061 E - - - -
TM7 1062 T 7.35x34 GLP-1 receptor 5NX2 - -
TM7 1063 I 7.36x35 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM7 1064 V 7.37x36 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM7 1065 M 7.38x37 GLP-1 receptor 5NX2 - -
TM7 1066 A 7.39x38 GLP-1 receptor 5NX2 - -
TM7 1067 Y 7.40x39 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM7 1068 L 7.41x40 GLP-1 receptor 5NX2 - -
TM7 1069 F 7.42x41 GLP-1 receptor 5NX2 - -
TM7 1070 T 7.43x42 GLP-1 receptor 5NX2 - -
TM7 1071 I 7.44x43 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM7 1072 F 7.45x44 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 1073 N 7.46x45 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM7 1074 A 7.47x46 GLP-1 receptor 5NX2 - -
TM7 1075 F 7.48x47 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 1076 Q 7.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 1077 G 7.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 1078 V 7.51x51 GLP-1 receptor 5NX2 - -
TM7 1079 F 7.52x52 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM7 1080 I 7.53x53 GLP-1 receptor 5NX2 - -
TM7 1081 F 7.54x54 GLP-1 receptor 5NX2 - -
TM7 1082 I 7.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 1083 F 7.56x56 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM7 1084 H 7.57x57 GLP-1 receptor 5NX2 - -
TM7 1085 C 7.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 1086 A 7.59x59 GLP-1 receptor 5NX2 - -
TM7 1087 L 7.60x60 GLP-1 receptor 5NX2 secretin receptor 6WZG
H8 1088 Q 8.47x47 GLP-1 receptor 5NX2 - -
H8 1089 K 8.48x48 GLP-1 receptor 5NX2 glucagon receptor 5XEZ
H8 1090 K 8.49x49 GLP-1 receptor 5NX2 - -
H8 1091 V 8.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 1092 R 8.51x51 GLP-1 receptor 5NX2 CRF1 receptor 6P9X
H8 1093 K 8.52x52 GLP-1 receptor 5NX2 - -
H8 1094 E 8.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 1095 Y 8.54x54 GLP-1 receptor 5NX2 - -
H8 1096 G 8.55x55 GLP-1 receptor 5NX2 - -
H8 1097 K 8.56x56 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 1098 C 8.57x57 GLP-1 receptor 5NX2 - -
H8 1099 F 8.58x58 secretin receptor 6WZG - -
H8 1100 R 8.59x59 secretin receptor 6WZG PAC1 receptor 6P9Y
H8 1101 H 8.60x60 secretin receptor 6WZG - -
H8 1102 S 8.61x61 secretin receptor 6WZG - -
H8 1103 Y 8.62x62 secretin receptor 6WZG - -
H8 1104 C 8.63x63 secretin receptor 6WZG - -
C-term 1105 C - - - -
C-term 1106 G - - - -
C-term 1107 G - - - -
C-term 1108 L - - - -
C-term 1109 P - - - -