ADGRL3 homology model

PROTEIN CLASS

Class B2 (Adhesion)

RECEPTOR

ADGRL3

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2021-10-06

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

GLP-1 receptor (sequence similarity: 8%) PDB: 5NX2
Align

TEMPLATES

5NX2 (GLP-1 receptor)
6X1A (GLP-1 receptor)
7D77 (ADGRG3)
6PB1 (CRF2 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 81.3 5.5 13.2
Side-chains 22.0 30.4 47.6

Number of backbone templates: 4
Number of rotamer templates: 17

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 854 K - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
N-term 855 H - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
N-term 856 S - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
N-term 857 D - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
N-term 858 A - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 859 V 1.34x34 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM1 860 H 1.35x35 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 861 D 1.36x36 GLP-1 receptor 5NX2 - -
TM1 862 L 1.37x37 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 863 L 1.38x38 GLP-1 receptor 5NX2 - -
TM1 864 L 1.39x39 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 865 D 1.40x40 GLP-1 receptor 5NX2 - -
TM1 866 V 1.41x41 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 867 I 1.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 868 T 1.43x43 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM1 869 W 1.44x44 GLP-1 receptor 5NX2 - -
TM1 870 V 1.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 871 G 1.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 872 I 1.47x47 GLP-1 receptor 5NX2 - -
TM1 873 L 1.48x48 GLP-1 receptor 5NX2 - -
TM1 874 L 1.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 875 S 1.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 876 L 1.51x51 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM1 877 V 1.52x52 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM1 878 C 1.53x53 GLP-1 receptor 5NX2 - -
TM1 879 L 1.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 880 L 1.55x55 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM1 881 I 1.56x56 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 882 C 1.57x57 GLP-1 receptor 5NX2 - -
TM1 883 I 1.58x58 GLP-1 receptor 5NX2 ADGRG3 7D77
TM1 884 F 1.59x59 GLP-1 receptor 5NX2 - -
TM1 885 T 1.60x60 GLP-1 receptor 5NX2 - -
TM1 886 F 1.61x61 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 887 C 1.62x62 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM1 888 F 1.63x63 GLP-1 receptor 5NX2 ADGRG3 7D77
TM1 889 F 1.64x64 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ICL1 890 R 12.48x48 - - - -
ICL1 891 G 12.49x49 ADGRG3 7D77 - -
ICL1 892 L 12.50x50 ADGRG3 7D77 GLP-1 receptor 5NX2
ICL1 893 Q 12.51x51 - - - -
TM2 894 S 2.44x44 GLP-1 receptor 5NX2 - -
TM2 895 D 2.45x45 GLP-1 receptor 5NX2 ADGRG3 7D77
TM2 896 R 2.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 897 N 2.47x47 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 898 T 2.48x48 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM2 899 I 2.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 900 H 2.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 901 K 2.51x51 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM2 902 N 2.52x52 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 903 L 2.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 904 C 2.54x54 GLP-1 receptor 5NX2 - -
TM2 905 I 2.55x55 GLP-1 receptor 5NX2 VPAC1 receptor 6VN7
TM2 906 S 2.56x56 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 907 L 2.57x57 GLP-1 receptor 5NX2 ADGRG3 7D77
TM2 908 F 2.58x58 GLP-1 receptor 5NX2 ADGRG3 7D77
TM2 909 V 2.59x59 GLP-1 receptor 5NX2 - -
TM2 910 A 2.60x60 GLP-1 receptor 5NX2 - -
TM2 911 E 2.61x61 GLP-1 receptor 5NX2 - -
TM2 912 L 2.62x62 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 913 L 2.63x63 GLP-1 receptor 5NX2 - -
TM2 914 F 2.64x64 GLP-1 receptor 5NX2 ADGRG3 7D77
TM2 915 L 2.65x65 GLP-1 receptor 5NX2 ADGRG3 7D77
TM2 916 I 2.66x66 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 917 G 2.67x67 GLP-1 receptor 5NX2 - -
TM2 918 I 2.68x68 GLP-1 receptor 5NX2 - -
TM2 919 N 2.69x69 GLP-1 receptor 5NX2 - -
TM2 920 R 2.70x70 GLP-1 receptor 5NX2 - -
ECL1 921 T - - - - -
ECL1 922 D - - - - -
ECL1 923 Q - - - - -
ECL1 924 P - - - - -
TM3 925 I 3.27x27 GLP-1 receptor 5NX2 PTH2 receptor 7F16
TM3 926 A 3.28x28 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 927 C 3.29x29 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 928 A 3.30x30 GLP-1 receptor 5NX2 - -
TM3 929 V 3.31x31 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM3 930 F 3.32x32 GLP-1 receptor 5NX2 - -
TM3 931 A 3.33x33 GLP-1 receptor 5NX2 glucagon receptor 5YQZ
TM3 932 A 3.34x34 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 933 L 3.35x35 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM3 934 L 3.36x36 GLP-1 receptor 5NX2 GLP-2 receptor 7D68
TM3 935 H 3.37x37 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 936 F 3.38x38 GLP-1 receptor 5NX2 GHRH receptor 7CZ5
TM3 937 F 3.39x39 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 938 F 3.40x40 GLP-1 receptor 5NX2 - -
TM3 939 L 3.41x41 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 940 A 3.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 941 A 3.43x43 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 942 F 3.44x44 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 943 T 3.45x45 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 944 W 3.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 945 M 3.47x47 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 946 F 3.48x48 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM3 947 L 3.49x49 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 948 E 3.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 949 G 3.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 950 V 3.52x52 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 951 Q 3.53x53 GLP-1 receptor 5NX2 - -
TM3 952 L 3.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 953 Y 3.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 954 I 3.56x56 GLP-1 receptor 5NX2 - -
TM3 955 M 3.57x57 GLP-1 receptor 5NX2 - -
TM3 956 L 3.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 957 V 3.59x59 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 958 E 3.60x60 GLP-1 receptor 5NX2 - -
ICL2 959 V - - - - -
ICL2 960 F - - - - -
ICL2 961 E - - - - -
ICL2 962 S - - - - -
ICL2 963 E - - - - -
ICL2 964 H - - - - -
TM4 965 S 4.40x41 GLP-1 receptor 5NX2 glucagon receptor 5EE7
TM4 966 R 4.41x42 GLP-1 receptor 5NX2 CT receptor 6NIY
TM4 967 R 4.42x43 GLP-1 receptor 5NX2 - -
TM4 968 K 4.43x44 GLP-1 receptor 5NX2 GLP-1 receptor 5VAI
TM4 969 Y 4.44x45 GLP-1 receptor 5NX2 GIP receptor 7DTY
TM4 970 F 4.45x46 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM4 971 Y 4.46x47 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM4 972 L 4.47x48 GLP-1 receptor 5NX2 ADGRG3 7D77
TM4 973 V 4.48x49 GLP-1 receptor 5NX2 ADGRG3 7D77
TM4 974 G 4.49x491 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 975 Y 4.50x50 GLP-1 receptor 5NX2 - -
TM4 976 G 4.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 977 M 4.52x52 GLP-1 receptor 5NX2 - -
TM4 978 P 4.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 979 A 4.54x54 GLP-1 receptor 5NX2 ADGRG3 7D77
TM4 980 L 4.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 981 I 4.56x56 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM4 982 V 4.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 983 A 4.58x58 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 984 V 4.59x59 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM4 985 S 4.60x60 GLP-1 receptor 5NX2 - -
TM4 986 A 4.61x61 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM4 987 A 4.62x62 GLP-1 receptor 5NX2 - -
TM4 988 V 4.63x63 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 989 D 4.64x64 GLP-1 receptor 5NX2 - -
ECL2 990 Y - - - - -
ECL2 991 R - - - - -
ECL2 992 S - - - - -
ECL2 993 Y - - - - -
ECL2 994 G - - - - -
ECL2 995 T - - - - -
ECL2 996 D - - - - -
ECL2 997 K - - - - -
ECL2 998 V - - - - -
ECL2 999 C 45.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 1000 W 45.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 1001 L 45.52x52 GLP-1 receptor 5NX2 CT receptor 6NIY
ECL2 1002 R - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 1003 L - GLP-1 receptor 5NX2 - -
ECL2 1004 D - GLP-1 receptor 5NX2 - -
TM5 1005 T 5.33x33 GLP-1 receptor 5NX2 - -
TM5 1006 Y 5.34x34 GLP-1 receptor 5NX2 ADGRG3 7D77
TM5 1007 F 5.35x35 GLP-1 receptor 5NX2 - -
TM5 1008 I 5.36x36 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 1009 W 5.37x37 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 1010 S 5.38x38 GLP-1 receptor 5NX2 - -
TM5 1011 F 5.39x39 GLP-1 receptor 5NX2 - -
TM5 1012 I 5.40x40 GLP-1 receptor 5NX2 - -
TM5 1013 G 5.41x41 GLP-1 receptor 5NX2 ADGRG3 7D77
TM5 1014 P 5.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 1015 A 5.43x43 GLP-1 receptor 5NX2 - -
TM5 1016 T 5.44x44 GLP-1 receptor 5NX2 - -
TM5 1017 L 5.45x45 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM5 1018 I 5.46x46 GLP-1 receptor 5NX2 - -
TM5 1019 I 5.47x47 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 1020 M 5.48x48 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM5 1021 L 5.49x49 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM5 1022 N 5.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 1023 V 5.51x51 GLP-1 receptor 5NX2 - -
TM5 1024 I 5.52x52 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM5 1025 F 5.53x53 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM5 1026 L 5.54x54 GLP-1 receptor 5NX2 ADGRG3 7D77
TM5 1027 G 5.55x55 GLP-1 receptor 5NX2 - -
TM5 1028 I 5.56x56 GLP-1 receptor 5NX2 - -
TM5 1029 A 5.57x57 GLP-1 receptor 5NX2 - -
TM5 1030 L 5.58x58 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 1031 Y 5.59x59 GLP-1 receptor 5NX2 - -
TM5 1032 K 5.60x60 GLP-1 receptor 5NX2 ADGRG3 7D77
TM5 1033 M 5.61x61 GLP-1 receptor 5NX2 - -
TM5 1034 F 5.62x62 GLP-1 receptor 5NX2 ADGRG3 7D77
TM5 1035 H 5.63x63 GLP-1 receptor 5NX2 - -
TM5 1036 H 5.64x64 GLP-1 receptor 5NX2 - -
TM5 1037 T 5.65x65 GLP-1 receptor 5NX2 - -
TM5 1038 A 5.66x66 ADGRG3 7D77 - -
TM5 1039 I 5.67x67 ADGRG3 7D77 - -
TM5 1040 L 5.68x68 ADGRG3 7D77 - -
ICL3 1041 K - - - - -
ICL3 1042 P - - - - -
ICL3 1043 E - - - - -
ICL3 1044 S - - - - -
ICL3 1045 G - - - - -
ICL3 1046 C - - - - -
ICL3 1047 L - - - - -
ICL3 1048 D - - - - -
TM6 1049 N 6.34x34 GLP-1 receptor 5NX2 - -
TM6 1050 I 6.35x35 GLP-1 receptor 5NX2 - -
TM6 1051 K 6.36x36 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM6 1052 S 6.37x37 GLP-1 receptor 5NX2 - -
TM6 1053 W 6.38x38 GLP-1 receptor 5NX2 - -
TM6 1054 V 6.39x39 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 1055 I 6.40x40 GLP-1 receptor 5NX2 - -
TM6 1056 G 6.41x41 GLP-1 receptor 5NX2 - -
TM6 1057 A 6.42x42 GLP-1 receptor 5NX2 - -
TM6 1058 I 6.43x43 GLP-1 receptor 5NX2 - -
TM6 1059 A 6.44x44 GLP-1 receptor 5NX2 - -
TM6 1060 L 6.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 1061 L 6.46x46 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM6 1062 C 6.47x47 GLP-1 receptor 5NX2 - -
TM6 1063 L 6.48x48 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 1064 L 6.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 1065 G 6.50x50 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 1066 L 6.51x51 GLP-1 receptor 5NX2 - -
TM6 1067 T 6.52x52 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 1068 W 6.53x53 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 1069 A 6.54x54 GLP-1 receptor 5NX2 - -
TM6 1070 F 6.55x55 GLP-1 receptor 5NX2 - -
TM6 1071 G 6.56x56 GLP-1 receptor 5NX2 - -
TM6 1072 L 6.57x57 GLP-1 receptor 5NX2 - -
TM6 1073 M 6.58x58 GLP-1 receptor 5NX2 - -
ECL3 1074 Y - - - - -
ECL3 1075 I - GLP-1 receptor 6X1A - -
ECL3 1076 N - GLP-1 receptor 6X1A - -
ECL3 1077 E - GLP-1 receptor 6X1A - -
ECL3 1078 S - - - - -
TM7 1079 T 7.35x34 GLP-1 receptor 5NX2 - -
TM7 1080 V 7.36x35 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM7 1081 I 7.37x36 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 1082 M 7.38x37 GLP-1 receptor 5NX2 - -
TM7 1083 A 7.39x38 GLP-1 receptor 5NX2 - -
TM7 1084 Y 7.40x39 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 1085 L 7.41x40 GLP-1 receptor 5NX2 GHRH receptor 7CZ5
TM7 1086 F 7.42x41 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 1087 T 7.43x42 GLP-1 receptor 5NX2 - -
TM7 1088 I 7.44x43 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM7 1089 F 7.45x44 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 1090 N 7.46x45 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 1091 S 7.47x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 1092 L 7.48x47 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 1093 Q 7.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 1094 G 7.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 1095 M 7.51x51 GLP-1 receptor 5NX2 - -
TM7 1096 F 7.52x52 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 1097 I 7.53x53 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 1098 F 7.54x54 GLP-1 receptor 5NX2 - -
TM7 1099 I 7.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 1100 F 7.56x56 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM7 1101 H 7.57x57 GLP-1 receptor 5NX2 - -
TM7 1102 C 7.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 1103 V 7.59x59 GLP-1 receptor 5NX2 - -
TM7 1104 L 7.60x60 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 1105 Q 7.61x61 ADGRG3 7D77 - -
H8 1106 K 8.48x48 GLP-1 receptor 5NX2 GIP receptor 7DTY
H8 1107 K 8.49x49 GLP-1 receptor 5NX2 - -
H8 1108 V 8.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 1109 R 8.51x51 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
H8 1110 K 8.52x52 GLP-1 receptor 5NX2 - -
H8 1111 E 8.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 1112 Y 8.54x54 GLP-1 receptor 5NX2 - -
H8 1113 G 8.55x55 GLP-1 receptor 5NX2 - -
H8 1114 K 8.56x56 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 1115 C 8.57x57 GLP-1 receptor 5NX2 - -
H8 1116 L 8.58x58 CRF2 receptor 6PB1 - -
H8 1117 R 8.59x59 CRF2 receptor 6PB1 PAC1 receptor 6P9Y
H8 1118 T 8.60x60 CRF2 receptor 6PB1 - -
H8 1119 H 8.61x61 CRF2 receptor 6PB1 - -
H8 1120 C 8.62x62 CRF2 receptor 6PB1 - -
H8 1121 C 8.63x63 CRF2 receptor 6PB1 - -
C-term 1122 S - - - - -
C-term 1123 G - - - - -
C-term 1124 K - - - - -
C-term 1125 S - - - - -
C-term 1126 T - - - - -