ADGRL4 homology model

PROTEIN CLASS

Class B2 (Adhesion)

RECEPTOR

ADGRL4

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2021-09-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

GLP-1 receptor (sequence similarity: 16%) PDB: 5NX2
Align

TEMPLATES

5NX2 (GLP-1 receptor)
6X1A (GLP-1 receptor)
7D77 (ADGRG3)
7JHJ (BILF1)
6WZG (secretin receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 80.6 6.2 13.2
Side-chains 20.9 32.2 46.9

Number of backbone templates: 5
Number of rotamer templates: 16

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 417 P - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
N-term 418 S - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
N-term 419 I - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
N-term 420 G - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
N-term 421 I - GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 422 K 1.34x34 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM1 423 D 1.35x35 GLP-1 receptor 5NX2 - -
TM1 424 Y 1.36x36 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 425 N 1.37x37 GLP-1 receptor 5NX2 - -
TM1 426 I 1.38x38 GLP-1 receptor 5NX2 ADGRG3 7D77
TM1 427 L 1.39x39 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 428 T 1.40x40 GLP-1 receptor 5NX2 ADGRG3 7D77
TM1 429 R 1.41x41 GLP-1 receptor 5NX2 ADGRG3 7D77
TM1 430 I 1.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 431 T 1.43x43 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM1 432 Q 1.44x44 GLP-1 receptor 5NX2 ADGRG3 7D77
TM1 433 L 1.45x45 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 434 G 1.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 435 I 1.47x47 GLP-1 receptor 5NX2 - -
TM1 436 I 1.48x48 GLP-1 receptor 5NX2 - -
TM1 437 I 1.49x49 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM1 438 S 1.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 439 L 1.51x51 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM1 440 I 1.52x52 GLP-1 receptor 5NX2 ADGRG3 7D77
TM1 441 C 1.53x53 GLP-1 receptor 5NX2 - -
TM1 442 L 1.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 443 A 1.55x55 GLP-1 receptor 5NX2 ADGRG3 7D77
TM1 444 I 1.56x56 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 445 C 1.57x57 GLP-1 receptor 5NX2 - -
TM1 446 I 1.58x58 GLP-1 receptor 5NX2 ADGRG3 7D77
TM1 447 F 1.59x59 GLP-1 receptor 5NX2 - -
TM1 448 T 1.60x60 GLP-1 receptor 5NX2 - -
TM1 449 F 1.61x61 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM1 450 W 1.62x62 GLP-1 receptor 5NX2 - -
TM1 451 F 1.63x63 GLP-1 receptor 5NX2 ADGRG3 7D77
TM1 452 F 1.64x64 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ICL1 453 S 12.48x48 - - - -
ICL1 454 E 12.49x49 ADGRG3 7D77 - -
ICL1 455 I 12.50x50 ADGRG3 7D77 CRF1 receptor 4Z9G
ICL1 456 Q 12.51x51 - - - -
TM2 457 S 2.44x44 GLP-1 receptor 5NX2 - -
TM2 458 T 2.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 459 R 2.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 460 T 2.47x47 GLP-1 receptor 5NX2 - -
TM2 461 T 2.48x48 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM2 462 I 2.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 463 H 2.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 464 K 2.51x51 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM2 465 N 2.52x52 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 466 L 2.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 467 C 2.54x54 GLP-1 receptor 5NX2 - -
TM2 468 C 2.55x55 GLP-1 receptor 5NX2 - -
TM2 469 S 2.56x56 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 470 L 2.57x57 GLP-1 receptor 5NX2 ADGRG3 7D77
TM2 471 F 2.58x58 GLP-1 receptor 5NX2 ADGRG3 7D77
TM2 472 L 2.59x59 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 473 A 2.60x60 GLP-1 receptor 5NX2 - -
TM2 474 E 2.61x61 GLP-1 receptor 5NX2 - -
TM2 475 L 2.62x62 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 476 V 2.63x63 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM2 477 F 2.64x64 GLP-1 receptor 5NX2 ADGRG3 7D77
TM2 478 L 2.65x65 GLP-1 receptor 5NX2 ADGRG3 7D77
TM2 479 V 2.66x66 GLP-1 receptor 5NX2 ADGRG3 7D77
TM2 480 G 2.67x67 GLP-1 receptor 5NX2 - -
TM2 481 I 2.68x68 GLP-1 receptor 5NX2 - -
TM2 482 N 2.69x69 GLP-1 receptor 5NX2 - -
TM2 483 T 2.70x70 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
ECL1 484 N - - - - -
ECL1 485 T - - - - -
ECL1 486 N - - - - -
ECL1 487 K - - - - -
TM3 488 L 3.27x27 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 489 F 3.28x28 GLP-1 receptor 5NX2 - -
TM3 490 C 3.29x29 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 491 S 3.30x30 GLP-1 receptor 5NX2 - -
TM3 492 I 3.31x31 GLP-1 receptor 5NX2 CT receptor 6NIY
TM3 493 I 3.32x32 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM3 494 A 3.33x33 GLP-1 receptor 5NX2 glucagon receptor 5YQZ
TM3 495 G 3.34x34 GLP-1 receptor 5NX2 - -
TM3 496 L 3.35x35 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM3 497 L 3.36x36 GLP-1 receptor 5NX2 GLP-2 receptor 7D68
TM3 498 H 3.37x37 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 499 Y 3.38x38 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 500 F 3.39x39 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 501 F 3.40x40 GLP-1 receptor 5NX2 - -
TM3 502 L 3.41x41 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 503 A 3.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 504 A 3.43x43 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 505 F 3.44x44 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 506 A 3.45x45 GLP-1 receptor 5NX2 - -
TM3 507 W 3.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 508 M 3.47x47 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 509 C 3.48x48 GLP-1 receptor 5NX2 - -
TM3 510 I 3.49x49 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM3 511 E 3.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 512 G 3.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 513 I 3.52x52 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM3 514 H 3.53x53 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 515 L 3.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 516 Y 3.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 517 L 3.56x56 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 518 I 3.57x57 GLP-1 receptor 5NX2 - -
TM3 519 V 3.58x58 GLP-1 receptor 5NX2 - -
TM3 520 V 3.59x59 GLP-1 receptor 5NX2 ADGRG3 7D77
TM3 521 G 3.60x60 GLP-1 receptor 5NX2 - -
ICL2 522 V - - - - -
ICL2 523 I - - - - -
ICL2 524 Y - - - - -
ICL2 525 N - - - - -
ICL2 526 K - - - - -
ICL2 527 G - - - - -
TM4 528 F 4.40x41 GLP-1 receptor 5NX2 - -
TM4 529 L 4.41x42 GLP-1 receptor 5NX2 GLP-2 receptor 7D68
TM4 530 H 4.42x43 GLP-1 receptor 5NX2 - -
TM4 531 K 4.43x44 GLP-1 receptor 5NX2 GLP-1 receptor 5VAI
TM4 532 N 4.44x45 GLP-1 receptor 5NX2 - -
TM4 533 F 4.45x46 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 534 Y 4.46x47 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM4 535 I 4.47x48 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM4 536 F 4.48x49 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 537 G 4.49x491 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 538 Y 4.50x50 GLP-1 receptor 5NX2 - -
TM4 539 L 4.51x51 GLP-1 receptor 5NX2 - -
TM4 540 S 4.52x52 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 541 P 4.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 542 A 4.54x54 GLP-1 receptor 5NX2 ADGRG3 7D77
TM4 543 V 4.55x55 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM4 544 V 4.56x56 GLP-1 receptor 5NX2 - -
TM4 545 V 4.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 546 G 4.58x58 GLP-1 receptor 5NX2 GHRH receptor 7CZ5
TM4 547 F 4.59x59 GLP-1 receptor 5NX2 - -
TM4 548 S 4.60x60 GLP-1 receptor 5NX2 - -
TM4 549 A 4.61x61 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 550 A 4.62x62 GLP-1 receptor 5NX2 - -
TM4 551 L 4.63x63 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM4 552 G 4.64x64 GLP-1 receptor 5NX2 - -
ECL2 553 Y - - - - -
ECL2 554 R - - - - -
ECL2 555 Y - - - - -
ECL2 556 Y - - - - -
ECL2 557 G - - - - -
ECL2 558 T - - - - -
ECL2 559 T - - - - -
ECL2 560 K - - - - -
ECL2 561 V - - - - -
ECL2 562 C 45.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 563 W 45.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 564 L 45.52x52 GLP-1 receptor 5NX2 CT receptor 6NIY
ECL2 565 S - GLP-1 receptor 5NX2 - -
ECL2 566 T - GLP-1 receptor 5NX2 - -
ECL2 567 E - GLP-1 receptor 5NX2 - -
TM5 568 N 5.33x33 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 569 N 5.34x34 GLP-1 receptor 5NX2 - -
TM5 570 F 5.35x35 GLP-1 receptor 5NX2 - -
TM5 571 I 5.36x36 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 572 W 5.37x37 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 573 S 5.38x38 BILF1 7JHJ - -
TM5 574 F 5.39x39 BILF1 7JHJ - -
TM5 575 I 5.40x40 GLP-1 receptor 5NX2 - -
TM5 576 G 5.41x41 GLP-1 receptor 5NX2 ADGRG3 7D77
TM5 577 P 5.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 578 A 5.43x43 GLP-1 receptor 5NX2 - -
TM5 579 C 5.44x44 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM5 580 L 5.45x45 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 581 I 5.46x46 GLP-1 receptor 5NX2 - -
TM5 582 I 5.47x47 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 583 L 5.48x48 GLP-1 receptor 5NX2 ADGRG3 7D77
TM5 584 V 5.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 585 N 5.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 586 L 5.51x51 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM5 587 L 5.52x52 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 588 A 5.53x53 GLP-1 receptor 5NX2 - -
TM5 589 F 5.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 590 G 5.55x55 GLP-1 receptor 5NX2 - -
TM5 591 V 5.56x56 GLP-1 receptor 5NX2 - -
TM5 592 I 5.57x57 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 593 I 5.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 594 Y 5.59x59 GLP-1 receptor 5NX2 - -
TM5 595 K 5.60x60 GLP-1 receptor 5NX2 ADGRG3 7D77
TM5 596 V 5.61x61 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 597 F 5.62x62 GLP-1 receptor 5NX2 ADGRG3 7D77
TM5 598 R 5.63x63 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 599 H 5.64x64 GLP-1 receptor 5NX2 - -
TM5 600 T 5.65x65 GLP-1 receptor 5NX2 - -
TM5 601 A 5.66x66 ADGRG3 7D77 - -
TM5 602 G 5.67x67 ADGRG3 7D77 - -
TM5 603 L 5.68x68 ADGRG3 7D77 - -
ICL3 604 K - - - - -
ICL3 605 P - - - - -
ICL3 606 E - - - - -
ICL3 607 V - - - - -
ICL3 608 S - - - - -
ICL3 609 C - - - - -
ICL3 610 F - - - - -
ICL3 611 E - - - - -
TM6 612 N 6.34x34 GLP-1 receptor 5NX2 - -
TM6 613 I 6.35x35 GLP-1 receptor 5NX2 - -
TM6 614 R 6.36x36 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 615 S 6.37x37 GLP-1 receptor 5NX2 - -
TM6 616 C 6.38x38 GLP-1 receptor 5NX2 - -
TM6 617 A 6.39x39 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 618 R 6.40x40 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM6 619 G 6.41x41 GLP-1 receptor 5NX2 - -
TM6 620 A 6.42x42 GLP-1 receptor 5NX2 - -
TM6 621 L 6.43x43 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 622 A 6.44x44 GLP-1 receptor 5NX2 - -
TM6 623 L 6.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 624 L 6.46x46 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM6 625 F 6.47x47 GLP-1 receptor 5NX2 - -
TM6 626 L 6.48x48 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 627 L 6.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 628 G 6.50x50 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 629 T 6.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 630 T 6.52x52 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 631 W 6.53x53 GLP-1 receptor 5NX2 ADGRG3 7D77
TM6 632 I 6.54x54 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM6 633 F 6.55x55 GLP-1 receptor 5NX2 - -
TM6 634 G 6.56x56 GLP-1 receptor 5NX2 - -
TM6 635 V 6.57x57 GLP-1 receptor 5NX2 - -
TM6 636 L 6.58x58 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
ECL3 637 H - - - - -
ECL3 638 V - GLP-1 receptor 6X1A - -
ECL3 639 V - GLP-1 receptor 6X1A - -
ECL3 640 H - GLP-1 receptor 6X1A - -
ECL3 641 A - - - - -
TM7 642 S 7.35x34 GLP-1 receptor 5NX2 - -
TM7 643 V 7.36x35 GLP-1 receptor 5NX2 CRF1 receptor 6PB0
TM7 644 V 7.37x36 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM7 645 T 7.38x37 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 646 A 7.39x38 GLP-1 receptor 5NX2 BILF1 7JHJ
TM7 647 Y 7.40x39 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 648 L 7.41x40 GLP-1 receptor 5NX2 GHRH receptor 7CZ5
TM7 649 F 7.42x41 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 650 T 7.43x42 GLP-1 receptor 5NX2 - -
TM7 651 V 7.44x43 GLP-1 receptor 5NX2 VPAC1 receptor 6VN7
TM7 652 S 7.45x44 GLP-1 receptor 5NX2 - -
TM7 653 N 7.46x45 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 654 A 7.47x46 GLP-1 receptor 5NX2 BILF1 7JHJ
TM7 655 F 7.48x47 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 656 Q 7.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 657 G 7.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 658 M 7.51x51 GLP-1 receptor 5NX2 - -
TM7 659 F 7.52x52 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 660 I 7.53x53 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 661 F 7.54x54 GLP-1 receptor 5NX2 - -
TM7 662 L 7.55x55 GLP-1 receptor 5NX2 GLP-2 receptor 7D68
TM7 663 F 7.56x56 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM7 664 L 7.57x57 GLP-1 receptor 5NX2 - -
TM7 665 C 7.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 666 V 7.59x59 GLP-1 receptor 5NX2 - -
TM7 667 L 7.60x60 GLP-1 receptor 5NX2 ADGRG3 7D77
TM7 668 S 7.61x61 ADGRG3 7D77 - -
H8 669 R 8.48x48 GLP-1 receptor 5NX2 - -
H8 670 K 8.49x49 GLP-1 receptor 5NX2 - -
H8 671 I 8.50x50 GLP-1 receptor 5NX2 - -
H8 672 Q 8.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 673 E 8.52x52 GLP-1 receptor 5NX2 - -
H8 674 E 8.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 675 Y 8.54x54 GLP-1 receptor 5NX2 - -
H8 676 Y 8.55x55 GLP-1 receptor 5NX2 - -
H8 677 R 8.56x56 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
H8 678 L 8.57x57 GLP-1 receptor 5NX2 - -
H8 679 F 8.58x58 secretin receptor 6WZG - -
H8 680 K 8.59x59 secretin receptor 6WZG - -
H8 681 N 8.60x60 secretin receptor 6WZG - -
H8 682 V 8.61x61 secretin receptor 6WZG - -
H8 683 P 8.62x62 secretin receptor 6WZG - -
H8 684 C 8.63x63 secretin receptor 6WZG - -
C-term 685 C - - - - -
C-term 686 F - - - - -
C-term 687 G - - - - -
C-term 688 C - - - - -
C-term 689 L - - - - -