CaS receptor homology model

PROTEIN CLASS

Class C (Glutamate)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2022-06-19

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

mGlu5 receptor (sequence similarity: 21%) PDB: 6N51

TEMPLATES

7M3G (CaS receptor)
7DD6 (CaS receptor)
7M3J (CaS receptor)
7DTW (CaS receptor)
7SIM (CaS receptor)
7M3F (CaS receptor)
7M3E (CaS receptor)
7DD5 (CaS receptor)
6N51 (mGlu5 receptor)
4OO9 (mGlu5 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 74.5 12.2 13.3
Side-chains 18.5 60.9 20.7

Number of backbone templates: 10
Number of rotamer templates: 15

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
TM1 610 E 1.37x37 CaS receptor 7M3G CaS receptor 7M3G
TM1 611 P 1.38x38 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 612 F 1.39x39 mGlu5 receptor 6N51 CaS receptor 7DD5
TM1 613 G 1.40x40 mGlu5 receptor 6N51 CaS receptor 7DD5
TM1 614 I 1.41x41 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 615 A 1.42x42 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 616 L 1.43x43 mGlu5 receptor 6N51 CaS receptor 7DD5
TM1 617 T 1.44x44 mGlu5 receptor 6N51 CaS receptor 7DD5
TM1 618 L 1.45x45 mGlu5 receptor 6N51 CaS receptor 7DD5
TM1 619 F 1.46x46 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 620 A 1.47x47 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 621 V 1.48x48 mGlu5 receptor 6N51 CaS receptor 7DD5
TM1 622 L 1.49x49 mGlu5 receptor 6N51 CaS receptor 7DD5
TM1 623 G 1.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 624 I 1.51x51 mGlu5 receptor 6N51 CaS receptor 7DD5
TM1 625 F 1.52x52 mGlu5 receptor 6N51 CaS receptor 7DD5
TM1 626 L 1.53x53 mGlu5 receptor 6N51 CaS receptor 7DD5
TM1 627 T 1.54x54 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 628 A 1.55x55 mGlu5 receptor 6N51 CaS receptor 7M3G
TM1 629 F 1.56x56 mGlu5 receptor 6N51 CaS receptor 7DD5
TM1 630 V 1.57x57 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM1 631 L 1.58x58 mGlu5 receptor 6N51 CaS receptor 7DD5
TM1 632 G 1.59x59 mGlu5 receptor 6N51 CaS receptor 7DD5
TM1 633 V 1.60x60 mGlu5 receptor 6N51 CaS receptor 7DD5
TM1 634 F 1.61x61 mGlu5 receptor 6N51 CaS receptor 7DD5
TM1 635 I 1.62x62 mGlu5 receptor 6N51 CaS receptor 7M3G
TM1 636 K 1.63x63 CaS receptor 7DD6 CaS receptor 7DD6
TM1 637 F 1.64x64 CaS receptor 7DD6 CaS receptor 7DD6
ICL1 638 R - - - - -
ICL1 639 N - CaS receptor 7DD6 CaS receptor 7DD6
ICL1 640 T 12.47x47 CaS receptor 7DD6 CaS receptor 7DD6
ICL1 641 P 12.48x48 CaS receptor 7DD6 CaS receptor 7DD6
ICL1 642 I 12.49x49 CaS receptor 7DD6 CaS receptor 7DD6
ICL1 643 V 12.50x50 CaS receptor 7DD6 CaS receptor 7DD6
ICL1 644 K 12.51x51 CaS receptor 7DD6 CaS receptor 7M3G
ICL1 645 A 12.52x52 CaS receptor 7DD6 CaS receptor 7DD6
ICL1 646 T 12.53x53 - - - -
TM2 647 N 2.35x35 mGlu5 receptor 6N51 CaS receptor 7DD5
TM2 648 R 2.36x36 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 649 E 2.37x37 mGlu5 receptor 6N51 CaS receptor 7DD5
TM2 650 L 2.38x38 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 651 S 2.39x39 mGlu5 receptor 6N51 CaS receptor 7DD5
TM2 652 Y 2.40x40 mGlu5 receptor 6N51 CaS receptor 7DD5
TM2 653 L 2.41x41 mGlu5 receptor 6N51 CaS receptor 7DD5
TM2 654 L 2.42x42 mGlu5 receptor 6N51 CaS receptor 7DD5
TM2 655 L 2.43x43 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM2 656 F 2.44x44 mGlu5 receptor 6N51 CaS receptor 7DD5
TM2 657 S 2.45x45 mGlu5 receptor 6N51 CaS receptor 7DD5
TM2 658 L 2.46x46 mGlu5 receptor 6N51 CaS receptor 7DD5
TM2 659 L 2.47x47 mGlu5 receptor 6N51 CaS receptor 7DD5
TM2 660 C 2.48x48 mGlu5 receptor 6N51 CaS receptor 7DD5
TM2 661 C 2.49x49 mGlu5 receptor 6N51 CaS receptor 7DD5
TM2 662 F 2.50x50 mGlu5 receptor 6N51 CaS receptor 7DD5
TM2 663 S 2.51x51 mGlu5 receptor 6N51 CaS receptor 7DD5
TM2 664 S 2.52x52 mGlu5 receptor 6N51 CaS receptor 7DD5
TM2 665 S 2.53x53 mGlu5 receptor 6N51 CaS receptor 7DD5
TM2 666 L 2.54x54 mGlu5 receptor 6N51 CaS receptor 7DD5
TM2 667 F 2.55x55 mGlu5 receptor 6N51 CaS receptor 7DD5
TM2 668 F 2.56x56 CaS receptor 7M3J CaS receptor 7M3J
TM2 669 I 2.57x57 CaS receptor 7M3J mGlu2 receptor 7E9G
ECL1 670 G - - - - -
ECL1 671 E - CaS receptor 7M3J - -
ECL1 672 P - - - - -
TM3 673 Q 3.25x25 mGlu5 receptor 6N51 CaS receptor 7DD5
TM3 674 D 3.26x26 mGlu5 receptor 6N51 CaS receptor 7M3G
TM3 675 W 3.27x27 mGlu5 receptor 6N51 CaS receptor 7DD5
TM3 676 T 3.28x28 mGlu5 receptor 6N51 CaS receptor 7DD5
TM3 677 C 3.29x29 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 678 R 3.30x30 mGlu5 receptor 6N51 CaS receptor 7DD5
TM3 679 L 3.31x31 mGlu5 receptor 6N51 CaS receptor 7DD5
TM3 680 R 3.32x32 mGlu5 receptor 6N51 CaS receptor 7M3G
TM3 681 Q 3.33x33 mGlu5 receptor 6N51 CaS receptor 7DD5
TM3 682 P 3.34x34 mGlu5 receptor 6N51 CaS receptor 7DD5
TM3 683 A 3.35x35 mGlu5 receptor 6N51 CaS receptor 7DD5
TM3 684 F 3.36x36 mGlu5 receptor 6N51 CaS receptor 7DD5
TM3 685 G 3.37x37 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 686 I 3.38x38 mGlu5 receptor 6N51 CaS receptor 7DD5
TM3 687 S 3.39x39 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 688 F 3.40x40 mGlu5 receptor 6N51 CaS receptor 7DD5
TM3 689 V 3.41x41 mGlu5 receptor 6N51 CaS receptor 7DD5
TM3 690 L 3.42x42 mGlu5 receptor 6N51 CaS receptor 7DD5
TM3 691 C 3.43x43 mGlu5 receptor 6N51 CaS receptor 7DD5
TM3 692 I 3.44x44 mGlu5 receptor 6N51 CaS receptor 7DD5
TM3 693 S 3.45x45 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 694 C 3.46x46 mGlu5 receptor 6N51 CaS receptor 7DD5
TM3 695 I 3.47x47 mGlu5 receptor 6N51 CaS receptor 7DD5
TM3 696 L 3.48x48 mGlu5 receptor 6N51 CaS receptor 7DD5
TM3 697 V 3.49x49 mGlu5 receptor 6N51 CaS receptor 7DD5
TM3 698 K 3.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 699 T 3.51x51 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 700 N 3.52x52 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 701 R 3.53x53 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM3 702 V 3.54x54 mGlu5 receptor 6N51 CaS receptor 7SIL
TM3 703 L 3.55x55 mGlu5 receptor 6N51 CaS receptor 7SIL
TM3 704 L 3.56x56 mGlu5 receptor 6N51 CaS receptor 7E6T
TM3 705 V 3.57x57 mGlu5 receptor 6N51 GPR158 7SHE
TM3 706 F 3.58x58 mGlu5 receptor 6N51 mGlu2 receptor 7EPE
ICL2 707 E - - - - -
ICL2 708 A - - - - -
ICL2 709 K - - - - -
ICL2 710 I - - - - -
ICL2 711 P - - - - -
ICL2 712 T - - - - -
ICL2 713 S - - - - -
ICL2 714 F - - - - -
ICL2 715 H - - - - -
ICL2 716 R - - - - -
ICL2 717 K - - - - -
ICL2 718 W - - - - -
ICL2 719 W - - - - -
TM4 720 G 4.28x28 mGlu5 receptor 6N51 - -
TM4 721 L 4.29x29 mGlu5 receptor 6N51 CaS receptor 7E6U
TM4 722 N 4.30x30 mGlu5 receptor 6N51 CaS receptor 7DD5
TM4 723 L 4.31x31 mGlu5 receptor 6N51 CaS receptor 7DD5
TM4 724 Q 4.32x32 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 725 F 4.33x33 mGlu5 receptor 6N51 CaS receptor 7DD5
TM4 726 L 4.34x34 mGlu5 receptor 6N51 CaS receptor 7DD5
TM4 727 L 4.35x35 mGlu5 receptor 6N51 CaS receptor 7DD5
TM4 728 V 4.36x36 mGlu5 receptor 6N51 CaS receptor 7DD5
TM4 729 F 4.37x37 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 730 L 4.38x38 mGlu5 receptor 6N51 CaS receptor 7DD5
TM4 731 C 4.39x39 mGlu5 receptor 6N51 CaS receptor 7DD5
TM4 732 T 4.40x40 mGlu5 receptor 6N51 CaS receptor 7DD5
TM4 733 F 4.41x41 mGlu5 receptor 6N51 CaS receptor 7DD5
TM4 734 M 4.42x42 mGlu5 receptor 6N51 CaS receptor 7M3G
TM4 735 Q 4.43x43 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 736 I 4.44x44 mGlu5 receptor 6N51 CaS receptor 7DD5
TM4 737 V 4.45x45 mGlu5 receptor 6N51 CaS receptor 7DD5
TM4 738 I 4.46x46 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM4 739 C 4.47x47 mGlu5 receptor 6N51 CaS receptor 7DD5
TM4 740 V 4.48x48 mGlu5 receptor 6N51 CaS receptor 7DD5
TM4 741 I 4.49x49 mGlu5 receptor 6N51 CaS receptor 7DD5
TM4 742 W 4.50x50 mGlu5 receptor 6N51 CaS receptor 7DD5
TM4 743 L 4.51x51 mGlu5 receptor 6N51 CaS receptor 7DD5
TM4 744 Y 4.52x52 mGlu5 receptor 6N51 CaS receptor 7DD5
TM4 745 T 4.53x53 mGlu5 receptor 6N51 CaS receptor 7DD6
TM4 746 A 4.54x54 mGlu5 receptor 6N51 CaS receptor 7DD6
ECL2 747 P - mGlu5 receptor 6N51 mGlu5 receptor 6N51
ECL2 748 P - mGlu5 receptor 6N51 mGlu5 receptor 6N51
ECL2 749 S - mGlu5 receptor 6N51 - -
ECL2 750 S - mGlu5 receptor 6N51 - -
ECL2 751 Y - mGlu5 receptor 6N51 - -
ECL2 752 R - mGlu5 receptor 6N51 - -
ECL2 753 N - mGlu5 receptor 6N51 - -
ECL2 754 Q - mGlu5 receptor 6N51 - -
ECL2 755 E - mGlu5 receptor 6N51 - -
ECL2 756 L - mGlu5 receptor 6N51 - -
ECL2 757 E - mGlu5 receptor 6N51 - -
ECL2 758 D - mGlu5 receptor 6N51 - -
ECL2 759 E - mGlu5 receptor 6N51 mGlu5 receptor 6N51
ECL2 760 I - mGlu5 receptor 6N51 - -
ECL2 761 I - mGlu5 receptor 6N51 - -
ECL2 762 F - mGlu5 receptor 6N51 - -
ECL2 763 I - mGlu5 receptor 6N51 mGlu5 receptor 6N51
ECL2 764 T - - - - -
ECL2 765 C 45.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
ECL2 766 H 45.51x51 mGlu5 receptor 6N51 CaS receptor 7DD5
ECL2 767 E 45.52x52 mGlu5 receptor 6N51 CaS receptor 7E6T
ECL2 768 G - - - - -
ECL2 769 S - - - - -
TM5 770 L 5.37x37 mGlu5 receptor 6N51 CaS receptor 7DD5
TM5 771 M 5.38x38 mGlu5 receptor 6N51 CaS receptor 7DD5
TM5 772 A 5.39x39 mGlu5 receptor 6N51 CaS receptor 7DD5
TM5 773 L 5.40x40 mGlu5 receptor 6N51 CaS receptor 7DD5
TM5 774 G 5.41x41 mGlu5 receptor 6N51 CaS receptor 7DD5
TM5 775 F 5.42x42 mGlu5 receptor 6N51 CaS receptor 7DD5
TM5 776 L 5.43x43 mGlu5 receptor 6N51 CaS receptor 7DD5
TM5 777 I 5.44x44 mGlu5 receptor 6N51 CaS receptor 7DD5
TM5 778 G 5.45x45 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 779 Y 5.46x46 mGlu5 receptor 6N51 CaS receptor 7DD5
TM5 780 T 5.47x47 mGlu5 receptor 6N51 CaS receptor 7DD5
TM5 781 C 5.48x48 mGlu5 receptor 6N51 CaS receptor 7DD5
TM5 782 L 5.49x49 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 783 L 5.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 784 A 5.51x51 mGlu5 receptor 6N51 CaS receptor 7DD5
TM5 785 A 5.52x52 mGlu5 receptor 6N51 CaS receptor 7DD5
TM5 786 I 5.53x53 mGlu5 receptor 6N51 CaS receptor 7DD5
TM5 787 C 5.54x54 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 788 F 5.55x55 mGlu5 receptor 6N51 CaS receptor 7DD5
TM5 789 F 5.56x56 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 790 F 5.57x57 mGlu5 receptor 6N51 CaS receptor 7DD5
TM5 791 A 5.58x58 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM5 792 F 5.59x59 CaS receptor 7DTW CaS receptor 7DD5
TM5 793 K 5.60x60 CaS receptor 7DTW CaS receptor 7DD5
TM5 794 S 5.61x61 CaS receptor 7DTW CaS receptor 7DD5
TM5 795 R 5.62x62 CaS receptor 7DTW CaS receptor 7DD5
TM5 796 K 5.63x63 CaS receptor 7DTW - -
TM5 797 L 5.64x64 CaS receptor 7DTW - -
ICL3 798 P - - - - -
ICL3 799 E - CaS receptor 7DTW - -
ICL3 800 N - CaS receptor 7DTW - -
ICL3 801 F - - - - -
TM6 802 N 6.34x34 CaS receptor 7SIM CaS receptor 7SIM
TM6 803 E 6.35x35 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 804 A 6.36x36 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 805 K 6.37x37 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 806 F 6.38x38 mGlu5 receptor 6N51 CaS receptor 7DD5
TM6 807 I 6.39x39 mGlu5 receptor 6N51 CaS receptor 7DD5
TM6 808 T 6.40x40 mGlu5 receptor 6N51 CaS receptor 7DD5
TM6 809 F 6.41x41 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 810 S 6.42x42 mGlu5 receptor 6N51 CaS receptor 7DD5
TM6 811 M 6.43x43 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 812 L 6.44x44 mGlu5 receptor 6N51 CaS receptor 7DD5
TM6 813 I 6.45x45 mGlu5 receptor 6N51 CaS receptor 7DD5
TM6 814 F 6.46x46 mGlu5 receptor 6N51 CaS receptor 7DD5
TM6 815 F 6.47x47 mGlu5 receptor 6N51 CaS receptor 7DD5
TM6 816 I 6.48x48 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 817 V 6.49x49 mGlu5 receptor 6N51 CaS receptor 7DD5
TM6 818 W 6.50x50 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 819 I 6.51x51 mGlu5 receptor 6N51 CaS receptor 7DD5
TM6 820 S 6.52x52 mGlu5 receptor 6N51 CaS receptor 7DD5
TM6 821 F 6.53x53 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 822 I 6.54x54 mGlu5 receptor 6N51 CaS receptor 7DD5
TM6 823 P 6.55x55 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM6 824 A 6.56x56 mGlu5 receptor 6N51 CaS receptor 7DD5
TM6 825 Y 6.57x57 mGlu5 receptor 6N51 CaS receptor 7DD5
TM6 826 A 6.58x58 mGlu5 receptor 6N51 CaS receptor 7DD5
TM6 827 S 6.59x59 mGlu5 receptor 6N51 CaS receptor 7DD5
TM6 828 T 6.60x60 CaS receptor 7M3F CaS receptor 7M3F
ECL3 829 Y - - - - -
TM7 830 G 7.25x26 CaS receptor 7M3E CaS receptor 7M3E
TM7 831 K 7.26x27 CaS receptor 7M3E CaS receptor 7M3E
TM7 832 F 7.27x28 CaS receptor 7M3E CaS receptor 7M3E
TM7 833 V 7.28x29 CaS receptor 7M3E CaS receptor 7M3E
TM7 834 S 7.29x30 mGlu5 receptor 6N51 CaS receptor 7DD5
TM7 835 A 7.30x31 mGlu5 receptor 6N51 CaS receptor 7DD5
TM7 836 V 7.31x32 mGlu5 receptor 6N51 CaS receptor 7DD5
TM7 837 E 7.32x33 mGlu5 receptor 6N51 CaS receptor 7DD5
TM7 838 V 7.33x34 mGlu5 receptor 6N51 CaS receptor 7DD5
TM7 839 I 7.34x35 mGlu5 receptor 6N51 CaS receptor 7DD5
TM7 840 A 7.35x36 mGlu5 receptor 6N51 CaS receptor 7DD5
TM7 841 I 7.36x37 mGlu5 receptor 6N51 CaS receptor 7DD5
TM7 842 L 7.37x38 mGlu5 receptor 6N51 CaS receptor 7DD5
TM7 843 A 7.38x39 mGlu5 receptor 6N51 CaS receptor 7DD5
TM7 844 A 7.39x40 mGlu5 receptor 6N51 CaS receptor 7DD5
TM7 845 S 7.40x41 mGlu5 receptor 6N51 CaS receptor 7DD5
TM7 846 F 7.41x42 mGlu5 receptor 6N51 CaS receptor 7DD5
TM7 847 G 7.42x43 mGlu5 receptor 6N51 CaS receptor 7DD5
TM7 848 L 7.43x44 mGlu5 receptor 6N51 CaS receptor 7DD5
TM7 849 L 7.44x45 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 850 A 7.45x46 mGlu5 receptor 6N51 CaS receptor 7DD5
TM7 851 C 7.46x47 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 852 I 7.47x471 mGlu5 receptor 6N51 CaS receptor 7DD5
TM7 853 F 7.48x48 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 854 F 7.49x49 mGlu5 receptor 6N51 CaS receptor 7DD5
TM7 855 N 7.50x50 mGlu5 receptor 6N51 CaS receptor 7DD5
TM7 856 K 7.51x51 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 857 I 7.52x52 mGlu5 receptor 6N51 CaS receptor 7M3G
TM7 858 Y 7.53x53 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 859 I 7.54x54 mGlu5 receptor 6N51 CaS receptor 7DD5
TM7 860 I 7.55x55 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 861 L 7.56x56 mGlu5 receptor 6N51 mGlu5 receptor 6N51
TM7 862 F 7.57x57 CaS receptor 7DD5 CaS receptor 7DD5
TM7 863 K 7.58x58 CaS receptor 7DD5 CaS receptor 7DD5
H8 864 P 8.46x46 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 865 S 8.47x47 mGlu5 receptor 4OO9 - -
H8 866 R 8.48x48 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 867 N 8.49x49 mGlu5 receptor 4OO9 mGlu5 receptor 4OO9
H8 868 T 8.50x50 - - - -
H8 869 I 8.51x51 - - - -
H8 870 E 8.52x52 - - - -
H8 871 E 8.53x53 - - - -
H8 872 V 8.54x54 - - - -
H8 873 R 8.55x55 - - - -
H8 874 C 8.56x56 - - - -
H8 875 S 8.57x57 - - - -
C-term 876 T - - - - -
C-term 877 A - - - - -
C-term 878 A - - - - -
C-term 879 H - - - - -
C-term 880 A - - - - -