CELSR1 homology model

PROTEIN CLASS

Class B2 (Adhesion)

RECEPTOR

CELSR1

SPECIES

Homo sapiens

STATE

Intermediate

VERSION

2021-01-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

GLP-1 receptor (sequence similarity: 34%) PDB: 5NX2
Align

TEMPLATES

6VN7 (VPAC1 receptor)
5NX2 (GLP-1 receptor)
6WZG (secretin receptor)
7D3S (secretin receptor)
6FJ3 (PTH1 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 80.1 6.5 13.4
Side-chains 17.8 27.5 54.7

Number of backbone templates: 5
Number of rotamer templates: 14

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 2451 F - - - -
N-term 2452 A - - - -
N-term 2453 V - - - -
N-term 2454 L - - - -
N-term 2455 M - - - -
TM1 2456 D 1.27x27 VPAC1 receptor 6VN7 - -
TM1 2457 I 1.28x28 VPAC1 receptor 6VN7 - -
TM1 2458 S 1.29x29 VPAC1 receptor 6VN7 - -
TM1 2459 R 1.30x30 VPAC1 receptor 6VN7 - -
TM1 2460 R 1.31x31 VPAC1 receptor 6VN7 PTH1 receptor 6FJ3
TM1 2461 E 1.32x32 VPAC1 receptor 6VN7 PTH1 receptor 6FJ3
TM1 2462 N 1.33x33 GLP-1 receptor 5NX2 - -
TM1 2463 G 1.34x34 GLP-1 receptor 5NX2 - -
TM1 2464 E 1.35x35 GLP-1 receptor 5NX2 - -
TM1 2465 V 1.36x36 GLP-1 receptor 5NX2 - -
TM1 2466 L 1.37x37 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 2467 P 1.38x38 GLP-1 receptor 5NX2 - -
TM1 2468 L 1.39x39 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 2469 K 1.40x40 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM1 2470 I 1.41x41 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 2471 V 1.42x42 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 2472 T 1.43x43 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM1 2473 Y 1.44x44 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 2474 A 1.45x45 GLP-1 receptor 5NX2 - -
TM1 2475 A 1.46x46 GLP-1 receptor 5NX2 - -
TM1 2476 V 1.47x47 GLP-1 receptor 5NX2 - -
TM1 2477 S 1.48x48 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM1 2478 L 1.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 2479 S 1.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 2480 L 1.51x51 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM1 2481 A 1.52x52 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM1 2482 A 1.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 2483 L 1.54x54 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 2484 L 1.55x55 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM1 2485 V 1.56x56 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM1 2486 A 1.57x57 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 2487 F 1.58x58 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 2488 V 1.59x59 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM1 2489 L 1.60x60 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM1 2490 L 1.61x61 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM1 2491 S 1.62x62 GLP-1 receptor 5NX2 VPAC1 receptor 6VN7
TM1 2492 L 1.63x63 GLP-1 receptor 5NX2 VPAC1 receptor 6VN7
TM1 2493 V 1.64x64 GLP-1 receptor 5NX2 - -
ICL1 2494 R 12.48x48 - - - -
ICL1 2495 M 12.49x49 secretin receptor 6WZG - -
ICL1 2496 L 12.50x50 secretin receptor 6WZG secretin receptor 6WZG
ICL1 2497 R 12.51x51 - - - -
TM2 2498 S 2.44x44 GLP-1 receptor 5NX2 - -
TM2 2499 N 2.45x45 GLP-1 receptor 5NX2 - -
TM2 2500 L 2.46x46 GLP-1 receptor 5NX2 - -
TM2 2501 H 2.47x47 GLP-1 receptor 5NX2 - -
TM2 2502 S 2.48x48 GLP-1 receptor 5NX2 - -
TM2 2503 I 2.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 2504 H 2.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 2505 K 2.51x51 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM2 2506 H 2.52x52 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM2 2507 L 2.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 2508 A 2.54x54 GLP-1 receptor 5NX2 - -
TM2 2509 V 2.55x55 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM2 2510 A 2.56x56 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM2 2511 L 2.57x57 GLP-1 receptor 5NX2 - -
TM2 2512 F 2.58x58 GLP-1 receptor 5NX2 - -
TM2 2513 L 2.59x59 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 2514 S 2.60x60 GLP-1 receptor 5NX2 - -
TM2 2515 Q 2.61x61 GLP-1 receptor 5NX2 - -
TM2 2516 L 2.62x62 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 2517 V 2.63x63 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM2 2518 F 2.64x64 GLP-1 receptor 5NX2 - -
TM2 2519 V 2.65x65 GLP-1 receptor 5NX2 - -
TM2 2520 I 2.66x66 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM2 2521 G 2.67x67 GLP-1 receptor 5NX2 - -
TM2 2522 I 2.68x68 GLP-1 receptor 5NX2 - -
TM2 2523 N 2.69x69 GLP-1 receptor 5NX2 - -
TM2 2524 Q 2.70x70 GLP-1 receptor 5NX2 - -
ECL1 2525 T - - - -
ECL1 2526 E - - - -
ECL1 2527 N - - - -
ECL1 2528 P - - - -
TM3 2529 F 3.27x27 GLP-1 receptor 5NX2 - -
TM3 2530 L 3.28x28 GLP-1 receptor 5NX2 GHRH receptor 7CZ5
TM3 2531 C 3.29x29 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 2532 T 3.30x30 GLP-1 receptor 5NX2 - -
TM3 2533 V 3.31x31 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM3 2534 V 3.32x32 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 2535 A 3.33x33 GLP-1 receptor 5NX2 glucagon receptor 5XEZ
TM3 2536 I 3.34x34 GLP-1 receptor 5NX2 - -
TM3 2537 L 3.35x35 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM3 2538 L 3.36x36 GLP-1 receptor 5NX2 - -
TM3 2539 H 3.37x37 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM3 2540 Y 3.38x38 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 2541 I 3.39x39 GLP-1 receptor 5NX2 - -
TM3 2542 Y 3.40x40 GLP-1 receptor 5NX2 - -
TM3 2543 M 3.41x41 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM3 2544 S 3.42x42 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM3 2545 T 3.43x43 GLP-1 receptor 5NX2 - -
TM3 2546 F 3.44x44 GLP-1 receptor 5NX2 VPAC1 receptor 6VN7
TM3 2547 A 3.45x45 GLP-1 receptor 5NX2 - -
TM3 2548 W 3.46x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 2549 T 3.47x47 GLP-1 receptor 5NX2 - -
TM3 2550 L 3.48x48 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 2551 V 3.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 2552 E 3.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 2553 S 3.51x51 GLP-1 receptor 5NX2 - -
TM3 2554 L 3.52x52 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM3 2555 H 3.53x53 GLP-1 receptor 5NX2 - -
TM3 2556 V 3.54x54 GLP-1 receptor 5NX2 - -
TM3 2557 Y 3.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 2558 R 3.56x56 GLP-1 receptor 5NX2 - -
TM3 2559 M 3.57x57 GLP-1 receptor 5NX2 - -
TM3 2560 L 3.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM3 2561 T 3.59x59 GLP-1 receptor 5NX2 - -
TM3 2562 E 3.60x60 GLP-1 receptor 5NX2 - -
ICL2 2563 V - - - -
ICL2 2564 R secretin receptor 7D3S - -
ICL2 2565 N - - - -
TM4 2566 I 4.37x38 secretin receptor 7D3S - -
TM4 2567 D 4.38x39 GLP-1 receptor 5NX2 - -
TM4 2568 T 4.39x40 GLP-1 receptor 5NX2 - -
TM4 2569 G 4.40x41 GLP-1 receptor 5NX2 - -
TM4 2570 P 4.41x42 GLP-1 receptor 5NX2 - -
TM4 2571 M 4.42x43 GLP-1 receptor 5NX2 - -
TM4 2572 R 4.43x44 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 2573 F 4.44x45 GLP-1 receptor 5NX2 - -
TM4 2574 Y 4.45x46 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 2575 Y 4.46x47 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM4 2576 V 4.47x48 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM4 2577 V 4.48x49 GLP-1 receptor 5NX2 - -
TM4 2578 G 4.49x491 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 2579 W 4.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 2580 G 4.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 2581 I 4.52x52 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM4 2582 P 4.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM4 2583 A 4.54x54 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 2584 I 4.55x55 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 2585 V 4.56x56 GLP-1 receptor 5NX2 - -
TM4 2586 T 4.57x57 GLP-1 receptor 5NX2 VPAC1 receptor 6VN7
TM4 2587 G 4.58x58 GLP-1 receptor 5NX2 GHRH receptor 7CZ5
TM4 2588 L 4.59x59 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM4 2589 A 4.60x60 GLP-1 receptor 5NX2 - -
TM4 2590 V 4.61x61 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM4 2591 G 4.62x62 GLP-1 receptor 5NX2 - -
TM4 2592 L 4.63x63 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM4 2593 D 4.64x64 GLP-1 receptor 5NX2 - -
TM4 2594 P 4.65x65 GLP-1 receptor 5NX2 - -
TM4 2595 Q 4.66x66 GLP-1 receptor 5NX2 - -
TM4 2596 G 4.67x67 GLP-1 receptor 5NX2 - -
TM4 2597 Y 4.68x68 secretin receptor 7D3S calcitonin receptor-like receptor 6UUS
ECL2 2598 G - - - -
ECL2 2599 N - - - -
ECL2 2600 P - - - -
ECL2 2601 D - - - -
ECL2 2602 F - - - -
ECL2 2603 C 45.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 2604 W 45.51x51 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
ECL2 2605 L 45.52x52 GLP-1 receptor 5NX2 CT receptor 6NIY
ECL2 2606 S - - - -
ECL2 2607 L - - - -
TM5 2608 Q 5.32x32 - - - -
TM5 2609 D 5.33x33 GLP-1 receptor 5NX2 - -
TM5 2610 T 5.34x34 GLP-1 receptor 5NX2 PAC1 receptor 6P9Y
TM5 2611 L 5.35x35 GLP-1 receptor 5NX2 - -
TM5 2612 I 5.36x36 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 2613 W 5.37x37 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 2614 S 5.38x38 GLP-1 receptor 5NX2 - -
TM5 2615 F 5.39x39 GLP-1 receptor 5NX2 - -
TM5 2616 A 5.40x40 GLP-1 receptor 5NX2 - -
TM5 2617 G 5.41x41 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 2618 P 5.42x42 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 2619 I 5.43x43 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 2620 G 5.44x44 GLP-1 receptor 5NX2 - -
TM5 2621 A 5.45x45 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM5 2622 V 5.46x46 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM5 2623 I 5.47x47 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 2624 I 5.48x48 GLP-1 receptor 5NX2 GLP-1 receptor 5VEW
TM5 2625 I 5.49x49 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM5 2626 N 5.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 2627 T 5.51x51 GLP-1 receptor 5NX2 - -
TM5 2628 V 5.52x52 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM5 2629 T 5.53x53 GLP-1 receptor 5NX2 - -
TM5 2630 S 5.54x54 GLP-1 receptor 5NX2 - -
TM5 2631 V 5.55x55 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM5 2632 L 5.56x56 GLP-1 receptor 5NX2 - -
TM5 2633 S 5.57x57 GLP-1 receptor 5NX2 - -
TM5 2634 A 5.58x58 GLP-1 receptor 5NX2 - -
TM5 2635 K 5.59x59 GLP-1 receptor 5NX2 - -
TM5 2636 V 5.60x60 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM5 2637 S 5.61x61 GLP-1 receptor 5NX2 - -
TM5 2638 C 5.62x62 GLP-1 receptor 5NX2 - -
TM5 2639 Q 5.63x63 GLP-1 receptor 5NX2 VPAC1 receptor 6VN7
TM5 2640 R 5.64x64 GLP-1 receptor 5NX2 - -
TM5 2641 K 5.65x65 GLP-1 receptor 5NX2 - -
ICL3 2642 H - - - -
ICL3 2643 H - - - -
ICL3 2644 Y - - - -
ICL3 2645 Y - - - -
ICL3 2646 G - - - -
ICL3 2647 K - - - -
ICL3 2648 K - - - -
TM6 2649 G 6.34x34 GLP-1 receptor 5NX2 - -
TM6 2650 I 6.35x35 GLP-1 receptor 5NX2 - -
TM6 2651 V 6.36x36 GLP-1 receptor 5NX2 - -
TM6 2652 S 6.37x37 GLP-1 receptor 5NX2 - -
TM6 2653 L 6.38x38 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 2654 L 6.39x39 GLP-1 receptor 5NX2 PTH1 receptor 6NBI
TM6 2655 R 6.40x40 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM6 2656 T 6.41x41 GLP-1 receptor 5NX2 - -
TM6 2657 A 6.42x42 GLP-1 receptor 5NX2 - -
TM6 2658 F 6.43x43 GLP-1 receptor 5NX2 - -
TM6 2659 L 6.44x44 GLP-1 receptor 5NX2 secretin receptor 6WZG
TM6 2660 L 6.45x45 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 2661 L 6.46x46 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM6 2662 L 6.47x47 GLP-1 receptor 5NX2 - -
TM6 2663 L 6.48x48 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM6 2664 I 6.49x49 GLP-1 receptor 5NX2 - -
TM6 2665 S 6.50x50 GLP-1 receptor 5NX2 - -
TM6 2666 A 6.51x51 GLP-1 receptor 5NX2 - -
TM6 2667 T 6.52x52 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM6 2668 W 6.53x53 GLP-1 receptor 5NX2 - -
TM6 2669 L 6.54x54 GLP-1 receptor 5NX2 - -
TM6 2670 L 6.55x55 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UVA
TM6 2671 G 6.56x56 GLP-1 receptor 5NX2 - -
TM6 2672 L 6.57x57 GLP-1 receptor 5NX2 - -
TM6 2673 L 6.58x58 GLP-1 receptor 5NX2 PTH1 receptor 6FJ3
TM6 2674 A 6.59x59 PTH1 receptor 6FJ3 - -
ECL3 2675 V - - - -
ECL3 2676 N - - - -
ECL3 2677 R - - - -
ECL3 2678 D - - - -
TM7 2679 A 7.35x34 GLP-1 receptor 5NX2 - -
TM7 2680 L 7.36x35 GLP-1 receptor 5NX2 - -
TM7 2681 S 7.37x36 GLP-1 receptor 5NX2 - -
TM7 2682 F 7.38x37 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM7 2683 H 7.39x38 GLP-1 receptor 5NX2 - -
TM7 2684 Y 7.40x39 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM7 2685 L 7.41x40 GLP-1 receptor 5NX2 GHRH receptor 7CZ5
TM7 2686 F 7.42x41 GLP-1 receptor 5NX2 - -
TM7 2687 A 7.43x42 GLP-1 receptor 5NX2 CRF1 receptor 4Z9G
TM7 2688 I 7.44x43 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
TM7 2689 F 7.45x44 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 2690 S 7.46x45 GLP-1 receptor 5NX2 glucagon receptor 5XEZ
TM7 2691 G 7.47x46 GLP-1 receptor 5NX2 - -
TM7 2692 L 7.48x47 GLP-1 receptor 5NX2 - -
TM7 2693 Q 7.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 2694 G 7.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 2695 P 7.51x51 GLP-1 receptor 5NX2 - -
TM7 2696 F 7.52x52 GLP-1 receptor 5NX2 CT receptor 6NIY
TM7 2697 V 7.53x53 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 2698 L 7.54x54 GLP-1 receptor 5NX2 - -
TM7 2699 L 7.55x55 GLP-1 receptor 5NX2 - -
TM7 2700 F 7.56x56 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
TM7 2701 H 7.57x57 GLP-1 receptor 5NX2 - -
TM7 2702 C 7.58x58 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
TM7 2703 V 7.59x59 GLP-1 receptor 5NX2 - -
TM7 2704 L 7.60x60 GLP-1 receptor 5NX2 secretin receptor 6WZG
H8 2705 N 8.47x47 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 2706 Q 8.48x48 GLP-1 receptor 5NX2 GHRH receptor 7CZ5
H8 2707 E 8.49x49 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 2708 V 8.50x50 GLP-1 receptor 5NX2 GLP-1 receptor 5NX2
H8 2709 R 8.51x51 GLP-1 receptor 5NX2 CRF2 receptor 6PB1
H8 2710 K 8.52x52 GLP-1 receptor 5NX2 - -
H8 2711 H 8.53x53 GLP-1 receptor 5NX2 - -
H8 2712 L 8.54x54 GLP-1 receptor 5NX2 calcitonin receptor-like receptor 6UUS
H8 2713 K 8.55x55 GLP-1 receptor 5NX2 CT receptor 6NIY
H8 2714 G 8.56x56 GLP-1 receptor 5NX2 - -
H8 2715 V 8.57x57 GLP-1 receptor 5NX2 - -
H8 2716 L 8.58x58 secretin receptor 6WZG - -
H8 2717 G 8.59x59 secretin receptor 6WZG - -
H8 2718 G 8.60x60 secretin receptor 6WZG GHRH receptor 7CZ5
H8 2719 R 8.61x61 secretin receptor 6WZG - -
H8 2720 K 8.62x62 secretin receptor 6WZG CT receptor 6NIY
H8 2721 L 8.63x63 secretin receptor 6WZG secretin receptor 6WZG
C-term 2722 H - - - -
C-term 2723 L - - - -
C-term 2724 E - - - -
C-term 2725 D - - - -
C-term 2726 S - - - -